Incidental Mutation 'IGL01884:Olfr809'
ID179069
Institutional Source Australian Phenomics Network (link to record)
Gene Symbol Olfr809
Ensembl Gene ENSMUSG00000050251
Gene Nameolfactory receptor 809
SynonymsMOR108-4, GA_x6K02T2PULF-11454600-11455541
Accession Numbers
Is this an essential gene? Probably non essential (E-score: 0.111) question?
Stock #IGL01884
Quality Score
Status
Chromosome10
Chromosomal Location129774638-129778937 bp(+) (GRCm38)
Type of Mutationmissense
DNA Base Change (assembly) A to G at 129776828 bp
ZygosityHeterozygous
Amino Acid Change Lysine to Glutamic Acid at position 320 (K320E)
Ref Sequence ENSEMBL: ENSMUSP00000151711 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000059891] [ENSMUST00000203598] [ENSMUST00000204622] [ENSMUST00000218237]
Predicted Effect probably benign
Transcript: ENSMUST00000059891
AA Change: K305E

PolyPhen 2 Score 0.123 (Sensitivity: 0.93; Specificity: 0.86)
SMART Domains Protein: ENSMUSP00000054949
Gene: ENSMUSG00000050251
AA Change: K305E

DomainStartEndE-ValueType
Pfam:7tm_4 44 321 3.5e-49 PFAM
Pfam:7tm_1 54 303 1.3e-21 PFAM
Predicted Effect probably benign
Transcript: ENSMUST00000203598
SMART Domains Protein: ENSMUSP00000145037
Gene: ENSMUSG00000050251

DomainStartEndE-ValueType
Pfam:7tm_4 29 148 8.1e-20 PFAM
Pfam:7tm_1 39 149 1.8e-17 PFAM
Predicted Effect noncoding transcript
Transcript: ENSMUST00000204622
AA Change: K320E
SMART Domains Protein: ENSMUSP00000145260
Gene: ENSMUSG00000052818
AA Change: K320E

DomainStartEndE-ValueType
Pfam:7tm_4 44 321 3.5e-49 PFAM
Pfam:7tm_1 54 303 1.3e-21 PFAM
Predicted Effect probably benign
Transcript: ENSMUST00000218237
AA Change: K320E

PolyPhen 2 Score 0.337 (Sensitivity: 0.90; Specificity: 0.89)
Coding Region Coverage
Validation Efficiency
MGI Phenotype FUNCTION: Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitter and hormone receptors and are responsible for the recognition and G protein-mediated transduction of odorant signals. The olfactory receptor gene family is the largest in the genome. The nomenclature assigned to the olfactory receptor genes and proteins for this organism is independent of other organisms. [provided by RefSeq, Jul 2008]
Allele List at MGI
Other mutations in this stock
Total: 23 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
1190005I06Rik G A 8: 120,609,035 probably benign Het
Col11a1 G A 3: 114,066,542 G206R unknown Het
Cyp2e1 T C 7: 140,773,750 Y426H probably benign Het
Fcrl1 A G 3: 87,384,737 K68E probably damaging Het
Gabbr2 A G 4: 46,875,711 V137A probably damaging Het
Gm10718 A T 9: 3,025,118 Y194F probably benign Het
Gm21738 G A 14: 19,416,979 S144L probably benign Het
Hacd1 G A 2: 14,035,782 P221S probably damaging Het
Kndc1 C T 7: 139,914,194 T535I probably damaging Het
Lce1f G T 3: 92,719,301 C16* probably null Het
Lrba C T 3: 86,310,412 A543V possibly damaging Het
Lrp1b A T 2: 41,284,213 C676* probably null Het
Mocos A G 18: 24,683,216 K617E probably damaging Het
Muc5b A G 7: 141,868,083 probably benign Het
Mylk A T 16: 34,988,877 probably benign Het
Naip2 A G 13: 100,188,821 probably benign Het
Pcdhb5 C T 18: 37,321,334 P256S probably benign Het
Rbl2 A G 8: 91,096,836 E464G probably damaging Het
Rfc1 A T 5: 65,274,460 L769Q possibly damaging Het
Setd7 T C 3: 51,542,711 Y98C possibly damaging Het
Tbc1d8 A G 1: 39,376,445 Y920H probably damaging Het
Tcte1 T C 17: 45,539,809 probably null Het
Vmn2r-ps159 C T 4: 156,338,254 noncoding transcript Het
Other mutations in Olfr809
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL02000:Olfr809 APN 10 129776069 missense probably benign 0.03
IGL02146:Olfr809 APN 10 129776858 utr 3 prime probably benign
IGL03087:Olfr809 APN 10 129776261 missense probably damaging 0.98
IGL03260:Olfr809 APN 10 129776652 missense probably damaging 1.00
PIT4466001:Olfr809 UTSW 10 129776273 missense probably benign 0.04
R0564:Olfr809 UTSW 10 129776136 missense probably damaging 1.00
R0613:Olfr809 UTSW 10 129776262 missense probably damaging 1.00
R1165:Olfr809 UTSW 10 129776433 missense probably damaging 0.99
R1556:Olfr809 UTSW 10 129776373 missense probably benign 0.05
R5392:Olfr809 UTSW 10 129776315 missense probably benign 0.01
R6665:Olfr809 UTSW 10 129776247 missense probably damaging 1.00
R7519:Olfr809 UTSW 10 129776222 missense probably benign 0.01
R7804:Olfr809 UTSW 10 129776222 missense probably benign 0.01
R8022:Olfr809 UTSW 10 129776785 missense possibly damaging 0.47
R8301:Olfr809 UTSW 10 129776840 missense probably benign 0.06
R8447:Olfr809 UTSW 10 129776502 missense possibly damaging 0.89
Z1176:Olfr809 UTSW 10 129776042 missense probably damaging 1.00
Posted On2014-05-07