Incidental Mutation 'R0100:Il17b'
ID 17907
Institutional Source Beutler Lab
Gene Symbol Il17b
Ensembl Gene ENSMUSG00000024578
Gene Name interleukin 17B
Synonyms 1110006O16Rik, 1700006N07Rik, Zcyto7
MMRRC Submission 038386-MU
Accession Numbers
Essential gene? Probably non essential (E-score: 0.150) question?
Stock # R0100 (G1)
Quality Score
Status Validated
Chromosome 18
Chromosomal Location 61821006-61825609 bp(+) (GRCm39)
Type of Mutation missense
DNA Base Change (assembly) A to G at 61823342 bp (GRCm39)
Zygosity Heterozygous
Amino Acid Change Methionine to Valine at position 59 (M59V)
Ref Sequence ENSEMBL: ENSMUSP00000025471 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000025471]
AlphaFold Q9QXT6
Predicted Effect probably benign
Transcript: ENSMUST00000025471
AA Change: M59V

PolyPhen 2 Score 0.088 (Sensitivity: 0.93; Specificity: 0.85)
SMART Domains Protein: ENSMUSP00000025471
Gene: ENSMUSG00000024578
AA Change: M59V

DomainStartEndE-ValueType
signal peptide 1 22 N/A INTRINSIC
Pfam:IL17 96 179 1.4e-29 PFAM
Predicted Effect noncoding transcript
Transcript: ENSMUST00000191654
Meta Mutation Damage Score 0.0600 question?
Coding Region Coverage
  • 1x: 90.3%
  • 3x: 88.1%
  • 10x: 82.7%
  • 20x: 75.2%
Validation Efficiency 89% (68/76)
MGI Phenotype FUNCTION: [Summary is not available for the mouse gene. This summary is for the human ortholog.] The protein encoded by this gene is a T cell-derived cytokine that shares sequence similarity with IL17. This cytokine was reported to stimulate the release of TNF alpha (TNF) and IL1 beta (IL1B) from a monocytic cell line. Immunohistochemical analysis of several nerve tissues indicated that this cytokine is primarily localized to neuronal cell bodies. Alternative splicing results in multiple splice variants. [provided by RefSeq, Dec 2015]
PHENOTYPE: Mice homozygous for a gene trap allele exhibit increased susceptibility to DDS-induced colitis and Citrobacter rodentium infection. [provided by MGI curators]
Allele List at MGI
Other mutations in this stock
Total: 42 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
Agrn A G 4: 156,259,415 (GRCm39) C814R probably damaging Het
Aoc1 T C 6: 48,885,538 (GRCm39) I681T possibly damaging Het
Atp13a4 T C 16: 29,240,542 (GRCm39) H793R probably damaging Het
Atp6v0a4 T C 6: 38,053,750 (GRCm39) I351V probably benign Het
Bbof1 T A 12: 84,457,829 (GRCm39) D31E probably benign Het
Cpxm2 T A 7: 131,656,600 (GRCm39) H554L possibly damaging Het
Ddx55 C T 5: 124,694,845 (GRCm39) T91I probably damaging Het
Dhx57 T C 17: 80,582,585 (GRCm39) D340G possibly damaging Het
Dnah1 C T 14: 30,984,109 (GRCm39) probably null Het
Dpp9 C T 17: 56,512,854 (GRCm39) G118D possibly damaging Het
Etl4 T C 2: 20,344,716 (GRCm39) S4P probably benign Het
Fat4 A C 3: 39,034,397 (GRCm39) N2683T probably damaging Het
Gabrb2 A G 11: 42,378,141 (GRCm39) D119G probably damaging Het
Garre1 A G 7: 33,953,436 (GRCm39) I442T possibly damaging Het
Greb1 T A 12: 16,730,225 (GRCm39) Q1734L probably benign Het
Gtf2ird2 T C 5: 134,245,857 (GRCm39) L705P probably damaging Het
H13 T A 2: 152,531,783 (GRCm39) probably null Het
Hgs T G 11: 120,373,678 (GRCm39) Y708D possibly damaging Het
Hip1 T C 5: 135,465,307 (GRCm39) D367G probably benign Het
Ift140 C T 17: 25,309,928 (GRCm39) Q1112* probably null Het
Lpin3 T C 2: 160,747,260 (GRCm39) Y829H probably damaging Het
Lrrk2 A T 15: 91,629,999 (GRCm39) N1230I probably damaging Het
Mindy2 C A 9: 70,514,731 (GRCm39) probably benign Het
Nup210 T G 6: 91,046,175 (GRCm39) E586A probably benign Het
Or1j17 A T 2: 36,578,923 (GRCm39) N303I probably benign Het
Or2bd2 C T 7: 6,443,399 (GRCm39) R167C probably damaging Het
Or5be3 T C 2: 86,863,939 (GRCm39) T209A probably benign Het
Osgepl1 A G 1: 53,362,372 (GRCm39) I405V probably damaging Het
Pdcd11 T C 19: 47,091,105 (GRCm39) S360P probably benign Het
Plekha6 T C 1: 133,197,915 (GRCm39) S271P probably damaging Het
Plekhs1 A G 19: 56,466,934 (GRCm39) E255G probably damaging Het
Pram1 T A 17: 33,860,373 (GRCm39) N313K possibly damaging Het
Rapgef5 C T 12: 117,685,034 (GRCm39) S261L probably benign Het
Spint5 T A 2: 164,558,920 (GRCm39) C49S probably damaging Het
Tex22 T A 12: 113,052,392 (GRCm39) I150N probably benign Het
Thoc6 A T 17: 23,888,824 (GRCm39) W195R probably damaging Het
Tmem106a T C 11: 101,477,084 (GRCm39) S98P probably benign Het
Tnfrsf18 A G 4: 156,112,823 (GRCm39) T170A probably benign Het
Tor1aip1 A T 1: 155,882,821 (GRCm39) D342E probably damaging Het
Trav7-6 T C 14: 53,954,529 (GRCm39) S20P probably damaging Het
Trpc6 C T 9: 8,653,035 (GRCm39) P614S probably damaging Het
Washc5 A G 15: 59,215,947 (GRCm39) F811L possibly damaging Het
Other mutations in Il17b
AlleleSourceChrCoordTypePredicted EffectPPH Score
R0045:Il17b UTSW 18 61,823,315 (GRCm39) missense probably damaging 0.99
R0100:Il17b UTSW 18 61,823,342 (GRCm39) missense probably benign 0.09
R1375:Il17b UTSW 18 61,823,325 (GRCm39) missense probably benign
R1468:Il17b UTSW 18 61,823,483 (GRCm39) splice site probably null
R1468:Il17b UTSW 18 61,823,483 (GRCm39) splice site probably null
R1517:Il17b UTSW 18 61,823,316 (GRCm39) missense probably damaging 0.98
R2157:Il17b UTSW 18 61,823,439 (GRCm39) missense probably damaging 0.98
R7869:Il17b UTSW 18 61,825,480 (GRCm39) missense probably damaging 0.99
R9310:Il17b UTSW 18 61,825,334 (GRCm39) nonsense probably null
R9616:Il17b UTSW 18 61,825,363 (GRCm39) missense probably benign 0.16
Posted On 2013-03-25