Incidental Mutation 'R0100:Il17b'
ID 17907
Institutional Source Beutler Lab
Gene Symbol Il17b
Ensembl Gene ENSMUSG00000024578
Gene Name interleukin 17B
Synonyms Zcyto7, 1700006N07Rik, 1110006O16Rik
MMRRC Submission 038386-MU
Accession Numbers
Essential gene? Probably non essential (E-score: 0.148) question?
Stock # R0100 (G1)
Quality Score
Status Validated
Chromosome 18
Chromosomal Location 61687935-61692537 bp(+) (GRCm38)
Type of Mutation missense
DNA Base Change (assembly) A to G at 61690271 bp (GRCm38)
Zygosity Heterozygous
Amino Acid Change Methionine to Valine at position 59 (M59V)
Ref Sequence ENSEMBL: ENSMUSP00000025471 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000025471]
AlphaFold Q9QXT6
Predicted Effect probably benign
Transcript: ENSMUST00000025471
AA Change: M59V

PolyPhen 2 Score 0.088 (Sensitivity: 0.93; Specificity: 0.85)
SMART Domains Protein: ENSMUSP00000025471
Gene: ENSMUSG00000024578
AA Change: M59V

signal peptide 1 22 N/A INTRINSIC
Pfam:IL17 96 179 1.4e-29 PFAM
Predicted Effect noncoding transcript
Transcript: ENSMUST00000191654
Meta Mutation Damage Score 0.0600 question?
Coding Region Coverage
  • 1x: 90.3%
  • 3x: 88.1%
  • 10x: 82.7%
  • 20x: 75.2%
Validation Efficiency 89% (68/76)
MGI Phenotype FUNCTION: [Summary is not available for the mouse gene. This summary is for the human ortholog.] The protein encoded by this gene is a T cell-derived cytokine that shares sequence similarity with IL17. This cytokine was reported to stimulate the release of TNF alpha (TNF) and IL1 beta (IL1B) from a monocytic cell line. Immunohistochemical analysis of several nerve tissues indicated that this cytokine is primarily localized to neuronal cell bodies. Alternative splicing results in multiple splice variants. [provided by RefSeq, Dec 2015]
PHENOTYPE: Mice homozygous for a gene trap allele exhibit increased susceptibility to DDS-induced colitis and Citrobacter rodentium infection. [provided by MGI curators]
Allele List at MGI
Other mutations in this stock
Total: 42 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
4931406P16Rik A G 7: 34,254,011 (GRCm38) I442T possibly damaging Het
Agrn A G 4: 156,174,958 (GRCm38) C814R probably damaging Het
Aoc1 T C 6: 48,908,604 (GRCm38) I681T possibly damaging Het
Atp13a4 T C 16: 29,421,724 (GRCm38) H793R probably damaging Het
Atp6v0a4 T C 6: 38,076,815 (GRCm38) I351V probably benign Het
Bbof1 T A 12: 84,411,055 (GRCm38) D31E probably benign Het
Cpxm2 T A 7: 132,054,871 (GRCm38) H554L possibly damaging Het
Ddx55 C T 5: 124,556,782 (GRCm38) T91I probably damaging Het
Dhx57 T C 17: 80,275,156 (GRCm38) D340G possibly damaging Het
Dnah1 C T 14: 31,262,152 (GRCm38) probably null Het
Dpp9 C T 17: 56,205,854 (GRCm38) G118D possibly damaging Het
Etl4 T C 2: 20,339,905 (GRCm38) S4P probably benign Het
Fat4 A C 3: 38,980,248 (GRCm38) N2683T probably damaging Het
Gabrb2 A G 11: 42,487,314 (GRCm38) D119G probably damaging Het
Greb1 T A 12: 16,680,224 (GRCm38) Q1734L probably benign Het
Gtf2ird2 T C 5: 134,217,015 (GRCm38) L705P probably damaging Het
H13 T A 2: 152,689,863 (GRCm38) probably null Het
Hgs T G 11: 120,482,852 (GRCm38) Y708D possibly damaging Het
Hip1 T C 5: 135,436,453 (GRCm38) D367G probably benign Het
Ift140 C T 17: 25,090,954 (GRCm38) Q1112* probably null Het
Lpin3 T C 2: 160,905,340 (GRCm38) Y829H probably damaging Het
Lrrk2 A T 15: 91,745,796 (GRCm38) N1230I probably damaging Het
Mindy2 C A 9: 70,607,449 (GRCm38) probably benign Het
Nup210 T G 6: 91,069,193 (GRCm38) E586A probably benign Het
Olfr1105 T C 2: 87,033,595 (GRCm38) T209A probably benign Het
Olfr1344 C T 7: 6,440,400 (GRCm38) R167C probably damaging Het
Olfr346 A T 2: 36,688,911 (GRCm38) N303I probably benign Het
Osgepl1 A G 1: 53,323,213 (GRCm38) I405V probably damaging Het
Pdcd11 T C 19: 47,102,666 (GRCm38) S360P probably benign Het
Plekha6 T C 1: 133,270,177 (GRCm38) S271P probably damaging Het
Plekhs1 A G 19: 56,478,502 (GRCm38) E255G probably damaging Het
Pram1 T A 17: 33,641,399 (GRCm38) N313K possibly damaging Het
Rapgef5 C T 12: 117,721,299 (GRCm38) S261L probably benign Het
Spint5 T A 2: 164,717,000 (GRCm38) C49S probably damaging Het
Tex22 T A 12: 113,088,772 (GRCm38) I150N probably benign Het
Thoc6 A T 17: 23,669,850 (GRCm38) W195R probably damaging Het
Tmem106a T C 11: 101,586,258 (GRCm38) S98P probably benign Het
Tnfrsf18 A G 4: 156,028,366 (GRCm38) T170A probably benign Het
Tor1aip1 A T 1: 156,007,075 (GRCm38) D342E probably damaging Het
Trav7-6 T C 14: 53,717,072 (GRCm38) S20P probably damaging Het
Trpc6 C T 9: 8,653,034 (GRCm38) P614S probably damaging Het
Washc5 A G 15: 59,344,098 (GRCm38) F811L possibly damaging Het
Other mutations in Il17b
AlleleSourceChrCoordTypePredicted EffectPPH Score
R0045:Il17b UTSW 18 61,690,244 (GRCm38) missense probably damaging 0.99
R0100:Il17b UTSW 18 61,690,271 (GRCm38) missense probably benign 0.09
R1375:Il17b UTSW 18 61,690,254 (GRCm38) missense probably benign
R1468:Il17b UTSW 18 61,690,412 (GRCm38) splice site probably null
R1468:Il17b UTSW 18 61,690,412 (GRCm38) splice site probably null
R1517:Il17b UTSW 18 61,690,245 (GRCm38) missense probably damaging 0.98
R2157:Il17b UTSW 18 61,690,368 (GRCm38) missense probably damaging 0.98
R7869:Il17b UTSW 18 61,692,409 (GRCm38) missense probably damaging 0.99
R9310:Il17b UTSW 18 61,692,263 (GRCm38) nonsense probably null
R9616:Il17b UTSW 18 61,692,292 (GRCm38) missense probably benign 0.16
Posted On 2013-03-25