Incidental Mutation 'IGL01885:Olfr1472'
ID 179089
Institutional Source Australian Phenomics Network (link to record)
Gene Symbol Olfr1472
Ensembl Gene ENSMUSG00000095189
Gene Name olfactory receptor 1472
Synonyms GA_x6K02T2RE5P-3787124-3786180, MOR202-16
Accession Numbers
Is this an essential gene? Probably non essential (E-score: 0.150) question?
Stock # IGL01885
Quality Score
Status
Chromosome 19
Chromosomal Location 13453280-13456086 bp(-) (GRCm38)
Type of Mutation missense
DNA Base Change (assembly) G to A at 13454085 bp (GRCm38)
Zygosity Heterozygous
Amino Acid Change Threonine to Isoleucine at position 144 (T144I)
Ref Sequence ENSEMBL: ENSMUSP00000093915 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000077501] [ENSMUST00000096201]
AlphaFold Q7TQQ9
Predicted Effect probably benign
Transcript: ENSMUST00000077501
AA Change: T144I

PolyPhen 2 Score 0.001 (Sensitivity: 0.99; Specificity: 0.15)
SMART Domains Protein: ENSMUSP00000076707
Gene: ENSMUSG00000095189
AA Change: T144I

DomainStartEndE-ValueType
Pfam:7tm_4 29 306 2.4e-51 PFAM
Pfam:7TM_GPCR_Srsx 33 303 5.2e-8 PFAM
Pfam:7tm_1 39 288 6.9e-20 PFAM
Predicted Effect probably benign
Transcript: ENSMUST00000096201
AA Change: T144I

PolyPhen 2 Score 0.001 (Sensitivity: 0.99; Specificity: 0.15)
SMART Domains Protein: ENSMUSP00000093915
Gene: ENSMUSG00000095189
AA Change: T144I

DomainStartEndE-ValueType
Pfam:7tm_4 30 306 3.9e-53 PFAM
Pfam:7TM_GPCR_Srsx 34 304 2.6e-6 PFAM
Pfam:7tm_1 40 289 1.2e-16 PFAM
Predicted Effect noncoding transcript
Transcript: ENSMUST00000213561
Coding Region Coverage
Validation Efficiency
MGI Phenotype FUNCTION: Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitter and hormone receptors and are responsible for the recognition and G protein-mediated transduction of odorant signals. The olfactory receptor gene family is the largest in the genome. The nomenclature assigned to the olfactory receptor genes and proteins for this organism is independent of other organisms. [provided by RefSeq, Jul 2008]
Allele List at MGI
Other mutations in this stock
Total: 40 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
Aars T C 8: 111,047,943 V568A possibly damaging Het
Abcb11 T A 2: 69,287,627 Q469L probably damaging Het
Ahsg G A 16: 22,898,981 G264E probably damaging Het
Ankar T C 1: 72,658,703 Y788C probably damaging Het
Birc6 T A 17: 74,604,516 F1508I possibly damaging Het
Cd6 C A 19: 10,799,237 Q141H probably benign Het
Cercam A C 2: 29,881,003 T471P probably damaging Het
Cux1 T C 5: 136,308,447 D729G possibly damaging Het
Dglucy T A 12: 100,850,281 F394Y probably damaging Het
E130308A19Rik A G 4: 59,720,004 N512S probably benign Het
Ephb4 T C 5: 137,357,797 C223R probably damaging Het
Gcn1l1 T A 5: 115,576,115 probably null Het
Gm10718 A T 9: 3,025,118 Y194F probably benign Het
Gm21738 G A 14: 19,416,979 S144L probably benign Het
Hirip3 T A 7: 126,864,209 S446T probably benign Het
Hoxa5 A T 6: 52,202,667 F243I probably damaging Het
Iars T C 13: 49,691,499 V162A probably benign Het
Lama2 G A 10: 27,105,139 R1840* probably null Het
Lbp T A 2: 158,324,573 L349Q probably damaging Het
Lrp4 T C 2: 91,501,107 I1604T probably benign Het
Mapk10 T C 5: 102,996,589 K121E probably damaging Het
Nav3 T A 10: 109,742,660 R1579* probably null Het
Obscn T C 11: 59,074,968 D652G possibly damaging Het
Olfr417 A G 1: 174,369,401 I161M probably damaging Het
Olfr849 A G 9: 19,441,464 I184V probably benign Het
Ostm1 C T 10: 42,698,151 S280L possibly damaging Het
Peak1 C T 9: 56,260,104 R180K probably damaging Het
Plcz1 T C 6: 140,002,111 Y515C probably benign Het
Postn T C 3: 54,376,034 probably benign Het
Ptchd4 C T 17: 42,503,602 T798I probably damaging Het
Rnf41 A T 10: 128,435,475 N85Y probably damaging Het
Shisa7 A T 7: 4,830,826 H323Q probably damaging Het
Slco2a1 T A 9: 103,074,430 M386K probably damaging Het
St18 G A 1: 6,844,372 probably null Het
Stra6 T A 9: 58,141,148 L175M probably damaging Het
Tmem67 A G 4: 12,057,389 L600P probably damaging Het
Try5 G T 6: 41,311,738 N182K possibly damaging Het
Vmn2r-ps159 C T 4: 156,338,254 noncoding transcript Het
Xpo7 G A 14: 70,666,035 T1078I probably benign Het
Zan G A 5: 137,464,124 T931I unknown Het
Other mutations in Olfr1472
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL00229:Olfr1472 APN 19 13453840 missense possibly damaging 0.46
IGL01755:Olfr1472 APN 19 13453815 missense probably damaging 1.00
IGL02366:Olfr1472 APN 19 13454127 missense probably damaging 1.00
IGL03074:Olfr1472 APN 19 13454053 missense probably damaging 0.98
R0592:Olfr1472 UTSW 19 13453705 missense probably benign 0.00
R1085:Olfr1472 UTSW 19 13454230 missense possibly damaging 0.75
R4207:Olfr1472 UTSW 19 13454471 missense probably benign 0.15
R4856:Olfr1472 UTSW 19 13454521 splice site probably null
R4886:Olfr1472 UTSW 19 13454521 splice site probably null
R5061:Olfr1472 UTSW 19 13453985 nonsense probably null
R5167:Olfr1472 UTSW 19 13454377 missense probably damaging 1.00
R5509:Olfr1472 UTSW 19 13453968 missense probably damaging 1.00
R5586:Olfr1472 UTSW 19 13454382 missense probably benign 0.02
R5987:Olfr1472 UTSW 19 13453960 missense possibly damaging 0.57
R6631:Olfr1472 UTSW 19 13453821 missense probably benign 0.00
R7976:Olfr1472 UTSW 19 13454199 missense probably benign
Posted On 2014-05-07