Incidental Mutation 'IGL01886:Olfr926'
ID 179124
Institutional Source Australian Phenomics Network (link to record)
Gene Symbol Olfr926
Ensembl Gene ENSMUSG00000064333
Gene Name olfactory receptor 926
Synonyms GA_x6K02T2PVTD-32573036-32573962, MOR171-8
Accession Numbers
Is this an essential gene? Probably non essential (E-score: 0.089) question?
Stock # IGL01886
Quality Score
Status
Chromosome 9
Chromosomal Location 38877126-38878176 bp(+) (GRCm38)
Type of Mutation missense
DNA Base Change (assembly) G to T at 38877548 bp (GRCm38)
Zygosity Heterozygous
Amino Acid Change Cysteine to Phenylalanine at position 124 (C124F)
Ref Sequence ENSEMBL: ENSMUSP00000077405 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000078289]
AlphaFold Q9EQ98
Predicted Effect probably damaging
Transcript: ENSMUST00000078289
AA Change: C124F

PolyPhen 2 Score 0.968 (Sensitivity: 0.77; Specificity: 0.95)
SMART Domains Protein: ENSMUSP00000077405
Gene: ENSMUSG00000064333
AA Change: C124F

DomainStartEndE-ValueType
Pfam:7tm_4 28 305 2.9e-53 PFAM
Pfam:7TM_GPCR_Srsx 32 282 8.6e-7 PFAM
Pfam:7tm_1 38 287 1.6e-20 PFAM
Coding Region Coverage
Validation Efficiency
MGI Phenotype FUNCTION: Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitter and hormone receptors and are responsible for the recognition and G protein-mediated transduction of odorant signals. The olfactory receptor gene family is the largest in the genome. The nomenclature assigned to the olfactory receptor genes and proteins for this organism is independent of other organisms. [provided by RefSeq, Jul 2008]
Allele List at MGI
Other mutations in this stock
Total: 43 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
Akt1 C T 12: 112,659,158 V136M probably benign Het
Ankrd34c A T 9: 89,730,265 L8M possibly damaging Het
Anks6 C A 4: 47,044,850 W352L probably damaging Het
Arhgap12 A T 18: 6,027,613 N768K probably damaging Het
C130026I21Rik A G 1: 85,254,186 probably benign Het
Clec7a A T 6: 129,463,177 probably benign Het
Cyp3a13 G A 5: 137,898,820 P411S probably damaging Het
Elavl2 A G 4: 91,264,093 V129A probably damaging Het
Ercc6 T A 14: 32,569,580 S994T possibly damaging Het
Esco1 T A 18: 10,595,262 K8I probably damaging Het
Esr1 T A 10: 4,856,861 I259K probably damaging Het
Filip1l A G 16: 57,571,250 I734V possibly damaging Het
Gm10717 C T 9: 3,025,616 S67L probably benign Het
Gm10718 A T 9: 3,025,118 Y194F probably benign Het
Gm21738 G A 14: 19,416,979 S144L probably benign Het
Grin3a T A 4: 49,702,814 I891F probably damaging Het
Kat7 T C 11: 95,306,133 T27A probably benign Het
Kdm1a A G 4: 136,561,016 probably null Het
Kifc5b T C 17: 26,932,117 V663A probably damaging Het
Lama1 T G 17: 67,807,797 S2314A probably benign Het
Lrrc69 C T 4: 14,703,984 V279I probably benign Het
Mast3 A T 8: 70,782,139 L774Q possibly damaging Het
Med27 C A 2: 29,413,482 P9Q probably damaging Het
Myo5a C A 9: 75,169,090 probably benign Het
Myoz1 T C 14: 20,655,309 K14E probably damaging Het
Neb T C 2: 52,183,845 probably benign Het
Nlrp1a T C 11: 71,123,501 T308A probably benign Het
Olfr364-ps1 A G 2: 37,146,509 Y99C probably damaging Het
Orc1 T A 4: 108,603,957 probably null Het
Pnkp G A 7: 44,862,207 A76T probably damaging Het
Polr3h T C 15: 81,917,390 E95G probably damaging Het
Prpf40b T A 15: 99,304,447 M62K unknown Het
Prpf8 C A 11: 75,495,744 Q1075K probably benign Het
Ptprg A G 14: 12,179,280 K766E probably benign Het
Rabgap1l A T 1: 160,342,042 N778K probably damaging Het
Riok3 T A 18: 12,139,385 N204K probably damaging Het
Shank3 A G 15: 89,531,663 K650E probably damaging Het
Sim1 T A 10: 50,984,315 S758T probably damaging Het
Slu7 T G 11: 43,439,260 N171K probably damaging Het
Sult6b2 A G 6: 142,790,126 probably null Het
Taf6l C T 19: 8,778,086 probably null Het
Ubtfl1 G A 9: 18,409,721 V182M possibly damaging Het
Vmn2r-ps159 C T 4: 156,338,254 noncoding transcript Het
Other mutations in Olfr926
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL02315:Olfr926 APN 9 38878057 missense probably damaging 1.00
IGL02626:Olfr926 APN 9 38877488 missense probably benign 0.05
IGL03001:Olfr926 APN 9 38878078 missense probably benign
IGL03085:Olfr926 APN 9 38877663 missense probably benign
R0365:Olfr926 UTSW 9 38877185 missense probably benign 0.00
R0600:Olfr926 UTSW 9 38877815 missense probably damaging 0.99
R0708:Olfr926 UTSW 9 38877275 missense probably damaging 0.97
R1178:Olfr926 UTSW 9 38877755 missense probably damaging 1.00
R1762:Olfr926 UTSW 9 38877785 missense probably damaging 0.98
R1856:Olfr926 UTSW 9 38877596 missense possibly damaging 0.58
R1924:Olfr926 UTSW 9 38877851 missense probably damaging 1.00
R2267:Olfr926 UTSW 9 38878063 missense probably benign 0.00
R3729:Olfr926 UTSW 9 38877251 missense probably damaging 1.00
R4290:Olfr926 UTSW 9 38877313 missense probably damaging 1.00
R4292:Olfr926 UTSW 9 38877313 missense probably damaging 1.00
R4293:Olfr926 UTSW 9 38877313 missense probably damaging 1.00
R4295:Olfr926 UTSW 9 38877313 missense probably damaging 1.00
R4973:Olfr926 UTSW 9 38878104 makesense probably null
R5026:Olfr926 UTSW 9 38877899 missense possibly damaging 0.95
R5086:Olfr926 UTSW 9 38877791 missense probably damaging 1.00
R5103:Olfr926 UTSW 9 38877576 missense probably damaging 1.00
R5817:Olfr926 UTSW 9 38877377 missense probably damaging 1.00
R5998:Olfr926 UTSW 9 38877869 missense probably damaging 0.99
R6101:Olfr926 UTSW 9 38877308 missense possibly damaging 0.95
R6105:Olfr926 UTSW 9 38877308 missense possibly damaging 0.95
R6176:Olfr926 UTSW 9 38877377 missense probably damaging 1.00
R6403:Olfr926 UTSW 9 38877242 missense probably damaging 0.97
R8116:Olfr926 UTSW 9 38877730 missense probably damaging 0.98
R8144:Olfr926 UTSW 9 38877366 missense probably damaging 1.00
R8972:Olfr926 UTSW 9 38877854 missense probably benign 0.00
RF014:Olfr926 UTSW 9 38877900 missense probably benign 0.14
X0022:Olfr926 UTSW 9 38877656 missense possibly damaging 0.84
Posted On 2014-05-07