Incidental Mutation 'IGL01886:Ptprg'
ID 179135
Institutional Source Australian Phenomics Network (link to record)
Gene Symbol Ptprg
Ensembl Gene ENSMUSG00000021745
Gene Name protein tyrosine phosphatase receptor type G
Synonyms RPTPgamma, 5430405N12Rik
Accession Numbers
Essential gene? Non essential (E-score: 0.000) question?
Stock # IGL01886
Quality Score
Status
Chromosome 14
Chromosomal Location 10227722-10916220 bp(-) (GRCm39)
Type of Mutation missense
DNA Base Change (assembly) A to G at 12179280 bp (GRCm38)
Zygosity Heterozygous
Amino Acid Change Lysine to Glutamic Acid at position 766 (K766E)
Ref Sequence ENSEMBL: ENSMUSP00000022264 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000022264] [ENSMUST00000142917] [ENSMUST00000226099]
AlphaFold no structure available at present
Predicted Effect probably benign
Transcript: ENSMUST00000022264
AA Change: K766E

PolyPhen 2 Score 0.225 (Sensitivity: 0.91; Specificity: 0.88)
SMART Domains Protein: ENSMUSP00000022264
Gene: ENSMUSG00000021745
AA Change: K766E

DomainStartEndE-ValueType
Carb_anhydrase 60 321 6.38e-109 SMART
FN3 347 433 5.4e-7 SMART
low complexity region 474 484 N/A INTRINSIC
low complexity region 515 525 N/A INTRINSIC
coiled coil region 581 617 N/A INTRINSIC
transmembrane domain 734 756 N/A INTRINSIC
PTPc 844 1118 1.76e-136 SMART
PTPc 1146 1409 1.32e-85 SMART
Predicted Effect probably benign
Transcript: ENSMUST00000142917
SMART Domains Protein: ENSMUSP00000121268
Gene: ENSMUSG00000021745

DomainStartEndE-ValueType
Carb_anhydrase 60 260 1.6e-50 SMART
Predicted Effect noncoding transcript
Transcript: ENSMUST00000223890
Predicted Effect probably benign
Transcript: ENSMUST00000226099
Coding Region Coverage
Validation Efficiency
MGI Phenotype FUNCTION: [Summary is not available for the mouse gene. This summary is for the human ortholog.] The protein encoded by this gene is a member of the protein tyrosine phosphatase (PTP) family. PTPs are known to be signaling molecules that regulate a variety of cellular processes including cell growth, differentiation, mitotic cycle, and oncogenic transformation. This PTP possesses an extracellular region, a single transmembrane region, and two tandem intracytoplasmic catalytic domains, and thus represents a receptor-type PTP. The extracellular region of this PTP contains a carbonic anhydrase-like (CAH) domain, which is also found in the extracellular region of PTPRBETA/ZETA. This gene is located in a chromosomal region that is frequently deleted in renal cell carcinoma and lung carcinoma, thus is thought to be a candidate tumor suppressor gene. [provided by RefSeq, Jul 2008]
PHENOTYPE: Mice homozygous for a knock-out allele are overtly normal but exhibit minor behavioral changes including specific motor deficits, reduced latency to react in the tail flick test, enhanced sensory processing for acoustic stimuli, and reduced performance with cued fear conditioning. [provided by MGI curators]
Allele List at MGI
Other mutations in this stock
Total: 43 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
Akt1 C T 12: 112,625,592 (GRCm39) V136M probably benign Het
Ankrd34c A T 9: 89,612,318 (GRCm39) L8M possibly damaging Het
Anks6 C A 4: 47,044,850 (GRCm39) W352L probably damaging Het
Arhgap12 A T 18: 6,027,613 (GRCm39) N768K probably damaging Het
Clec7a A T 6: 129,440,140 (GRCm39) probably benign Het
Cyp3a13 G A 5: 137,897,082 (GRCm39) P411S probably damaging Het
Elavl2 A G 4: 91,152,330 (GRCm39) V129A probably damaging Het
Ercc6 T A 14: 32,291,537 (GRCm39) S994T possibly damaging Het
Esco1 T A 18: 10,595,262 (GRCm39) K8I probably damaging Het
Esr1 T A 10: 4,806,861 (GRCm39) I259K probably damaging Het
Filip1l A G 16: 57,391,613 (GRCm39) I734V possibly damaging Het
Gm10717 C T 9: 3,025,616 (GRCm39) S67L probably benign Het
Gm10718 A T 9: 3,025,118 (GRCm39) Y194F probably benign Het
Gm21738 G A 14: 19,416,979 (GRCm38) S144L probably benign Het
Grin3a T A 4: 49,702,814 (GRCm39) I891F probably damaging Het
Kat7 T C 11: 95,196,959 (GRCm39) T27A probably benign Het
Kdm1a A G 4: 136,288,327 (GRCm39) probably null Het
Kifc5b T C 17: 27,151,091 (GRCm39) V663A probably damaging Het
Lama1 T G 17: 68,114,792 (GRCm39) S2314A probably benign Het
Lrrc69 C T 4: 14,703,984 (GRCm39) V279I probably benign Het
Mast3 A T 8: 71,234,783 (GRCm39) L774Q possibly damaging Het
Med27 C A 2: 29,303,494 (GRCm39) P9Q probably damaging Het
Myo5a C A 9: 75,076,372 (GRCm39) probably benign Het
Myoz1 T C 14: 20,705,377 (GRCm39) K14E probably damaging Het
Neb T C 2: 52,073,857 (GRCm39) probably benign Het
Nlrp1a T C 11: 71,014,327 (GRCm39) T308A probably benign Het
Or1l4b A G 2: 37,036,521 (GRCm39) Y99C probably damaging Het
Or8d2b G T 9: 38,788,844 (GRCm39) C124F probably damaging Het
Orc1 T A 4: 108,461,154 (GRCm39) probably null Het
Pnkp G A 7: 44,511,631 (GRCm39) A76T probably damaging Het
Polr3h T C 15: 81,801,591 (GRCm39) E95G probably damaging Het
Prpf40b T A 15: 99,202,328 (GRCm39) M62K unknown Het
Prpf8 C A 11: 75,386,570 (GRCm39) Q1075K probably benign Het
Rabgap1l A T 1: 160,169,612 (GRCm39) N778K probably damaging Het
Riok3 T A 18: 12,272,442 (GRCm39) N204K probably damaging Het
Shank3 A G 15: 89,415,866 (GRCm39) K650E probably damaging Het
Sim1 T A 10: 50,860,411 (GRCm39) S758T probably damaging Het
Slu7 T G 11: 43,330,087 (GRCm39) N171K probably damaging Het
Sp140l2 A G 1: 85,231,907 (GRCm39) probably benign Het
Sult6b2 A G 6: 142,735,852 (GRCm39) probably null Het
Taf6l C T 19: 8,755,450 (GRCm39) probably null Het
Ubtfl1 G A 9: 18,321,017 (GRCm39) V182M possibly damaging Het
Vmn2r129 C T 4: 156,690,549 (GRCm39) noncoding transcript Het
Other mutations in Ptprg
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL00402:Ptprg APN 14 12,215,992 (GRCm38) missense probably damaging 1.00
IGL00484:Ptprg APN 14 12,215,220 (GRCm38) missense probably damaging 0.99
IGL00847:Ptprg APN 14 12,215,265 (GRCm38) missense probably damaging 1.00
IGL01089:Ptprg APN 14 12,215,286 (GRCm38) missense probably damaging 0.97
IGL01382:Ptprg APN 14 12,237,797 (GRCm38) missense probably benign 0.16
IGL01470:Ptprg APN 14 12,213,702 (GRCm38) nonsense probably null
IGL01762:Ptprg APN 14 12,037,386 (GRCm38) missense probably benign 0.00
IGL01963:Ptprg APN 14 12,220,661 (GRCm38) missense probably damaging 1.00
IGL02015:Ptprg APN 14 12,237,782 (GRCm38) missense possibly damaging 0.46
IGL02086:Ptprg APN 14 12,110,080 (GRCm38) nonsense probably null
IGL02197:Ptprg APN 14 12,220,613 (GRCm38) missense probably damaging 0.98
IGL02341:Ptprg APN 14 12,154,360 (GRCm38) missense probably benign 0.00
IGL02732:Ptprg APN 14 12,225,617 (GRCm38) critical splice donor site probably null
IGL03011:Ptprg APN 14 12,219,029 (GRCm38) missense probably damaging 1.00
IGL03261:Ptprg APN 14 12,225,552 (GRCm38) missense probably damaging 0.99
R0038:Ptprg UTSW 14 12,213,710 (GRCm38) missense probably damaging 1.00
R0383:Ptprg UTSW 14 12,219,024 (GRCm38) missense possibly damaging 0.93
R0433:Ptprg UTSW 14 12,220,620 (GRCm38) missense probably damaging 1.00
R0488:Ptprg UTSW 14 12,220,653 (GRCm38) missense probably damaging 1.00
R0503:Ptprg UTSW 14 12,237,138 (GRCm38) missense possibly damaging 0.89
R0520:Ptprg UTSW 14 12,199,783 (GRCm38) missense possibly damaging 0.92
R0570:Ptprg UTSW 14 12,215,896 (GRCm38) missense probably damaging 1.00
R0606:Ptprg UTSW 14 12,154,131 (GRCm38) missense probably benign
R1086:Ptprg UTSW 14 11,952,706 (GRCm38) splice site probably benign
R1468:Ptprg UTSW 14 12,190,767 (GRCm38) missense probably benign 0.02
R1468:Ptprg UTSW 14 12,190,767 (GRCm38) missense probably benign 0.02
R1519:Ptprg UTSW 14 12,220,596 (GRCm38) missense probably damaging 1.00
R1662:Ptprg UTSW 14 12,207,357 (GRCm38) missense probably damaging 1.00
R1714:Ptprg UTSW 14 12,213,697 (GRCm38) missense probably damaging 1.00
R1716:Ptprg UTSW 14 12,154,360 (GRCm38) missense probably benign 0.00
R1797:Ptprg UTSW 14 12,199,743 (GRCm38) missense probably damaging 1.00
R1803:Ptprg UTSW 14 12,091,410 (GRCm38) splice site probably null
R2104:Ptprg UTSW 14 11,952,897 (GRCm38) critical splice donor site probably null
R2125:Ptprg UTSW 14 12,179,283 (GRCm38) missense possibly damaging 0.74
R2126:Ptprg UTSW 14 12,154,355 (GRCm38) missense probably benign
R2133:Ptprg UTSW 14 12,211,637 (GRCm38) missense probably damaging 1.00
R2471:Ptprg UTSW 14 12,210,327 (GRCm38) missense probably damaging 1.00
R2571:Ptprg UTSW 14 12,122,135 (GRCm38) missense probably benign
R3821:Ptprg UTSW 14 12,226,375 (GRCm38) missense probably benign 0.00
R4196:Ptprg UTSW 14 12,122,002 (GRCm38) missense possibly damaging 0.51
R4392:Ptprg UTSW 14 12,142,467 (GRCm38) missense possibly damaging 0.80
R4665:Ptprg UTSW 14 12,215,288 (GRCm38) missense possibly damaging 0.90
R4730:Ptprg UTSW 14 12,213,713 (GRCm38) missense probably damaging 1.00
R4737:Ptprg UTSW 14 12,226,314 (GRCm38) missense probably damaging 1.00
R4764:Ptprg UTSW 14 12,122,068 (GRCm38) missense probably benign 0.01
R4801:Ptprg UTSW 14 11,554,233 (GRCm38) utr 5 prime probably benign
R4825:Ptprg UTSW 14 12,220,654 (GRCm38) missense probably damaging 1.00
R4960:Ptprg UTSW 14 12,237,837 (GRCm38) missense probably benign 0.07
R4972:Ptprg UTSW 14 12,226,427 (GRCm38) missense possibly damaging 0.94
R4980:Ptprg UTSW 14 12,154,421 (GRCm38) missense probably benign 0.16
R5004:Ptprg UTSW 14 12,220,667 (GRCm38) missense probably damaging 1.00
R5058:Ptprg UTSW 14 12,037,387 (GRCm38) missense possibly damaging 0.82
R5182:Ptprg UTSW 14 12,154,174 (GRCm38) missense probably benign
R5258:Ptprg UTSW 14 12,142,431 (GRCm38) missense probably benign 0.11
R5338:Ptprg UTSW 14 12,154,111 (GRCm38) missense probably benign
R5353:Ptprg UTSW 14 11,554,235 (GRCm38) utr 5 prime probably benign
R5373:Ptprg UTSW 14 12,213,665 (GRCm38) missense probably benign 0.00
R5387:Ptprg UTSW 14 12,153,873 (GRCm38) missense probably damaging 1.00
R5616:Ptprg UTSW 14 12,122,120 (GRCm38) missense probably benign
R5623:Ptprg UTSW 14 12,153,857 (GRCm38) missense probably damaging 1.00
R5976:Ptprg UTSW 14 12,211,625 (GRCm38) missense probably damaging 0.96
R6027:Ptprg UTSW 14 12,220,613 (GRCm38) missense possibly damaging 0.87
R6091:Ptprg UTSW 14 12,215,979 (GRCm38) missense probably damaging 1.00
R6184:Ptprg UTSW 14 12,153,943 (GRCm38) missense probably benign 0.00
R6234:Ptprg UTSW 14 12,213,747 (GRCm38) missense probably damaging 1.00
R6318:Ptprg UTSW 14 12,237,118 (GRCm38) missense probably damaging 1.00
R6324:Ptprg UTSW 14 12,226,314 (GRCm38) missense probably damaging 1.00
R6334:Ptprg UTSW 14 12,166,832 (GRCm38) missense probably damaging 1.00
R6646:Ptprg UTSW 14 11,962,714 (GRCm38) missense probably damaging 1.00
R6647:Ptprg UTSW 14 11,962,714 (GRCm38) missense probably damaging 1.00
R6992:Ptprg UTSW 14 11,962,602 (GRCm38) missense probably damaging 1.00
R7088:Ptprg UTSW 14 12,207,365 (GRCm38) missense probably damaging 1.00
R7250:Ptprg UTSW 14 12,166,767 (GRCm38) missense probably benign 0.18
R7342:Ptprg UTSW 14 12,237,151 (GRCm38) missense possibly damaging 0.90
R7358:Ptprg UTSW 14 12,154,198 (GRCm38) missense possibly damaging 0.59
R7410:Ptprg UTSW 14 11,962,657 (GRCm38) missense probably damaging 1.00
R7448:Ptprg UTSW 14 12,142,461 (GRCm38) missense probably benign 0.12
R7514:Ptprg UTSW 14 12,179,342 (GRCm38) missense possibly damaging 0.86
R7523:Ptprg UTSW 14 12,237,130 (GRCm38) missense probably damaging 0.97
R7672:Ptprg UTSW 14 12,211,668 (GRCm38) missense probably benign 0.04
R7709:Ptprg UTSW 14 12,226,452 (GRCm38) missense probably damaging 1.00
R7720:Ptprg UTSW 14 12,211,703 (GRCm38) missense probably benign 0.31
R8860:Ptprg UTSW 14 12,213,685 (GRCm38) missense probably damaging 1.00
R8992:Ptprg UTSW 14 12,154,170 (GRCm38) missense probably benign 0.00
R9054:Ptprg UTSW 14 12,213,638 (GRCm38) missense possibly damaging 0.58
R9587:Ptprg UTSW 14 12,215,992 (GRCm38) missense probably damaging 1.00
R9621:Ptprg UTSW 14 12,237,809 (GRCm38) missense probably benign
R9625:Ptprg UTSW 14 12,152,027 (GRCm38) missense probably damaging 1.00
R9773:Ptprg UTSW 14 12,199,806 (GRCm38) missense probably damaging 0.97
X0020:Ptprg UTSW 14 12,110,070 (GRCm38) frame shift probably null
X0027:Ptprg UTSW 14 12,110,070 (GRCm38) frame shift probably null
Posted On 2014-05-07