Incidental Mutation 'IGL01887:Olfr1110'
ID179168
Institutional Source Australian Phenomics Network (link to record)
Gene Symbol Olfr1110
Ensembl Gene ENSMUSG00000075159
Gene Nameolfactory receptor 1110
SynonymsGA_x6K02T2Q125-48621299-48620361, MOR172-4
Accession Numbers
Is this an essential gene? Probably non essential (E-score: 0.091) question?
Stock #IGL01887
Quality Score
Status
Chromosome2
Chromosomal Location87133673-87140300 bp(-) (GRCm38)
Type of Mutationmissense
DNA Base Change (assembly) A to G at 87135541 bp
ZygosityHeterozygous
Amino Acid Change Isoleucine to Threonine at position 260 (I260T)
Ref Sequence ENSEMBL: ENSMUSP00000149495 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000099861] [ENSMUST00000152758]
Predicted Effect possibly damaging
Transcript: ENSMUST00000099861
AA Change: I260T

PolyPhen 2 Score 0.889 (Sensitivity: 0.82; Specificity: 0.94)
SMART Domains Protein: ENSMUSP00000097447
Gene: ENSMUSG00000075159
AA Change: I260T

DomainStartEndE-ValueType
Pfam:7tm_4 31 308 3.1e-53 PFAM
Pfam:7tm_1 41 290 1.4e-20 PFAM
Predicted Effect possibly damaging
Transcript: ENSMUST00000152758
AA Change: I260T

PolyPhen 2 Score 0.889 (Sensitivity: 0.82; Specificity: 0.94)
Coding Region Coverage
Validation Efficiency
MGI Phenotype FUNCTION: Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitter and hormone receptors and are responsible for the recognition and G protein-mediated transduction of odorant signals. The olfactory receptor gene family is the largest in the genome. The nomenclature assigned to the olfactory receptor genes and proteins for this organism is independent of other organisms. [provided by RefSeq, Jul 2008]
Allele List at MGI
Other mutations in this stock
Total: 20 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
1810041L15Rik A G 15: 84,406,650 L152P probably damaging Het
Appl2 C A 10: 83,621,522 probably benign Het
Faap20 T C 4: 155,256,200 V158A probably damaging Het
Fam214a A G 9: 75,017,057 I861V probably benign Het
Filip1 A T 9: 79,819,617 D573E probably benign Het
Gm10717 C T 9: 3,025,616 S67L probably benign Het
Gm10718 A T 9: 3,025,118 Y194F probably benign Het
Lins1 T C 7: 66,710,381 I168T probably damaging Het
Myo5b A G 18: 74,714,936 R1082G probably benign Het
Olfr1089 A G 2: 86,732,686 C309R probably benign Het
Pomt2 C T 12: 87,119,589 V439I probably damaging Het
Rars A T 11: 35,825,995 D231E probably benign Het
Slf1 A T 13: 77,100,982 N362K probably benign Het
Smad2 T C 18: 76,299,894 V299A probably damaging Het
Tead2 T C 7: 45,232,310 V84A probably damaging Het
Tnni3k A T 3: 154,875,187 probably null Het
Trp63 C T 16: 25,865,319 R319C probably damaging Het
Vmn1r203 G A 13: 22,524,876 V276I probably benign Het
Vmn2r-ps159 C T 4: 156,338,254 noncoding transcript Het
Zfp318 G T 17: 46,399,168 V606L probably benign Het
Other mutations in Olfr1110
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL01447:Olfr1110 APN 2 87135999 nonsense probably null
IGL01723:Olfr1110 APN 2 87135478 missense probably benign 0.01
IGL01903:Olfr1110 APN 2 87135379 splice site probably null
IGL02214:Olfr1110 APN 2 87135505 missense probably damaging 1.00
R0990:Olfr1110 UTSW 2 87135742 missense possibly damaging 0.69
R1933:Olfr1110 UTSW 2 87135844 missense probably damaging 1.00
R2226:Olfr1110 UTSW 2 87136246 missense possibly damaging 0.87
R3770:Olfr1110 UTSW 2 87135814 missense probably damaging 1.00
R4459:Olfr1110 UTSW 2 87135661 missense probably benign 0.00
R4461:Olfr1110 UTSW 2 87135661 missense probably benign 0.00
R4780:Olfr1110 UTSW 2 87135877 missense probably damaging 0.99
R5105:Olfr1110 UTSW 2 87136210 missense probably benign 0.01
R5995:Olfr1110 UTSW 2 87135856 missense probably damaging 1.00
R8177:Olfr1110 UTSW 2 87135950 missense possibly damaging 0.92
Z1177:Olfr1110 UTSW 2 87136297 missense probably benign 0.00
Posted On2014-05-07