Incidental Mutation 'IGL01889:Or10a3m'
ID 179199
Institutional Source Australian Phenomics Network (link to record)
Gene Symbol Or10a3m
Ensembl Gene ENSMUSG00000056946
Gene Name olfactory receptor family 10 subfamily A member 3M
Synonyms Olfr512, MOR268-3, GA_x6K02T2PBJ9-11043421-11044365
Accession Numbers
Essential gene? Probably non essential (E-score: 0.100) question?
Stock # IGL01889
Quality Score
Status
Chromosome 7
Chromosomal Location 108312562-108313542 bp(+) (GRCm39)
Type of Mutation missense
DNA Base Change (assembly) T to A at 108313089 bp (GRCm39)
Zygosity Heterozygous
Amino Acid Change Phenylalanine to Leucine at position 164 (F164L)
Ref Sequence ENSEMBL: ENSMUSP00000147972 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000074730] [ENSMUST00000209620]
AlphaFold Q8VFZ4
Predicted Effect probably benign
Transcript: ENSMUST00000074730
AA Change: F176L

PolyPhen 2 Score 0.017 (Sensitivity: 0.95; Specificity: 0.80)
SMART Domains Protein: ENSMUSP00000074291
Gene: ENSMUSG00000056946
AA Change: F176L

DomainStartEndE-ValueType
Pfam:7tm_4 43 320 7.8e-62 PFAM
Pfam:7TM_GPCR_Srsx 47 317 2.5e-6 PFAM
Pfam:7tm_1 53 302 2.3e-25 PFAM
Predicted Effect probably benign
Transcript: ENSMUST00000209620
AA Change: F164L

PolyPhen 2 Score 0.017 (Sensitivity: 0.95; Specificity: 0.80)
Coding Region Coverage
Validation Efficiency
MGI Phenotype FUNCTION: Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitter and hormone receptors and are responsible for the recognition and G protein-mediated transduction of odorant signals. The olfactory receptor gene family is the largest in the genome. The nomenclature assigned to the olfactory receptor genes and proteins for this organism is independent of other organisms. [provided by RefSeq, Jul 2008]
Allele List at MGI
Other mutations in this stock
Total: 21 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
A730049H05Rik G A 6: 92,804,981 (GRCm39) probably benign Het
Brap G A 5: 121,798,881 (GRCm39) V18I probably benign Het
Csmd1 C T 8: 16,048,857 (GRCm39) V2282M probably damaging Het
Flnb A G 14: 7,935,967 (GRCm38) E2269G possibly damaging Het
Gaa A G 11: 119,169,123 (GRCm39) I557V probably benign Het
Gapt T A 13: 110,490,501 (GRCm39) Q54L probably benign Het
Gsdmc A T 15: 63,651,852 (GRCm39) I253N possibly damaging Het
Kcnj3 T A 2: 55,327,216 (GRCm39) S2T possibly damaging Het
Mindy2 T C 9: 70,538,444 (GRCm39) probably benign Het
Ncor1 A G 11: 62,225,427 (GRCm39) V1048A possibly damaging Het
Nlrp4d A T 7: 10,112,261 (GRCm39) V636D unknown Het
Nphs1 G T 7: 30,159,936 (GRCm39) R82S probably damaging Het
Or4x6 A G 2: 89,949,309 (GRCm39) V211A possibly damaging Het
Or6z3 G A 7: 6,463,502 (GRCm39) probably benign Het
Papln T A 12: 83,833,609 (GRCm39) L1175Q probably benign Het
Rab22a T C 2: 173,530,031 (GRCm39) probably benign Het
Rel A G 11: 23,707,035 (GRCm39) Y56H probably damaging Het
Sdc4 A G 2: 164,273,127 (GRCm39) L61P probably damaging Het
Slc1a4 A G 11: 20,264,089 (GRCm39) probably benign Het
Ubr4 T A 4: 139,189,783 (GRCm39) C3989* probably null Het
Zfyve16 A G 13: 92,659,077 (GRCm39) V278A possibly damaging Het
Other mutations in Or10a3m
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL01912:Or10a3m APN 7 108,313,465 (GRCm39) missense possibly damaging 0.60
IGL02182:Or10a3m APN 7 108,313,075 (GRCm39) missense probably benign 0.02
IGL02409:Or10a3m APN 7 108,313,366 (GRCm39) missense probably benign 0.00
IGL02554:Or10a3m APN 7 108,312,949 (GRCm39) missense possibly damaging 0.94
IGL03210:Or10a3m APN 7 108,312,775 (GRCm39) missense probably damaging 1.00
IGL03373:Or10a3m APN 7 108,313,339 (GRCm39) missense probably damaging 1.00
IGL03400:Or10a3m APN 7 108,312,733 (GRCm39) missense probably benign 0.28
R0092:Or10a3m UTSW 7 108,313,031 (GRCm39) missense probably benign
R0741:Or10a3m UTSW 7 108,312,811 (GRCm39) missense probably benign 0.00
R1515:Or10a3m UTSW 7 108,313,148 (GRCm39) missense possibly damaging 0.94
R1982:Or10a3m UTSW 7 108,312,902 (GRCm39) missense probably damaging 1.00
R2176:Or10a3m UTSW 7 108,313,339 (GRCm39) missense probably damaging 1.00
R3967:Or10a3m UTSW 7 108,313,060 (GRCm39) missense probably benign
R4009:Or10a3m UTSW 7 108,313,366 (GRCm39) missense probably benign 0.00
R4010:Or10a3m UTSW 7 108,313,366 (GRCm39) missense probably benign 0.00
R4011:Or10a3m UTSW 7 108,313,366 (GRCm39) missense probably benign 0.00
R5095:Or10a3m UTSW 7 108,313,019 (GRCm39) missense probably damaging 1.00
R5271:Or10a3m UTSW 7 108,313,424 (GRCm39) missense probably damaging 1.00
R5864:Or10a3m UTSW 7 108,312,671 (GRCm39) missense probably benign
R5926:Or10a3m UTSW 7 108,312,794 (GRCm39) missense probably damaging 1.00
R6295:Or10a3m UTSW 7 108,312,845 (GRCm39) missense probably damaging 0.98
R6528:Or10a3m UTSW 7 108,312,638 (GRCm39) missense probably damaging 1.00
R6624:Or10a3m UTSW 7 108,312,743 (GRCm39) missense possibly damaging 0.50
R8029:Or10a3m UTSW 7 108,313,037 (GRCm39) missense possibly damaging 0.70
R8443:Or10a3m UTSW 7 108,313,418 (GRCm39) missense possibly damaging 0.79
R8737:Or10a3m UTSW 7 108,312,964 (GRCm39) missense probably damaging 1.00
R9415:Or10a3m UTSW 7 108,313,042 (GRCm39) missense probably damaging 1.00
R9622:Or10a3m UTSW 7 108,312,677 (GRCm39) missense probably benign 0.30
X0023:Or10a3m UTSW 7 108,313,217 (GRCm39) missense possibly damaging 0.79
Z1088:Or10a3m UTSW 7 108,312,745 (GRCm39) missense probably benign 0.06
Posted On 2014-05-07