Incidental Mutation 'IGL01890:Rexo1'
ID 179230
Institutional Source Australian Phenomics Network (link to record)
Gene Symbol Rexo1
Ensembl Gene ENSMUSG00000047417
Gene Name REX1, RNA exonuclease 1
Synonyms Rex1, Tceb3bp1, 2610511M11Rik, 1700021P10Rik
Accession Numbers
Essential gene? Possibly non essential (E-score: 0.413) question?
Stock # IGL01890
Quality Score
Status
Chromosome 10
Chromosomal Location 80376756-80397394 bp(-) (GRCm39)
Type of Mutation missense
DNA Base Change (assembly) A to T at 80378845 bp (GRCm39)
Zygosity Heterozygous
Amino Acid Change Tyrosine to Asparagine at position 1064 (Y1064N)
Ref Sequence ENSEMBL: ENSMUSP00000049705 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000020383] [ENSMUST00000057910] [ENSMUST00000183160] [ENSMUST00000220326] [ENSMUST00000219648]
AlphaFold Q7TT28
Predicted Effect probably benign
Transcript: ENSMUST00000020383
SMART Domains Protein: ENSMUSP00000020383
Gene: ENSMUSG00000003341

DomainStartEndE-ValueType
Pfam:PhoLip_ATPase_N 20 97 9.3e-29 PFAM
Pfam:E1-E2_ATPase 121 367 2.2e-10 PFAM
Pfam:HAD 404 866 3.7e-17 PFAM
Pfam:Cation_ATPase 481 580 8.3e-12 PFAM
Pfam:PhoLip_ATPase_C 883 1135 4.2e-61 PFAM
low complexity region 1140 1153 N/A INTRINSIC
Predicted Effect possibly damaging
Transcript: ENSMUST00000057910
AA Change: Y1064N

PolyPhen 2 Score 0.852 (Sensitivity: 0.83; Specificity: 0.93)
SMART Domains Protein: ENSMUSP00000049705
Gene: ENSMUSG00000047417
AA Change: Y1064N

DomainStartEndE-ValueType
low complexity region 34 53 N/A INTRINSIC
coiled coil region 83 113 N/A INTRINSIC
low complexity region 180 188 N/A INTRINSIC
low complexity region 365 381 N/A INTRINSIC
low complexity region 383 396 N/A INTRINSIC
low complexity region 440 453 N/A INTRINSIC
low complexity region 468 479 N/A INTRINSIC
low complexity region 507 525 N/A INTRINSIC
low complexity region 533 551 N/A INTRINSIC
low complexity region 561 583 N/A INTRINSIC
low complexity region 667 682 N/A INTRINSIC
Pfam:EloA-BP1 794 954 3.8e-72 PFAM
EXOIII 1051 1210 2.36e-38 SMART
Predicted Effect unknown
Transcript: ENSMUST00000182260
AA Change: Y386N
Predicted Effect noncoding transcript
Transcript: ENSMUST00000182604
Predicted Effect noncoding transcript
Transcript: ENSMUST00000182682
Predicted Effect probably benign
Transcript: ENSMUST00000183073
Predicted Effect noncoding transcript
Transcript: ENSMUST00000183139
Predicted Effect probably benign
Transcript: ENSMUST00000183160
Predicted Effect noncoding transcript
Transcript: ENSMUST00000183233
Predicted Effect probably benign
Transcript: ENSMUST00000220326
Predicted Effect probably benign
Transcript: ENSMUST00000219648
Coding Region Coverage
Validation Efficiency
Allele List at MGI
Other mutations in this stock
Total: 22 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
Actn1 A T 12: 80,231,642 (GRCm39) V265E probably damaging Het
Anks1b A G 10: 90,480,389 (GRCm39) I865V probably benign Het
Car5a G A 8: 122,650,349 (GRCm39) A182V probably benign Het
Ccdc47 A G 11: 106,096,277 (GRCm39) V249A probably damaging Het
Cyb561d2 A G 9: 107,418,722 (GRCm39) V34A probably damaging Het
Dmbt1 A G 7: 130,676,149 (GRCm39) probably benign Het
Entpd6 G A 2: 150,612,612 (GRCm39) D445N possibly damaging Het
Fastkd2 A G 1: 63,771,320 (GRCm39) I225M probably benign Het
Flcn A G 11: 59,685,996 (GRCm39) V424A probably benign Het
Gm10718 A T 9: 3,025,118 (GRCm39) Y194F probably benign Het
Gpn3 A G 5: 122,519,328 (GRCm39) M176V probably benign Het
Igkv12-38 C T 6: 69,920,389 (GRCm39) C43Y probably damaging Het
Oas1h A G 5: 121,000,852 (GRCm39) probably null Het
Skint1 G A 4: 111,867,878 (GRCm39) G2R probably damaging Het
Slc4a9 G A 18: 36,662,760 (GRCm39) A172T possibly damaging Het
Synpo2 A G 3: 122,906,146 (GRCm39) S727P probably damaging Het
Tmem131 A T 1: 36,862,237 (GRCm39) probably benign Het
Trpm3 G T 19: 22,689,083 (GRCm39) R4L probably damaging Het
Upf1 A T 8: 70,786,880 (GRCm39) V879E possibly damaging Het
Vmn1r194 A T 13: 22,428,776 (GRCm39) Y131F probably benign Het
Vmn2r129 C T 4: 156,690,549 (GRCm39) noncoding transcript Het
Vmn2r95 T A 17: 18,671,737 (GRCm39) N491K probably damaging Het
Other mutations in Rexo1
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL00970:Rexo1 APN 10 80,386,798 (GRCm39) missense probably damaging 0.99
IGL01128:Rexo1 APN 10 80,385,573 (GRCm39) missense probably benign
PIT4453001:Rexo1 UTSW 10 80,386,231 (GRCm39) missense probably damaging 0.97
R0044:Rexo1 UTSW 10 80,380,212 (GRCm39) missense probably benign 0.16
R0365:Rexo1 UTSW 10 80,378,410 (GRCm39) missense probably damaging 0.99
R0573:Rexo1 UTSW 10 80,380,684 (GRCm39) missense probably damaging 1.00
R1146:Rexo1 UTSW 10 80,380,239 (GRCm39) missense probably benign 0.04
R1146:Rexo1 UTSW 10 80,380,239 (GRCm39) missense probably benign 0.04
R1511:Rexo1 UTSW 10 80,385,884 (GRCm39) missense possibly damaging 0.93
R1523:Rexo1 UTSW 10 80,378,585 (GRCm39) missense probably benign 0.41
R1807:Rexo1 UTSW 10 80,378,413 (GRCm39) missense possibly damaging 0.95
R1868:Rexo1 UTSW 10 80,378,754 (GRCm39) missense probably damaging 1.00
R1935:Rexo1 UTSW 10 80,386,303 (GRCm39) missense probably benign 0.00
R1936:Rexo1 UTSW 10 80,386,303 (GRCm39) missense probably benign 0.00
R1957:Rexo1 UTSW 10 80,379,200 (GRCm39) missense probably damaging 0.96
R2084:Rexo1 UTSW 10 80,397,100 (GRCm39) missense probably benign 0.01
R2153:Rexo1 UTSW 10 80,379,943 (GRCm39) nonsense probably null
R2262:Rexo1 UTSW 10 80,385,403 (GRCm39) missense probably benign 0.02
R4471:Rexo1 UTSW 10 80,378,492 (GRCm39) missense probably damaging 1.00
R4472:Rexo1 UTSW 10 80,378,492 (GRCm39) missense probably damaging 1.00
R4690:Rexo1 UTSW 10 80,382,255 (GRCm39) missense probably benign 0.01
R4972:Rexo1 UTSW 10 80,385,527 (GRCm39) missense probably damaging 0.96
R6335:Rexo1 UTSW 10 80,379,915 (GRCm39) missense probably damaging 1.00
R6505:Rexo1 UTSW 10 80,378,845 (GRCm39) missense possibly damaging 0.85
R6615:Rexo1 UTSW 10 80,379,848 (GRCm39) missense possibly damaging 0.68
R6949:Rexo1 UTSW 10 80,386,470 (GRCm39) missense possibly damaging 0.46
R7612:Rexo1 UTSW 10 80,385,497 (GRCm39) missense probably benign 0.40
R7807:Rexo1 UTSW 10 80,385,970 (GRCm39) missense probably benign 0.09
R7840:Rexo1 UTSW 10 80,386,572 (GRCm39) missense probably benign
R8779:Rexo1 UTSW 10 80,384,292 (GRCm39) missense probably benign 0.26
R8897:Rexo1 UTSW 10 80,378,437 (GRCm39) missense probably damaging 0.98
R8995:Rexo1 UTSW 10 80,386,095 (GRCm39) missense probably damaging 0.96
R9094:Rexo1 UTSW 10 80,378,854 (GRCm39) missense probably damaging 1.00
R9411:Rexo1 UTSW 10 80,397,248 (GRCm39) missense
R9438:Rexo1 UTSW 10 80,378,848 (GRCm39) missense possibly damaging 0.46
R9524:Rexo1 UTSW 10 80,386,872 (GRCm39) missense probably damaging 1.00
R9648:Rexo1 UTSW 10 80,385,540 (GRCm39) missense probably damaging 0.97
Z1177:Rexo1 UTSW 10 80,385,609 (GRCm39) missense probably damaging 1.00
Posted On 2014-05-07