Incidental Mutation 'R0098:Or5b107'
ID 17924
Institutional Source Beutler Lab
Gene Symbol Or5b107
Ensembl Gene ENSMUSG00000045883
Gene Name olfactory receptor family 5 subfamily B member 107
Synonyms GA_x6K02T2RE5P-3491834-3492772, Olfr1461, MOR202-35
MMRRC Submission 038384-MU
Accession Numbers
Essential gene? Probably non essential (E-score: 0.116) question?
Stock # R0098 (G1)
Quality Score
Status Validated
Chromosome 19
Chromosomal Location 13142380-13143318 bp(+) (GRCm39)
Type of Mutation missense
DNA Base Change (assembly) T to A at 13143026 bp (GRCm39)
Zygosity Heterozygous
Amino Acid Change Isoleucine to Lysine at position 216 (I216K)
Ref Sequence ENSEMBL: ENSMUSP00000146358 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000053772] [ENSMUST00000207113] [ENSMUST00000208489]
AlphaFold Q8VEV7
Predicted Effect probably benign
Transcript: ENSMUST00000053772
AA Change: I216K

PolyPhen 2 Score 0.122 (Sensitivity: 0.93; Specificity: 0.86)
SMART Domains Protein: ENSMUSP00000053269
Gene: ENSMUSG00000045883
AA Change: I216K

DomainStartEndE-ValueType
Pfam:7tm_4 32 309 6e-55 PFAM
Pfam:7TM_GPCR_Srsx 36 306 8e-6 PFAM
Pfam:7tm_1 42 291 2e-18 PFAM
Predicted Effect probably benign
Transcript: ENSMUST00000207113
AA Change: I216K

PolyPhen 2 Score 0.122 (Sensitivity: 0.93; Specificity: 0.86)
Predicted Effect probably benign
Transcript: ENSMUST00000208489
Meta Mutation Damage Score 0.0898 question?
Coding Region Coverage
  • 1x: 90.4%
  • 3x: 88.1%
  • 10x: 82.9%
  • 20x: 75.6%
Validation Efficiency 93% (78/84)
MGI Phenotype FUNCTION: Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitter and hormone receptors and are responsible for the recognition and G protein-mediated transduction of odorant signals. The olfactory receptor gene family is the largest in the genome. The nomenclature assigned to the olfactory receptor genes and proteins for this organism is independent of other organisms. [provided by RefSeq, Jul 2008]
Allele List at MGI
Other mutations in this stock
Total: 59 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
2310061I04Rik A T 17: 36,207,309 (GRCm39) probably benign Het
Acad9 T C 3: 36,127,689 (GRCm39) I97T probably damaging Het
Adam32 T A 8: 25,404,405 (GRCm39) Y200F possibly damaging Het
Adcy4 T C 14: 56,007,284 (GRCm39) N976S possibly damaging Het
Adgrb2 C G 4: 129,901,624 (GRCm39) P416R probably damaging Het
Alpk2 A G 18: 65,482,982 (GRCm39) L342S probably damaging Het
Ambra1 T A 2: 91,598,056 (GRCm39) H72Q possibly damaging Het
Ankrd10 T C 8: 11,662,560 (GRCm39) H391R probably benign Het
Arfgef3 A G 10: 18,465,390 (GRCm39) V2151A probably damaging Het
Atm T C 9: 53,429,869 (GRCm39) D389G probably benign Het
Atp10b A T 11: 43,080,431 (GRCm39) S236C probably benign Het
B3gat1 C T 9: 26,668,237 (GRCm39) R276C probably damaging Het
Bcl9l C T 9: 44,416,914 (GRCm39) P251S probably benign Het
Cdhr5 C A 7: 140,849,781 (GRCm39) G331W probably damaging Het
Cmklr1 T C 5: 113,752,531 (GRCm39) T157A probably benign Het
Cndp1 T A 18: 84,646,949 (GRCm39) E246D probably damaging Het
Cntn4 A G 6: 106,595,385 (GRCm39) probably benign Het
Crebbp A G 16: 3,909,792 (GRCm39) L1078P probably damaging Het
Cyp20a1 G T 1: 60,426,413 (GRCm39) E452* probably null Het
Emb T C 13: 117,404,034 (GRCm39) V262A probably damaging Het
Ephb1 C T 9: 101,918,339 (GRCm39) R390H probably damaging Het
Faf1 T C 4: 109,792,696 (GRCm39) L556S probably damaging Het
Fat2 T C 11: 55,189,431 (GRCm39) T1196A probably damaging Het
Fbf1 A T 11: 116,038,945 (GRCm39) probably null Het
Gid8 T A 2: 180,356,528 (GRCm39) I55N possibly damaging Het
Hexa T C 9: 59,465,383 (GRCm39) Y213H probably damaging Het
Igf2bp1 T C 11: 95,863,989 (GRCm39) K234E probably damaging Het
Ighv1-58 C T 12: 115,275,919 (GRCm39) G73E probably benign Het
Kalrn A T 16: 33,795,989 (GRCm39) I1262K possibly damaging Het
Lrp1 C T 10: 127,388,607 (GRCm39) V3281I probably benign Het
Lrp2 T C 2: 69,305,756 (GRCm39) D2935G probably damaging Het
Lypd6 T A 2: 50,080,792 (GRCm39) V160E probably benign Het
Muc19 C T 15: 91,777,101 (GRCm39) noncoding transcript Het
Nrxn3 A G 12: 89,226,971 (GRCm39) D202G probably damaging Het
Nxn A T 11: 76,169,420 (GRCm39) probably benign Het
Palld C A 8: 61,978,120 (GRCm39) G890V probably damaging Het
Pcx C A 19: 4,651,775 (GRCm39) probably benign Het
Pik3c2g T C 6: 139,639,441 (GRCm39) S416P unknown Het
Ppa2 C T 3: 133,076,234 (GRCm39) probably benign Het
Ppp1r18 A G 17: 36,178,888 (GRCm39) I254M probably benign Het
Prune2 A G 19: 17,101,267 (GRCm39) E2257G possibly damaging Het
Rd3 A G 1: 191,717,261 (GRCm39) M244V probably benign Het
Rfx5 T A 3: 94,865,679 (GRCm39) V326E probably damaging Het
Rgs3 G C 4: 62,544,143 (GRCm39) R305P probably damaging Het
Rpp40 A G 13: 36,082,970 (GRCm39) Y173H probably benign Het
Ryr3 T C 2: 112,731,376 (GRCm39) N645D probably damaging Het
Sema3e T C 5: 14,302,446 (GRCm39) V657A possibly damaging Het
Serpina3n T A 12: 104,379,777 (GRCm39) V390E probably damaging Het
Shank1 A G 7: 43,962,709 (GRCm39) Y141C unknown Het
Smg1 A T 7: 117,744,690 (GRCm39) M3154K probably benign Het
Tdrd12 A G 7: 35,175,418 (GRCm39) L996P probably damaging Het
Tfrc G T 16: 32,442,244 (GRCm39) V490F probably damaging Het
Tie1 T C 4: 118,343,784 (GRCm39) S53G probably benign Het
Topaz1 T C 9: 122,619,188 (GRCm39) Y1262H possibly damaging Het
Ttc3 A T 16: 94,191,124 (GRCm39) H222L probably benign Het
Ubxn8 T C 8: 34,125,393 (GRCm39) probably benign Het
Unk A G 11: 115,940,995 (GRCm39) Y252C probably damaging Het
Vwc2l A G 1: 70,768,290 (GRCm39) Y71C probably damaging Het
Zfp386 T A 12: 116,022,834 (GRCm39) L184* probably null Het
Other mutations in Or5b107
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL01088:Or5b107 APN 19 13,142,735 (GRCm39) missense probably damaging 1.00
IGL01370:Or5b107 APN 19 13,142,663 (GRCm39) missense possibly damaging 0.95
IGL01936:Or5b107 APN 19 13,142,767 (GRCm39) missense probably damaging 1.00
R0270:Or5b107 UTSW 19 13,143,251 (GRCm39) missense probably damaging 1.00
R0575:Or5b107 UTSW 19 13,142,751 (GRCm39) nonsense probably null
R0627:Or5b107 UTSW 19 13,142,614 (GRCm39) missense probably benign 0.43
R1779:Or5b107 UTSW 19 13,142,404 (GRCm39) missense probably benign 0.00
R1956:Or5b107 UTSW 19 13,142,560 (GRCm39) missense probably damaging 1.00
R2446:Or5b107 UTSW 19 13,142,811 (GRCm39) missense probably benign 0.00
R3622:Or5b107 UTSW 19 13,143,020 (GRCm39) missense probably benign 0.06
R4485:Or5b107 UTSW 19 13,142,855 (GRCm39) missense possibly damaging 0.54
R4605:Or5b107 UTSW 19 13,142,612 (GRCm39) missense probably damaging 1.00
R4757:Or5b107 UTSW 19 13,143,277 (GRCm39) missense probably benign 0.01
R4816:Or5b107 UTSW 19 13,142,488 (GRCm39) missense probably benign 0.10
R5038:Or5b107 UTSW 19 13,142,955 (GRCm39) missense probably benign 0.39
R7026:Or5b107 UTSW 19 13,142,779 (GRCm39) missense probably benign 0.08
R8225:Or5b107 UTSW 19 13,142,507 (GRCm39) missense probably damaging 1.00
R8232:Or5b107 UTSW 19 13,142,683 (GRCm39) missense probably benign 0.28
R9095:Or5b107 UTSW 19 13,143,310 (GRCm39) missense probably benign 0.01
R9127:Or5b107 UTSW 19 13,142,396 (GRCm39) missense probably damaging 1.00
R9697:Or5b107 UTSW 19 13,142,888 (GRCm39) missense possibly damaging 0.91
R9784:Or5b107 UTSW 19 13,142,813 (GRCm39) missense probably damaging 1.00
Posted On 2013-03-25