Incidental Mutation 'IGL01892:Olfr628'
ID179258
Institutional Source Australian Phenomics Network (link to record)
Gene Symbol Olfr628
Ensembl Gene ENSMUSG00000096516
Gene Nameolfactory receptor 628
SynonymsGA_x6K02T2PBJ9-6457667-6458617, MOR22-4P, MOR22-4P, Olfr1526-ps1, MOR22-1
Accession Numbers
Is this an essential gene? Probably non essential (E-score: 0.103) question?
Stock #IGL01892
Quality Score
Status
Chromosome7
Chromosomal Location103730374-103733324 bp(+) (GRCm38)
Type of Mutationmissense
DNA Base Change (assembly) A to T at 103732480 bp
ZygosityHeterozygous
Amino Acid Change Methionine to Leucine at position 185 (M185L)
Ref Sequence ENSEMBL: ENSMUSP00000151622 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000098193] [ENSMUST00000218266]
Predicted Effect possibly damaging
Transcript: ENSMUST00000098193
AA Change: M185L

PolyPhen 2 Score 0.469 (Sensitivity: 0.89; Specificity: 0.90)
SMART Domains Protein: ENSMUSP00000095795
Gene: ENSMUSG00000096516
AA Change: M185L

DomainStartEndE-ValueType
Pfam:7tm_4 33 313 2.3e-106 PFAM
Pfam:7tm_1 43 295 1.5e-14 PFAM
Predicted Effect possibly damaging
Transcript: ENSMUST00000218266
AA Change: M185L

PolyPhen 2 Score 0.469 (Sensitivity: 0.89; Specificity: 0.90)
Coding Region Coverage
Validation Efficiency
MGI Phenotype FUNCTION: Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitter and hormone receptors and are responsible for the recognition and G protein-mediated transduction of odorant signals. The olfactory receptor gene family is the largest in the genome. The nomenclature assigned to the olfactory receptor genes and proteins for this organism is independent of other organisms. [provided by RefSeq, Jul 2008]
Allele List at MGI
Other mutations in this stock
Total: 26 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
2410089E03Rik A T 15: 8,242,265 probably benign Het
Cyp2c68 T A 19: 39,734,344 E253D probably benign Het
Gbp2b A G 3: 142,603,620 D164G probably benign Het
Gm10717 C T 9: 3,025,616 S67L probably benign Het
Gm21738 G A 14: 19,416,979 S144L probably benign Het
Lct G T 1: 128,307,605 T555N probably damaging Het
Ncam2 T A 16: 81,589,699 H655Q possibly damaging Het
Olfr983 C A 9: 40,092,818 L45F probably damaging Het
Pglyrp4 A G 3: 90,739,041 N293S probably benign Het
Pofut2 C A 10: 77,265,883 D251E probably benign Het
Prdm2 T C 4: 143,134,404 E772G probably damaging Het
Prkd3 A T 17: 78,972,501 D254E probably benign Het
Prr36 G A 8: 4,215,243 P169L probably damaging Het
Pwp2 T C 10: 78,179,007 Y381C probably damaging Het
Rasgrp1 G A 2: 117,293,842 T293M probably damaging Het
Snd1 G A 6: 28,888,124 probably null Het
Suclg2 A T 6: 95,579,188 D237E probably damaging Het
Tenm3 T C 8: 48,276,396 N1509S probably benign Het
Thbd A T 2: 148,407,068 H293Q possibly damaging Het
Tie1 T A 4: 118,475,918 Y871F probably benign Het
Vmn1r38 A T 6: 66,776,376 V252D probably benign Het
Vmn1r60 C A 7: 5,544,310 V264F probably benign Het
Vmn1r68 T C 7: 10,527,407 T255A possibly damaging Het
Vmn2r49 A T 7: 9,984,763 V458E probably benign Het
Vmn2r9 A T 5: 108,847,834 V316D probably damaging Het
Wfdc15b A T 2: 164,215,468 M1K probably null Het
Other mutations in Olfr628
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL02121:Olfr628 APN 7 103732469 missense probably damaging 1.00
R0140:Olfr628 UTSW 7 103732142 missense probably damaging 1.00
R0505:Olfr628 UTSW 7 103732376 missense probably benign 0.09
R0582:Olfr628 UTSW 7 103732673 missense possibly damaging 0.82
R1585:Olfr628 UTSW 7 103732378 missense possibly damaging 0.56
R1907:Olfr628 UTSW 7 103731983 missense probably damaging 1.00
R4766:Olfr628 UTSW 7 103732250 missense possibly damaging 0.70
R4954:Olfr628 UTSW 7 103732207 missense probably damaging 1.00
R5464:Olfr628 UTSW 7 103732189 missense probably damaging 1.00
R6737:Olfr628 UTSW 7 103732150 missense probably damaging 1.00
R6761:Olfr628 UTSW 7 103732484 missense probably damaging 1.00
R6782:Olfr628 UTSW 7 103732342 missense possibly damaging 0.67
R7015:Olfr628 UTSW 7 103732817 missense probably null 0.85
R7503:Olfr628 UTSW 7 103732267 missense probably damaging 1.00
X0058:Olfr628 UTSW 7 103732282 missense probably damaging 1.00
Posted On2014-05-07