Incidental Mutation 'IGL01892:Vmn2r49'
| ID |
179260 |
| Institutional Source |
Australian Phenomics Network
(link to record)
|
| Gene Symbol |
Vmn2r49
|
| Ensembl Gene |
ENSMUSG00000096180 |
| Gene Name |
vomeronasal 2, receptor 49 |
| Synonyms |
|
| Accession Numbers |
|
| Essential gene? |
Probably non essential
(E-score: 0.108)
|
| Stock # |
IGL01892
|
| Quality Score |
|
|
Status
|
|
| Chromosome |
7 |
| Chromosomal Location |
9710172-9726066 bp(-) (GRCm39) |
| Type of Mutation |
missense |
| DNA Base Change (assembly) |
A to T
at 9718690 bp (GRCm39)
|
| Zygosity |
Heterozygous |
| Amino Acid Change |
Valine to Glutamic Acid
at position 458
(V458E)
|
| Ref Sequence |
ENSEMBL: ENSMUSP00000104190
(fasta)
|
| Gene Model |
predicted gene model for transcript(s):
[ENSMUST00000108550]
|
| AlphaFold |
D3Z6L3 |
| Predicted Effect |
probably benign
Transcript: ENSMUST00000108550
AA Change: V458E
PolyPhen 2
Score 0.001 (Sensitivity: 0.99; Specificity: 0.15)
|
| SMART Domains |
Protein: ENSMUSP00000104190
Gene: ENSMUSG00000096180
AA Change: V458E
| Domain | Start | End | E-Value | Type |
|---|
|
signal peptide
|
1 |
18 |
N/A |
INTRINSIC |
|
Pfam:ANF_receptor
|
73 |
469 |
1.4e-33 |
PFAM |
|
Pfam:NCD3G
|
512 |
565 |
5.1e-21 |
PFAM |
|
Pfam:7tm_3
|
598 |
833 |
3.5e-55 |
PFAM |
|
| Coding Region Coverage |
|
| Validation Efficiency |
|
| Allele List at MGI |
|
| Other mutations in this stock |
Total: 26 list
| Gene | Ref | Var | Chr/Loc | Mutation | Predicted Effect | Zygosity |
|---|
| Cplane1 |
A |
T |
15: 8,271,749 (GRCm39) |
|
probably benign |
Het |
| Cyp2c68 |
T |
A |
19: 39,722,788 (GRCm39) |
E253D |
probably benign |
Het |
| Gbp2b |
A |
G |
3: 142,309,381 (GRCm39) |
D164G |
probably benign |
Het |
| Gm10717 |
C |
T |
9: 3,025,616 (GRCm39) |
S67L |
probably benign |
Het |
| Gm21738 |
G |
A |
14: 19,416,979 (GRCm38) |
S144L |
probably benign |
Het |
| Lct |
G |
T |
1: 128,235,342 (GRCm39) |
T555N |
probably damaging |
Het |
| Ncam2 |
T |
A |
16: 81,386,587 (GRCm39) |
H655Q |
possibly damaging |
Het |
| Or52a24 |
A |
T |
7: 103,381,687 (GRCm39) |
M185L |
possibly damaging |
Het |
| Or8b57 |
C |
A |
9: 40,004,114 (GRCm39) |
L45F |
probably damaging |
Het |
| Pglyrp4 |
A |
G |
3: 90,646,348 (GRCm39) |
N293S |
probably benign |
Het |
| Pofut2 |
C |
A |
10: 77,101,717 (GRCm39) |
D251E |
probably benign |
Het |
| Prdm2 |
T |
C |
4: 142,860,974 (GRCm39) |
E772G |
probably damaging |
Het |
| Prkd3 |
A |
T |
17: 79,279,930 (GRCm39) |
D254E |
probably benign |
Het |
| Prr36 |
G |
A |
8: 4,265,243 (GRCm39) |
P169L |
probably damaging |
Het |
| Pwp2 |
T |
C |
10: 78,014,841 (GRCm39) |
Y381C |
probably damaging |
Het |
| Rasgrp1 |
G |
A |
2: 117,124,323 (GRCm39) |
T293M |
probably damaging |
Het |
| Snd1 |
G |
A |
6: 28,888,123 (GRCm39) |
|
probably null |
Het |
| Suclg2 |
A |
T |
6: 95,556,169 (GRCm39) |
D237E |
probably damaging |
Het |
| Tenm3 |
T |
C |
8: 48,729,431 (GRCm39) |
N1509S |
probably benign |
Het |
| Thbd |
A |
T |
2: 148,248,988 (GRCm39) |
H293Q |
possibly damaging |
Het |
| Tie1 |
T |
A |
4: 118,333,115 (GRCm39) |
Y871F |
probably benign |
Het |
| Vmn1r38 |
A |
T |
6: 66,753,360 (GRCm39) |
V252D |
probably benign |
Het |
| Vmn1r60 |
C |
A |
7: 5,547,309 (GRCm39) |
V264F |
probably benign |
Het |
| Vmn1r68 |
T |
C |
7: 10,261,334 (GRCm39) |
T255A |
possibly damaging |
Het |
| Vmn2r9 |
A |
T |
5: 108,995,700 (GRCm39) |
V316D |
probably damaging |
Het |
| Wfdc15b |
A |
T |
2: 164,057,388 (GRCm39) |
M1K |
probably null |
Het |
|
| Other mutations in Vmn2r49 |
| Allele | Source | Chr | Coord | Type | Predicted Effect | PPH Score |
|---|
|
IGL01800:Vmn2r49
|
APN |
7 |
9,710,601 (GRCm39) |
nonsense |
probably null |
|
|
IGL02505:Vmn2r49
|
APN |
7 |
9,710,378 (GRCm39) |
missense |
probably benign |
0.27 |
|
IGL03345:Vmn2r49
|
APN |
7 |
9,718,621 (GRCm39) |
missense |
probably damaging |
1.00 |
|
PIT4434001:Vmn2r49
|
UTSW |
7 |
9,710,762 (GRCm39) |
missense |
probably damaging |
1.00 |
|
PIT4520001:Vmn2r49
|
UTSW |
7 |
9,722,988 (GRCm39) |
missense |
probably benign |
0.06 |
|
R0367:Vmn2r49
|
UTSW |
7 |
9,710,357 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R0609:Vmn2r49
|
UTSW |
7 |
9,710,233 (GRCm39) |
missense |
probably benign |
0.40 |
|
R0931:Vmn2r49
|
UTSW |
7 |
9,720,325 (GRCm39) |
missense |
possibly damaging |
0.55 |
|
R1594:Vmn2r49
|
UTSW |
7 |
9,710,550 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R1969:Vmn2r49
|
UTSW |
7 |
9,720,235 (GRCm39) |
missense |
probably damaging |
0.99 |
|
R4831:Vmn2r49
|
UTSW |
7 |
9,720,352 (GRCm39) |
missense |
probably benign |
|
|
R4944:Vmn2r49
|
UTSW |
7 |
9,722,959 (GRCm39) |
missense |
probably benign |
|
|
R4945:Vmn2r49
|
UTSW |
7 |
9,720,214 (GRCm39) |
nonsense |
probably null |
|
|
R5109:Vmn2r49
|
UTSW |
7 |
9,710,204 (GRCm39) |
missense |
probably benign |
0.01 |
|
R5141:Vmn2r49
|
UTSW |
7 |
9,720,300 (GRCm39) |
missense |
probably benign |
0.01 |
|
R5778:Vmn2r49
|
UTSW |
7 |
9,710,274 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R6168:Vmn2r49
|
UTSW |
7 |
9,718,713 (GRCm39) |
missense |
probably benign |
0.01 |
|
R6513:Vmn2r49
|
UTSW |
7 |
9,710,524 (GRCm39) |
missense |
probably damaging |
0.99 |
|
R7347:Vmn2r49
|
UTSW |
7 |
9,720,741 (GRCm39) |
missense |
probably benign |
0.00 |
|
R7464:Vmn2r49
|
UTSW |
7 |
9,722,820 (GRCm39) |
missense |
probably benign |
0.03 |
|
R7495:Vmn2r49
|
UTSW |
7 |
9,710,826 (GRCm39) |
nonsense |
probably null |
|
|
R7750:Vmn2r49
|
UTSW |
7 |
9,710,185 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R8031:Vmn2r49
|
UTSW |
7 |
9,720,408 (GRCm39) |
missense |
possibly damaging |
0.67 |
|
R9158:Vmn2r49
|
UTSW |
7 |
9,722,835 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R9347:Vmn2r49
|
UTSW |
7 |
9,718,674 (GRCm39) |
missense |
probably benign |
0.00 |
|
R9553:Vmn2r49
|
UTSW |
7 |
9,720,849 (GRCm39) |
missense |
probably benign |
0.41 |
|
| Posted On |
2014-05-07 |
Incidental Mutation