Mutagenetix > Incidental Mutation

Incidental Mutation 'IGL01894:Tmem184c'

179340

Institutional Source

Australian Phenomics Network (link to record)

Gene Symbol

Tmem184c

Ensembl Gene

ENSMUSG00000031617

Gene Name

transmembrane protein 184C

Synonyms

Tmem34, 8430433H16Rik

Accession Numbers

Essential gene?

Probably non essential (E-score: 0.183) question?

Stock #

IGL01894

Quality Score

Status

Chromosome

Chromosomal Location

77595982-77610698 bp(-) (GRCm38)

Type of Mutation

nonsense

DNA Base Change (assembly)

A to T at 77597146 bp (GRCm38)

Zygosity

Heterozygous

Amino Acid Change

Cysteine to Stop codon at position 362 (C362*)

Ref Sequence

ENSEMBL: ENSMUSP00000034030 (fasta)

Gene Model

predicted gene model for transcript(s): [ENSMUST00000034030]

AlphaFold

no structure available at present

Predicted Effect

probably null
Transcript: ENSMUST00000034030
AA Change: C362*

SMART Domains

Protein: ENSMUSP00000034030
Gene: ENSMUSG00000031617
AA Change: C362*

Domain	Start	End	E-Value	Type
transmembrane domain	13	35	N/A	INTRINSIC
Pfam:Solute_trans_a	48	317	1.9e-101	PFAM
low complexity region	373	388	N/A	INTRINSIC
low complexity region	404	415	N/A	INTRINSIC
internal_repeat_1	422	485	1.18e-11	PROSPERO
low complexity region	500	512	N/A	INTRINSIC
internal_repeat_1	519	599	1.18e-11	PROSPERO
low complexity region	600	621	N/A	INTRINSIC

Coding Region Coverage

Validation Efficiency

Allele List at MGI

Other mutations in this stock

Total: 25 list
Gene	Ref	Var	Chr/Loc	Mutation	Predicted Effect	Zygosity
Adam29	T	A	8: 55,871,830	I530L	probably benign	Het
Adam3	T	C	8: 24,687,938	D653G	probably benign	Het
Car13	T	C	3: 14,661,465	F227S	probably damaging	Het
Cdc27	T	C	11: 104,526,921	N300S	probably benign	Het
Fat3	C	T	9: 16,375,849	V793I	probably benign	Het
Gm10718	A	T	9: 3,025,118	Y194F	probably benign	Het
Gm21738	G	A	14: 19,416,979	S144L	probably benign	Het
Gpa33	T	A	1: 166,165,216	D299E	probably benign	Het
Kif5a	C	T	10: 127,262,779	V40I	probably benign	Het
Lama3	A	G	18: 12,572,064	H1455R	probably benign	Het
Lamc1	T	C	1: 153,247,082	K751E	possibly damaging	Het
Nek5	T	A	8: 22,113,819	H114L	probably damaging	Het
Nipal1	G	A	5: 72,663,539	A37T	probably benign	Het
Olfr1446	T	C	19: 12,889,643		probably benign	Het
Olfr1453	G	T	19: 13,028,285	L15I	probably damaging	Het
Olfr538	T	C	7: 140,574,770	Y206H	possibly damaging	Het
Pik3ca	T	C	3: 32,450,026	Y622H	possibly damaging	Het
Pknox2	G	T	9: 36,923,742	H144N	probably damaging	Het
Ppp4r4	A	G	12: 103,593,138	Y526C	probably damaging	Het
Prdm10	A	G	9: 31,316,261	D54G	probably damaging	Het
Rpn2	C	T	2: 157,294,173	T167I	probably benign	Het
Slc22a30	G	T	19: 8,386,657	H218Q	probably benign	Het
Supt6	A	G	11: 78,222,838	S878P	probably benign	Het
Vmn2r-ps159	C	T	4: 156,338,254		noncoding transcript	Het
Wscd2	C	T	5: 113,572,296	R294W	probably damaging	Het

Other mutations in Tmem184c

Allele	Source	Chr	Coord	Type	Predicted Effect	PPH Score
IGL02024:Tmem184c	APN	8	77604814	missense	probably benign	0.10
IGL02231:Tmem184c	APN	8	77604812	missense	probably damaging	1.00
IGL02736:Tmem184c	APN	8	77597846	missense	probably damaging	1.00
IGL02934:Tmem184c	APN	8	77597820	missense	probably damaging	1.00
IGL03046:Tmem184c	UTSW	8	77599657	nonsense	probably null
R0107:Tmem184c	UTSW	8	77597073	missense	possibly damaging	0.78
R0107:Tmem184c	UTSW	8	77597073	missense	possibly damaging	0.78
R0189:Tmem184c	UTSW	8	77597812	missense	possibly damaging	0.92
R0564:Tmem184c	UTSW	8	77606160	splice site	probably null
R0946:Tmem184c	UTSW	8	77604757	missense	probably damaging	1.00
R1629:Tmem184c	UTSW	8	77602922	missense	possibly damaging	0.87
R1629:Tmem184c	UTSW	8	77606162	critical splice donor site	probably null
R2261:Tmem184c	UTSW	8	77597043	missense	probably damaging	1.00
R2261:Tmem184c	UTSW	8	77597175	missense	probably damaging	0.99
R2919:Tmem184c	UTSW	8	77604647	missense	probably damaging	1.00
R3805:Tmem184c	UTSW	8	77596875	missense	unknown
R5418:Tmem184c	UTSW	8	77597820	missense	probably damaging	1.00
R5716:Tmem184c	UTSW	8	77606407	missense	possibly damaging	0.90
R5934:Tmem184c	UTSW	8	77604723	nonsense	probably null
R5951:Tmem184c	UTSW	8	77598662	splice site	probably null
R6150:Tmem184c	UTSW	8	77596440	missense	probably benign	0.04
R7206:Tmem184c	UTSW	8	77596577	missense	possibly damaging	0.46
R7387:Tmem184c	UTSW	8	77597930	nonsense	probably null
R7899:Tmem184c	UTSW	8	77597811	missense	probably damaging	1.00
R7959:Tmem184c	UTSW	8	77602903	missense	possibly damaging	0.94
R8100:Tmem184c	UTSW	8	77604782	missense	possibly damaging	0.92
R8246:Tmem184c	UTSW	8	77610185	missense	probably damaging	1.00
R9800:Tmem184c	UTSW	8	77596458	missense	probably benign	0.10

Posted On

2014-05-07