Incidental Mutation 'IGL01895:Cyp2c65'
ID 179348
Institutional Source Australian Phenomics Network (link to record)
Gene Symbol Cyp2c65
Ensembl Gene ENSMUSG00000067231
Gene Name cytochrome P450, family 2, subfamily c, polypeptide 65
Synonyms 2210009K14Rik
Accession Numbers
Essential gene? Probably non essential (E-score: 0.082) question?
Stock # IGL01895
Quality Score
Status
Chromosome 19
Chromosomal Location 39049459-39082388 bp(+) (GRCm39)
Type of Mutation missense
DNA Base Change (assembly) T to A at 39060676 bp (GRCm39)
Zygosity Heterozygous
Amino Acid Change Cysteine to Serine at position 179 (C179S)
Ref Sequence ENSEMBL: ENSMUSP00000084489 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000087236]
AlphaFold Q148B1
Predicted Effect possibly damaging
Transcript: ENSMUST00000087236
AA Change: C179S

PolyPhen 2 Score 0.900 (Sensitivity: 0.82; Specificity: 0.94)
SMART Domains Protein: ENSMUSP00000084489
Gene: ENSMUSG00000067231
AA Change: C179S

DomainStartEndE-ValueType
signal peptide 1 25 N/A INTRINSIC
Pfam:p450 30 487 2.1e-160 PFAM
Coding Region Coverage
Validation Efficiency
Allele List at MGI
Other mutations in this stock
Total: 38 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
Abcc6 A T 7: 45,678,482 (GRCm39) I56N possibly damaging Het
Akr1c13 A T 13: 4,255,372 (GRCm39) E321V possibly damaging Het
Atp8b3 A T 10: 80,357,662 (GRCm39) V1119D possibly damaging Het
Cacna1e G T 1: 154,319,646 (GRCm39) F1351L probably damaging Het
Cadps2 A G 6: 23,427,274 (GRCm39) W585R probably damaging Het
Ccdc113 C T 8: 96,263,086 (GRCm39) probably benign Het
Ccer1 A T 10: 97,529,912 (GRCm39) I192F unknown Het
Chd8 T C 14: 52,436,551 (GRCm39) N90S probably benign Het
Clca3a1 A T 3: 144,453,333 (GRCm39) C463* probably null Het
Cplane1 T A 15: 8,258,591 (GRCm39) V2279E possibly damaging Het
Dennd4b A G 3: 90,182,874 (GRCm39) Q35R probably benign Het
Enpep T C 3: 129,063,983 (GRCm39) E928G possibly damaging Het
Fem1c T C 18: 46,638,629 (GRCm39) T458A probably benign Het
Fezf2 A T 14: 12,342,498 (GRCm38) *456R probably null Het
Gm10718 A T 9: 3,025,118 (GRCm39) Y194F probably benign Het
Gm21738 G A 14: 19,416,979 (GRCm38) S144L probably benign Het
Iqcm T G 8: 76,615,188 (GRCm39) L423R probably damaging Het
Kcnc4 C A 3: 107,355,534 (GRCm39) V305L probably benign Het
Kif1a G A 1: 92,953,455 (GRCm39) T1337I possibly damaging Het
Lpxn A G 19: 12,810,450 (GRCm39) D298G probably damaging Het
Lypd8 A G 11: 58,281,046 (GRCm39) T203A possibly damaging Het
Mrps28 C T 3: 8,965,119 (GRCm39) V107M probably damaging Het
Myo15b A G 11: 115,774,324 (GRCm39) E586G possibly damaging Het
Pdzk1 C T 3: 96,776,417 (GRCm39) A459V possibly damaging Het
Rbpj A G 5: 53,808,728 (GRCm39) D285G probably damaging Het
Rimbp3 T C 16: 17,029,300 (GRCm39) L908P probably damaging Het
Samd4b T C 7: 28,101,334 (GRCm39) probably null Het
Slc28a2b A C 2: 122,355,572 (GRCm39) Y588S possibly damaging Het
Stau2 C T 1: 16,416,161 (GRCm39) G401S probably damaging Het
Trpa1 A T 1: 14,957,867 (GRCm39) I697K possibly damaging Het
Ttc17 A C 2: 94,205,491 (GRCm39) V285G possibly damaging Het
Unc5b A G 10: 60,602,864 (GRCm39) F845S probably damaging Het
Vmn1r19 A T 6: 57,382,245 (GRCm39) Q266L probably benign Het
Vmn2r106 T C 17: 20,499,227 (GRCm39) N228S probably benign Het
Vps13d A G 4: 144,882,836 (GRCm39) F919S possibly damaging Het
Zbtb38 C T 9: 96,570,461 (GRCm39) V208I probably benign Het
Zfp990 A T 4: 145,263,427 (GRCm39) T142S probably damaging Het
Zfp990 C A 4: 145,263,428 (GRCm39) T142N probably damaging Het
Other mutations in Cyp2c65
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL01122:Cyp2c65 APN 19 39,060,621 (GRCm39) critical splice acceptor site probably null
IGL01124:Cyp2c65 APN 19 39,081,954 (GRCm39) utr 3 prime probably benign
IGL02544:Cyp2c65 APN 19 39,079,082 (GRCm39) missense probably damaging 1.00
R0172:Cyp2c65 UTSW 19 39,076,100 (GRCm39) missense possibly damaging 0.86
R0378:Cyp2c65 UTSW 19 39,061,662 (GRCm39) missense probably benign 0.19
R0517:Cyp2c65 UTSW 19 39,070,792 (GRCm39) splice site probably benign
R0585:Cyp2c65 UTSW 19 39,057,686 (GRCm39) missense probably benign 0.00
R1770:Cyp2c65 UTSW 19 39,070,642 (GRCm39) missense probably benign 0.07
R2051:Cyp2c65 UTSW 19 39,070,675 (GRCm39) missense probably benign 0.12
R2310:Cyp2c65 UTSW 19 39,081,826 (GRCm39) missense probably benign 0.02
R2911:Cyp2c65 UTSW 19 39,076,126 (GRCm39) missense probably damaging 0.96
R4208:Cyp2c65 UTSW 19 39,079,099 (GRCm39) missense probably damaging 1.00
R4258:Cyp2c65 UTSW 19 39,081,872 (GRCm39) missense probably benign 0.41
R4734:Cyp2c65 UTSW 19 39,060,778 (GRCm39) missense probably benign 0.00
R4821:Cyp2c65 UTSW 19 39,060,635 (GRCm39) missense probably damaging 1.00
R4926:Cyp2c65 UTSW 19 39,049,597 (GRCm39) missense probably benign 0.00
R5060:Cyp2c65 UTSW 19 39,049,514 (GRCm39) missense unknown
R5091:Cyp2c65 UTSW 19 39,076,009 (GRCm39) critical splice acceptor site probably null
R5433:Cyp2c65 UTSW 19 39,081,928 (GRCm39) missense probably benign 0.00
R6051:Cyp2c65 UTSW 19 39,049,610 (GRCm39) missense probably benign 0.29
R6182:Cyp2c65 UTSW 19 39,049,606 (GRCm39) missense probably benign 0.18
R6400:Cyp2c65 UTSW 19 39,049,558 (GRCm39) missense possibly damaging 0.80
R6586:Cyp2c65 UTSW 19 39,070,662 (GRCm39) missense possibly damaging 0.89
R6672:Cyp2c65 UTSW 19 39,076,118 (GRCm39) missense probably damaging 1.00
R6850:Cyp2c65 UTSW 19 39,057,535 (GRCm39) missense probably benign 0.15
R8075:Cyp2c65 UTSW 19 39,060,682 (GRCm39) missense probably benign 0.10
R8756:Cyp2c65 UTSW 19 39,049,552 (GRCm39) nonsense probably null
R9006:Cyp2c65 UTSW 19 39,070,714 (GRCm39) missense probably damaging 1.00
R9031:Cyp2c65 UTSW 19 39,061,663 (GRCm39) nonsense probably null
R9231:Cyp2c65 UTSW 19 39,060,661 (GRCm39) missense possibly damaging 0.92
R9663:Cyp2c65 UTSW 19 39,079,070 (GRCm39) critical splice acceptor site probably null
Posted On 2014-05-07