Mutagenetix > Incidental Mutation

Incidental Mutation 'IGL01895:Vmn2r106'

179362

Institutional Source

Australian Phenomics Network (link to record)

Gene Symbol

Vmn2r106

Ensembl Gene

ENSMUSG00000091656

Gene Name

vomeronasal 2, receptor 106

Synonyms

EG224576

Accession Numbers

Essential gene?

Probably non essential (E-score: 0.123) question?

Stock #

IGL01895

Quality Score

Status

Chromosome

Chromosomal Location

20267547-20285430 bp(-) (GRCm38)

Type of Mutation

missense

DNA Base Change (assembly)

T to C at 20278965 bp (GRCm38)

Zygosity

Heterozygous

Amino Acid Change

Asparagine to Serine at position 228 (N228S)

Ref Sequence

ENSEMBL: ENSMUSP00000126534 (fasta)

Gene Model

predicted gene model for transcript(s): [ENSMUST00000167464]

AlphaFold

E9PY92

Predicted Effect

probably benign
Transcript: ENSMUST00000167464
AA Change: N228S

PolyPhen 2 Score 0.022 (Sensitivity: 0.95; Specificity: 0.81)

SMART Domains

Protein: ENSMUSP00000126534
Gene: ENSMUSG00000091656
AA Change: N228S

Domain	Start	End	E-Value	Type
signal peptide	1	19	N/A	INTRINSIC
Pfam:ANF_receptor	83	471	3.8e-37	PFAM
Pfam:NCD3G	514	567	5.7e-22	PFAM
Pfam:7tm_3	596	835	1.3e-49	PFAM

Coding Region Coverage

Validation Efficiency

Allele List at MGI

Other mutations in this stock

Total: 38 list
Gene	Ref	Var	Chr/Loc	Mutation	Predicted Effect	Zygosity
2410089E03Rik	T	A	15: 8,229,107	V2279E	possibly damaging	Het
Abcc6	A	T	7: 46,029,058	I56N	possibly damaging	Het
Akr1c13	A	T	13: 4,205,373	E321V	possibly damaging	Het
Atp8b3	A	T	10: 80,521,828	V1119D	possibly damaging	Het
Cacna1e	G	T	1: 154,443,900	F1351L	probably damaging	Het
Cadps2	A	G	6: 23,427,275	W585R	probably damaging	Het
Ccdc113	C	T	8: 95,536,458		probably benign	Het
Ccer1	A	T	10: 97,694,050	I192F	unknown	Het
Chd8	T	C	14: 52,199,094	N90S	probably benign	Het
Clca3a1	A	T	3: 144,747,572	C463*	probably null	Het
Cyp2c65	T	A	19: 39,072,232	C179S	possibly damaging	Het
Dennd4b	A	G	3: 90,275,567	Q35R	probably benign	Het
Enpep	T	C	3: 129,270,334	E928G	possibly damaging	Het
Fem1c	T	C	18: 46,505,562	T458A	probably benign	Het
Fezf2	A	T	14: 12,342,498	*456R	probably null	Het
Gm10718	A	T	9: 3,025,118	Y194F	probably benign	Het
Gm14085	A	C	2: 122,525,091	Y588S	possibly damaging	Het
Gm21738	G	A	14: 19,416,979	S144L	probably benign	Het
Iqcm	T	G	8: 75,888,560	L423R	probably damaging	Het
Kcnc4	C	A	3: 107,448,218	V305L	probably benign	Het
Kif1a	G	A	1: 93,025,733	T1337I	possibly damaging	Het
Lpxn	A	G	19: 12,833,086	D298G	probably damaging	Het
Lypd8	A	G	11: 58,390,220	T203A	possibly damaging	Het
Mrps28	C	T	3: 8,900,059	V107M	probably damaging	Het
Myo15b	A	G	11: 115,883,498	E586G	possibly damaging	Het
Pdzk1	C	T	3: 96,869,101	A459V	possibly damaging	Het
Rbpj	A	G	5: 53,651,386	D285G	probably damaging	Het
Rimbp3	T	C	16: 17,211,436	L908P	probably damaging	Het
Samd4b	T	C	7: 28,401,909		probably null	Het
Stau2	C	T	1: 16,345,937	G401S	probably damaging	Het
Trpa1	A	T	1: 14,887,643	I697K	possibly damaging	Het
Ttc17	A	C	2: 94,375,146	V285G	possibly damaging	Het
Unc5b	A	G	10: 60,767,085	F845S	probably damaging	Het
Vmn1r19	A	T	6: 57,405,260	Q266L	probably benign	Het
Vps13d	A	G	4: 145,156,266	F919S	possibly damaging	Het
Zbtb38	C	T	9: 96,688,408	V208I	probably benign	Het
Zfp990	A	T	4: 145,536,857	T142S	probably damaging	Het
Zfp990	C	A	4: 145,536,858	T142N	probably damaging	Het

Other mutations in Vmn2r106

Allele	Source	Chr	Coord	Type	Predicted Effect	PPH Score
IGL00979:Vmn2r106	APN	17	20277575	missense	possibly damaging	0.90
IGL01313:Vmn2r106	APN	17	20278389	missense	probably damaging	0.99
IGL01419:Vmn2r106	APN	17	20279545	missense	probably benign	0.06
IGL01574:Vmn2r106	APN	17	20268310	missense	possibly damaging	0.94
IGL01796:Vmn2r106	APN	17	20268052	missense	possibly damaging	0.79
IGL01893:Vmn2r106	APN	17	20277468	missense	probably benign	0.06
IGL02378:Vmn2r106	APN	17	20277529	missense	probably damaging	1.00
IGL02430:Vmn2r106	APN	17	20278896	missense	probably benign	0.38
IGL02664:Vmn2r106	APN	17	20268082	missense	possibly damaging	0.88
IGL03308:Vmn2r106	APN	17	20278523	nonsense	probably null
IGL03384:Vmn2r106	APN	17	20268143	missense	probably damaging	0.99
R0401:Vmn2r106	UTSW	17	20279019	missense	possibly damaging	0.86
R0842:Vmn2r106	UTSW	17	20268203	missense	probably damaging	1.00
R0964:Vmn2r106	UTSW	17	20267597	missense	probably benign	0.00
R1235:Vmn2r106	UTSW	17	20279479	missense	probably benign	0.00
R1709:Vmn2r106	UTSW	17	20279111	missense	probably benign	0.12
R1712:Vmn2r106	UTSW	17	20278735	missense	probably benign	0.01
R1770:Vmn2r106	UTSW	17	20268298	missense	probably damaging	0.99
R2049:Vmn2r106	UTSW	17	20268304	missense	possibly damaging	0.90
R2245:Vmn2r106	UTSW	17	20268161	missense	probably benign	0.13
R2336:Vmn2r106	UTSW	17	20268208	missense	probably benign	0.18
R2910:Vmn2r106	UTSW	17	20278684	missense	probably damaging	1.00
R3025:Vmn2r106	UTSW	17	20278885	missense	probably benign	0.00
R3944:Vmn2r106	UTSW	17	20267651	missense	probably damaging	1.00
R4081:Vmn2r106	UTSW	17	20267556	nonsense	probably null
R4153:Vmn2r106	UTSW	17	20267818	missense	probably damaging	1.00
R4356:Vmn2r106	UTSW	17	20279648	missense	probably benign	0.06
R4426:Vmn2r106	UTSW	17	20285379	missense	probably benign	0.00
R4590:Vmn2r106	UTSW	17	20277466	missense	probably damaging	0.99
R4661:Vmn2r106	UTSW	17	20267623	missense	probably benign	0.10
R5106:Vmn2r106	UTSW	17	20279133	critical splice acceptor site	probably null
R5341:Vmn2r106	UTSW	17	20277526	missense	probably benign	0.00
R5509:Vmn2r106	UTSW	17	20278422	missense	probably damaging	0.99
R5826:Vmn2r106	UTSW	17	20278871	missense	probably benign
R5859:Vmn2r106	UTSW	17	20285321	missense	possibly damaging	0.72
R5937:Vmn2r106	UTSW	17	20285405	nonsense	probably null
R5972:Vmn2r106	UTSW	17	20278476	missense	probably benign
R6056:Vmn2r106	UTSW	17	20267544	splice site	probably null
R6108:Vmn2r106	UTSW	17	20268376	missense	probably benign	0.11
R6114:Vmn2r106	UTSW	17	20268376	missense	probably benign	0.11
R6115:Vmn2r106	UTSW	17	20268376	missense	probably benign	0.11
R6132:Vmn2r106	UTSW	17	20268404	missense	probably benign
R6208:Vmn2r106	UTSW	17	20268329	missense	probably damaging	0.99
R6217:Vmn2r106	UTSW	17	20268239	missense	probably benign	0.10
R6289:Vmn2r106	UTSW	17	20268463	missense	probably damaging	1.00
R6378:Vmn2r106	UTSW	17	20278405	missense	probably benign	0.19
R6390:Vmn2r106	UTSW	17	20268463	missense	probably damaging	1.00
R6391:Vmn2r106	UTSW	17	20268463	missense	probably damaging	1.00
R6392:Vmn2r106	UTSW	17	20268463	missense	probably damaging	1.00
R6405:Vmn2r106	UTSW	17	20279099	missense	probably benign	0.22
R6427:Vmn2r106	UTSW	17	20268463	missense	probably damaging	1.00
R6428:Vmn2r106	UTSW	17	20268463	missense	probably damaging	1.00
R6435:Vmn2r106	UTSW	17	20268463	missense	probably damaging	1.00
R6436:Vmn2r106	UTSW	17	20268463	missense	probably damaging	1.00
R6437:Vmn2r106	UTSW	17	20268463	missense	probably damaging	1.00
R6511:Vmn2r106	UTSW	17	20268463	missense	probably damaging	1.00
R6512:Vmn2r106	UTSW	17	20268463	missense	probably damaging	1.00
R6587:Vmn2r106	UTSW	17	20268463	missense	probably damaging	1.00
R6703:Vmn2r106	UTSW	17	20268463	missense	probably damaging	1.00
R6730:Vmn2r106	UTSW	17	20278834	missense	possibly damaging	0.64
R6961:Vmn2r106	UTSW	17	20268384	nonsense	probably null
R7054:Vmn2r106	UTSW	17	20278920	missense	probably damaging	0.96
R7379:Vmn2r106	UTSW	17	20267775	missense	possibly damaging	0.75
R7402:Vmn2r106	UTSW	17	20267621	missense	probably damaging	0.99
R7497:Vmn2r106	UTSW	17	20267939	missense	probably damaging	1.00
R7692:Vmn2r106	UTSW	17	20285228	missense	possibly damaging	0.96
R8539:Vmn2r106	UTSW	17	20279009	missense	probably benign	0.00
R8827:Vmn2r106	UTSW	17	20267606	missense	probably benign	0.05
R8872:Vmn2r106	UTSW	17	20268139	missense	probably benign	0.19
R9118:Vmn2r106	UTSW	17	20285405	missense	probably benign	0.00
R9254:Vmn2r106	UTSW	17	20275804	missense	probably damaging	1.00
R9379:Vmn2r106	UTSW	17	20275804	missense	probably damaging	1.00
R9571:Vmn2r106	UTSW	17	20285379	missense	probably benign	0.17

Posted On

2014-05-07