Incidental Mutation 'IGL01895:Vmn2r106'
ID 179362
Institutional Source Australian Phenomics Network (link to record)
Gene Symbol Vmn2r106
Ensembl Gene ENSMUSG00000091656
Gene Name vomeronasal 2, receptor 106
Synonyms EG224576
Accession Numbers
Essential gene? Probably non essential (E-score: 0.166) question?
Stock # IGL01895
Quality Score
Status
Chromosome 17
Chromosomal Location 20487809-20505692 bp(-) (GRCm39)
Type of Mutation missense
DNA Base Change (assembly) T to C at 20499227 bp (GRCm39)
Zygosity Heterozygous
Amino Acid Change Asparagine to Serine at position 228 (N228S)
Ref Sequence ENSEMBL: ENSMUSP00000126534 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000167464]
AlphaFold E9PY92
Predicted Effect probably benign
Transcript: ENSMUST00000167464
AA Change: N228S

PolyPhen 2 Score 0.022 (Sensitivity: 0.95; Specificity: 0.81)
SMART Domains Protein: ENSMUSP00000126534
Gene: ENSMUSG00000091656
AA Change: N228S

DomainStartEndE-ValueType
signal peptide 1 19 N/A INTRINSIC
Pfam:ANF_receptor 83 471 3.8e-37 PFAM
Pfam:NCD3G 514 567 5.7e-22 PFAM
Pfam:7tm_3 596 835 1.3e-49 PFAM
Coding Region Coverage
Validation Efficiency
Allele List at MGI
Other mutations in this stock
Total: 38 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
Abcc6 A T 7: 45,678,482 (GRCm39) I56N possibly damaging Het
Akr1c13 A T 13: 4,255,372 (GRCm39) E321V possibly damaging Het
Atp8b3 A T 10: 80,357,662 (GRCm39) V1119D possibly damaging Het
Cacna1e G T 1: 154,319,646 (GRCm39) F1351L probably damaging Het
Cadps2 A G 6: 23,427,274 (GRCm39) W585R probably damaging Het
Ccdc113 C T 8: 96,263,086 (GRCm39) probably benign Het
Ccer1 A T 10: 97,529,912 (GRCm39) I192F unknown Het
Chd8 T C 14: 52,436,551 (GRCm39) N90S probably benign Het
Clca3a1 A T 3: 144,453,333 (GRCm39) C463* probably null Het
Cplane1 T A 15: 8,258,591 (GRCm39) V2279E possibly damaging Het
Cyp2c65 T A 19: 39,060,676 (GRCm39) C179S possibly damaging Het
Dennd4b A G 3: 90,182,874 (GRCm39) Q35R probably benign Het
Enpep T C 3: 129,063,983 (GRCm39) E928G possibly damaging Het
Fem1c T C 18: 46,638,629 (GRCm39) T458A probably benign Het
Fezf2 A T 14: 12,342,498 (GRCm38) *456R probably null Het
Gm10718 A T 9: 3,025,118 (GRCm39) Y194F probably benign Het
Gm21738 G A 14: 19,416,979 (GRCm38) S144L probably benign Het
Iqcm T G 8: 76,615,188 (GRCm39) L423R probably damaging Het
Kcnc4 C A 3: 107,355,534 (GRCm39) V305L probably benign Het
Kif1a G A 1: 92,953,455 (GRCm39) T1337I possibly damaging Het
Lpxn A G 19: 12,810,450 (GRCm39) D298G probably damaging Het
Lypd8 A G 11: 58,281,046 (GRCm39) T203A possibly damaging Het
Mrps28 C T 3: 8,965,119 (GRCm39) V107M probably damaging Het
Myo15b A G 11: 115,774,324 (GRCm39) E586G possibly damaging Het
Pdzk1 C T 3: 96,776,417 (GRCm39) A459V possibly damaging Het
Rbpj A G 5: 53,808,728 (GRCm39) D285G probably damaging Het
Rimbp3 T C 16: 17,029,300 (GRCm39) L908P probably damaging Het
Samd4b T C 7: 28,101,334 (GRCm39) probably null Het
Slc28a2b A C 2: 122,355,572 (GRCm39) Y588S possibly damaging Het
Stau2 C T 1: 16,416,161 (GRCm39) G401S probably damaging Het
Trpa1 A T 1: 14,957,867 (GRCm39) I697K possibly damaging Het
Ttc17 A C 2: 94,205,491 (GRCm39) V285G possibly damaging Het
Unc5b A G 10: 60,602,864 (GRCm39) F845S probably damaging Het
Vmn1r19 A T 6: 57,382,245 (GRCm39) Q266L probably benign Het
Vps13d A G 4: 144,882,836 (GRCm39) F919S possibly damaging Het
Zbtb38 C T 9: 96,570,461 (GRCm39) V208I probably benign Het
Zfp990 A T 4: 145,263,427 (GRCm39) T142S probably damaging Het
Zfp990 C A 4: 145,263,428 (GRCm39) T142N probably damaging Het
Other mutations in Vmn2r106
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL00979:Vmn2r106 APN 17 20,497,837 (GRCm39) missense possibly damaging 0.90
IGL01313:Vmn2r106 APN 17 20,498,651 (GRCm39) missense probably damaging 0.99
IGL01419:Vmn2r106 APN 17 20,499,807 (GRCm39) missense probably benign 0.06
IGL01574:Vmn2r106 APN 17 20,488,572 (GRCm39) missense possibly damaging 0.94
IGL01796:Vmn2r106 APN 17 20,488,314 (GRCm39) missense possibly damaging 0.79
IGL01893:Vmn2r106 APN 17 20,497,730 (GRCm39) missense probably benign 0.06
IGL02378:Vmn2r106 APN 17 20,497,791 (GRCm39) missense probably damaging 1.00
IGL02430:Vmn2r106 APN 17 20,499,158 (GRCm39) missense probably benign 0.38
IGL02664:Vmn2r106 APN 17 20,488,344 (GRCm39) missense possibly damaging 0.88
IGL03308:Vmn2r106 APN 17 20,498,785 (GRCm39) nonsense probably null
IGL03384:Vmn2r106 APN 17 20,488,405 (GRCm39) missense probably damaging 0.99
R0401:Vmn2r106 UTSW 17 20,499,281 (GRCm39) missense possibly damaging 0.86
R0842:Vmn2r106 UTSW 17 20,488,465 (GRCm39) missense probably damaging 1.00
R0964:Vmn2r106 UTSW 17 20,487,859 (GRCm39) missense probably benign 0.00
R1235:Vmn2r106 UTSW 17 20,499,741 (GRCm39) missense probably benign 0.00
R1709:Vmn2r106 UTSW 17 20,499,373 (GRCm39) missense probably benign 0.12
R1712:Vmn2r106 UTSW 17 20,498,997 (GRCm39) missense probably benign 0.01
R1770:Vmn2r106 UTSW 17 20,488,560 (GRCm39) missense probably damaging 0.99
R2049:Vmn2r106 UTSW 17 20,488,566 (GRCm39) missense possibly damaging 0.90
R2245:Vmn2r106 UTSW 17 20,488,423 (GRCm39) missense probably benign 0.13
R2336:Vmn2r106 UTSW 17 20,488,470 (GRCm39) missense probably benign 0.18
R2910:Vmn2r106 UTSW 17 20,498,946 (GRCm39) missense probably damaging 1.00
R3025:Vmn2r106 UTSW 17 20,499,147 (GRCm39) missense probably benign 0.00
R3944:Vmn2r106 UTSW 17 20,487,913 (GRCm39) missense probably damaging 1.00
R4081:Vmn2r106 UTSW 17 20,487,818 (GRCm39) nonsense probably null
R4153:Vmn2r106 UTSW 17 20,488,080 (GRCm39) missense probably damaging 1.00
R4356:Vmn2r106 UTSW 17 20,499,910 (GRCm39) missense probably benign 0.06
R4426:Vmn2r106 UTSW 17 20,505,641 (GRCm39) missense probably benign 0.00
R4590:Vmn2r106 UTSW 17 20,497,728 (GRCm39) missense probably damaging 0.99
R4661:Vmn2r106 UTSW 17 20,487,885 (GRCm39) missense probably benign 0.10
R5106:Vmn2r106 UTSW 17 20,499,395 (GRCm39) critical splice acceptor site probably null
R5341:Vmn2r106 UTSW 17 20,497,788 (GRCm39) missense probably benign 0.00
R5509:Vmn2r106 UTSW 17 20,498,684 (GRCm39) missense probably damaging 0.99
R5826:Vmn2r106 UTSW 17 20,499,133 (GRCm39) missense probably benign
R5859:Vmn2r106 UTSW 17 20,505,583 (GRCm39) missense possibly damaging 0.72
R5937:Vmn2r106 UTSW 17 20,505,667 (GRCm39) nonsense probably null
R5972:Vmn2r106 UTSW 17 20,498,738 (GRCm39) missense probably benign
R6056:Vmn2r106 UTSW 17 20,487,806 (GRCm39) splice site probably null
R6108:Vmn2r106 UTSW 17 20,488,638 (GRCm39) missense probably benign 0.11
R6114:Vmn2r106 UTSW 17 20,488,638 (GRCm39) missense probably benign 0.11
R6115:Vmn2r106 UTSW 17 20,488,638 (GRCm39) missense probably benign 0.11
R6132:Vmn2r106 UTSW 17 20,488,666 (GRCm39) missense probably benign
R6208:Vmn2r106 UTSW 17 20,488,591 (GRCm39) missense probably damaging 0.99
R6217:Vmn2r106 UTSW 17 20,488,501 (GRCm39) missense probably benign 0.10
R6289:Vmn2r106 UTSW 17 20,488,725 (GRCm39) missense probably damaging 1.00
R6378:Vmn2r106 UTSW 17 20,498,667 (GRCm39) missense probably benign 0.19
R6390:Vmn2r106 UTSW 17 20,488,725 (GRCm39) missense probably damaging 1.00
R6391:Vmn2r106 UTSW 17 20,488,725 (GRCm39) missense probably damaging 1.00
R6392:Vmn2r106 UTSW 17 20,488,725 (GRCm39) missense probably damaging 1.00
R6405:Vmn2r106 UTSW 17 20,499,361 (GRCm39) missense probably benign 0.22
R6427:Vmn2r106 UTSW 17 20,488,725 (GRCm39) missense probably damaging 1.00
R6428:Vmn2r106 UTSW 17 20,488,725 (GRCm39) missense probably damaging 1.00
R6435:Vmn2r106 UTSW 17 20,488,725 (GRCm39) missense probably damaging 1.00
R6436:Vmn2r106 UTSW 17 20,488,725 (GRCm39) missense probably damaging 1.00
R6437:Vmn2r106 UTSW 17 20,488,725 (GRCm39) missense probably damaging 1.00
R6511:Vmn2r106 UTSW 17 20,488,725 (GRCm39) missense probably damaging 1.00
R6512:Vmn2r106 UTSW 17 20,488,725 (GRCm39) missense probably damaging 1.00
R6587:Vmn2r106 UTSW 17 20,488,725 (GRCm39) missense probably damaging 1.00
R6703:Vmn2r106 UTSW 17 20,488,725 (GRCm39) missense probably damaging 1.00
R6730:Vmn2r106 UTSW 17 20,499,096 (GRCm39) missense possibly damaging 0.64
R6961:Vmn2r106 UTSW 17 20,488,646 (GRCm39) nonsense probably null
R7054:Vmn2r106 UTSW 17 20,499,182 (GRCm39) missense probably damaging 0.96
R7379:Vmn2r106 UTSW 17 20,488,037 (GRCm39) missense possibly damaging 0.75
R7402:Vmn2r106 UTSW 17 20,487,883 (GRCm39) missense probably damaging 0.99
R7497:Vmn2r106 UTSW 17 20,488,201 (GRCm39) missense probably damaging 1.00
R7692:Vmn2r106 UTSW 17 20,505,490 (GRCm39) missense possibly damaging 0.96
R8539:Vmn2r106 UTSW 17 20,499,271 (GRCm39) missense probably benign 0.00
R8827:Vmn2r106 UTSW 17 20,487,868 (GRCm39) missense probably benign 0.05
R8872:Vmn2r106 UTSW 17 20,488,401 (GRCm39) missense probably benign 0.19
R9118:Vmn2r106 UTSW 17 20,505,667 (GRCm39) missense probably benign 0.00
R9254:Vmn2r106 UTSW 17 20,496,066 (GRCm39) missense probably damaging 1.00
R9379:Vmn2r106 UTSW 17 20,496,066 (GRCm39) missense probably damaging 1.00
R9571:Vmn2r106 UTSW 17 20,505,641 (GRCm39) missense probably benign 0.17
Posted On 2014-05-07