Mutagenetix > Incidental Mutation

Incidental Mutation 'IGL01895:Fem1c'

179372

Institutional Source

Australian Phenomics Network (link to record)

Gene Symbol

Fem1c

Ensembl Gene

ENSMUSG00000033319

Gene Name

fem-1 homolog c (C.elegans)

Synonyms

Accession Numbers

Essential gene?

Non essential (E-score: 0.000) question?

Stock #

IGL01895

Quality Score

Status

Chromosome

Chromosomal Location

46501746-46525971 bp(-) (GRCm38)

Type of Mutation

missense

DNA Base Change (assembly)

T to C at 46505562 bp (GRCm38)

Zygosity

Heterozygous

Amino Acid Change

Threonine to Alanine at position 458 (T458A)

Ref Sequence

ENSEMBL: ENSMUSP00000038816 (fasta)

Gene Model

predicted gene model for transcript(s): [ENSMUST00000036226]

AlphaFold

Q8CEF1

Predicted Effect

probably benign
Transcript: ENSMUST00000036226
AA Change: T458A

PolyPhen 2 Score 0.001 (Sensitivity: 0.99; Specificity: 0.15)

SMART Domains

Protein: ENSMUSP00000038816
Gene: ENSMUSG00000033319
AA Change: T458A

Domain	Start	End	E-Value	Type
ANK	2	31	1.12e3	SMART
ANK	40	70	1.51e-4	SMART
ANK	82	111	2.77e-3	SMART
ANK	115	144	1.12e-3	SMART
ANK	148	177	7.24e-7	SMART
ANK	181	210	9.13e-4	SMART
ANK	213	243	5.67e0	SMART
low complexity region	381	394	N/A	INTRINSIC
ANK	481	523	5.67e0	SMART
ANK	527	556	1.88e-5	SMART

Coding Region Coverage

Validation Efficiency

MGI Phenotype

PHENOTYPE: Homozygous mutant mice are fertile and show no overt abnormalities. [provided by MGI curators]

Allele List at MGI

Other mutations in this stock

Total: 38 list
Gene	Ref	Var	Chr/Loc	Mutation	Predicted Effect	Zygosity
2410089E03Rik	T	A	15: 8,229,107	V2279E	possibly damaging	Het
Abcc6	A	T	7: 46,029,058	I56N	possibly damaging	Het
Akr1c13	A	T	13: 4,205,373	E321V	possibly damaging	Het
Atp8b3	A	T	10: 80,521,828	V1119D	possibly damaging	Het
Cacna1e	G	T	1: 154,443,900	F1351L	probably damaging	Het
Cadps2	A	G	6: 23,427,275	W585R	probably damaging	Het
Ccdc113	C	T	8: 95,536,458		probably benign	Het
Ccer1	A	T	10: 97,694,050	I192F	unknown	Het
Chd8	T	C	14: 52,199,094	N90S	probably benign	Het
Clca3a1	A	T	3: 144,747,572	C463*	probably null	Het
Cyp2c65	T	A	19: 39,072,232	C179S	possibly damaging	Het
Dennd4b	A	G	3: 90,275,567	Q35R	probably benign	Het
Enpep	T	C	3: 129,270,334	E928G	possibly damaging	Het
Fezf2	A	T	14: 12,342,498	*456R	probably null	Het
Gm10718	A	T	9: 3,025,118	Y194F	probably benign	Het
Gm14085	A	C	2: 122,525,091	Y588S	possibly damaging	Het
Gm21738	G	A	14: 19,416,979	S144L	probably benign	Het
Iqcm	T	G	8: 75,888,560	L423R	probably damaging	Het
Kcnc4	C	A	3: 107,448,218	V305L	probably benign	Het
Kif1a	G	A	1: 93,025,733	T1337I	possibly damaging	Het
Lpxn	A	G	19: 12,833,086	D298G	probably damaging	Het
Lypd8	A	G	11: 58,390,220	T203A	possibly damaging	Het
Mrps28	C	T	3: 8,900,059	V107M	probably damaging	Het
Myo15b	A	G	11: 115,883,498	E586G	possibly damaging	Het
Pdzk1	C	T	3: 96,869,101	A459V	possibly damaging	Het
Rbpj	A	G	5: 53,651,386	D285G	probably damaging	Het
Rimbp3	T	C	16: 17,211,436	L908P	probably damaging	Het
Samd4b	T	C	7: 28,401,909		probably null	Het
Stau2	C	T	1: 16,345,937	G401S	probably damaging	Het
Trpa1	A	T	1: 14,887,643	I697K	possibly damaging	Het
Ttc17	A	C	2: 94,375,146	V285G	possibly damaging	Het
Unc5b	A	G	10: 60,767,085	F845S	probably damaging	Het
Vmn1r19	A	T	6: 57,405,260	Q266L	probably benign	Het
Vmn2r106	T	C	17: 20,278,965	N228S	probably benign	Het
Vps13d	A	G	4: 145,156,266	F919S	possibly damaging	Het
Zbtb38	C	T	9: 96,688,408	V208I	probably benign	Het
Zfp990	A	T	4: 145,536,857	T142S	probably damaging	Het
Zfp990	C	A	4: 145,536,858	T142N	probably damaging	Het

Other mutations in Fem1c

Allele	Source	Chr	Coord	Type	Predicted Effect	PPH Score
IGL01594:Fem1c	APN	18	46506276	missense	probably benign	0.00
IGL02612:Fem1c	APN	18	46505714	missense	probably benign	0.05
IGL02628:Fem1c	APN	18	46505952	missense	probably damaging	1.00
R0605:Fem1c	UTSW	18	46505160	missense	probably benign	0.18
R0655:Fem1c	UTSW	18	46505160	missense	probably benign	0.18
R0735:Fem1c	UTSW	18	46505160	missense	probably benign	0.18
R1476:Fem1c	UTSW	18	46524485	missense	probably damaging	1.00
R1509:Fem1c	UTSW	18	46524213	missense	probably benign
R1704:Fem1c	UTSW	18	46506196	missense	probably benign	0.05
R1834:Fem1c	UTSW	18	46505282	missense	probably damaging	1.00
R2297:Fem1c	UTSW	18	46506161	missense	possibly damaging	0.84
R4609:Fem1c	UTSW	18	46505948	missense	probably damaging	1.00
R5119:Fem1c	UTSW	18	46506369	missense	probably damaging	1.00
R6505:Fem1c	UTSW	18	46505875	missense	possibly damaging	0.68
R7501:Fem1c	UTSW	18	46505801	missense	probably damaging	1.00
R7749:Fem1c	UTSW	18	46524118	missense	probably damaging	1.00
R7919:Fem1c	UTSW	18	46524303	missense	probably damaging	1.00
R8730:Fem1c	UTSW	18	46505601	missense	possibly damaging	0.83
R9597:Fem1c	UTSW	18	46505295	missense	probably damaging	1.00
R9651:Fem1c	UTSW	18	46524607	missense
R9716:Fem1c	UTSW	18	46524494	missense	probably damaging	0.99

Posted On

2014-05-07