Incidental Mutation 'IGL01895:Iqcm'
ID 179376
Institutional Source Australian Phenomics Network (link to record)
Gene Symbol Iqcm
Ensembl Gene ENSMUSG00000031620
Gene Name IQ motif containing M
Synonyms 1700007B14Rik
Accession Numbers
Essential gene? Probably non essential (E-score: 0.065) question?
Stock # IGL01895
Quality Score
Status
Chromosome 8
Chromosomal Location 76175322-76711131 bp(+) (GRCm39)
Type of Mutation missense
DNA Base Change (assembly) T to G at 76615188 bp (GRCm39)
Zygosity Heterozygous
Amino Acid Change Leucine to Arginine at position 423 (L423R)
Ref Sequence ENSEMBL: ENSMUSP00000148495 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000034033] [ENSMUST00000121983] [ENSMUST00000212704]
AlphaFold Q149I8
Predicted Effect probably damaging
Transcript: ENSMUST00000034033
AA Change: L423R

PolyPhen 2 Score 0.997 (Sensitivity: 0.41; Specificity: 0.98)
SMART Domains Protein: ENSMUSP00000034033
Gene: ENSMUSG00000031620
AA Change: L423R

DomainStartEndE-ValueType
IQ 281 303 2.54e-3 SMART
Predicted Effect probably damaging
Transcript: ENSMUST00000121983
AA Change: L423R

PolyPhen 2 Score 0.997 (Sensitivity: 0.41; Specificity: 0.98)
SMART Domains Protein: ENSMUSP00000112901
Gene: ENSMUSG00000031620
AA Change: L423R

DomainStartEndE-ValueType
IQ 281 303 2.54e-3 SMART
Predicted Effect probably damaging
Transcript: ENSMUST00000212704
AA Change: L423R

PolyPhen 2 Score 0.997 (Sensitivity: 0.41; Specificity: 0.98)
Coding Region Coverage
Validation Efficiency
Allele List at MGI
Other mutations in this stock
Total: 38 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
Abcc6 A T 7: 45,678,482 (GRCm39) I56N possibly damaging Het
Akr1c13 A T 13: 4,255,372 (GRCm39) E321V possibly damaging Het
Atp8b3 A T 10: 80,357,662 (GRCm39) V1119D possibly damaging Het
Cacna1e G T 1: 154,319,646 (GRCm39) F1351L probably damaging Het
Cadps2 A G 6: 23,427,274 (GRCm39) W585R probably damaging Het
Ccdc113 C T 8: 96,263,086 (GRCm39) probably benign Het
Ccer1 A T 10: 97,529,912 (GRCm39) I192F unknown Het
Chd8 T C 14: 52,436,551 (GRCm39) N90S probably benign Het
Clca3a1 A T 3: 144,453,333 (GRCm39) C463* probably null Het
Cplane1 T A 15: 8,258,591 (GRCm39) V2279E possibly damaging Het
Cyp2c65 T A 19: 39,060,676 (GRCm39) C179S possibly damaging Het
Dennd4b A G 3: 90,182,874 (GRCm39) Q35R probably benign Het
Enpep T C 3: 129,063,983 (GRCm39) E928G possibly damaging Het
Fem1c T C 18: 46,638,629 (GRCm39) T458A probably benign Het
Fezf2 A T 14: 12,342,498 (GRCm38) *456R probably null Het
Gm10718 A T 9: 3,025,118 (GRCm39) Y194F probably benign Het
Gm21738 G A 14: 19,416,979 (GRCm38) S144L probably benign Het
Kcnc4 C A 3: 107,355,534 (GRCm39) V305L probably benign Het
Kif1a G A 1: 92,953,455 (GRCm39) T1337I possibly damaging Het
Lpxn A G 19: 12,810,450 (GRCm39) D298G probably damaging Het
Lypd8 A G 11: 58,281,046 (GRCm39) T203A possibly damaging Het
Mrps28 C T 3: 8,965,119 (GRCm39) V107M probably damaging Het
Myo15b A G 11: 115,774,324 (GRCm39) E586G possibly damaging Het
Pdzk1 C T 3: 96,776,417 (GRCm39) A459V possibly damaging Het
Rbpj A G 5: 53,808,728 (GRCm39) D285G probably damaging Het
Rimbp3 T C 16: 17,029,300 (GRCm39) L908P probably damaging Het
Samd4b T C 7: 28,101,334 (GRCm39) probably null Het
Slc28a2b A C 2: 122,355,572 (GRCm39) Y588S possibly damaging Het
Stau2 C T 1: 16,416,161 (GRCm39) G401S probably damaging Het
Trpa1 A T 1: 14,957,867 (GRCm39) I697K possibly damaging Het
Ttc17 A C 2: 94,205,491 (GRCm39) V285G possibly damaging Het
Unc5b A G 10: 60,602,864 (GRCm39) F845S probably damaging Het
Vmn1r19 A T 6: 57,382,245 (GRCm39) Q266L probably benign Het
Vmn2r106 T C 17: 20,499,227 (GRCm39) N228S probably benign Het
Vps13d A G 4: 144,882,836 (GRCm39) F919S possibly damaging Het
Zbtb38 C T 9: 96,570,461 (GRCm39) V208I probably benign Het
Zfp990 A T 4: 145,263,427 (GRCm39) T142S probably damaging Het
Zfp990 C A 4: 145,263,428 (GRCm39) T142N probably damaging Het
Other mutations in Iqcm
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL02835:Iqcm APN 8 76,281,511 (GRCm39) utr 5 prime probably benign
R0056:Iqcm UTSW 8 76,480,014 (GRCm39) missense probably benign
R2146:Iqcm UTSW 8 76,615,241 (GRCm39) missense probably damaging 1.00
R2910:Iqcm UTSW 8 76,441,404 (GRCm39) missense probably benign
R3801:Iqcm UTSW 8 76,396,021 (GRCm39) missense possibly damaging 0.59
R3804:Iqcm UTSW 8 76,396,021 (GRCm39) missense possibly damaging 0.59
R3834:Iqcm UTSW 8 76,304,380 (GRCm39) missense possibly damaging 0.93
R3897:Iqcm UTSW 8 76,480,028 (GRCm39) missense probably damaging 1.00
R4447:Iqcm UTSW 8 76,356,394 (GRCm39) missense probably damaging 0.97
R4448:Iqcm UTSW 8 76,356,394 (GRCm39) missense probably damaging 0.97
R4450:Iqcm UTSW 8 76,356,394 (GRCm39) missense probably damaging 0.97
R4687:Iqcm UTSW 8 76,489,617 (GRCm39) missense probably damaging 1.00
R4810:Iqcm UTSW 8 76,615,281 (GRCm39) missense probably damaging 1.00
R4845:Iqcm UTSW 8 76,472,980 (GRCm39) missense probably damaging 0.99
R4856:Iqcm UTSW 8 76,615,228 (GRCm39) missense possibly damaging 0.95
R4886:Iqcm UTSW 8 76,615,228 (GRCm39) missense possibly damaging 0.95
R5063:Iqcm UTSW 8 76,472,914 (GRCm39) missense probably damaging 1.00
R5460:Iqcm UTSW 8 76,441,417 (GRCm39) missense probably benign
R6403:Iqcm UTSW 8 76,304,624 (GRCm39) critical splice donor site probably null
R6667:Iqcm UTSW 8 76,479,980 (GRCm39) missense probably damaging 1.00
R7187:Iqcm UTSW 8 76,480,044 (GRCm39) missense probably benign 0.22
R7263:Iqcm UTSW 8 76,489,701 (GRCm39) missense probably benign
R7701:Iqcm UTSW 8 76,281,539 (GRCm39) missense probably benign 0.02
R7916:Iqcm UTSW 8 76,304,578 (GRCm39) missense probably benign
R7938:Iqcm UTSW 8 76,304,596 (GRCm39) missense probably benign
R7974:Iqcm UTSW 8 76,281,520 (GRCm39) start codon destroyed probably null 0.66
R8039:Iqcm UTSW 8 76,489,733 (GRCm39) missense probably damaging 1.00
R8311:Iqcm UTSW 8 76,480,118 (GRCm39) splice site probably benign
R8703:Iqcm UTSW 8 76,615,271 (GRCm39) missense probably damaging 1.00
R9175:Iqcm UTSW 8 76,710,867 (GRCm39) missense possibly damaging 0.84
R9475:Iqcm UTSW 8 76,480,083 (GRCm39) missense probably damaging 1.00
RF002:Iqcm UTSW 8 76,304,527 (GRCm39) missense probably benign 0.01
X0018:Iqcm UTSW 8 76,710,840 (GRCm39) nonsense probably null
Posted On 2014-05-07