Mutagenetix > Incidental Mutation

Incidental Mutation 'IGL01896:Ttc24'

179417

Institutional Source

Australian Phenomics Network (link to record)

Gene Symbol

Ttc24

Ensembl Gene

ENSMUSG00000051036

Gene Name

tetratricopeptide repeat domain 24

Synonyms

A430025D11Rik

Accession Numbers

Essential gene?

Probably non essential (E-score: 0.050) question?

Stock #

IGL01896

Quality Score

Status

Chromosome

Chromosomal Location

87976717-87985611 bp(-) (GRCm39)

Type of Mutation

critical splice acceptor site

DNA Base Change (assembly)

T to C at 87977720 bp (GRCm39)

Zygosity

Heterozygous

Amino Acid Change

Ref Sequence

ENSEMBL: ENSMUSP00000066531 (fasta)

Gene Model

predicted gene model for transcript(s): [ENSMUST00000050258] [ENSMUST00000064550]

AlphaFold

Q8BYG0

Predicted Effect

probably null
Transcript: ENSMUST00000050258

SMART Domains

Protein: ENSMUSP00000061571
Gene: ENSMUSG00000051036

Domain	Start	End	E-Value	Type
TPR	35	68	3.5e0	SMART
TPR	72	105	4.09e-1	SMART
TPR	112	145	3.41e1	SMART
TPR	152	185	6.95e-4	SMART

Predicted Effect

probably null
Transcript: ENSMUST00000064550

Coding Region Coverage

Validation Efficiency

Allele List at MGI

Other mutations in this stock

Total: 37 list
Gene	Ref	Var	Chr/Loc	Mutation	Predicted Effect	Zygosity
9330159F19Rik	T	A	10: 29,101,154 (GRCm39)	F509Y	possibly damaging	Het
Acot11	T	A	4: 106,628,564 (GRCm39)	I75F	probably damaging	Het
Atp1a2	T	A	1: 172,113,578 (GRCm39)	N427Y	probably damaging	Het
Cd19	T	C	7: 126,013,522 (GRCm39)	D89G	possibly damaging	Het
Clca3a1	T	A	3: 144,721,438 (GRCm39)	T378S	possibly damaging	Het
Cltc	A	T	11: 86,615,959 (GRCm39)	C436S	probably damaging	Het
Def8	G	A	8: 124,186,634 (GRCm39)	V429M	probably benign	Het
Dnah9	A	T	11: 66,021,492 (GRCm39)	D311E	possibly damaging	Het
Dpy19l4	T	C	4: 11,267,752 (GRCm39)	K396R	possibly damaging	Het
Eif4b	T	C	15: 102,003,721 (GRCm39)	S597P	probably benign	Het
Ezh1	A	T	11: 101,104,581 (GRCm39)	N155K	probably benign	Het
Glud1	A	G	14: 34,041,862 (GRCm39)	S157G	probably benign	Het
Gm10718	A	T	9: 3,025,118 (GRCm39)	Y194F	probably benign	Het
Gm21738	G	A	14: 19,416,979 (GRCm38)	S144L	probably benign	Het
Gm5600	T	C	7: 113,307,221 (GRCm39)		noncoding transcript	Het
Hnf4g	T	A	3: 3,716,470 (GRCm39)	V298E	probably damaging	Het
Hspd1	C	T	1: 55,118,268 (GRCm39)	R446Q	probably benign	Het
Lyst	A	G	13: 13,810,162 (GRCm39)	I611V	probably benign	Het
Map4k3	T	C	17: 80,921,360 (GRCm39)	E524G	probably benign	Het
Mepe	A	G	5: 104,486,135 (GRCm39)	D425G	possibly damaging	Het
Myo1a	G	T	10: 127,555,773 (GRCm39)	V921L	probably benign	Het
Plxdc1	A	T	11: 97,815,408 (GRCm39)	M470K	probably damaging	Het
Prim1	A	G	10: 127,858,758 (GRCm39)	Y222C	probably damaging	Het
Ptpn13	A	G	5: 103,649,389 (GRCm39)	N264S	possibly damaging	Het
Qrsl1	T	C	10: 43,752,500 (GRCm39)	D441G	probably benign	Het
Samd9l	G	T	6: 3,375,120 (GRCm39)	Q714K	probably benign	Het
Scrib	T	C	15: 75,937,967 (GRCm39)	E293G	possibly damaging	Het
Slc12a2	T	A	18: 58,029,380 (GRCm39)	N255K	probably benign	Het
Slc6a6	T	C	6: 91,703,050 (GRCm39)	I141T	probably damaging	Het
Slc9a1	T	C	4: 133,145,370 (GRCm39)	L485P	probably damaging	Het
Slfn8	A	T	11: 82,894,522 (GRCm39)	Y706N	probably damaging	Het
Tlr5	T	C	1: 182,802,444 (GRCm39)	F583L	possibly damaging	Het
Tmprss15	A	G	16: 78,887,678 (GRCm39)	V43A	probably benign	Het
Ttc7	A	G	17: 87,666,552 (GRCm39)	T606A	probably damaging	Het
Ubap2	G	T	4: 41,202,362 (GRCm39)	P689T	possibly damaging	Het
Vmn2r129	C	T	4: 156,690,549 (GRCm39)		noncoding transcript	Het
Wfdc8	A	T	2: 164,447,700 (GRCm39)	M120K	probably damaging	Het

Other mutations in Ttc24

Allele	Source	Chr	Coord	Type	Predicted Effect	PPH Score
IGL03069:Ttc24	APN	3	87,977,408 (GRCm39)	missense	probably benign	0.07
R0153:Ttc24	UTSW	3	87,982,234 (GRCm39)	unclassified	probably benign
R1626:Ttc24	UTSW	3	87,977,366 (GRCm39)	missense	probably benign	0.00
R1735:Ttc24	UTSW	3	87,980,401 (GRCm39)	splice site	probably null
R1938:Ttc24	UTSW	3	87,982,181 (GRCm39)	missense	probably benign	0.28
R4112:Ttc24	UTSW	3	87,981,946 (GRCm39)	missense	probably damaging	0.99
R4200:Ttc24	UTSW	3	87,981,824 (GRCm39)	missense	probably benign	0.01
R7600:Ttc24	UTSW	3	87,979,320 (GRCm39)	start codon destroyed	probably null
R7939:Ttc24	UTSW	3	87,981,945 (GRCm39)	missense	possibly damaging	0.83
R8432:Ttc24	UTSW	3	87,977,366 (GRCm39)	missense	probably benign	0.15
R8519:Ttc24	UTSW	3	87,980,369 (GRCm39)	missense	probably damaging	1.00
R8784:Ttc24	UTSW	3	87,980,033 (GRCm39)	nonsense	probably null
R9164:Ttc24	UTSW	3	87,980,295 (GRCm39)	nonsense	probably null
R9370:Ttc24	UTSW	3	87,980,136 (GRCm39)	missense	probably benign	0.20
R9531:Ttc24	UTSW	3	87,978,416 (GRCm39)	missense	possibly damaging	0.79
Z1176:Ttc24	UTSW	3	87,979,293 (GRCm39)	missense	probably benign	0.06
Z1176:Ttc24	UTSW	3	87,978,365 (GRCm39)	frame shift	probably null

Posted On

2014-05-07