Incidental Mutation 'R0096:Vmn2r105'
| ID |
17942 |
| Institutional Source |
Beutler Lab
|
| Gene Symbol |
Vmn2r105
|
| Ensembl Gene |
ENSMUSG00000091670 |
| Gene Name |
vomeronasal 2, receptor 105 |
| Synonyms |
EG627743 |
| MMRRC Submission |
038382-MU
|
| Accession Numbers |
|
| Essential gene? |
Non essential
(E-score: 0.000)
|
| Stock # |
R0096 (G1)
|
| Quality Score |
|
|
Status
|
Validated
|
| Chromosome |
17 |
| Chromosomal Location |
20208230-20234872 bp(-) (GRCm38) |
| Type of Mutation |
missense |
| DNA Base Change (assembly) |
A to G
at 20227479 bp (GRCm38)
|
| Zygosity |
Heterozygous |
| Amino Acid Change |
Phenylalanine to Serine
at position 361
(F361S)
|
| Ref Sequence |
ENSEMBL: ENSMUSP00000129762
(fasta)
|
| Gene Model |
predicted gene model for transcript(s):
[ENSMUST00000167382]
|
| AlphaFold |
E9Q3A5 |
| Predicted Effect |
possibly damaging
Transcript: ENSMUST00000167382
AA Change: F361S
PolyPhen 2
Score 0.485 (Sensitivity: 0.88; Specificity: 0.90)
|
| SMART Domains |
Protein: ENSMUSP00000129762
Gene: ENSMUSG00000091670
AA Change: F361S
| Domain | Start | End | E-Value | Type |
|---|
|
Pfam:ANF_receptor
|
85 |
469 |
6.5e-42 |
PFAM |
|
Pfam:NCD3G
|
512 |
565 |
3.2e-21 |
PFAM |
|
Pfam:7tm_3
|
598 |
833 |
2.5e-51 |
PFAM |
|
| Meta Mutation Damage Score |
0.1795 |
| Coding Region Coverage |
- 1x: 90.0%
- 3x: 87.5%
- 10x: 81.4%
- 20x: 72.0%
|
| Validation Efficiency |
89% (76/85) |
| Allele List at MGI |
|
| Other mutations in this stock |
Total: 51 list
| Gene | Ref | Var | Chr/Loc | Mutation | Predicted Effect | Zygosity |
|---|
| 1600015I10Rik |
A |
C |
6: 48,931,188 (GRCm38) |
Q374P |
probably damaging |
Het |
| 4933405L10Rik |
A |
T |
8: 105,708,931 (GRCm38) |
|
probably null |
Het |
| AC132131.1 |
T |
C |
10: 90,074,062 (GRCm38) |
S48P |
possibly damaging |
Het |
| Adamts3 |
G |
A |
5: 89,701,717 (GRCm38) |
Q615* |
probably null |
Het |
| Adamtsl3 |
T |
A |
7: 82,465,699 (GRCm38) |
|
probably benign |
Het |
| Arhgap42 |
G |
T |
9: 9,009,313 (GRCm38) |
N524K |
probably damaging |
Het |
| Arhgef28 |
T |
G |
13: 97,931,254 (GRCm38) |
T1388P |
probably damaging |
Het |
| Arid4b |
T |
C |
13: 14,129,194 (GRCm38) |
V68A |
probably benign |
Het |
| Bard1 |
A |
T |
1: 71,053,730 (GRCm38) |
|
probably benign |
Het |
| BC005537 |
T |
C |
13: 24,805,940 (GRCm38) |
F129L |
probably damaging |
Het |
| Capn3 |
A |
T |
2: 120,502,529 (GRCm38) |
H592L |
possibly damaging |
Het |
| Ccdc105 |
T |
A |
10: 78,748,705 (GRCm38) |
I328L |
probably benign |
Het |
| Cilp |
A |
G |
9: 65,273,670 (GRCm38) |
T256A |
possibly damaging |
Het |
| Cpne8 |
T |
A |
15: 90,499,915 (GRCm38) |
I481L |
probably benign |
Het |
| Dglucy |
A |
T |
12: 100,838,651 (GRCm38) |
I134F |
possibly damaging |
Het |
| Dnaic2 |
A |
C |
11: 114,754,332 (GRCm38) |
D531A |
probably benign |
Het |
| Dthd1 |
A |
T |
5: 62,843,040 (GRCm38) |
R568S |
possibly damaging |
Het |
| Efr3a |
A |
G |
15: 65,855,441 (GRCm38) |
N613S |
probably damaging |
Het |
| Ermp1 |
A |
G |
19: 29,631,388 (GRCm38) |
Y164H |
possibly damaging |
Het |
| Fbrs |
C |
T |
7: 127,489,487 (GRCm38) |
A145V |
probably damaging |
Het |
| Gm9873 |
A |
T |
2: 169,021,109 (GRCm38) |
|
noncoding transcript |
Het |
| Grik1 |
T |
C |
16: 88,034,226 (GRCm38) |
M219V |
possibly damaging |
Het |
| Gucy1a2 |
A |
T |
9: 3,758,928 (GRCm38) |
|
probably benign |
Het |
| Itih5 |
G |
A |
2: 10,251,378 (GRCm38) |
R885Q |
probably benign |
Het |
| Kat2a |
A |
T |
11: 100,706,471 (GRCm38) |
V625E |
probably damaging |
Het |
| Kdm4c |
A |
G |
4: 74,357,343 (GRCm38) |
E752G |
probably damaging |
Het |
| Ksr1 |
A |
G |
11: 79,038,247 (GRCm38) |
|
probably benign |
Het |
| Lama1 |
T |
A |
17: 67,805,413 (GRCm38) |
F2283I |
probably benign |
Het |
| Luc7l3 |
A |
G |
11: 94,301,494 (GRCm38) |
|
probably benign |
Het |
| Map1a |
A |
G |
2: 121,301,505 (GRCm38) |
E696G |
probably damaging |
Het |
| Mrps34 |
A |
G |
17: 24,895,669 (GRCm38) |
D110G |
probably damaging |
Het |
| Myh11 |
T |
A |
16: 14,204,367 (GRCm38) |
K1710M |
possibly damaging |
Het |
| Myo1d |
A |
G |
11: 80,484,332 (GRCm38) |
L972P |
probably damaging |
Het |
| Nol4 |
T |
G |
18: 22,921,858 (GRCm38) |
T58P |
possibly damaging |
Het |
| Nos1ap |
T |
C |
1: 170,329,247 (GRCm38) |
D214G |
probably damaging |
Het |
| Olfr1224-ps1 |
A |
T |
2: 89,156,296 (GRCm38) |
M293K |
probably benign |
Het |
| Pde4dip |
A |
C |
3: 97,767,467 (GRCm38) |
D44E |
probably damaging |
Het |
| Pip4k2a |
G |
A |
2: 18,889,039 (GRCm38) |
|
probably benign |
Het |
| Prmt8 |
T |
A |
6: 127,732,627 (GRCm38) |
|
probably benign |
Het |
| Pygl |
A |
T |
12: 70,191,166 (GRCm38) |
|
probably benign |
Het |
| Ralgapa1 |
T |
C |
12: 55,739,505 (GRCm38) |
D643G |
probably damaging |
Het |
| Sdk2 |
A |
G |
11: 113,903,144 (GRCm38) |
|
probably benign |
Het |
| Skint5 |
A |
T |
4: 113,597,768 (GRCm38) |
|
probably benign |
Het |
| Slc27a6 |
T |
C |
18: 58,598,757 (GRCm38) |
|
probably benign |
Het |
| Spata46 |
C |
T |
1: 170,312,034 (GRCm38) |
Q201* |
probably null |
Het |
| Sptbn1 |
A |
T |
11: 30,114,739 (GRCm38) |
V1920E |
probably damaging |
Het |
| Sycp2 |
G |
T |
2: 178,403,735 (GRCm38) |
Q31K |
probably damaging |
Het |
| Taf6l |
A |
G |
19: 8,778,517 (GRCm38) |
F256L |
probably benign |
Het |
| Trf |
A |
G |
9: 103,222,159 (GRCm38) |
F300L |
probably damaging |
Het |
| Vmn2r79 |
A |
G |
7: 87,037,319 (GRCm38) |
Y636C |
probably damaging |
Het |
| Wdr59 |
T |
C |
8: 111,504,373 (GRCm38) |
N68D |
probably damaging |
Het |
|
| Other mutations in Vmn2r105 |
| Allele | Source | Chr | Coord | Type | Predicted Effect | PPH Score |
|---|
|
IGL01433:Vmn2r105
|
APN |
17 |
20,228,555 (GRCm38) |
missense |
probably benign |
0.01 |
|
IGL01909:Vmn2r105
|
APN |
17 |
20,224,656 (GRCm38) |
missense |
probably damaging |
1.00 |
|
IGL01925:Vmn2r105
|
APN |
17 |
20,208,711 (GRCm38) |
missense |
possibly damaging |
0.94 |
|
IGL02021:Vmn2r105
|
APN |
17 |
20,227,895 (GRCm38) |
missense |
possibly damaging |
0.49 |
|
IGL02828:Vmn2r105
|
APN |
17 |
20,209,083 (GRCm38) |
missense |
possibly damaging |
0.80 |
|
IGL02838:Vmn2r105
|
APN |
17 |
20,227,585 (GRCm38) |
missense |
probably damaging |
1.00 |
|
IGL03343:Vmn2r105
|
APN |
17 |
20,226,369 (GRCm38) |
nonsense |
probably null |
|
|
R0096:Vmn2r105
|
UTSW |
17 |
20,227,479 (GRCm38) |
missense |
possibly damaging |
0.49 |
|
R0212:Vmn2r105
|
UTSW |
17 |
20,208,565 (GRCm38) |
missense |
possibly damaging |
0.90 |
|
R0268:Vmn2r105
|
UTSW |
17 |
20,208,676 (GRCm38) |
missense |
probably benign |
0.18 |
|
R0271:Vmn2r105
|
UTSW |
17 |
20,234,703 (GRCm38) |
missense |
probably damaging |
0.96 |
|
R0613:Vmn2r105
|
UTSW |
17 |
20,208,316 (GRCm38) |
missense |
probably damaging |
1.00 |
|
R0765:Vmn2r105
|
UTSW |
17 |
20,227,857 (GRCm38) |
missense |
probably damaging |
0.98 |
|
R0765:Vmn2r105
|
UTSW |
17 |
20,227,711 (GRCm38) |
missense |
probably benign |
0.20 |
|
R1162:Vmn2r105
|
UTSW |
17 |
20,227,711 (GRCm38) |
missense |
probably benign |
0.20 |
|
R1263:Vmn2r105
|
UTSW |
17 |
20,208,322 (GRCm38) |
missense |
probably damaging |
1.00 |
|
R1363:Vmn2r105
|
UTSW |
17 |
20,208,670 (GRCm38) |
missense |
probably benign |
0.00 |
|
R1464:Vmn2r105
|
UTSW |
17 |
20,228,742 (GRCm38) |
splice site |
probably benign |
|
|
R2029:Vmn2r105
|
UTSW |
17 |
20,224,578 (GRCm38) |
missense |
probably damaging |
0.99 |
|
R2420:Vmn2r105
|
UTSW |
17 |
20,227,835 (GRCm38) |
missense |
probably benign |
0.15 |
|
R2421:Vmn2r105
|
UTSW |
17 |
20,227,835 (GRCm38) |
missense |
probably benign |
0.15 |
|
R2422:Vmn2r105
|
UTSW |
17 |
20,227,835 (GRCm38) |
missense |
probably benign |
0.15 |
|
R2570:Vmn2r105
|
UTSW |
17 |
20,227,323 (GRCm38) |
missense |
probably damaging |
1.00 |
|
R3847:Vmn2r105
|
UTSW |
17 |
20,208,690 (GRCm38) |
missense |
possibly damaging |
0.85 |
|
R3848:Vmn2r105
|
UTSW |
17 |
20,208,690 (GRCm38) |
missense |
possibly damaging |
0.85 |
|
R4030:Vmn2r105
|
UTSW |
17 |
20,208,754 (GRCm38) |
missense |
probably damaging |
0.99 |
|
R4275:Vmn2r105
|
UTSW |
17 |
20,228,640 (GRCm38) |
missense |
probably damaging |
1.00 |
|
R4551:Vmn2r105
|
UTSW |
17 |
20,226,351 (GRCm38) |
missense |
probably benign |
|
|
R4801:Vmn2r105
|
UTSW |
17 |
20,227,294 (GRCm38) |
missense |
probably benign |
0.00 |
|
R4802:Vmn2r105
|
UTSW |
17 |
20,227,294 (GRCm38) |
missense |
probably benign |
0.00 |
|
R4816:Vmn2r105
|
UTSW |
17 |
20,208,691 (GRCm38) |
missense |
probably benign |
0.27 |
|
R4929:Vmn2r105
|
UTSW |
17 |
20,228,018 (GRCm38) |
missense |
probably benign |
0.44 |
|
R5022:Vmn2r105
|
UTSW |
17 |
20,208,414 (GRCm38) |
missense |
probably damaging |
0.99 |
|
R5475:Vmn2r105
|
UTSW |
17 |
20,234,782 (GRCm38) |
missense |
probably benign |
|
|
R5576:Vmn2r105
|
UTSW |
17 |
20,224,574 (GRCm38) |
critical splice donor site |
probably null |
|
|
R5795:Vmn2r105
|
UTSW |
17 |
20,228,736 (GRCm38) |
missense |
probably benign |
0.00 |
|
R5895:Vmn2r105
|
UTSW |
17 |
20,228,667 (GRCm38) |
missense |
probably benign |
0.10 |
|
R6017:Vmn2r105
|
UTSW |
17 |
20,208,627 (GRCm38) |
missense |
probably damaging |
0.97 |
|
R6210:Vmn2r105
|
UTSW |
17 |
20,228,496 (GRCm38) |
missense |
probably damaging |
1.00 |
|
R6491:Vmn2r105
|
UTSW |
17 |
20,227,730 (GRCm38) |
nonsense |
probably null |
|
|
R6542:Vmn2r105
|
UTSW |
17 |
20,228,541 (GRCm38) |
missense |
probably benign |
0.03 |
|
R6729:Vmn2r105
|
UTSW |
17 |
20,208,343 (GRCm38) |
missense |
probably damaging |
0.99 |
|
R7020:Vmn2r105
|
UTSW |
17 |
20,209,074 (GRCm38) |
missense |
probably damaging |
1.00 |
|
R7033:Vmn2r105
|
UTSW |
17 |
20,208,612 (GRCm38) |
missense |
probably damaging |
0.97 |
|
R7488:Vmn2r105
|
UTSW |
17 |
20,208,783 (GRCm38) |
missense |
probably damaging |
1.00 |
|
R7491:Vmn2r105
|
UTSW |
17 |
20,228,565 (GRCm38) |
missense |
probably benign |
0.02 |
|
R7555:Vmn2r105
|
UTSW |
17 |
20,227,675 (GRCm38) |
missense |
probably damaging |
0.98 |
|
R7863:Vmn2r105
|
UTSW |
17 |
20,208,675 (GRCm38) |
missense |
probably benign |
0.18 |
|
R8137:Vmn2r105
|
UTSW |
17 |
20,234,704 (GRCm38) |
missense |
probably benign |
0.02 |
|
R8166:Vmn2r105
|
UTSW |
17 |
20,208,642 (GRCm38) |
missense |
probably benign |
0.07 |
|
R8186:Vmn2r105
|
UTSW |
17 |
20,224,618 (GRCm38) |
nonsense |
probably null |
|
|
R8214:Vmn2r105
|
UTSW |
17 |
20,228,513 (GRCm38) |
missense |
probably benign |
0.02 |
|
R8497:Vmn2r105
|
UTSW |
17 |
20,234,872 (GRCm38) |
start codon destroyed |
probably null |
0.75 |
|
R8850:Vmn2r105
|
UTSW |
17 |
20,208,610 (GRCm38) |
missense |
probably damaging |
1.00 |
|
R8880:Vmn2r105
|
UTSW |
17 |
20,208,967 (GRCm38) |
missense |
probably damaging |
0.99 |
|
R9272:Vmn2r105
|
UTSW |
17 |
20,227,423 (GRCm38) |
missense |
probably damaging |
1.00 |
|
R9506:Vmn2r105
|
UTSW |
17 |
20,209,142 (GRCm38) |
missense |
probably benign |
0.00 |
|
R9549:Vmn2r105
|
UTSW |
17 |
20,227,761 (GRCm38) |
missense |
probably benign |
0.12 |
|
| Posted On |
2013-03-25 |
Incidental Mutation