Incidental Mutation 'IGL01898:Igkv5-45'
ID179463
Institutional Source Australian Phenomics Network (link to record)
Gene Symbol Igkv5-45
Ensembl Gene ENSMUSG00000094094
Gene Nameimmunoglobulin kappa chain variable 5-45
SynonymsGm16850
Accession Numbers
Is this an essential gene? Possibly non essential (E-score: 0.386) question?
Stock #IGL01898
Quality Score
Status
Chromosome6
Chromosomal Location69775750-69776306 bp(-) (GRCm38)
Type of Mutationnonsense
DNA Base Change (assembly) T to A at 69775892 bp
ZygosityHeterozygous
Amino Acid Change Lysine to Stop codon at position 69 (K69*)
Ref Sequence ENSEMBL: ENSMUSP00000100167 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000103366]
Predicted Effect probably null
Transcript: ENSMUST00000103366
AA Change: K69*
SMART Domains Protein: ENSMUSP00000100167
Gene: ENSMUSG00000094094
AA Change: K69*

DomainStartEndE-ValueType
IGv 38 110 3.76e-17 SMART
Coding Region Coverage
Validation Efficiency
Allele List at MGI
Other mutations in this stock
Total: 23 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
Actl10 A T 2: 154,552,713 D195V probably damaging Het
Aqp11 A G 7: 97,726,663 W260R probably benign Het
Atp8a2 T C 14: 60,023,513 T390A probably damaging Het
Atp8b4 T C 2: 126,389,361 N431S probably benign Het
C130026I21Rik A G 1: 85,254,186 probably benign Het
Ccdc110 T G 8: 45,942,124 S351A possibly damaging Het
Cntnap4 T C 8: 112,856,307 F1006L possibly damaging Het
Ddr2 A G 1: 169,998,156 F292L possibly damaging Het
F830104G03Rik G A 3: 56,890,216 Q97* probably null Het
Fam171a2 T C 11: 102,439,756 T267A possibly damaging Het
Gm10718 A T 9: 3,025,118 Y194F probably benign Het
Gm21738 G A 14: 19,416,979 S144L probably benign Het
Mios T C 6: 8,222,668 I534T probably benign Het
Nus1 A G 10: 52,430,067 D185G probably benign Het
Proc A G 18: 32,133,145 probably null Het
Psma3 T A 12: 70,984,674 H36Q probably benign Het
Sh3rf3 G T 10: 59,049,530 A412S probably damaging Het
Smgc A T 15: 91,844,524 probably null Het
Spta1 T A 1: 174,213,862 S1297R probably benign Het
Steap3 T C 1: 120,241,574 D293G probably benign Het
Tbx18 A T 9: 87,707,859 M342K possibly damaging Het
Trip11 T C 12: 101,885,676 M425V probably benign Het
Vmn2r-ps159 C T 4: 156,338,254 noncoding transcript Het
Other mutations in Igkv5-45
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL02010:Igkv5-45 APN 6 69775952 missense probably benign
R3547:Igkv5-45 UTSW 6 69776256 critical splice donor site probably benign
R3744:Igkv5-45 UTSW 6 69775937 missense probably benign 0.06
R6196:Igkv5-45 UTSW 6 69775981 missense possibly damaging 0.52
Posted On2014-05-07