Incidental Mutation 'IGL01899:Sytl1'
ID 179490
Institutional Source Australian Phenomics Network (link to record)
Gene Symbol Sytl1
Ensembl Gene ENSMUSG00000028860
Gene Name synaptotagmin-like 1
Synonyms PSGL-1, Slp1
Accession Numbers
Essential gene? Non essential (E-score: 0.000) question?
Stock # IGL01899
Quality Score
Status
Chromosome 4
Chromosomal Location 132980401-132990398 bp(-) (GRCm39)
Type of Mutation splice site (5 bp from exon)
DNA Base Change (assembly) C to T at 132986167 bp (GRCm39)
Zygosity Heterozygous
Amino Acid Change
Ref Sequence ENSEMBL: ENSMUSP00000101528 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000030674] [ENSMUST00000105908]
AlphaFold no structure available at present
Predicted Effect probably null
Transcript: ENSMUST00000030674
SMART Domains Protein: ENSMUSP00000030674
Gene: ENSMUSG00000028860

DomainStartEndE-ValueType
PDB:3BC1|F 40 92 2e-9 PDB
low complexity region 169 183 N/A INTRINSIC
low complexity region 235 262 N/A INTRINSIC
C2 288 389 2.36e-17 SMART
C2 429 532 6.96e-6 SMART
Predicted Effect probably null
Transcript: ENSMUST00000105908
SMART Domains Protein: ENSMUSP00000101528
Gene: ENSMUSG00000028860

DomainStartEndE-ValueType
PDB:3BC1|F 40 92 2e-9 PDB
low complexity region 157 171 N/A INTRINSIC
low complexity region 223 250 N/A INTRINSIC
C2 276 359 3.15e-4 SMART
C2 364 467 6.96e-6 SMART
Predicted Effect noncoding transcript
Transcript: ENSMUST00000142039
Predicted Effect noncoding transcript
Transcript: ENSMUST00000154911
Coding Region Coverage
Validation Efficiency
MGI Phenotype PHENOTYPE: Mice homozygous for a null allele exhibit increased number of acinar zygomen granules in a fasted state that can be released by strong stimuli of the fed state. [provided by MGI curators]
Allele List at MGI
Other mutations in this stock
Total: 25 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
Bicral G A 17: 47,135,600 (GRCm39) P537S probably benign Het
Cadm1 A G 9: 47,721,389 (GRCm39) T260A probably damaging Het
Ddr2 C A 1: 169,811,991 (GRCm39) G744C probably damaging Het
Epha6 A C 16: 59,659,666 (GRCm39) N817K probably benign Het
Far2 A G 6: 148,047,527 (GRCm39) K69E probably benign Het
Fasn G A 11: 120,710,975 (GRCm39) probably benign Het
Ficd A G 5: 113,875,158 (GRCm39) T76A probably benign Het
Flot1 A T 17: 36,141,573 (GRCm39) I327L probably benign Het
Fscn3 A T 6: 28,436,078 (GRCm39) E458V probably damaging Het
Gm21738 G A 14: 19,416,979 (GRCm38) S144L probably benign Het
Lepr A G 4: 101,637,184 (GRCm39) E691G possibly damaging Het
Ly9 T A 1: 171,434,815 (GRCm39) Q26L probably damaging Het
Or5p60 T C 7: 107,724,048 (GRCm39) T141A probably benign Het
Pisd C A 5: 32,896,476 (GRCm39) probably null Het
Plxna2 C T 1: 194,433,796 (GRCm39) S615L probably damaging Het
Ppfia2 T C 10: 106,751,612 (GRCm39) probably null Het
Ppox A G 1: 171,104,655 (GRCm39) V470A probably benign Het
Rptor T A 11: 119,748,279 (GRCm39) S4T probably benign Het
Sf3a1 T A 11: 4,121,063 (GRCm39) I218N probably damaging Het
Stxbp5l T C 16: 37,020,954 (GRCm39) S647G probably benign Het
Tbx6 C T 7: 126,383,704 (GRCm39) probably benign Het
Thg1l C A 11: 45,845,018 (GRCm39) R78L probably damaging Het
Tlr1 T C 5: 65,084,359 (GRCm39) K73E probably damaging Het
Trpm1 T A 7: 63,884,742 (GRCm39) F808I probably benign Het
Vmn2r129 C T 4: 156,690,549 (GRCm39) noncoding transcript Het
Other mutations in Sytl1
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL02693:Sytl1 APN 4 132,985,057 (GRCm39) missense probably benign 0.03
IGL02721:Sytl1 APN 4 132,986,189 (GRCm39) missense probably benign 0.25
IGL02975:Sytl1 APN 4 132,988,343 (GRCm39) missense probably benign 0.05
FR4304:Sytl1 UTSW 4 132,984,304 (GRCm39) small deletion probably benign
R0242:Sytl1 UTSW 4 132,980,768 (GRCm39) missense probably damaging 1.00
R0242:Sytl1 UTSW 4 132,980,768 (GRCm39) missense probably damaging 1.00
R0677:Sytl1 UTSW 4 132,980,536 (GRCm39) missense possibly damaging 0.89
R1135:Sytl1 UTSW 4 132,984,281 (GRCm39) missense probably damaging 1.00
R1269:Sytl1 UTSW 4 132,983,426 (GRCm39) missense probably damaging 1.00
R2018:Sytl1 UTSW 4 132,983,471 (GRCm39) missense probably damaging 0.99
R2106:Sytl1 UTSW 4 132,984,774 (GRCm39) missense probably benign 0.00
R3938:Sytl1 UTSW 4 132,982,935 (GRCm39) nonsense probably null
R4210:Sytl1 UTSW 4 132,980,876 (GRCm39) missense probably damaging 1.00
R4970:Sytl1 UTSW 4 132,982,893 (GRCm39) nonsense probably null
R5027:Sytl1 UTSW 4 132,983,530 (GRCm39) intron probably benign
R5325:Sytl1 UTSW 4 132,988,382 (GRCm39) start gained probably benign
R5557:Sytl1 UTSW 4 132,986,667 (GRCm39) missense probably damaging 1.00
R6310:Sytl1 UTSW 4 132,988,309 (GRCm39) missense probably benign 0.34
R8235:Sytl1 UTSW 4 132,988,257 (GRCm39) missense probably damaging 1.00
R9086:Sytl1 UTSW 4 132,988,175 (GRCm39) missense possibly damaging 0.75
R9183:Sytl1 UTSW 4 132,980,934 (GRCm39) missense possibly damaging 0.77
R9515:Sytl1 UTSW 4 132,986,291 (GRCm39) critical splice donor site probably null
R9516:Sytl1 UTSW 4 132,986,291 (GRCm39) critical splice donor site probably null
T0722:Sytl1 UTSW 4 132,984,164 (GRCm39) splice site probably benign
T0722:Sytl1 UTSW 4 132,984,162 (GRCm39) splice site probably benign
T0975:Sytl1 UTSW 4 132,984,305 (GRCm39) small deletion probably benign
Z1176:Sytl1 UTSW 4 132,984,248 (GRCm39) missense probably benign 0.00
Posted On 2014-05-07