Incidental Mutation 'IGL01901:Vmn1r75'
ID 179519
Institutional Source Australian Phenomics Network (link to record)
Gene Symbol Vmn1r75
Ensembl Gene ENSMUSG00000043308
Gene Name vomeronasal 1 receptor 75
Synonyms V1rg6
Accession Numbers
Essential gene? Probably non essential (E-score: 0.052) question?
Stock # IGL01901
Quality Score
Status
Chromosome 7
Chromosomal Location 11614270-11615187 bp(+) (GRCm39)
Type of Mutation missense
DNA Base Change (assembly) A to G at 11614739 bp (GRCm39)
Zygosity Heterozygous
Amino Acid Change Tyrosine to Cysteine at position 157 (Y157C)
Ref Sequence ENSEMBL: ENSMUSP00000154577 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000057229] [ENSMUST00000226622] [ENSMUST00000226855] [ENSMUST00000227611] [ENSMUST00000228268] [ENSMUST00000228463] [ENSMUST00000228646]
AlphaFold Q8R289
Predicted Effect probably damaging
Transcript: ENSMUST00000057229
AA Change: Y157C

PolyPhen 2 Score 0.999 (Sensitivity: 0.14; Specificity: 0.99)
SMART Domains Protein: ENSMUSP00000051510
Gene: ENSMUSG00000043308
AA Change: Y157C

DomainStartEndE-ValueType
Pfam:TAS2R 1 294 2.9e-10 PFAM
Pfam:V1R 35 293 1e-29 PFAM
Predicted Effect probably damaging
Transcript: ENSMUST00000226622
AA Change: Y157C

PolyPhen 2 Score 0.999 (Sensitivity: 0.14; Specificity: 0.99)
Predicted Effect probably damaging
Transcript: ENSMUST00000226855
AA Change: Y157C

PolyPhen 2 Score 0.999 (Sensitivity: 0.14; Specificity: 0.99)
Predicted Effect probably damaging
Transcript: ENSMUST00000227611
AA Change: Y115C

PolyPhen 2 Score 0.996 (Sensitivity: 0.55; Specificity: 0.98)
Predicted Effect probably damaging
Transcript: ENSMUST00000228268
AA Change: Y115C

PolyPhen 2 Score 0.996 (Sensitivity: 0.55; Specificity: 0.98)
Predicted Effect probably damaging
Transcript: ENSMUST00000228463
AA Change: Y157C

PolyPhen 2 Score 0.999 (Sensitivity: 0.14; Specificity: 0.99)
Predicted Effect probably damaging
Transcript: ENSMUST00000228646
AA Change: Y115C

PolyPhen 2 Score 0.996 (Sensitivity: 0.55; Specificity: 0.98)
Coding Region Coverage
Validation Efficiency
Allele List at MGI
Other mutations in this stock
Total: 40 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
Adam2 A G 14: 66,272,678 (GRCm39) probably benign Het
Aldh1a7 T G 19: 20,695,103 (GRCm39) Y154S probably damaging Het
Casc3 A G 11: 98,713,947 (GRCm39) D393G probably damaging Het
Cd180 A G 13: 102,842,936 (GRCm39) I661V probably benign Het
Cdh1 T C 8: 107,384,392 (GRCm39) S287P probably damaging Het
Clnk T C 5: 38,952,321 (GRCm39) N6S probably damaging Het
Cstdc6 C A 16: 36,154,625 (GRCm39) A11S probably damaging Het
Cyp17a1 C T 19: 46,659,531 (GRCm39) V100M possibly damaging Het
Ddhd2 A G 8: 26,238,621 (GRCm39) V53A probably damaging Het
Elovl7 T A 13: 108,410,927 (GRCm39) probably null Het
Gm10717 C T 9: 3,025,616 (GRCm39) S67L probably benign Het
Gm10718 A T 9: 3,025,118 (GRCm39) Y194F probably benign Het
Gm14180 A G 11: 99,625,053 (GRCm39) S22P unknown Het
Gm21738 G A 14: 19,416,979 (GRCm38) S144L probably benign Het
Golga5 G A 12: 102,446,061 (GRCm39) probably null Het
Gpr162 A T 6: 124,838,370 (GRCm39) F93L possibly damaging Het
Kcnh8 G A 17: 53,201,148 (GRCm39) probably benign Het
Lamp3 A T 16: 19,492,169 (GRCm39) F358L probably damaging Het
Mdn1 T G 4: 32,669,591 (GRCm39) D409E probably damaging Het
Ms4a10 T C 19: 10,940,374 (GRCm39) D211G probably benign Het
Ms4a3 T C 19: 11,616,630 (GRCm39) E4G possibly damaging Het
Myo15a A G 11: 60,418,260 (GRCm39) probably benign Het
Or2ag16 A G 7: 106,351,752 (GRCm39) V281A possibly damaging Het
Or4c10b A G 2: 89,711,826 (GRCm39) I219V probably damaging Het
Or51aa2 A T 7: 103,188,177 (GRCm39) L88Q probably damaging Het
Or51q1c A G 7: 103,653,274 (GRCm39) H264R probably damaging Het
Or5b12 T C 19: 12,896,947 (GRCm39) H242R probably damaging Het
Or6c217 A G 10: 129,737,722 (GRCm39) F286L probably benign Het
Penk T C 4: 4,134,465 (GRCm39) I61V probably benign Het
Pkhd1 T A 1: 20,290,307 (GRCm39) K2860N probably benign Het
Prtg C T 9: 72,762,348 (GRCm39) P492S probably damaging Het
Spata31e2 A G 1: 26,721,665 (GRCm39) F1172L probably benign Het
Tdrd7 T C 4: 45,989,225 (GRCm39) probably benign Het
Terf2ip A G 8: 112,738,700 (GRCm39) N196S probably benign Het
Tgtp1 T C 11: 48,878,382 (GRCm39) N108D possibly damaging Het
Thumpd3 A G 6: 113,036,932 (GRCm39) H277R probably benign Het
Tshz2 T A 2: 169,727,456 (GRCm39) L215Q possibly damaging Het
Ube3c T A 5: 29,873,005 (GRCm39) V1015E probably damaging Het
Utrn T A 10: 12,516,672 (GRCm39) K2307N probably damaging Het
Vmn2r129 C T 4: 156,690,549 (GRCm39) noncoding transcript Het
Other mutations in Vmn1r75
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL02175:Vmn1r75 APN 7 11,614,774 (GRCm39) missense probably damaging 1.00
IGL02399:Vmn1r75 APN 7 11,615,093 (GRCm39) missense possibly damaging 0.82
IGL02648:Vmn1r75 APN 7 11,615,091 (GRCm39) missense probably benign 0.04
IGL03372:Vmn1r75 APN 7 11,614,496 (GRCm39) missense probably benign 0.29
R0538:Vmn1r75 UTSW 7 11,614,797 (GRCm39) missense probably damaging 0.97
R0599:Vmn1r75 UTSW 7 11,615,189 (GRCm39) splice site probably null
R3910:Vmn1r75 UTSW 7 11,614,757 (GRCm39) missense possibly damaging 0.92
R4491:Vmn1r75 UTSW 7 11,614,909 (GRCm39) missense probably damaging 0.97
R5566:Vmn1r75 UTSW 7 11,614,407 (GRCm39) missense probably damaging 1.00
R6051:Vmn1r75 UTSW 7 11,614,978 (GRCm39) missense probably damaging 1.00
R6230:Vmn1r75 UTSW 7 11,614,966 (GRCm39) missense probably damaging 0.98
R6490:Vmn1r75 UTSW 7 11,615,003 (GRCm39) missense probably damaging 1.00
R6570:Vmn1r75 UTSW 7 11,614,883 (GRCm39) missense probably damaging 0.98
R7184:Vmn1r75 UTSW 7 11,614,915 (GRCm39) nonsense probably null
R7189:Vmn1r75 UTSW 7 11,614,475 (GRCm39) missense possibly damaging 0.93
R7501:Vmn1r75 UTSW 7 11,614,997 (GRCm39) missense possibly damaging 0.67
R7973:Vmn1r75 UTSW 7 11,614,961 (GRCm39) missense probably benign 0.04
R7997:Vmn1r75 UTSW 7 11,614,600 (GRCm39) missense probably damaging 1.00
R8372:Vmn1r75 UTSW 7 11,614,657 (GRCm39) missense probably benign 0.10
R8812:Vmn1r75 UTSW 7 11,614,630 (GRCm39) missense possibly damaging 0.54
R8932:Vmn1r75 UTSW 7 11,614,838 (GRCm39) missense probably damaging 1.00
R9089:Vmn1r75 UTSW 7 11,614,453 (GRCm39) missense probably damaging 1.00
R9129:Vmn1r75 UTSW 7 11,614,513 (GRCm39) missense probably benign 0.15
Posted On 2014-05-07