Mutagenetix > Incidental Mutation

Incidental Mutation 'IGL01902:Cyp2c67'

179549

Institutional Source

Australian Phenomics Network (link to record)

Gene Symbol

Cyp2c67

Ensembl Gene

ENSMUSG00000062624

Gene Name

cytochrome P450, family 2, subfamily c, polypeptide 67

Synonyms

C730004C24Rik

Accession Numbers

Essential gene?

Probably non essential (E-score: 0.077) question?

Stock #

IGL01902

Quality Score

Status

Chromosome

Chromosomal Location

39597288-39637497 bp(-) (GRCm39)

Type of Mutation

missense

DNA Base Change (assembly)

T to A at 39637470 bp (GRCm39)

Zygosity

Heterozygous

Amino Acid Change

Aspartic acid to Valine at position 2 (D2V)

Ref Sequence

ENSEMBL: ENSMUSP00000065796 (fasta)

Gene Model

predicted gene model for transcript(s): [ENSMUST00000067328]

AlphaFold

Q569X9

Predicted Effect

probably damaging
Transcript: ENSMUST00000067328
AA Change: D2V

PolyPhen 2 Score 1.000 (Sensitivity: 0.00; Specificity: 1.00)

SMART Domains

Protein: ENSMUSP00000065796
Gene: ENSMUSG00000062624
AA Change: D2V

Domain	Start	End	E-Value	Type
signal peptide	1	25	N/A	INTRINSIC
Pfam:p450	30	487	8.5e-150	PFAM

Coding Region Coverage

Validation Efficiency

Allele List at MGI

Other mutations in this stock

Total: 27 list
Gene	Ref	Var	Chr/Loc	Mutation	Predicted Effect	Zygosity
4931406B18Rik	A	G	7: 43,147,267 (GRCm39)	S228P	probably damaging	Het
Adamtsl2	A	T	2: 26,977,264 (GRCm39)	I242F	probably damaging	Het
Bicdl1	A	G	5: 115,789,933 (GRCm39)	L284P	probably damaging	Het
Bnc2	A	G	4: 84,309,181 (GRCm39)	I138T	probably damaging	Het
Cep350	A	G	1: 155,737,731 (GRCm39)	L2704S	probably damaging	Het
Col7a1	C	A	9: 108,806,895 (GRCm39)	P2442T	unknown	Het
Cpne6	A	T	14: 55,750,207 (GRCm39)	T113S	possibly damaging	Het
Crnkl1	T	C	2: 145,766,632 (GRCm39)		probably null	Het
Frzb	T	A	2: 80,243,711 (GRCm39)	S323C	probably damaging	Het
Gm21738	G	A	14: 19,416,979 (GRCm38)	S144L	probably benign	Het
Gm5862	A	C	5: 26,227,769 (GRCm39)	W41G	probably benign	Het
Ins2	C	T	7: 142,233,179 (GRCm39)	C31Y	probably damaging	Het
Lipf	A	T	19: 33,948,179 (GRCm39)	N234Y	probably benign	Het
Mtf1	T	C	4: 124,698,720 (GRCm39)	F73L	probably damaging	Het
Nrxn1	A	G	17: 91,395,919 (GRCm39)		probably null	Het
Pcnx1	A	G	12: 82,025,868 (GRCm39)	T1538A	probably damaging	Het
Polr1a	T	A	6: 71,940,732 (GRCm39)	V47D	probably damaging	Het
Prune2	A	G	19: 17,096,002 (GRCm39)	E502G	probably benign	Het
Ralgapa2	C	T	2: 146,156,934 (GRCm39)	V1886M	probably damaging	Het
Rapgef3	T	A	15: 97,648,181 (GRCm39)	H676L	probably benign	Het
Rbm20	A	T	19: 53,829,422 (GRCm39)	N607Y	probably damaging	Het
Smc5	G	A	19: 23,237,132 (GRCm39)	T233I	possibly damaging	Het
Snx13	A	T	12: 35,183,306 (GRCm39)		probably null	Het
Suz12	T	A	11: 79,916,776 (GRCm39)	C510S	probably benign	Het
Tab2	A	T	10: 7,795,756 (GRCm39)	M242K	probably benign	Het
Tep1	A	G	14: 51,103,548 (GRCm39)		probably benign	Het
Vmn2r129	C	T	4: 156,690,549 (GRCm39)		noncoding transcript	Het

Other mutations in Cyp2c67

Allele	Source	Chr	Coord	Type	Predicted Effect	PPH Score
IGL00955:Cyp2c67	APN	19	39,631,829 (GRCm39)	missense	possibly damaging	0.95
IGL01025:Cyp2c67	APN	19	39,628,376 (GRCm39)	nonsense	probably null
IGL01363:Cyp2c67	APN	19	39,628,411 (GRCm39)	missense	probably damaging	0.99
IGL01819:Cyp2c67	APN	19	39,604,165 (GRCm39)	missense	probably damaging	0.98
IGL02172:Cyp2c67	APN	19	39,637,446 (GRCm39)	missense	possibly damaging	0.76
IGL02351:Cyp2c67	APN	19	39,605,861 (GRCm39)	missense	probably damaging	1.00
IGL02355:Cyp2c67	APN	19	39,605,826 (GRCm39)	nonsense	probably null
IGL02355:Cyp2c67	APN	19	39,631,849 (GRCm39)	missense	probably benign	0.34
IGL02358:Cyp2c67	APN	19	39,605,861 (GRCm39)	missense	probably damaging	1.00
IGL02362:Cyp2c67	APN	19	39,605,826 (GRCm39)	nonsense	probably null
IGL02362:Cyp2c67	APN	19	39,631,849 (GRCm39)	missense	probably benign	0.34
IGL02388:Cyp2c67	APN	19	39,631,799 (GRCm39)	missense	probably benign	0.20
IGL03106:Cyp2c67	APN	19	39,632,119 (GRCm39)	missense	probably benign	0.27
IGL03219:Cyp2c67	APN	19	39,631,738 (GRCm39)	missense	possibly damaging	0.54
IGL03326:Cyp2c67	APN	19	39,631,713 (GRCm39)	critical splice donor site	probably null
IGL03349:Cyp2c67	APN	19	39,632,128 (GRCm39)	missense	probably damaging	1.00
IGL03356:Cyp2c67	APN	19	39,628,405 (GRCm39)	missense	probably damaging	1.00
IGL03052:Cyp2c67	UTSW	19	39,637,329 (GRCm39)	missense	possibly damaging	0.88
R0585:Cyp2c67	UTSW	19	39,627,138 (GRCm39)	missense	possibly damaging	0.59
R0975:Cyp2c67	UTSW	19	39,597,622 (GRCm39)	missense	possibly damaging	0.49
R0976:Cyp2c67	UTSW	19	39,631,818 (GRCm39)	missense	probably damaging	1.00
R1252:Cyp2c67	UTSW	19	39,614,585 (GRCm39)	missense	possibly damaging	0.93
R1398:Cyp2c67	UTSW	19	39,627,069 (GRCm39)	missense	probably damaging	0.96
R1411:Cyp2c67	UTSW	19	39,627,035 (GRCm39)	missense	probably damaging	1.00
R1505:Cyp2c67	UTSW	19	39,637,408 (GRCm39)	missense	probably benign	0.00
R1543:Cyp2c67	UTSW	19	39,631,708 (GRCm39)	splice site	probably benign
R1613:Cyp2c67	UTSW	19	39,614,643 (GRCm39)	missense	probably benign	0.00
R1618:Cyp2c67	UTSW	19	39,631,708 (GRCm39)	splice site	probably benign
R1667:Cyp2c67	UTSW	19	39,632,034 (GRCm39)	critical splice donor site	probably null
R1852:Cyp2c67	UTSW	19	39,605,811 (GRCm39)	missense	probably benign	0.01
R2005:Cyp2c67	UTSW	19	39,631,789 (GRCm39)	missense	probably damaging	1.00
R2105:Cyp2c67	UTSW	19	39,614,681 (GRCm39)	missense	probably benign	0.24
R2181:Cyp2c67	UTSW	19	39,597,541 (GRCm39)	missense	possibly damaging	0.94
R3817:Cyp2c67	UTSW	19	39,627,127 (GRCm39)	missense	probably benign	0.00
R4669:Cyp2c67	UTSW	19	39,632,098 (GRCm39)	missense	probably benign	0.00
R4689:Cyp2c67	UTSW	19	39,627,032 (GRCm39)	missense	probably benign	0.00
R4756:Cyp2c67	UTSW	19	39,632,188 (GRCm39)	missense	probably benign	0.03
R4823:Cyp2c67	UTSW	19	39,604,168 (GRCm39)	missense	probably benign	0.13
R5152:Cyp2c67	UTSW	19	39,627,132 (GRCm39)	missense	probably benign	0.00
R5345:Cyp2c67	UTSW	19	39,614,676 (GRCm39)	missense	probably benign	0.01
R5580:Cyp2c67	UTSW	19	39,604,094 (GRCm39)	missense	probably damaging	0.99
R5644:Cyp2c67	UTSW	19	39,604,138 (GRCm39)	missense	possibly damaging	0.84
R6116:Cyp2c67	UTSW	19	39,605,879 (GRCm39)	missense	probably damaging	1.00
R6516:Cyp2c67	UTSW	19	39,605,873 (GRCm39)	missense	probably damaging	1.00
R6550:Cyp2c67	UTSW	19	39,605,854 (GRCm39)	nonsense	probably null
R6939:Cyp2c67	UTSW	19	39,631,778 (GRCm39)	missense	possibly damaging	0.68
R6995:Cyp2c67	UTSW	19	39,604,123 (GRCm39)	missense	probably damaging	0.96
R7028:Cyp2c67	UTSW	19	39,628,341 (GRCm39)	missense	possibly damaging	0.68
R7144:Cyp2c67	UTSW	19	39,604,138 (GRCm39)	missense	probably benign	0.00
R7242:Cyp2c67	UTSW	19	39,605,783 (GRCm39)	missense	probably benign	0.30
R7335:Cyp2c67	UTSW	19	39,628,451 (GRCm39)	nonsense	probably null
R7337:Cyp2c67	UTSW	19	39,597,708 (GRCm39)	splice site	probably null
R7474:Cyp2c67	UTSW	19	39,605,876 (GRCm39)	missense	probably null	0.05
R7642:Cyp2c67	UTSW	19	39,604,084 (GRCm39)	missense	probably damaging	0.97
R7870:Cyp2c67	UTSW	19	39,597,669 (GRCm39)	missense	probably damaging	1.00
R8152:Cyp2c67	UTSW	19	39,628,452 (GRCm39)	missense	probably benign	0.21
R8367:Cyp2c67	UTSW	19	39,627,118 (GRCm39)	missense	probably benign	0.01
R8717:Cyp2c67	UTSW	19	39,627,155 (GRCm39)	missense	probably benign	0.05
R8728:Cyp2c67	UTSW	19	39,614,605 (GRCm39)	missense	probably damaging	1.00
R9275:Cyp2c67	UTSW	19	39,597,699 (GRCm39)	missense	probably damaging	1.00
R9278:Cyp2c67	UTSW	19	39,597,699 (GRCm39)	missense	probably damaging	1.00
R9376:Cyp2c67	UTSW	19	39,627,178 (GRCm39)	missense	probably damaging	1.00
Z1177:Cyp2c67	UTSW	19	39,632,123 (GRCm39)	missense	possibly damaging	0.89

Posted On

2014-05-07