Incidental Mutation 'IGL01904:Olfr449'
Institutional Source Australian Phenomics Network (link to record)
Gene Symbol Olfr449
Ensembl Gene ENSMUSG00000049168
Gene Nameolfactory receptor 449
SynonymsGA_x6K02T2P3E9-4722003-4721068, MOR103-1
Accession Numbers
Is this an essential gene? Probably non essential (E-score: 0.090) question?
Stock #IGL01904
Quality Score
Chromosomal Location42834384-42839516 bp(+) (GRCm38)
Type of Mutationmissense
DNA Base Change (assembly) T to C at 42838289 bp
Amino Acid Change Methionine to Threonine at position 136 (M136T)
Ref Sequence ENSEMBL: ENSMUSP00000148895 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000050729] [ENSMUST00000204072] [ENSMUST00000204229] [ENSMUST00000214687]
AlphaFold Q8VGW8
Predicted Effect possibly damaging
Transcript: ENSMUST00000050729
AA Change: M136T

PolyPhen 2 Score 0.759 (Sensitivity: 0.85; Specificity: 0.92)
SMART Domains Protein: ENSMUSP00000059233
Gene: ENSMUSG00000049168
AA Change: M136T

Pfam:7tm_4 31 306 2.7e-52 PFAM
Pfam:7tm_1 41 288 2e-21 PFAM
Predicted Effect noncoding transcript
Transcript: ENSMUST00000203135
AA Change: M136T
SMART Domains Protein: ENSMUSP00000144965
Gene: ENSMUSG00000049168
AA Change: M136T

Pfam:7tm_4 31 193 2.1e-32 PFAM
Pfam:7tm_1 41 193 7.7e-20 PFAM
Predicted Effect possibly damaging
Transcript: ENSMUST00000204072
AA Change: M136T

PolyPhen 2 Score 0.759 (Sensitivity: 0.85; Specificity: 0.92)
Predicted Effect probably benign
Transcript: ENSMUST00000204229
SMART Domains Protein: ENSMUSP00000145055
Gene: ENSMUSG00000049168

Pfam:7tm_4 31 130 1.7e-20 PFAM
Pfam:7tm_1 41 130 2.6e-14 PFAM
Predicted Effect possibly damaging
Transcript: ENSMUST00000214687
AA Change: M136T

PolyPhen 2 Score 0.759 (Sensitivity: 0.85; Specificity: 0.92)
Coding Region Coverage
Validation Efficiency
MGI Phenotype FUNCTION: Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitter and hormone receptors and are responsible for the recognition and G protein-mediated transduction of odorant signals. The olfactory receptor gene family is the largest in the genome. The nomenclature assigned to the olfactory receptor genes and proteins for this organism is independent of other organisms. [provided by RefSeq, Jul 2008]
Allele List at MGI
Other mutations in this stock
Total: 24 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
4933402N22Rik A C 5: 11,921,456 N125T probably benign Het
Dnah5 T C 15: 28,307,364 I1746T probably benign Het
Eml3 T C 19: 8,936,766 probably benign Het
Eml6 C A 11: 29,838,613 E491* probably null Het
Gm10717 C T 9: 3,025,616 S67L probably benign Het
Gm10718 A T 9: 3,025,118 Y194F probably benign Het
Gm21738 G A 14: 19,416,979 S144L probably benign Het
Hs3st2 C T 7: 121,500,984 P351L probably damaging Het
Igf2r A T 17: 12,714,911 Y819N probably damaging Het
Kifc3 C A 8: 95,137,957 A42S possibly damaging Het
Mrps17 A G 5: 129,716,801 T20A probably damaging Het
Msh6 T C 17: 87,984,732 V305A probably benign Het
Olfr872 T G 9: 20,260,290 M150R probably damaging Het
Pappa2 A G 1: 158,783,941 L1484P probably damaging Het
Polr3c A T 3: 96,716,665 probably null Het
Ros1 C A 10: 52,077,911 E1877D probably damaging Het
Slc5a4b T C 10: 76,060,426 N565S probably damaging Het
Slf2 T C 19: 44,949,141 probably null Het
Suclg2 A T 6: 95,588,934 probably benign Het
Sult2a8 T C 7: 14,425,457 E79G probably damaging Het
Triobp A G 15: 78,967,364 T573A possibly damaging Het
Vmn2r-ps159 C T 4: 156,338,254 noncoding transcript Het
Zfand5 C T 19: 21,279,758 probably benign Het
Zfhx4 C A 3: 5,412,709 H3461Q probably damaging Het
Other mutations in Olfr449
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL02193:Olfr449 APN 6 42838819 utr 3 prime probably benign
IGL02496:Olfr449 APN 6 42838804 missense probably benign 0.00
IGL03302:Olfr449 APN 6 42838003 nonsense probably null
IGL03333:Olfr449 APN 6 42838703 missense possibly damaging 0.95
R1340:Olfr449 UTSW 6 42838009 missense probably benign 0.00
R1926:Olfr449 UTSW 6 42838313 missense probably damaging 1.00
R2418:Olfr449 UTSW 6 42838049 missense probably benign 0.03
R4837:Olfr449 UTSW 6 42837849 splice site probably null
R5466:Olfr449 UTSW 6 42838093 missense probably benign 0.08
R5733:Olfr449 UTSW 6 42838246 missense probably damaging 0.97
R6411:Olfr449 UTSW 6 42838720 missense possibly damaging 0.57
R6626:Olfr449 UTSW 6 42838648 missense probably benign 0.14
R6912:Olfr449 UTSW 6 42838802 missense probably benign
R7278:Olfr449 UTSW 6 42834396 splice site probably null
R7399:Olfr449 UTSW 6 42838746 nonsense probably null
R7703:Olfr449 UTSW 6 42838004 missense probably damaging 1.00
R8325:Olfr449 UTSW 6 42838190 missense probably damaging 1.00
Z1176:Olfr449 UTSW 6 42837977 missense probably damaging 1.00
Z1177:Olfr449 UTSW 6 42838376 missense probably benign
Posted On2014-05-07