Incidental Mutation 'IGL01904:Zfand5'
| ID |
179631 |
| Institutional Source |
Australian Phenomics Network
(link to record)
|
| Gene Symbol |
Zfand5
|
| Ensembl Gene |
ENSMUSG00000024750 |
| Gene Name |
zinc finger, AN1-type domain 5 |
| Synonyms |
5830475F03Rik, Zfp216, Za20d2, 2310057A04Rik |
| Accession Numbers |
|
| Essential gene? |
Probably essential
(E-score: 0.840)
|
| Stock # |
IGL01904
|
| Quality Score |
|
|
Status
|
|
| Chromosome |
19 |
| Chromosomal Location |
21249642-21264204 bp(+) (GRCm39) |
| Type of Mutation |
unclassified |
| DNA Base Change (assembly) |
C to T
at 21257122 bp (GRCm39)
|
| Zygosity |
Heterozygous |
| Amino Acid Change |
|
| Ref Sequence |
ENSEMBL: ENSMUSP00000123555
(fasta)
|
| Gene Model |
predicted gene model for transcript(s):
[ENSMUST00000025659]
[ENSMUST00000149144]
[ENSMUST00000152338]
|
| AlphaFold |
O88878 |
| Predicted Effect |
probably benign
Transcript: ENSMUST00000025659
|
| SMART Domains |
Protein: ENSMUSP00000025659
Gene: ENSMUSG00000024750
| Domain | Start | End | E-Value | Type |
|---|
|
ZnF_A20
|
11 |
35 |
1.91e-10 |
SMART |
|
low complexity region
|
118 |
151 |
N/A |
INTRINSIC |
|
ZnF_AN1
|
154 |
191 |
1.52e-18 |
SMART |
|
| Predicted Effect |
noncoding transcript
Transcript: ENSMUST00000133175
|
| Predicted Effect |
noncoding transcript
Transcript: ENSMUST00000141568
|
| Predicted Effect |
probably benign
Transcript: ENSMUST00000149144
|
| SMART Domains |
Protein: ENSMUSP00000122782
Gene: ENSMUSG00000024750
| Domain | Start | End | E-Value | Type |
|---|
|
ZnF_A20
|
11 |
35 |
1.91e-10 |
SMART |
|
low complexity region
|
91 |
103 |
N/A |
INTRINSIC |
|
| Predicted Effect |
probably benign
Transcript: ENSMUST00000152338
|
| SMART Domains |
Protein: ENSMUSP00000123555
Gene: ENSMUSG00000024750
| Domain | Start | End | E-Value | Type |
|---|
|
ZnF_A20
|
11 |
35 |
1.2e-12 |
SMART |
|
| Coding Region Coverage |
|
| Validation Efficiency |
|
| MGI Phenotype |
PHENOTYPE: Homozygous null mice display resistance to age related obesity and resistance to induced muscular atrophy. [provided by MGI curators]
|
| Allele List at MGI |
|
| Other mutations in this stock |
Total: 24 list
| Gene | Ref | Var | Chr/Loc | Mutation | Predicted Effect | Zygosity |
|---|
| Dnah5 |
T |
C |
15: 28,307,510 (GRCm39) |
I1746T |
probably benign |
Het |
| Eml3 |
T |
C |
19: 8,914,130 (GRCm39) |
|
probably benign |
Het |
| Eml6 |
C |
A |
11: 29,788,613 (GRCm39) |
E491* |
probably null |
Het |
| Gm10717 |
C |
T |
9: 3,025,616 (GRCm39) |
S67L |
probably benign |
Het |
| Gm10718 |
A |
T |
9: 3,025,118 (GRCm39) |
Y194F |
probably benign |
Het |
| Gm21738 |
G |
A |
14: 19,416,979 (GRCm38) |
S144L |
probably benign |
Het |
| Hs3st2 |
C |
T |
7: 121,100,207 (GRCm39) |
P351L |
probably damaging |
Het |
| Igf2r |
A |
T |
17: 12,933,798 (GRCm39) |
Y819N |
probably damaging |
Het |
| Kifc3 |
C |
A |
8: 95,864,585 (GRCm39) |
A42S |
possibly damaging |
Het |
| Mrps17 |
A |
G |
5: 129,793,865 (GRCm39) |
T20A |
probably damaging |
Het |
| Msh6 |
T |
C |
17: 88,292,160 (GRCm39) |
V305A |
probably benign |
Het |
| Or6b1 |
T |
C |
6: 42,815,223 (GRCm39) |
M136T |
possibly damaging |
Het |
| Or7e176 |
T |
G |
9: 20,171,586 (GRCm39) |
M150R |
probably damaging |
Het |
| Pappa2 |
A |
G |
1: 158,611,511 (GRCm39) |
L1484P |
probably damaging |
Het |
| Polr3c |
A |
T |
3: 96,623,981 (GRCm39) |
|
probably null |
Het |
| Ros1 |
C |
A |
10: 51,954,007 (GRCm39) |
E1877D |
probably damaging |
Het |
| Slc5a4b |
T |
C |
10: 75,896,260 (GRCm39) |
N565S |
probably damaging |
Het |
| Slf2 |
T |
C |
19: 44,937,580 (GRCm39) |
|
probably null |
Het |
| Speer1m |
A |
C |
5: 11,971,423 (GRCm39) |
N125T |
probably benign |
Het |
| Suclg2 |
A |
T |
6: 95,565,915 (GRCm39) |
|
probably benign |
Het |
| Sult2a8 |
T |
C |
7: 14,159,382 (GRCm39) |
E79G |
probably damaging |
Het |
| Triobp |
A |
G |
15: 78,851,564 (GRCm39) |
T573A |
possibly damaging |
Het |
| Vmn2r129 |
C |
T |
4: 156,690,549 (GRCm39) |
|
noncoding transcript |
Het |
| Zfhx4 |
C |
A |
3: 5,477,769 (GRCm39) |
H3461Q |
probably damaging |
Het |
|
| Other mutations in Zfand5 |
| Allele | Source | Chr | Coord | Type | Predicted Effect | PPH Score |
|---|
|
R0089:Zfand5
|
UTSW |
19 |
21,257,122 (GRCm39) |
unclassified |
probably benign |
|
|
R0321:Zfand5
|
UTSW |
19 |
21,253,879 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R1766:Zfand5
|
UTSW |
19 |
21,257,888 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R1774:Zfand5
|
UTSW |
19 |
21,253,895 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R4741:Zfand5
|
UTSW |
19 |
21,253,845 (GRCm39) |
missense |
probably damaging |
0.99 |
|
R4812:Zfand5
|
UTSW |
19 |
21,255,101 (GRCm39) |
missense |
probably benign |
0.04 |
|
R5117:Zfand5
|
UTSW |
19 |
21,257,009 (GRCm39) |
missense |
probably benign |
0.00 |
|
R6273:Zfand5
|
UTSW |
19 |
21,257,060 (GRCm39) |
missense |
probably benign |
0.02 |
|
R8995:Zfand5
|
UTSW |
19 |
21,254,387 (GRCm39) |
missense |
probably benign |
0.05 |
|
| Posted On |
2014-05-07 |
Incidental Mutation