Incidental Mutation 'IGL01905:Csnk1d'
ID 179633
Institutional Source Australian Phenomics Network (link to record)
Gene Symbol Csnk1d
Ensembl Gene ENSMUSG00000025162
Gene Name casein kinase 1, delta
Synonyms 1200006A05Rik
Accession Numbers
Essential gene? Essential (E-score: 1.000) question?
Stock # IGL01905
Quality Score
Status
Chromosome 11
Chromosomal Location 120849816-120882156 bp(-) (GRCm39)
Type of Mutation missense
DNA Base Change (assembly) A to T at 120864789 bp (GRCm39)
Zygosity Heterozygous
Amino Acid Change Isoleucine to Asparagine at position 65 (I65N)
Ref Sequence ENSEMBL: ENSMUSP00000070721 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000018274] [ENSMUST00000070575]
AlphaFold Q9DC28
Predicted Effect probably damaging
Transcript: ENSMUST00000018274
AA Change: I65N

PolyPhen 2 Score 0.998 (Sensitivity: 0.27; Specificity: 0.99)
SMART Domains Protein: ENSMUSP00000018274
Gene: ENSMUSG00000025162
AA Change: I65N

DomainStartEndE-ValueType
Pfam:Pkinase_Tyr 9 273 3.7e-18 PFAM
Pfam:Pkinase 9 277 1.8e-28 PFAM
low complexity region 299 314 N/A INTRINSIC
Predicted Effect probably damaging
Transcript: ENSMUST00000070575
AA Change: I65N

PolyPhen 2 Score 0.998 (Sensitivity: 0.27; Specificity: 0.99)
SMART Domains Protein: ENSMUSP00000070721
Gene: ENSMUSG00000025162
AA Change: I65N

DomainStartEndE-ValueType
Pfam:Pkinase_Tyr 9 273 1.6e-18 PFAM
Pfam:Pkinase 9 280 2.8e-41 PFAM
low complexity region 299 314 N/A INTRINSIC
Predicted Effect noncoding transcript
Transcript: ENSMUST00000141071
Predicted Effect probably benign
Transcript: ENSMUST00000146837
SMART Domains Protein: ENSMUSP00000115055
Gene: ENSMUSG00000025162

DomainStartEndE-ValueType
Pfam:Pkinase 2 55 6.6e-6 PFAM
Predicted Effect unknown
Transcript: ENSMUST00000154483
AA Change: I69N
SMART Domains Protein: ENSMUSP00000117472
Gene: ENSMUSG00000025162
AA Change: I69N

DomainStartEndE-ValueType
low complexity region 12 25 N/A INTRINSIC
Pfam:Pkinase_Tyr 27 210 2.5e-12 PFAM
Pfam:Pkinase 28 218 3.4e-21 PFAM
Coding Region Coverage
Validation Efficiency
MGI Phenotype FUNCTION: This gene encodes a member of the casein kinase I (CKI) family of serine/threonine protein kinases. A highly similar human protein regulates an array of cellular processes by influencing the Wnt and hedgehog signaling pathways. The encoded protein may also be involved in the regulation of apoptosis, circadian rhythm, microtubule dynamics, chromosome segregation, and p53-mediated effects on growth. Alternatively spliced transcript variants encoding different isoforms have been described. [provided by RefSeq, Jul 2008]
PHENOTYPE: Homozygous null mice die 1.5 to 5 days after birth and fetal weight is significantly smaller than controls. [provided by MGI curators]
Allele List at MGI
Other mutations in this stock
Total: 26 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
2610008E11Rik A T 10: 78,903,582 (GRCm39) C245S probably damaging Het
Apol10b A G 15: 77,469,559 (GRCm39) I206T possibly damaging Het
Bax A T 7: 45,115,542 (GRCm39) I31N probably damaging Het
Ccdc116 C A 16: 16,960,425 (GRCm39) V131L probably damaging Het
Ces2b C A 8: 105,560,594 (GRCm39) N136K probably damaging Het
Fam167b A G 4: 129,470,892 (GRCm39) M152T probably damaging Het
Gm10718 A T 9: 3,025,118 (GRCm39) Y194F probably benign Het
Gm21738 G A 14: 19,416,979 (GRCm38) S144L probably benign Het
Gm5862 A C 5: 26,227,769 (GRCm39) W41G probably benign Het
Heatr6 C T 11: 83,672,538 (GRCm39) S1182L probably benign Het
Lpcat4 T C 2: 112,073,388 (GRCm39) probably null Het
Myh8 T C 11: 67,175,477 (GRCm39) Y311H possibly damaging Het
Naaladl1 G A 19: 6,165,577 (GRCm39) D744N possibly damaging Het
Pik3r4 C A 9: 105,522,077 (GRCm39) Y214* probably null Het
Proca1 A G 11: 78,095,716 (GRCm39) H29R probably damaging Het
Prrc2c T C 1: 162,532,898 (GRCm39) probably benign Het
Rcor3 G A 1: 191,785,302 (GRCm39) P489S probably damaging Het
Rela A T 19: 5,695,592 (GRCm39) N337I probably benign Het
Rnf123 C T 9: 107,948,569 (GRCm39) probably benign Het
Septin9 T A 11: 117,109,715 (GRCm39) S12T probably benign Het
Serpina1c A T 12: 103,863,318 (GRCm39) L294Q possibly damaging Het
Slc12a5 A G 2: 164,832,301 (GRCm39) D740G probably benign Het
Vmn2r129 C T 4: 156,690,549 (GRCm39) noncoding transcript Het
Zfp473 T C 7: 44,383,151 (GRCm39) K394R probably benign Het
Zkscan7 C T 9: 122,719,826 (GRCm39) P171S possibly damaging Het
Zmynd19 T A 2: 24,841,541 (GRCm39) F36L probably benign Het
Other mutations in Csnk1d
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL01689:Csnk1d APN 11 120,862,393 (GRCm39) missense probably benign 0.06
IGL02476:Csnk1d APN 11 120,863,338 (GRCm39) missense probably damaging 1.00
R1971:Csnk1d UTSW 11 120,863,274 (GRCm39) missense possibly damaging 0.95
R2245:Csnk1d UTSW 11 120,863,229 (GRCm39) missense probably damaging 1.00
R4472:Csnk1d UTSW 11 120,855,800 (GRCm39) unclassified probably benign
R4767:Csnk1d UTSW 11 120,859,954 (GRCm39) missense probably benign
R4809:Csnk1d UTSW 11 120,854,668 (GRCm39) unclassified probably benign
R4870:Csnk1d UTSW 11 120,874,014 (GRCm39) intron probably benign
R6522:Csnk1d UTSW 11 120,862,449 (GRCm39) missense probably damaging 1.00
R6657:Csnk1d UTSW 11 120,855,820 (GRCm39) missense possibly damaging 0.75
RF009:Csnk1d UTSW 11 120,862,453 (GRCm39) missense possibly damaging 0.81
Posted On 2014-05-07