Incidental Mutation 'IGL01905:Zkscan7'
ID179646
Institutional Source Australian Phenomics Network (link to record)
Gene Symbol Zkscan7
Ensembl Gene ENSMUSG00000063488
Gene Namezinc finger with KRAB and SCAN domains 7
SynonymsZfp167
Accession Numbers
Is this an essential gene? Non essential (E-score: 0.000) question?
Stock #IGL01905
Quality Score
Status
Chromosome9
Chromosomal Location122885685-122898618 bp(+) (GRCm38)
Type of Mutationmissense
DNA Base Change (assembly) C to T at 122890761 bp
ZygosityHeterozygous
Amino Acid Change Proline to Serine at position 171 (P171S)
Ref Sequence ENSEMBL: ENSMUSP00000071695 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000063980] [ENSMUST00000215872]
Predicted Effect possibly damaging
Transcript: ENSMUST00000063980
AA Change: P171S

PolyPhen 2 Score 0.930 (Sensitivity: 0.81; Specificity: 0.94)
SMART Domains Protein: ENSMUSP00000071695
Gene: ENSMUSG00000063488
AA Change: P171S

DomainStartEndE-ValueType
SCAN 45 156 1.18e-65 SMART
ZnF_C2H2 350 372 5.59e-4 SMART
ZnF_C2H2 378 400 3.69e-4 SMART
ZnF_C2H2 434 456 8.4e1 SMART
ZnF_C2H2 487 509 4.24e-4 SMART
ZnF_C2H2 515 537 8.34e-3 SMART
ZnF_C2H2 543 565 7.37e-4 SMART
ZnF_C2H2 571 593 1.92e-2 SMART
ZnF_C2H2 599 621 1.13e-4 SMART
ZnF_C2H2 627 649 2.24e-3 SMART
ZnF_C2H2 655 677 4.17e-3 SMART
ZnF_C2H2 683 705 1.04e-3 SMART
Predicted Effect noncoding transcript
Transcript: ENSMUST00000180486
Predicted Effect noncoding transcript
Transcript: ENSMUST00000180877
Predicted Effect noncoding transcript
Transcript: ENSMUST00000214426
Predicted Effect possibly damaging
Transcript: ENSMUST00000215872
AA Change: P171S

PolyPhen 2 Score 0.490 (Sensitivity: 0.88; Specificity: 0.90)
Coding Region Coverage
Validation Efficiency
Allele List at MGI
Other mutations in this stock
Total: 26 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
2610008E11Rik A T 10: 79,067,748 C245S probably damaging Het
Apol10b A G 15: 77,585,359 I206T possibly damaging Het
Bax A T 7: 45,466,118 I31N probably damaging Het
Ccdc116 C A 16: 17,142,561 V131L probably damaging Het
Ces2b C A 8: 104,833,962 N136K probably damaging Het
Csnk1d A T 11: 120,973,963 I65N probably damaging Het
Fam167b A G 4: 129,577,099 M152T probably damaging Het
Gm10718 A T 9: 3,025,118 Y194F probably benign Het
Gm21738 G A 14: 19,416,979 S144L probably benign Het
Gm5862 A C 5: 26,022,771 W41G probably benign Het
Heatr6 C T 11: 83,781,712 S1182L probably benign Het
Lpcat4 T C 2: 112,243,043 probably null Het
Myh8 T C 11: 67,284,651 Y311H possibly damaging Het
Naaladl1 G A 19: 6,115,547 D744N possibly damaging Het
Pik3r4 C A 9: 105,644,878 Y214* probably null Het
Proca1 A G 11: 78,204,890 H29R probably damaging Het
Prrc2c T C 1: 162,705,329 probably benign Het
Rcor3 G A 1: 192,101,002 P489S probably damaging Het
Rela A T 19: 5,645,564 N337I probably benign Het
Rnf123 C T 9: 108,071,370 probably benign Het
Sept9 T A 11: 117,218,889 S12T probably benign Het
Serpina1c A T 12: 103,897,059 L294Q possibly damaging Het
Slc12a5 A G 2: 164,990,381 D740G probably benign Het
Vmn2r-ps159 C T 4: 156,338,254 noncoding transcript Het
Zfp473 T C 7: 44,733,727 K394R probably benign Het
Zmynd19 T A 2: 24,951,529 F36L probably benign Het
Other mutations in Zkscan7
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL00594:Zkscan7 APN 9 122895594 missense possibly damaging 0.95
IGL01650:Zkscan7 APN 9 122894827 missense probably benign
IGL02466:Zkscan7 APN 9 122888885 missense probably damaging 0.98
R0310:Zkscan7 UTSW 9 122888893 nonsense probably null
R0355:Zkscan7 UTSW 9 122888807 missense probably damaging 1.00
R0477:Zkscan7 UTSW 9 122890809 splice site probably null
R1276:Zkscan7 UTSW 9 122890723 missense probably damaging 0.98
R1426:Zkscan7 UTSW 9 122895163 missense probably benign
R2055:Zkscan7 UTSW 9 122888937 missense probably damaging 1.00
R2195:Zkscan7 UTSW 9 122895621 missense possibly damaging 0.73
R2354:Zkscan7 UTSW 9 122894827 missense probably benign
R4878:Zkscan7 UTSW 9 122890800 nonsense probably null
R5106:Zkscan7 UTSW 9 122896133 unclassified probably benign
R6266:Zkscan7 UTSW 9 122895234 nonsense probably null
R6299:Zkscan7 UTSW 9 122888717 missense probably damaging 1.00
R6513:Zkscan7 UTSW 9 122896105 missense probably benign 0.00
R6881:Zkscan7 UTSW 9 122888701 missense possibly damaging 0.96
R7640:Zkscan7 UTSW 9 122896056 missense possibly damaging 0.71
Posted On2014-05-07