Incidental Mutation 'IGL01906:Scgb1b24'
ID179667
Institutional Source Australian Phenomics Network (link to record)
Gene Symbol Scgb1b24
Ensembl Gene ENSMUSG00000078753
Gene Namesecretoglobin, family 1B, member 24
SynonymsGm12769, Abpa24
Accession Numbers
Is this an essential gene? Probably non essential (E-score: 0.057) question?
Stock #IGL01906
Quality Score
Status
Chromosome7
Chromosomal Location33743799-33744982 bp(+) (GRCm38)
Type of Mutationmissense
DNA Base Change (assembly) T to C at 33744113 bp
ZygosityHeterozygous
Amino Acid Change Cysteine to Arginine at position 66 (C66R)
Ref Sequence ENSEMBL: ENSMUSP00000103722 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000055444] [ENSMUST00000108087]
Predicted Effect probably benign
Transcript: ENSMUST00000055444
SMART Domains Protein: ENSMUSP00000052456
Gene: ENSMUSG00000046438

DomainStartEndE-ValueType
low complexity region 5 11 N/A INTRINSIC
Pfam:Feld-I_B 24 90 5.9e-33 PFAM
Predicted Effect probably damaging
Transcript: ENSMUST00000108087
AA Change: C66R

PolyPhen 2 Score 0.979 (Sensitivity: 0.75; Specificity: 0.96)
SMART Domains Protein: ENSMUSP00000103722
Gene: ENSMUSG00000078753
AA Change: C66R

DomainStartEndE-ValueType
signal peptide 1 22 N/A INTRINSIC
UTG 23 92 4.95e-15 SMART
Coding Region Coverage
Validation Efficiency
Allele List at MGI
Other mutations in this stock
Total: 38 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
Abca13 A T 11: 9,216,225 Q24L probably damaging Het
Adam1b A T 5: 121,501,475 N502K probably benign Het
Adam6a T A 12: 113,544,331 M108K probably benign Het
Akr1b10 A G 6: 34,387,811 K69R probably benign Het
Ap5b1 T A 19: 5,570,979 L809* probably null Het
Asxl3 A T 18: 22,522,281 H1116L probably benign Het
Birc6 A G 17: 74,638,358 T2794A probably damaging Het
Bst1 T C 5: 43,837,519 F248L probably damaging Het
C130026I21Rik A G 1: 85,254,186 probably benign Het
Cep120 A T 18: 53,714,912 V625E probably benign Het
Cgnl1 T C 9: 71,724,567 M501V probably benign Het
Col19a1 T A 1: 24,317,429 D661V probably damaging Het
Copb2 A T 9: 98,580,330 E456V probably benign Het
Csk A G 9: 57,629,021 I201T probably damaging Het
Cttnbp2 G T 6: 18,378,376 S977* probably null Het
Ddr2 A G 1: 169,982,099 W770R probably damaging Het
Dnah7b T C 1: 46,175,453 I1126T probably damaging Het
Dusp27 A C 1: 166,099,523 L840R probably damaging Het
Ephb4 A T 5: 137,361,194 E342V probably damaging Het
Erc2 T A 14: 28,141,306 L496Q probably damaging Het
Faim2 G A 15: 99,514,433 T140I probably damaging Het
Gm21738 G A 14: 19,416,979 S144L probably benign Het
Haus3 A C 5: 34,168,323 probably benign Het
Hmcn1 T C 1: 150,667,887 T2846A probably benign Het
Mto1 T C 9: 78,464,931 V561A probably benign Het
Myb T C 10: 21,152,634 Y110C probably damaging Het
Olfr1280 T C 2: 111,315,901 C141R probably damaging Het
Plcd3 T C 11: 103,076,856 Y420C probably damaging Het
Plk4 G T 3: 40,810,381 M603I probably null Het
Sec23a T C 12: 59,007,044 Y56C probably damaging Het
Setd1b C A 5: 123,157,667 D1099E unknown Het
Sh2d7 G A 9: 54,539,466 probably benign Het
Slc30a10 A T 1: 185,456,396 K221* probably null Het
Slc5a1 T C 5: 33,154,653 L463P probably damaging Het
Strc T C 2: 121,377,634 T419A probably benign Het
Ttc39a T C 4: 109,421,394 M82T probably benign Het
Vmn2r-ps159 C T 4: 156,338,254 noncoding transcript Het
Vps13b T C 15: 35,639,847 probably benign Het
Other mutations in Scgb1b24
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL01072:Scgb1b24 APN 7 33744009 missense probably damaging 1.00
IGL02268:Scgb1b24 APN 7 33744963 missense possibly damaging 0.95
R0268:Scgb1b24 UTSW 7 33743853 missense probably null 1.00
R1869:Scgb1b24 UTSW 7 33744044 missense probably damaging 0.99
R5229:Scgb1b24 UTSW 7 33744095 missense possibly damaging 0.95
R6292:Scgb1b24 UTSW 7 33744152 missense possibly damaging 0.90
R7444:Scgb1b24 UTSW 7 33744141 missense possibly damaging 0.64
Posted On2014-05-07