Mutagenetix > Incidental Mutation

Incidental Mutation 'IGL01906:Dusp27'

179670

Institutional Source

Australian Phenomics Network (link to record)

Gene Symbol

Dusp27

Ensembl Gene

ENSMUSG00000026564

Gene Name

dual specificity phosphatase 27 (putative)

Synonyms

C130085G02Rik

Accession Numbers

Essential gene?

Non essential (E-score: 0.000) question?

Stock #

IGL01906

Quality Score

Status

Chromosome

Chromosomal Location

166098148-166127922 bp(-) (GRCm38)

Type of Mutation

missense

DNA Base Change (assembly)

A to C at 166099523 bp (GRCm38)

Zygosity

Heterozygous

Amino Acid Change

Leucine to Arginine at position 840 (L840R)

Ref Sequence

ENSEMBL: ENSMUSP00000141564 (fasta)

Gene Model

predicted gene model for transcript(s): [ENSMUST00000085992] [ENSMUST00000192369]

AlphaFold

Q148W8

Predicted Effect

probably damaging
Transcript: ENSMUST00000085992
AA Change: L840R

PolyPhen 2 Score 0.999 (Sensitivity: 0.14; Specificity: 0.99)

SMART Domains

Protein: ENSMUSP00000083155
Gene: ENSMUSG00000026564
AA Change: L840R

Domain	Start	End	E-Value	Type
low complexity region	6	20	N/A	INTRINSIC
DSPc	133	277	2.45e-30	SMART
low complexity region	339	348	N/A	INTRINSIC
low complexity region	404	425	N/A	INTRINSIC
low complexity region	429	439	N/A	INTRINSIC
low complexity region	618	635	N/A	INTRINSIC
low complexity region	655	666	N/A	INTRINSIC
low complexity region	773	788	N/A	INTRINSIC
coiled coil region	813	839	N/A	INTRINSIC
low complexity region	851	860	N/A	INTRINSIC
low complexity region	936	950	N/A	INTRINSIC
low complexity region	1001	1019	N/A	INTRINSIC
low complexity region	1026	1040	N/A	INTRINSIC
low complexity region	1074	1091	N/A	INTRINSIC
low complexity region	1108	1120	N/A	INTRINSIC

Predicted Effect

probably damaging
Transcript: ENSMUST00000192369
AA Change: L840R

PolyPhen 2 Score 0.999 (Sensitivity: 0.14; Specificity: 0.99)

SMART Domains

Protein: ENSMUSP00000141564
Gene: ENSMUSG00000026564
AA Change: L840R

Domain	Start	End	E-Value	Type
low complexity region	6	20	N/A	INTRINSIC
DSPc	133	277	2.45e-30	SMART
low complexity region	339	348	N/A	INTRINSIC
low complexity region	404	425	N/A	INTRINSIC
low complexity region	429	439	N/A	INTRINSIC
low complexity region	618	635	N/A	INTRINSIC
low complexity region	655	666	N/A	INTRINSIC
low complexity region	773	788	N/A	INTRINSIC
coiled coil region	813	839	N/A	INTRINSIC
low complexity region	851	860	N/A	INTRINSIC
low complexity region	936	950	N/A	INTRINSIC
low complexity region	1001	1019	N/A	INTRINSIC
low complexity region	1026	1040	N/A	INTRINSIC
low complexity region	1074	1091	N/A	INTRINSIC
low complexity region	1108	1120	N/A	INTRINSIC

Coding Region Coverage

Validation Efficiency

Allele List at MGI

Other mutations in this stock

Total: 38 list
Gene	Ref	Var	Chr/Loc	Mutation	Predicted Effect	Zygosity
Abca13	A	T	11: 9,216,225	Q24L	probably damaging	Het
Adam1b	A	T	5: 121,501,475	N502K	probably benign	Het
Adam6a	T	A	12: 113,544,331	M108K	probably benign	Het
Akr1b10	A	G	6: 34,387,811	K69R	probably benign	Het
Ap5b1	T	A	19: 5,570,979	L809*	probably null	Het
Asxl3	A	T	18: 22,522,281	H1116L	probably benign	Het
Birc6	A	G	17: 74,638,358	T2794A	probably damaging	Het
Bst1	T	C	5: 43,837,519	F248L	probably damaging	Het
C130026I21Rik	A	G	1: 85,254,186		probably benign	Het
Cep120	A	T	18: 53,714,912	V625E	probably benign	Het
Cgnl1	T	C	9: 71,724,567	M501V	probably benign	Het
Col19a1	T	A	1: 24,317,429	D661V	probably damaging	Het
Copb2	A	T	9: 98,580,330	E456V	probably benign	Het
Csk	A	G	9: 57,629,021	I201T	probably damaging	Het
Cttnbp2	G	T	6: 18,378,376	S977*	probably null	Het
Ddr2	A	G	1: 169,982,099	W770R	probably damaging	Het
Dnah7b	T	C	1: 46,175,453	I1126T	probably damaging	Het
Ephb4	A	T	5: 137,361,194	E342V	probably damaging	Het
Erc2	T	A	14: 28,141,306	L496Q	probably damaging	Het
Faim2	G	A	15: 99,514,433	T140I	probably damaging	Het
Gm21738	G	A	14: 19,416,979	S144L	probably benign	Het
Haus3	A	C	5: 34,168,323		probably benign	Het
Hmcn1	T	C	1: 150,667,887	T2846A	probably benign	Het
Mto1	T	C	9: 78,464,931	V561A	probably benign	Het
Myb	T	C	10: 21,152,634	Y110C	probably damaging	Het
Olfr1280	T	C	2: 111,315,901	C141R	probably damaging	Het
Plcd3	T	C	11: 103,076,856	Y420C	probably damaging	Het
Plk4	G	T	3: 40,810,381	M603I	probably null	Het
Scgb1b24	T	C	7: 33,744,113	C66R	probably damaging	Het
Sec23a	T	C	12: 59,007,044	Y56C	probably damaging	Het
Setd1b	C	A	5: 123,157,667	D1099E	unknown	Het
Sh2d7	G	A	9: 54,539,466		probably benign	Het
Slc30a10	A	T	1: 185,456,396	K221*	probably null	Het
Slc5a1	T	C	5: 33,154,653	L463P	probably damaging	Het
Strc	T	C	2: 121,377,634	T419A	probably benign	Het
Ttc39a	T	C	4: 109,421,394	M82T	probably benign	Het
Vmn2r-ps159	C	T	4: 156,338,254		noncoding transcript	Het
Vps13b	T	C	15: 35,639,847		probably benign	Het

Other mutations in Dusp27

Allele	Source	Chr	Coord	Type	Predicted Effect	PPH Score
IGL00706:Dusp27	APN	1	166100552	missense	probably benign	0.00
IGL00973:Dusp27	APN	1	166099458	missense	probably benign
IGL01331:Dusp27	APN	1	166108180	missense	probably damaging	1.00
IGL01466:Dusp27	APN	1	166100504	missense	probably damaging	1.00
IGL01572:Dusp27	APN	1	166100372	missense	probably benign	0.18
IGL01974:Dusp27	APN	1	166100536	nonsense	probably null
IGL02112:Dusp27	APN	1	166099671	nonsense	probably null
IGL02805:Dusp27	APN	1	166099061	missense	probably damaging	1.00
IGL03343:Dusp27	APN	1	166099448	missense	probably benign	0.00
R0116:Dusp27	UTSW	1	166099701	missense	probably benign	0.19
R0367:Dusp27	UTSW	1	166100763	missense	probably benign	0.05
R0499:Dusp27	UTSW	1	166099101	missense	probably benign	0.00
R0542:Dusp27	UTSW	1	166101284	missense	possibly damaging	0.90
R1312:Dusp27	UTSW	1	166099291	missense	possibly damaging	0.46
R1572:Dusp27	UTSW	1	166099455	missense	possibly damaging	0.68
R1598:Dusp27	UTSW	1	166110259	missense	probably benign	0.10
R1858:Dusp27	UTSW	1	166100846	missense	possibly damaging	0.87
R2021:Dusp27	UTSW	1	166100823	missense	probably benign	0.00
R2970:Dusp27	UTSW	1	166099229	missense	probably benign	0.04
R3727:Dusp27	UTSW	1	166099506	missense	probably damaging	1.00
R4041:Dusp27	UTSW	1	166100111	missense	probably benign	0.01
R4245:Dusp27	UTSW	1	166101116	missense	probably damaging	1.00
R4955:Dusp27	UTSW	1	166108092	missense	probably damaging	1.00
R4967:Dusp27	UTSW	1	166127106	missense	probably damaging	1.00
R5040:Dusp27	UTSW	1	166100345	missense	probably benign	0.17
R5342:Dusp27	UTSW	1	166110250	missense	probably benign	0.01
R5467:Dusp27	UTSW	1	166112030	critical splice donor site	probably null
R5742:Dusp27	UTSW	1	166099454	missense	probably benign	0.00
R6222:Dusp27	UTSW	1	166098645	missense	probably benign	0.26
R6239:Dusp27	UTSW	1	166098819	missense	probably damaging	1.00
R6531:Dusp27	UTSW	1	166110046	splice site	probably null
R6586:Dusp27	UTSW	1	166100885	missense	possibly damaging	0.79
R6958:Dusp27	UTSW	1	166107996	missense	probably damaging	1.00
R7006:Dusp27	UTSW	1	166099094	missense	probably benign
R7111:Dusp27	UTSW	1	166127154	missense	possibly damaging	0.66
R7310:Dusp27	UTSW	1	166098731	missense	possibly damaging	0.46
R7312:Dusp27	UTSW	1	166127107	missense	probably damaging	0.99
R7378:Dusp27	UTSW	1	166112063	nonsense	probably null
R7398:Dusp27	UTSW	1	166100475	missense	probably damaging	1.00
R7442:Dusp27	UTSW	1	166101015	missense	probably benign	0.01
R7569:Dusp27	UTSW	1	166108035	missense	probably damaging	1.00
R7920:Dusp27	UTSW	1	166099896	missense	possibly damaging	0.72
R7954:Dusp27	UTSW	1	166099280	missense	probably benign	0.05
R7972:Dusp27	UTSW	1	166099139	missense	probably damaging	1.00
R8186:Dusp27	UTSW	1	166100079	missense	probably damaging	1.00
R8354:Dusp27	UTSW	1	166108133	missense	probably damaging	1.00
R8454:Dusp27	UTSW	1	166108133	missense	probably damaging	1.00
R8535:Dusp27	UTSW	1	166101161	missense	probably benign	0.01
R9419:Dusp27	UTSW	1	166100186	missense	probably damaging	1.00
R9493:Dusp27	UTSW	1	166098841	missense	probably damaging	1.00
R9694:Dusp27	UTSW	1	166101085	missense	probably damaging	1.00
Z1088:Dusp27	UTSW	1	166099283	missense	probably damaging	1.00

Posted On

2014-05-07