Mutagenetix > Incidental Mutation

Incidental Mutation 'IGL01907:Cyrib'

179715

Institutional Source

Australian Phenomics Network (link to record)

Gene Symbol

Cyrib

Ensembl Gene

ENSMUSG00000022378

Gene Name

CYFIP related Rac1 interactor B

Synonyms

0910001A06Rik, Fam49b

Accession Numbers

Essential gene?

Non essential (E-score: 0.000) question?

Stock #

IGL01907

Quality Score

Status

Chromosome

Chromosomal Location

63800946-63932327 bp(-) (GRCm39)

Type of Mutation

splice site

DNA Base Change (assembly)

A to G at 63803535 bp (GRCm39)

Zygosity

Heterozygous

Amino Acid Change

Ref Sequence

ENSEMBL: ENSMUSP00000154320 (fasta)

Gene Model

predicted gene model for transcript(s): [ENSMUST00000063838] [ENSMUST00000164532] [ENSMUST00000228226]

AlphaFold

Q921M7

Predicted Effect

probably benign
Transcript: ENSMUST00000063838

SMART Domains

Protein: ENSMUSP00000066359
Gene: ENSMUSG00000022378

Domain	Start	End	E-Value	Type
Pfam:DUF1394	16	320	1e-179	PFAM

Predicted Effect

probably benign
Transcript: ENSMUST00000164532

SMART Domains

Protein: ENSMUSP00000132486
Gene: ENSMUSG00000022378

Domain	Start	End	E-Value	Type
Pfam:DUF1394	18	320	3e-155	PFAM

Predicted Effect

probably benign
Transcript: ENSMUST00000228226

Coding Region Coverage

Validation Efficiency

Allele List at MGI

Other mutations in this stock

Total: 25 list
Gene	Ref	Var	Chr/Loc	Mutation	Predicted Effect	Zygosity
Ap1g1	T	C	8: 110,569,975 (GRCm39)		probably benign	Het
Asph	A	T	4: 9,514,643 (GRCm39)	D491E	possibly damaging	Het
D930020B18Rik	A	G	10: 121,477,915 (GRCm39)	N47D	probably damaging	Het
Gad1	T	C	2: 70,404,470 (GRCm39)	V120A	possibly damaging	Het
Gm10717	C	T	9: 3,025,616 (GRCm39)	S67L	probably benign	Het
Gm10717	A	T	9: 3,026,287 (GRCm39)	Y195F	probably damaging	Het
Grin2b	T	G	6: 135,710,738 (GRCm39)	E936A	probably damaging	Het
Iars1	T	C	13: 49,863,131 (GRCm39)	F528L	probably damaging	Het
Iyd	C	T	10: 3,490,407 (GRCm39)	P38S	probably damaging	Het
Krt24	A	G	11: 99,176,030 (GRCm39)	F2L	unknown	Het
Mnat1	T	A	12: 73,319,213 (GRCm39)	S279T	probably benign	Het
Mptx1	A	T	1: 174,160,212 (GRCm39)	I173L	probably benign	Het
Or9g20	T	A	2: 85,629,946 (GRCm39)	T223S	probably benign	Het
Per1	T	C	11: 68,996,425 (GRCm39)	S810P	probably benign	Het
Racgap1	T	A	15: 99,524,214 (GRCm39)	K398*	probably null	Het
Rnf133	T	C	6: 23,649,303 (GRCm39)	N209D	probably benign	Het
Rp1	T	C	1: 4,418,730 (GRCm39)	E794G	possibly damaging	Het
Ryr3	A	T	2: 112,699,346 (GRCm39)		probably benign	Het
Slc27a2	A	G	2: 126,429,794 (GRCm39)	T465A	probably benign	Het
Smarca2	T	C	19: 26,675,865 (GRCm39)	M1035T	possibly damaging	Het
Spink5	A	G	18: 44,129,743 (GRCm39)	N445D	probably damaging	Het
Stard3nl	G	A	13: 19,556,759 (GRCm39)	A127V	probably damaging	Het
Trim69	C	T	2: 121,998,142 (GRCm39)	T38M	probably benign	Het
Vmn2r129	C	T	4: 156,690,549 (GRCm39)		noncoding transcript	Het
Zfp438	G	A	18: 5,213,815 (GRCm39)	A381V	probably damaging	Het

Other mutations in Cyrib

Allele	Source	Chr	Coord	Type	Predicted Effect	PPH Score
IGL01983:Cyrib	APN	15	63,809,236 (GRCm39)	missense	probably benign	0.00
Topsy	UTSW	15	63,810,526 (GRCm39)	missense	probably damaging	0.99
turvey	UTSW	15	63,828,447 (GRCm39)	critical splice donor site	probably null
Upsidedown	UTSW	15	63,810,507 (GRCm39)	splice site	probably null
PIT4480001:Cyrib	UTSW	15	63,828,490 (GRCm39)	missense	probably benign	0.42
R3956:Cyrib	UTSW	15	63,813,823 (GRCm39)	missense	probably damaging	1.00
R5181:Cyrib	UTSW	15	63,810,526 (GRCm39)	missense	probably damaging	0.99
R5484:Cyrib	UTSW	15	63,815,056 (GRCm39)	missense	probably damaging	1.00
R5723:Cyrib	UTSW	15	63,828,447 (GRCm39)	critical splice donor site	probably null
R7260:Cyrib	UTSW	15	63,829,438 (GRCm39)	missense	possibly damaging	0.65
R7368:Cyrib	UTSW	15	63,810,507 (GRCm39)	splice site	probably null
R8053:Cyrib	UTSW	15	63,813,832 (GRCm39)	missense	probably damaging	1.00

Posted On

2014-05-07