Mutagenetix > Incidental Mutation

Incidental Mutation 'IGL01909:Vmn2r71'

179744

Institutional Source

Australian Phenomics Network (link to record)

Gene Symbol

Vmn2r71

Ensembl Gene

ENSMUSG00000091205

Gene Name

vomeronasal 2, receptor 71

Synonyms

EG233445

Accession Numbers

Essential gene?

Probably non essential (E-score: 0.067) question?

Stock #

IGL01909

Quality Score

Status

Chromosome

Chromosomal Location

85264670-85273755 bp(+) (GRCm39)

Type of Mutation

missense

DNA Base Change (assembly)

C to T at 85270001 bp (GRCm39)

Zygosity

Heterozygous

Amino Acid Change

Threonine to Isoleucine at position 504 (T504I)

Ref Sequence

ENSEMBL: ENSMUSP00000132337 (fasta)

Gene Model

predicted gene model for transcript(s): [ENSMUST00000172338]

AlphaFold

L7N2D8

Predicted Effect

probably benign
Transcript: ENSMUST00000172338
AA Change: T504I

PolyPhen 2 Score 0.001 (Sensitivity: 0.99; Specificity: 0.15)

SMART Domains

Protein: ENSMUSP00000132337
Gene: ENSMUSG00000091205
AA Change: T504I

Domain	Start	End	E-Value	Type
signal peptide	1	18	N/A	INTRINSIC
Pfam:ANF_receptor	77	468	2.1e-31	PFAM
Pfam:NCD3G	511	563	8.7e-20	PFAM
Pfam:7tm_3	593	831	2e-55	PFAM

Predicted Effect

noncoding transcript
Transcript: ENSMUST00000208273

Predicted Effect

noncoding transcript
Transcript: ENSMUST00000208545

Coding Region Coverage

Validation Efficiency

Allele List at MGI

Other mutations in this stock

Total: 35 list
Gene	Ref	Var	Chr/Loc	Mutation	Predicted Effect	Zygosity
1700111E14Rik	A	T	6: 36,914,152 (GRCm39)		probably benign	Het
Actn2	A	T	13: 12,324,479 (GRCm39)		probably null	Het
Apom	C	T	17: 35,350,208 (GRCm39)	A78T	probably benign	Het
Bambi	A	G	18: 3,508,229 (GRCm39)	Y7C	possibly damaging	Het
Cdc42bpb	T	C	12: 111,289,576 (GRCm39)	M418V	probably benign	Het
Clptm1	T	C	7: 19,389,701 (GRCm39)	N43D	probably benign	Het
Cspp1	T	C	1: 10,136,886 (GRCm39)	V241A	probably benign	Het
Ctnna3	T	A	10: 63,339,910 (GRCm39)	I32N	probably benign	Het
Elp2	A	G	18: 24,752,576 (GRCm39)		probably benign	Het
Frmd4a	A	G	2: 4,608,844 (GRCm39)	D893G	probably benign	Het
Gm10718	A	T	9: 3,025,118 (GRCm39)	Y194F	probably benign	Het
Gm21738	G	A	14: 19,416,979 (GRCm38)	S144L	probably benign	Het
Gm5862	A	C	5: 26,227,769 (GRCm39)	W41G	probably benign	Het
H2-M10.1	C	A	17: 36,635,971 (GRCm39)	G154*	probably null	Het
Igdcc3	C	T	9: 65,051,819 (GRCm39)	R141W	probably damaging	Het
Igkv14-130	A	G	6: 67,768,323 (GRCm39)	K60E	possibly damaging	Het
Kcnmb2	A	G	3: 32,252,512 (GRCm39)		probably benign	Het
Lrp4	T	C	2: 91,324,529 (GRCm39)	L1288P	possibly damaging	Het
Mavs	T	A	2: 131,087,441 (GRCm39)	M313K	probably benign	Het
Mia2	A	G	12: 59,154,731 (GRCm39)	E148G	possibly damaging	Het
Or6c76b	A	T	10: 129,692,950 (GRCm39)	T188S	probably damaging	Het
Or8b12b	T	A	9: 37,684,159 (GRCm39)	I68K	possibly damaging	Het
Or8d1	T	A	9: 38,767,013 (GRCm39)	Y218*	probably null	Het
Plekha3	C	T	2: 76,517,047 (GRCm39)	T133M	probably damaging	Het
Plxna1	A	T	6: 89,309,066 (GRCm39)		probably null	Het
Septin2	A	G	1: 93,426,823 (GRCm39)	N144S	probably damaging	Het
Slc9a4	T	C	1: 40,651,451 (GRCm39)		probably benign	Het
Slco1b2	T	A	6: 141,594,312 (GRCm39)	I59K	probably damaging	Het
Sp140l2	A	G	1: 85,231,907 (GRCm39)		probably benign	Het
Tnrc6b	A	G	15: 80,786,184 (GRCm39)	S1243G	possibly damaging	Het
Unc13a	T	A	8: 72,091,854 (GRCm39)		probably benign	Het
Vmn2r105	T	C	17: 20,444,918 (GRCm39)	R525G	probably damaging	Het
Vmn2r129	C	T	4: 156,690,549 (GRCm39)		noncoding transcript	Het
Vmn2r37	T	A	7: 9,219,032 (GRCm39)	K451*	probably null	Het
Zfp668	A	T	7: 127,465,994 (GRCm39)	C397S	probably damaging	Het

Other mutations in Vmn2r71

Allele	Source	Chr	Coord	Type	Predicted Effect	PPH Score
IGL00922:Vmn2r71	APN	7	85,267,901 (GRCm39)	missense	probably benign
IGL00960:Vmn2r71	APN	7	85,273,582 (GRCm39)	missense	probably damaging	1.00
IGL01372:Vmn2r71	APN	7	85,270,022 (GRCm39)	splice site	probably benign
IGL01690:Vmn2r71	APN	7	85,264,782 (GRCm39)	missense	probably damaging	1.00
IGL01950:Vmn2r71	APN	7	85,264,827 (GRCm39)	missense	probably damaging	0.98
IGL02570:Vmn2r71	APN	7	85,264,748 (GRCm39)	missense	possibly damaging	0.95
IGL02650:Vmn2r71	APN	7	85,273,535 (GRCm39)	missense	probably damaging	1.00
IGL02901:Vmn2r71	APN	7	85,268,470 (GRCm39)	missense	probably benign	0.00
IGL03128:Vmn2r71	APN	7	85,268,795 (GRCm39)	missense	probably damaging	1.00
IGL03328:Vmn2r71	APN	7	85,273,499 (GRCm39)	missense	probably damaging	1.00
R0533:Vmn2r71	UTSW	7	85,268,426 (GRCm39)	frame shift	probably null
R0707:Vmn2r71	UTSW	7	85,268,640 (GRCm39)	missense	probably benign
R0841:Vmn2r71	UTSW	7	85,267,749 (GRCm39)	missense	possibly damaging	0.62
R0865:Vmn2r71	UTSW	7	85,268,516 (GRCm39)	missense	probably benign	0.01
R0883:Vmn2r71	UTSW	7	85,272,842 (GRCm39)	missense	probably benign	0.19
R0939:Vmn2r71	UTSW	7	85,272,889 (GRCm39)	missense	possibly damaging	0.70
R1597:Vmn2r71	UTSW	7	85,273,352 (GRCm39)	missense	possibly damaging	0.46
R1646:Vmn2r71	UTSW	7	85,270,476 (GRCm39)	missense	probably damaging	0.99
R1719:Vmn2r71	UTSW	7	85,270,435 (GRCm39)	missense	probably damaging	1.00
R1860:Vmn2r71	UTSW	7	85,264,782 (GRCm39)	missense	probably damaging	1.00
R2013:Vmn2r71	UTSW	7	85,269,845 (GRCm39)	missense	probably benign	0.38
R2014:Vmn2r71	UTSW	7	85,269,845 (GRCm39)	missense	probably benign	0.38
R2015:Vmn2r71	UTSW	7	85,269,845 (GRCm39)	missense	probably benign	0.38
R2050:Vmn2r71	UTSW	7	85,273,681 (GRCm39)	missense	probably damaging	1.00
R2084:Vmn2r71	UTSW	7	85,267,945 (GRCm39)	missense	probably benign	0.03
R2221:Vmn2r71	UTSW	7	85,273,301 (GRCm39)	missense	probably benign	0.40
R2223:Vmn2r71	UTSW	7	85,273,301 (GRCm39)	missense	probably benign	0.40
R2245:Vmn2r71	UTSW	7	85,273,388 (GRCm39)	missense	probably damaging	1.00
R3115:Vmn2r71	UTSW	7	85,272,866 (GRCm39)	missense	probably damaging	0.97
R3122:Vmn2r71	UTSW	7	85,264,828 (GRCm39)	nonsense	probably null
R3609:Vmn2r71	UTSW	7	85,268,870 (GRCm39)	missense	probably damaging	1.00
R4093:Vmn2r71	UTSW	7	85,270,442 (GRCm39)	missense	probably benign	0.00
R4305:Vmn2r71	UTSW	7	85,273,360 (GRCm39)	missense	probably damaging	1.00
R4306:Vmn2r71	UTSW	7	85,273,360 (GRCm39)	missense	probably damaging	1.00
R4334:Vmn2r71	UTSW	7	85,269,042 (GRCm39)	missense	probably benign	0.01
R4569:Vmn2r71	UTSW	7	85,273,402 (GRCm39)	missense	possibly damaging	0.66
R4622:Vmn2r71	UTSW	7	85,269,817 (GRCm39)	missense	probably benign	0.00
R4915:Vmn2r71	UTSW	7	85,270,476 (GRCm39)	missense	probably damaging	0.99
R4956:Vmn2r71	UTSW	7	85,268,436 (GRCm39)	missense	probably benign	0.19
R5005:Vmn2r71	UTSW	7	85,273,352 (GRCm39)	missense	probably damaging	1.00
R5045:Vmn2r71	UTSW	7	85,273,597 (GRCm39)	missense	probably benign	0.00
R5153:Vmn2r71	UTSW	7	85,268,430 (GRCm39)	missense	possibly damaging	0.94
R5236:Vmn2r71	UTSW	7	85,272,877 (GRCm39)	missense	probably damaging	1.00
R5373:Vmn2r71	UTSW	7	85,267,750 (GRCm39)	missense	possibly damaging	0.79
R5405:Vmn2r71	UTSW	7	85,268,622 (GRCm39)	missense	probably benign
R5831:Vmn2r71	UTSW	7	85,272,922 (GRCm39)	missense	probably benign	0.16
R6061:Vmn2r71	UTSW	7	85,268,482 (GRCm39)	missense	probably benign
R6518:Vmn2r71	UTSW	7	85,270,436 (GRCm39)	missense	probably damaging	1.00
R6751:Vmn2r71	UTSW	7	85,269,095 (GRCm39)	critical splice donor site	probably null
R6920:Vmn2r71	UTSW	7	85,273,108 (GRCm39)	missense	probably damaging	1.00
R7358:Vmn2r71	UTSW	7	85,273,468 (GRCm39)	missense	possibly damaging	0.81
R7453:Vmn2r71	UTSW	7	85,273,297 (GRCm39)	missense	probably benign	0.21
R7560:Vmn2r71	UTSW	7	85,273,115 (GRCm39)	missense	probably benign	0.06
R7871:Vmn2r71	UTSW	7	85,272,869 (GRCm39)	missense	possibly damaging	0.81
R8267:Vmn2r71	UTSW	7	85,264,704 (GRCm39)	missense	probably benign	0.02
R8377:Vmn2r71	UTSW	7	85,264,707 (GRCm39)	missense	probably benign
R9278:Vmn2r71	UTSW	7	85,269,788 (GRCm39)	missense	probably benign	0.19
R9319:Vmn2r71	UTSW	7	85,273,694 (GRCm39)	missense	probably damaging	1.00
R9329:Vmn2r71	UTSW	7	85,267,950 (GRCm39)	missense	probably benign	0.00
R9368:Vmn2r71	UTSW	7	85,273,442 (GRCm39)	missense	probably damaging	1.00
R9636:Vmn2r71	UTSW	7	85,268,388 (GRCm39)	missense	possibly damaging	0.80
R9756:Vmn2r71	UTSW	7	85,268,573 (GRCm39)	nonsense	probably null
X0025:Vmn2r71	UTSW	7	85,267,873 (GRCm39)	missense	probably benign
Z1186:Vmn2r71	UTSW	7	85,273,094 (GRCm39)	missense	probably damaging	1.00

Posted On

2014-05-07