Mutagenetix > Incidental Mutation

Incidental Mutation 'IGL01909:Vmn2r105'

179754

Institutional Source

Australian Phenomics Network (link to record)

Gene Symbol

Vmn2r105

Ensembl Gene

ENSMUSG00000091670

Gene Name

vomeronasal 2, receptor 105

Synonyms

EG627743

Accession Numbers

Essential gene?

Non essential (E-score: 0.000) question?

Stock #

IGL01909

Quality Score

Status

Chromosome

Chromosomal Location

20428492-20455134 bp(-) (GRCm39)

Type of Mutation

missense

DNA Base Change (assembly)

T to C at 20444918 bp (GRCm39)

Zygosity

Heterozygous

Amino Acid Change

Arginine to Glycine at position 525 (R525G)

Ref Sequence

ENSEMBL: ENSMUSP00000129762 (fasta)

Gene Model

predicted gene model for transcript(s): [ENSMUST00000167382]

AlphaFold

E9Q3A5

Predicted Effect

probably damaging
Transcript: ENSMUST00000167382
AA Change: R525G

PolyPhen 2 Score 1.000 (Sensitivity: 0.00; Specificity: 1.00)

SMART Domains

Protein: ENSMUSP00000129762
Gene: ENSMUSG00000091670
AA Change: R525G

Domain	Start	End	E-Value	Type
Pfam:ANF_receptor	85	469	6.5e-42	PFAM
Pfam:NCD3G	512	565	3.2e-21	PFAM
Pfam:7tm_3	598	833	2.5e-51	PFAM

Coding Region Coverage

Validation Efficiency

Allele List at MGI

Other mutations in this stock

Total: 35 list
Gene	Ref	Var	Chr/Loc	Mutation	Predicted Effect	Zygosity
1700111E14Rik	A	T	6: 36,914,152 (GRCm39)		probably benign	Het
Actn2	A	T	13: 12,324,479 (GRCm39)		probably null	Het
Apom	C	T	17: 35,350,208 (GRCm39)	A78T	probably benign	Het
Bambi	A	G	18: 3,508,229 (GRCm39)	Y7C	possibly damaging	Het
Cdc42bpb	T	C	12: 111,289,576 (GRCm39)	M418V	probably benign	Het
Clptm1	T	C	7: 19,389,701 (GRCm39)	N43D	probably benign	Het
Cspp1	T	C	1: 10,136,886 (GRCm39)	V241A	probably benign	Het
Ctnna3	T	A	10: 63,339,910 (GRCm39)	I32N	probably benign	Het
Elp2	A	G	18: 24,752,576 (GRCm39)		probably benign	Het
Frmd4a	A	G	2: 4,608,844 (GRCm39)	D893G	probably benign	Het
Gm10718	A	T	9: 3,025,118 (GRCm39)	Y194F	probably benign	Het
Gm21738	G	A	14: 19,416,979 (GRCm38)	S144L	probably benign	Het
Gm5862	A	C	5: 26,227,769 (GRCm39)	W41G	probably benign	Het
H2-M10.1	C	A	17: 36,635,971 (GRCm39)	G154*	probably null	Het
Igdcc3	C	T	9: 65,051,819 (GRCm39)	R141W	probably damaging	Het
Igkv14-130	A	G	6: 67,768,323 (GRCm39)	K60E	possibly damaging	Het
Kcnmb2	A	G	3: 32,252,512 (GRCm39)		probably benign	Het
Lrp4	T	C	2: 91,324,529 (GRCm39)	L1288P	possibly damaging	Het
Mavs	T	A	2: 131,087,441 (GRCm39)	M313K	probably benign	Het
Mia2	A	G	12: 59,154,731 (GRCm39)	E148G	possibly damaging	Het
Or6c76b	A	T	10: 129,692,950 (GRCm39)	T188S	probably damaging	Het
Or8b12b	T	A	9: 37,684,159 (GRCm39)	I68K	possibly damaging	Het
Or8d1	T	A	9: 38,767,013 (GRCm39)	Y218*	probably null	Het
Plekha3	C	T	2: 76,517,047 (GRCm39)	T133M	probably damaging	Het
Plxna1	A	T	6: 89,309,066 (GRCm39)		probably null	Het
Septin2	A	G	1: 93,426,823 (GRCm39)	N144S	probably damaging	Het
Slc9a4	T	C	1: 40,651,451 (GRCm39)		probably benign	Het
Slco1b2	T	A	6: 141,594,312 (GRCm39)	I59K	probably damaging	Het
Sp140l2	A	G	1: 85,231,907 (GRCm39)		probably benign	Het
Tnrc6b	A	G	15: 80,786,184 (GRCm39)	S1243G	possibly damaging	Het
Unc13a	T	A	8: 72,091,854 (GRCm39)		probably benign	Het
Vmn2r129	C	T	4: 156,690,549 (GRCm39)		noncoding transcript	Het
Vmn2r37	T	A	7: 9,219,032 (GRCm39)	K451*	probably null	Het
Vmn2r71	C	T	7: 85,270,001 (GRCm39)	T504I	probably benign	Het
Zfp668	A	T	7: 127,465,994 (GRCm39)	C397S	probably damaging	Het

Other mutations in Vmn2r105

Allele	Source	Chr	Coord	Type	Predicted Effect	PPH Score
IGL01433:Vmn2r105	APN	17	20,448,817 (GRCm39)	missense	probably benign	0.01
IGL01925:Vmn2r105	APN	17	20,428,973 (GRCm39)	missense	possibly damaging	0.94
IGL02021:Vmn2r105	APN	17	20,448,157 (GRCm39)	missense	possibly damaging	0.49
IGL02828:Vmn2r105	APN	17	20,429,345 (GRCm39)	missense	possibly damaging	0.80
IGL02838:Vmn2r105	APN	17	20,447,847 (GRCm39)	missense	probably damaging	1.00
IGL03343:Vmn2r105	APN	17	20,446,631 (GRCm39)	nonsense	probably null
R0096:Vmn2r105	UTSW	17	20,447,741 (GRCm39)	missense	possibly damaging	0.49
R0096:Vmn2r105	UTSW	17	20,447,741 (GRCm39)	missense	possibly damaging	0.49
R0212:Vmn2r105	UTSW	17	20,428,827 (GRCm39)	missense	possibly damaging	0.90
R0268:Vmn2r105	UTSW	17	20,428,938 (GRCm39)	missense	probably benign	0.18
R0271:Vmn2r105	UTSW	17	20,454,965 (GRCm39)	missense	probably damaging	0.96
R0613:Vmn2r105	UTSW	17	20,428,578 (GRCm39)	missense	probably damaging	1.00
R0765:Vmn2r105	UTSW	17	20,448,119 (GRCm39)	missense	probably damaging	0.98
R0765:Vmn2r105	UTSW	17	20,447,973 (GRCm39)	missense	probably benign	0.20
R1162:Vmn2r105	UTSW	17	20,447,973 (GRCm39)	missense	probably benign	0.20
R1263:Vmn2r105	UTSW	17	20,428,584 (GRCm39)	missense	probably damaging	1.00
R1363:Vmn2r105	UTSW	17	20,428,932 (GRCm39)	missense	probably benign	0.00
R1464:Vmn2r105	UTSW	17	20,449,004 (GRCm39)	splice site	probably benign
R2029:Vmn2r105	UTSW	17	20,444,840 (GRCm39)	missense	probably damaging	0.99
R2420:Vmn2r105	UTSW	17	20,448,097 (GRCm39)	missense	probably benign	0.15
R2421:Vmn2r105	UTSW	17	20,448,097 (GRCm39)	missense	probably benign	0.15
R2422:Vmn2r105	UTSW	17	20,448,097 (GRCm39)	missense	probably benign	0.15
R2570:Vmn2r105	UTSW	17	20,447,585 (GRCm39)	missense	probably damaging	1.00
R3847:Vmn2r105	UTSW	17	20,428,952 (GRCm39)	missense	possibly damaging	0.85
R3848:Vmn2r105	UTSW	17	20,428,952 (GRCm39)	missense	possibly damaging	0.85
R4030:Vmn2r105	UTSW	17	20,429,016 (GRCm39)	missense	probably damaging	0.99
R4275:Vmn2r105	UTSW	17	20,448,902 (GRCm39)	missense	probably damaging	1.00
R4551:Vmn2r105	UTSW	17	20,446,613 (GRCm39)	missense	probably benign
R4801:Vmn2r105	UTSW	17	20,447,556 (GRCm39)	missense	probably benign	0.00
R4802:Vmn2r105	UTSW	17	20,447,556 (GRCm39)	missense	probably benign	0.00
R4816:Vmn2r105	UTSW	17	20,428,953 (GRCm39)	missense	probably benign	0.27
R4929:Vmn2r105	UTSW	17	20,448,280 (GRCm39)	missense	probably benign	0.44
R5022:Vmn2r105	UTSW	17	20,428,676 (GRCm39)	missense	probably damaging	0.99
R5475:Vmn2r105	UTSW	17	20,455,044 (GRCm39)	missense	probably benign
R5576:Vmn2r105	UTSW	17	20,444,836 (GRCm39)	critical splice donor site	probably null
R5795:Vmn2r105	UTSW	17	20,448,998 (GRCm39)	missense	probably benign	0.00
R5895:Vmn2r105	UTSW	17	20,448,929 (GRCm39)	missense	probably benign	0.10
R6017:Vmn2r105	UTSW	17	20,428,889 (GRCm39)	missense	probably damaging	0.97
R6210:Vmn2r105	UTSW	17	20,448,758 (GRCm39)	missense	probably damaging	1.00
R6491:Vmn2r105	UTSW	17	20,447,992 (GRCm39)	nonsense	probably null
R6542:Vmn2r105	UTSW	17	20,448,803 (GRCm39)	missense	probably benign	0.03
R6729:Vmn2r105	UTSW	17	20,428,605 (GRCm39)	missense	probably damaging	0.99
R7020:Vmn2r105	UTSW	17	20,429,336 (GRCm39)	missense	probably damaging	1.00
R7033:Vmn2r105	UTSW	17	20,428,874 (GRCm39)	missense	probably damaging	0.97
R7488:Vmn2r105	UTSW	17	20,429,045 (GRCm39)	missense	probably damaging	1.00
R7491:Vmn2r105	UTSW	17	20,448,827 (GRCm39)	missense	probably benign	0.02
R7555:Vmn2r105	UTSW	17	20,447,937 (GRCm39)	missense	probably damaging	0.98
R7863:Vmn2r105	UTSW	17	20,428,937 (GRCm39)	missense	probably benign	0.18
R8137:Vmn2r105	UTSW	17	20,454,966 (GRCm39)	missense	probably benign	0.02
R8166:Vmn2r105	UTSW	17	20,428,904 (GRCm39)	missense	probably benign	0.07
R8186:Vmn2r105	UTSW	17	20,444,880 (GRCm39)	nonsense	probably null
R8214:Vmn2r105	UTSW	17	20,448,775 (GRCm39)	missense	probably benign	0.02
R8497:Vmn2r105	UTSW	17	20,455,134 (GRCm39)	start codon destroyed	probably null	0.75
R8850:Vmn2r105	UTSW	17	20,428,872 (GRCm39)	missense	probably damaging	1.00
R8880:Vmn2r105	UTSW	17	20,429,229 (GRCm39)	missense	probably damaging	0.99
R9272:Vmn2r105	UTSW	17	20,447,685 (GRCm39)	missense	probably damaging	1.00
R9506:Vmn2r105	UTSW	17	20,429,404 (GRCm39)	missense	probably benign	0.00
R9549:Vmn2r105	UTSW	17	20,448,023 (GRCm39)	missense	probably benign	0.12

Posted On

2014-05-07