Incidental Mutation 'IGL01909:Zfp668'
| ID |
179756 |
| Institutional Source |
Australian Phenomics Network
(link to record)
|
| Gene Symbol |
Zfp668
|
| Ensembl Gene |
ENSMUSG00000049728 |
| Gene Name |
zinc finger protein 668 |
| Synonyms |
E130018B19Rik |
| Accession Numbers |
|
| Essential gene? |
Probably non essential
(E-score: 0.147)
|
| Stock # |
IGL01909
|
| Quality Score |
|
|
Status
|
|
| Chromosome |
7 |
| Chromosomal Location |
127462219-127476000 bp(-) (GRCm39) |
| Type of Mutation |
missense |
| DNA Base Change (assembly) |
A to T
at 127465994 bp (GRCm39)
|
| Zygosity |
Heterozygous |
| Amino Acid Change |
Cysteine to Serine
at position 397
(C397S)
|
| Ref Sequence |
ENSEMBL: ENSMUSP00000101870
(fasta)
|
| Gene Model |
predicted gene model for transcript(s):
[ENSMUST00000054415]
[ENSMUST00000106261]
[ENSMUST00000106262]
[ENSMUST00000106263]
[ENSMUST00000144721]
|
| AlphaFold |
Q8K2R5 |
| Predicted Effect |
probably damaging
Transcript: ENSMUST00000054415
AA Change: C397S
PolyPhen 2
Score 1.000 (Sensitivity: 0.00; Specificity: 1.00)
|
| SMART Domains |
Protein: ENSMUSP00000056105
Gene: ENSMUSG00000049728
AA Change: C397S
| Domain | Start | End | E-Value | Type |
|---|
|
ZnF_C2H2
|
22 |
44 |
7.67e-2 |
SMART |
|
ZnF_C2H2
|
84 |
106 |
9.44e-2 |
SMART |
|
ZnF_C2H2
|
112 |
134 |
3.63e-3 |
SMART |
|
ZnF_C2H2
|
140 |
162 |
2.36e-2 |
SMART |
|
ZnF_C2H2
|
168 |
190 |
1.98e-4 |
SMART |
|
ZnF_C2H2
|
196 |
218 |
2.91e-2 |
SMART |
|
ZnF_C2H2
|
224 |
246 |
1.26e-2 |
SMART |
|
ZnF_C2H2
|
252 |
274 |
5.21e-4 |
SMART |
|
ZnF_C2H2
|
280 |
302 |
2.57e-3 |
SMART |
|
ZnF_C2H2
|
308 |
330 |
5.59e-4 |
SMART |
|
ZnF_C2H2
|
336 |
358 |
1.79e-2 |
SMART |
|
ZnF_C2H2
|
364 |
386 |
7.9e-4 |
SMART |
|
ZnF_C2H2
|
392 |
414 |
5.5e-3 |
SMART |
|
low complexity region
|
428 |
470 |
N/A |
INTRINSIC |
|
ZnF_C2H2
|
516 |
538 |
3.63e-3 |
SMART |
|
ZnF_C2H2
|
544 |
566 |
1.3e-4 |
SMART |
|
ZnF_C2H2
|
572 |
594 |
5.59e-4 |
SMART |
|
| Predicted Effect |
probably damaging
Transcript: ENSMUST00000106261
AA Change: C397S
PolyPhen 2
Score 1.000 (Sensitivity: 0.00; Specificity: 1.00)
|
| SMART Domains |
Protein: ENSMUSP00000101868
Gene: ENSMUSG00000049728
AA Change: C397S
| Domain | Start | End | E-Value | Type |
|---|
|
ZnF_C2H2
|
22 |
44 |
7.67e-2 |
SMART |
|
ZnF_C2H2
|
84 |
106 |
9.44e-2 |
SMART |
|
ZnF_C2H2
|
112 |
134 |
3.63e-3 |
SMART |
|
ZnF_C2H2
|
140 |
162 |
2.36e-2 |
SMART |
|
ZnF_C2H2
|
168 |
190 |
1.98e-4 |
SMART |
|
ZnF_C2H2
|
196 |
218 |
2.91e-2 |
SMART |
|
ZnF_C2H2
|
224 |
246 |
1.26e-2 |
SMART |
|
ZnF_C2H2
|
252 |
274 |
5.21e-4 |
SMART |
|
ZnF_C2H2
|
280 |
302 |
2.57e-3 |
SMART |
|
ZnF_C2H2
|
308 |
330 |
5.59e-4 |
SMART |
|
ZnF_C2H2
|
336 |
358 |
1.79e-2 |
SMART |
|
ZnF_C2H2
|
364 |
386 |
7.9e-4 |
SMART |
|
ZnF_C2H2
|
392 |
414 |
5.5e-3 |
SMART |
|
low complexity region
|
428 |
470 |
N/A |
INTRINSIC |
|
ZnF_C2H2
|
516 |
538 |
3.63e-3 |
SMART |
|
ZnF_C2H2
|
544 |
566 |
1.3e-4 |
SMART |
|
ZnF_C2H2
|
572 |
594 |
5.59e-4 |
SMART |
|
| Predicted Effect |
probably damaging
Transcript: ENSMUST00000106262
AA Change: C397S
PolyPhen 2
Score 1.000 (Sensitivity: 0.00; Specificity: 1.00)
|
| SMART Domains |
Protein: ENSMUSP00000101869
Gene: ENSMUSG00000049728
AA Change: C397S
| Domain | Start | End | E-Value | Type |
|---|
|
ZnF_C2H2
|
22 |
44 |
7.67e-2 |
SMART |
|
ZnF_C2H2
|
84 |
106 |
9.44e-2 |
SMART |
|
ZnF_C2H2
|
112 |
134 |
3.63e-3 |
SMART |
|
ZnF_C2H2
|
140 |
162 |
2.36e-2 |
SMART |
|
ZnF_C2H2
|
168 |
190 |
1.98e-4 |
SMART |
|
ZnF_C2H2
|
196 |
218 |
2.91e-2 |
SMART |
|
ZnF_C2H2
|
224 |
246 |
1.26e-2 |
SMART |
|
ZnF_C2H2
|
252 |
274 |
5.21e-4 |
SMART |
|
ZnF_C2H2
|
280 |
302 |
2.57e-3 |
SMART |
|
ZnF_C2H2
|
308 |
330 |
5.59e-4 |
SMART |
|
ZnF_C2H2
|
336 |
358 |
1.79e-2 |
SMART |
|
ZnF_C2H2
|
364 |
386 |
7.9e-4 |
SMART |
|
ZnF_C2H2
|
392 |
414 |
5.5e-3 |
SMART |
|
low complexity region
|
428 |
470 |
N/A |
INTRINSIC |
|
ZnF_C2H2
|
516 |
538 |
3.63e-3 |
SMART |
|
ZnF_C2H2
|
544 |
566 |
1.3e-4 |
SMART |
|
ZnF_C2H2
|
572 |
594 |
5.59e-4 |
SMART |
|
| Predicted Effect |
probably damaging
Transcript: ENSMUST00000106263
AA Change: C397S
PolyPhen 2
Score 1.000 (Sensitivity: 0.00; Specificity: 1.00)
|
| SMART Domains |
Protein: ENSMUSP00000101870
Gene: ENSMUSG00000049728
AA Change: C397S
| Domain | Start | End | E-Value | Type |
|---|
|
ZnF_C2H2
|
22 |
44 |
7.67e-2 |
SMART |
|
ZnF_C2H2
|
84 |
106 |
9.44e-2 |
SMART |
|
ZnF_C2H2
|
112 |
134 |
3.63e-3 |
SMART |
|
ZnF_C2H2
|
140 |
162 |
2.36e-2 |
SMART |
|
ZnF_C2H2
|
168 |
190 |
1.98e-4 |
SMART |
|
ZnF_C2H2
|
196 |
218 |
2.91e-2 |
SMART |
|
ZnF_C2H2
|
224 |
246 |
1.26e-2 |
SMART |
|
ZnF_C2H2
|
252 |
274 |
5.21e-4 |
SMART |
|
ZnF_C2H2
|
280 |
302 |
2.57e-3 |
SMART |
|
ZnF_C2H2
|
308 |
330 |
5.59e-4 |
SMART |
|
ZnF_C2H2
|
336 |
358 |
1.79e-2 |
SMART |
|
ZnF_C2H2
|
364 |
386 |
7.9e-4 |
SMART |
|
ZnF_C2H2
|
392 |
414 |
5.5e-3 |
SMART |
|
low complexity region
|
428 |
470 |
N/A |
INTRINSIC |
|
ZnF_C2H2
|
516 |
538 |
3.63e-3 |
SMART |
|
ZnF_C2H2
|
544 |
566 |
1.3e-4 |
SMART |
|
ZnF_C2H2
|
572 |
594 |
5.59e-4 |
SMART |
|
| Predicted Effect |
probably benign
Transcript: ENSMUST00000144721
|
| SMART Domains |
Protein: ENSMUSP00000116730
Gene: ENSMUSG00000049728
| Domain | Start | End | E-Value | Type |
|---|
|
ZnF_C2H2
|
22 |
44 |
7.67e-2 |
SMART |
|
ZnF_C2H2
|
84 |
106 |
9.44e-2 |
SMART |
|
| Coding Region Coverage |
|
| Validation Efficiency |
|
| Allele List at MGI |
|
| Other mutations in this stock |
Total: 35 list
| Gene | Ref | Var | Chr/Loc | Mutation | Predicted Effect | Zygosity |
|---|
| 1700111E14Rik |
A |
T |
6: 36,914,152 (GRCm39) |
|
probably benign |
Het |
| Actn2 |
A |
T |
13: 12,324,479 (GRCm39) |
|
probably null |
Het |
| Apom |
C |
T |
17: 35,350,208 (GRCm39) |
A78T |
probably benign |
Het |
| Bambi |
A |
G |
18: 3,508,229 (GRCm39) |
Y7C |
possibly damaging |
Het |
| Cdc42bpb |
T |
C |
12: 111,289,576 (GRCm39) |
M418V |
probably benign |
Het |
| Clptm1 |
T |
C |
7: 19,389,701 (GRCm39) |
N43D |
probably benign |
Het |
| Cspp1 |
T |
C |
1: 10,136,886 (GRCm39) |
V241A |
probably benign |
Het |
| Ctnna3 |
T |
A |
10: 63,339,910 (GRCm39) |
I32N |
probably benign |
Het |
| Elp2 |
A |
G |
18: 24,752,576 (GRCm39) |
|
probably benign |
Het |
| Frmd4a |
A |
G |
2: 4,608,844 (GRCm39) |
D893G |
probably benign |
Het |
| Gm10718 |
A |
T |
9: 3,025,118 (GRCm39) |
Y194F |
probably benign |
Het |
| Gm21738 |
G |
A |
14: 19,416,979 (GRCm38) |
S144L |
probably benign |
Het |
| Gm5862 |
A |
C |
5: 26,227,769 (GRCm39) |
W41G |
probably benign |
Het |
| H2-M10.1 |
C |
A |
17: 36,635,971 (GRCm39) |
G154* |
probably null |
Het |
| Igdcc3 |
C |
T |
9: 65,051,819 (GRCm39) |
R141W |
probably damaging |
Het |
| Igkv14-130 |
A |
G |
6: 67,768,323 (GRCm39) |
K60E |
possibly damaging |
Het |
| Kcnmb2 |
A |
G |
3: 32,252,512 (GRCm39) |
|
probably benign |
Het |
| Lrp4 |
T |
C |
2: 91,324,529 (GRCm39) |
L1288P |
possibly damaging |
Het |
| Mavs |
T |
A |
2: 131,087,441 (GRCm39) |
M313K |
probably benign |
Het |
| Mia2 |
A |
G |
12: 59,154,731 (GRCm39) |
E148G |
possibly damaging |
Het |
| Or6c76b |
A |
T |
10: 129,692,950 (GRCm39) |
T188S |
probably damaging |
Het |
| Or8b12b |
T |
A |
9: 37,684,159 (GRCm39) |
I68K |
possibly damaging |
Het |
| Or8d1 |
T |
A |
9: 38,767,013 (GRCm39) |
Y218* |
probably null |
Het |
| Plekha3 |
C |
T |
2: 76,517,047 (GRCm39) |
T133M |
probably damaging |
Het |
| Plxna1 |
A |
T |
6: 89,309,066 (GRCm39) |
|
probably null |
Het |
| Septin2 |
A |
G |
1: 93,426,823 (GRCm39) |
N144S |
probably damaging |
Het |
| Slc9a4 |
T |
C |
1: 40,651,451 (GRCm39) |
|
probably benign |
Het |
| Slco1b2 |
T |
A |
6: 141,594,312 (GRCm39) |
I59K |
probably damaging |
Het |
| Sp140l2 |
A |
G |
1: 85,231,907 (GRCm39) |
|
probably benign |
Het |
| Tnrc6b |
A |
G |
15: 80,786,184 (GRCm39) |
S1243G |
possibly damaging |
Het |
| Unc13a |
T |
A |
8: 72,091,854 (GRCm39) |
|
probably benign |
Het |
| Vmn2r105 |
T |
C |
17: 20,444,918 (GRCm39) |
R525G |
probably damaging |
Het |
| Vmn2r129 |
C |
T |
4: 156,690,549 (GRCm39) |
|
noncoding transcript |
Het |
| Vmn2r37 |
T |
A |
7: 9,219,032 (GRCm39) |
K451* |
probably null |
Het |
| Vmn2r71 |
C |
T |
7: 85,270,001 (GRCm39) |
T504I |
probably benign |
Het |
|
| Other mutations in Zfp668 |
| Allele | Source | Chr | Coord | Type | Predicted Effect | PPH Score |
|---|
|
IGL00944:Zfp668
|
APN |
7 |
127,467,079 (GRCm39) |
missense |
probably damaging |
1.00 |
|
IGL01063:Zfp668
|
APN |
7 |
127,465,454 (GRCm39) |
missense |
probably damaging |
1.00 |
|
IGL02404:Zfp668
|
APN |
7 |
127,465,532 (GRCm39) |
missense |
probably damaging |
1.00 |
|
IGL02543:Zfp668
|
APN |
7 |
127,467,494 (GRCm39) |
nonsense |
probably null |
|
|
IGL02946:Zfp668
|
APN |
7 |
127,465,690 (GRCm39) |
missense |
possibly damaging |
0.70 |
|
R0078:Zfp668
|
UTSW |
7 |
127,467,210 (GRCm39) |
missense |
possibly damaging |
0.94 |
|
R1521:Zfp668
|
UTSW |
7 |
127,466,252 (GRCm39) |
missense |
probably benign |
0.09 |
|
R1775:Zfp668
|
UTSW |
7 |
127,465,778 (GRCm39) |
missense |
possibly damaging |
0.75 |
|
R1873:Zfp668
|
UTSW |
7 |
127,465,654 (GRCm39) |
splice site |
probably null |
|
|
R1875:Zfp668
|
UTSW |
7 |
127,465,654 (GRCm39) |
splice site |
probably null |
|
|
R2066:Zfp668
|
UTSW |
7 |
127,466,203 (GRCm39) |
missense |
probably damaging |
0.98 |
|
R2068:Zfp668
|
UTSW |
7 |
127,465,837 (GRCm39) |
missense |
probably benign |
0.06 |
|
R2278:Zfp668
|
UTSW |
7 |
127,465,998 (GRCm39) |
missense |
probably benign |
0.05 |
|
R5516:Zfp668
|
UTSW |
7 |
127,466,318 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R5569:Zfp668
|
UTSW |
7 |
127,466,995 (GRCm39) |
nonsense |
probably null |
|
|
R5875:Zfp668
|
UTSW |
7 |
127,465,474 (GRCm39) |
missense |
possibly damaging |
0.61 |
|
R6663:Zfp668
|
UTSW |
7 |
127,466,941 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R8543:Zfp668
|
UTSW |
7 |
127,466,392 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R8822:Zfp668
|
UTSW |
7 |
127,466,315 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R8905:Zfp668
|
UTSW |
7 |
127,465,598 (GRCm39) |
missense |
probably benign |
0.04 |
|
R9191:Zfp668
|
UTSW |
7 |
127,465,658 (GRCm39) |
missense |
probably benign |
|
|
R9217:Zfp668
|
UTSW |
7 |
127,465,804 (GRCm39) |
nonsense |
probably null |
|
|
R9655:Zfp668
|
UTSW |
7 |
127,466,113 (GRCm39) |
missense |
possibly damaging |
0.70 |
|
| Posted On |
2014-05-07 |
Incidental Mutation