Incidental Mutation 'IGL01910:Xcl1'
ID179775
Institutional Source Australian Phenomics Network (link to record)
Gene Symbol Xcl1
Ensembl Gene ENSMUSG00000026573
Gene Namechemokine (C motif) ligand 1
SynonymsSCM-1, LTN, lymphotactin, ATAC, Scyc1, SCM-1a, Lptn
Accession Numbers
Is this an essential gene? Not available question?
Stock #IGL01910
Quality Score
Status
Chromosome1
Chromosomal Location164931644-164935527 bp(-) (GRCm38)
Type of Mutationmissense
DNA Base Change (assembly) T to A at 164931889 bp
ZygosityHeterozygous
Amino Acid Change Isoleucine to Phenylalanine at position 81 (I81F)
Ref Sequence ENSEMBL: ENSMUSP00000027860 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000027860]
Predicted Effect probably damaging
Transcript: ENSMUST00000027860
AA Change: I81F

PolyPhen 2 Score 0.999 (Sensitivity: 0.14; Specificity: 0.99)
SMART Domains Protein: ENSMUSP00000027860
Gene: ENSMUSG00000026573
AA Change: I81F

DomainStartEndE-ValueType
signal peptide 1 21 N/A INTRINSIC
SCY 28 84 2.18e-19 SMART
Predicted Effect noncoding transcript
Transcript: ENSMUST00000194322
Coding Region Coverage
Validation Efficiency
MGI Phenotype FUNCTION: [Summary is not available for the mouse gene. This summary is for the human ortholog.] This antimicrobial gene encodes a member of the chemokine superfamily. Chemokines function in inflammatory and immunological responses, inducing leukocyte migration and activation. The encoded protein is a member of the C-chemokine subfamily, retaining only two of four cysteines conserved in other chemokines, and is thought to be specifically chemotactic for T cells. This gene and a closely related family member are located on the long arm of chromosome 1. [provided by RefSeq, Sep 2014]
PHENOTYPE: Mice homozygous for a knock-out allele exhibit decreased stimulated cytotoxic T cell cytolysis. [provided by MGI curators]
Allele List at MGI
Other mutations in this stock
Total: 23 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
Ammecr1l A G 18: 31,771,942 M79V probably benign Het
Arhgap5 T A 12: 52,516,861 V205E probably benign Het
BC061237 T C 14: 44,505,988 probably benign Het
Calr T A 8: 84,844,969 probably benign Het
Celsr1 T C 15: 85,929,895 N1942S probably benign Het
Cfap100 T C 6: 90,409,624 D373G probably damaging Het
Chst9 C A 18: 15,452,874 A211S possibly damaging Het
Ephb1 T C 9: 102,001,857 E478G probably benign Het
Fbrsl1 A T 5: 110,363,736 V387D probably damaging Het
Fxyd5 T C 7: 31,035,218 I161V probably damaging Het
Gm10718 A T 9: 3,025,118 Y194F probably benign Het
Gm21738 G A 14: 19,416,979 S144L probably benign Het
Hmx2 C T 7: 131,555,672 R172C probably damaging Het
Itgam C T 7: 128,083,776 A320V probably damaging Het
Macrod2 T A 2: 142,296,565 N361K probably benign Het
Mbl1 T C 14: 41,153,746 probably null Het
Nudt9 G A 5: 104,054,309 G79R probably damaging Het
Ppan C T 9: 20,890,936 R208C probably damaging Het
Rpl23a-ps1 A G 1: 45,981,780 noncoding transcript Het
Slc17a1 A G 13: 23,878,457 probably benign Het
Tep1 T C 14: 50,844,112 T1269A probably benign Het
Vmn2r16 A T 5: 109,340,085 N275Y probably damaging Het
Wdr93 T C 7: 79,771,573 S405P probably damaging Het
Other mutations in Xcl1
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL03295:Xcl1 APN 1 164935435 missense unknown
R7742:Xcl1 UTSW 1 164935472 missense unknown
Posted On2014-05-07