Incidental Mutation 'IGL01910:Xcl1'
ID 179775
Institutional Source Australian Phenomics Network (link to record)
Gene Symbol Xcl1
Ensembl Gene ENSMUSG00000026573
Gene Name chemokine (C motif) ligand 1
Synonyms SCM-1, Lptn, LTN, ATAC, Scyc1, lymphotactin, SCM-1a
Accession Numbers
Essential gene? Non essential (E-score: 0.000) question?
Stock # IGL01910
Quality Score
Status
Chromosome 1
Chromosomal Location 164759216-164763094 bp(-) (GRCm39)
Type of Mutation missense
DNA Base Change (assembly) T to A at 164759458 bp (GRCm39)
Zygosity Heterozygous
Amino Acid Change Isoleucine to Phenylalanine at position 81 (I81F)
Ref Sequence ENSEMBL: ENSMUSP00000027860 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000027860]
AlphaFold P47993
Predicted Effect probably damaging
Transcript: ENSMUST00000027860
AA Change: I81F

PolyPhen 2 Score 0.999 (Sensitivity: 0.14; Specificity: 0.99)
SMART Domains Protein: ENSMUSP00000027860
Gene: ENSMUSG00000026573
AA Change: I81F

DomainStartEndE-ValueType
signal peptide 1 21 N/A INTRINSIC
SCY 28 84 2.18e-19 SMART
Predicted Effect noncoding transcript
Transcript: ENSMUST00000194322
Coding Region Coverage
Validation Efficiency
MGI Phenotype FUNCTION: [Summary is not available for the mouse gene. This summary is for the human ortholog.] This antimicrobial gene encodes a member of the chemokine superfamily. Chemokines function in inflammatory and immunological responses, inducing leukocyte migration and activation. The encoded protein is a member of the C-chemokine subfamily, retaining only two of four cysteines conserved in other chemokines, and is thought to be specifically chemotactic for T cells. This gene and a closely related family member are located on the long arm of chromosome 1. [provided by RefSeq, Sep 2014]
PHENOTYPE: Mice homozygous for a knock-out allele exhibit decreased stimulated cytotoxic T cell cytolysis. [provided by MGI curators]
Allele List at MGI
Other mutations in this stock
Total: 23 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
Ammecr1l A G 18: 31,904,995 (GRCm39) M79V probably benign Het
Arhgap5 T A 12: 52,563,644 (GRCm39) V205E probably benign Het
BC061237 T C 14: 44,743,445 (GRCm39) probably benign Het
Calr T A 8: 85,571,598 (GRCm39) probably benign Het
Celsr1 T C 15: 85,814,096 (GRCm39) N1942S probably benign Het
Cfap100 T C 6: 90,386,606 (GRCm39) D373G probably damaging Het
Chst9 C A 18: 15,585,931 (GRCm39) A211S possibly damaging Het
Ephb1 T C 9: 101,879,056 (GRCm39) E478G probably benign Het
Fbrsl1 A T 5: 110,511,602 (GRCm39) V387D probably damaging Het
Fxyd5 T C 7: 30,734,643 (GRCm39) I161V probably damaging Het
Gm10718 A T 9: 3,025,118 (GRCm39) Y194F probably benign Het
Gm21738 G A 14: 19,416,979 (GRCm38) S144L probably benign Het
Hmx2 C T 7: 131,157,401 (GRCm39) R172C probably damaging Het
Itgam C T 7: 127,682,948 (GRCm39) A320V probably damaging Het
Macrod2 T A 2: 142,138,485 (GRCm39) N361K probably benign Het
Mbl1 T C 14: 40,875,703 (GRCm39) probably null Het
Nudt9 G A 5: 104,202,175 (GRCm39) G79R probably damaging Het
Ppan C T 9: 20,802,232 (GRCm39) R208C probably damaging Het
Rpl23a-ps1 A G 1: 46,020,940 (GRCm39) noncoding transcript Het
Slc17a1 A G 13: 24,062,440 (GRCm39) probably benign Het
Tep1 T C 14: 51,081,569 (GRCm39) T1269A probably benign Het
Vmn2r16 A T 5: 109,487,951 (GRCm39) N275Y probably damaging Het
Wdr93 T C 7: 79,421,321 (GRCm39) S405P probably damaging Het
Other mutations in Xcl1
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL03295:Xcl1 APN 1 164,763,004 (GRCm39) missense unknown
R7742:Xcl1 UTSW 1 164,763,041 (GRCm39) missense unknown
R8532:Xcl1 UTSW 1 164,759,515 (GRCm39) missense probably damaging 1.00
R8671:Xcl1 UTSW 1 164,759,419 (GRCm39) missense probably benign 0.01
R8697:Xcl1 UTSW 1 164,763,008 (GRCm39) missense unknown
R8843:Xcl1 UTSW 1 164,763,079 (GRCm39) start gained probably benign
Posted On 2014-05-07