Incidental Mutation 'IGL01912:Nat3'
ID 179842
Institutional Source Australian Phenomics Network (link to record)
Gene Symbol Nat3
Ensembl Gene ENSMUSG00000056426
Gene Name N-acetyltransferase 3
Synonyms
Accession Numbers
Is this an essential gene? Non essential (E-score: 0.000) question?
Stock # IGL01912
Quality Score
Status
Chromosome 8
Chromosomal Location 67523854-67548627 bp(+) (GRCm38)
Type of Mutation nonsense
DNA Base Change (assembly) T to A at 67547746 bp (GRCm38)
Zygosity Heterozygous
Amino Acid Change Cysteine to Stop codon at position 92 (C92*)
Ref Sequence ENSEMBL: ENSMUSP00000069359 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000070514]
AlphaFold P50296
Predicted Effect probably null
Transcript: ENSMUST00000070514
AA Change: C92*
SMART Domains Protein: ENSMUSP00000069359
Gene: ENSMUSG00000056426
AA Change: C92*

DomainStartEndE-ValueType
Pfam:Acetyltransf_2 20 280 3.6e-91 PFAM
Coding Region Coverage
Validation Efficiency
MGI Phenotype PHENOTYPE: Mice homozygous for a null mutation are viable and fertile with no gross abnormalities. [provided by MGI curators]
Allele List at MGI
Other mutations in this stock
Total: 27 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
Abcc8 A T 7: 46,120,510 D860E probably damaging Het
Actl11 C A 9: 107,929,645 P389Q probably damaging Het
Bsg G T 10: 79,710,140 G103W probably null Het
Camk2d T A 3: 126,810,632 probably null Het
Clcn7 T C 17: 25,153,009 probably benign Het
Dctd C T 8: 48,111,662 probably benign Het
Dpy19l1 C T 9: 24,485,069 R117Q probably damaging Het
Esyt2 T C 12: 116,339,609 I289T probably damaging Het
Exoc6b A C 6: 84,625,174 C753G probably damaging Het
Gm10718 A T 9: 3,025,118 Y194F probably benign Het
Gm21738 G A 14: 19,416,979 S144L probably benign Het
Gm3633 T C 14: 42,640,786 probably benign Het
Hrh3 A T 2: 180,101,376 V153D probably damaging Het
Krt77 T A 15: 101,863,851 probably benign Het
Nckap1l T A 15: 103,474,146 L525M probably benign Het
Nrp2 T A 1: 62,771,737 C646S probably damaging Het
Olfr512 T C 7: 108,714,258 Y290H possibly damaging Het
Olfr659 T C 7: 104,671,233 I177T possibly damaging Het
Olfr698 T A 7: 106,752,992 Y132F probably damaging Het
Orc1 T C 4: 108,590,744 Y63H probably damaging Het
Otud4 T C 8: 79,673,837 V1059A probably benign Het
Ptprm A G 17: 67,046,118 V235A probably benign Het
Rab3ip G T 10: 116,907,092 Q443K probably benign Het
Tnc C A 4: 64,008,740 D850Y probably damaging Het
Ubxn2b T A 4: 6,203,767 probably null Het
Vmn1r233 T A 17: 20,994,205 Y161F probably benign Het
Vmn1r54 T C 6: 90,269,460 S119P probably damaging Het
Other mutations in Nat3
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL03277:Nat3 APN 8 67547689 missense probably benign 0.11
IGL02802:Nat3 UTSW 8 67547508 missense probably benign 0.08
R0266:Nat3 UTSW 8 67547780 missense probably benign
R0842:Nat3 UTSW 8 67547997 missense probably benign 0.01
R5245:Nat3 UTSW 8 67548180 missense probably benign 0.09
R5461:Nat3 UTSW 8 67547862 missense probably damaging 1.00
R5892:Nat3 UTSW 8 67547938 missense probably benign 0.01
R6371:Nat3 UTSW 8 67524179 splice site probably null
R7523:Nat3 UTSW 8 67547574 missense probably damaging 0.99
R7587:Nat3 UTSW 8 67547574 missense probably damaging 0.99
R7677:Nat3 UTSW 8 67547487 missense probably damaging 1.00
R8052:Nat3 UTSW 8 67547826 missense possibly damaging 0.71
R8757:Nat3 UTSW 8 67547550 missense probably damaging 1.00
R9322:Nat3 UTSW 8 67547510 nonsense probably null
X0067:Nat3 UTSW 8 67548334 missense probably benign 0.09
Z1176:Nat3 UTSW 8 67547814 missense possibly damaging 0.93
Posted On 2014-05-07