Incidental Mutation 'IGL01913:Tmem151a'
ID179854
Institutional Source Australian Phenomics Network (link to record)
Gene Symbol Tmem151a
Ensembl Gene ENSMUSG00000061451
Gene Nametransmembrane protein 151A
SynonymsLOC381199, Tmem151
Accession Numbers
Is this an essential gene? Probably non essential (E-score: 0.077) question?
Stock #IGL01913
Quality Score
Status
Chromosome19
Chromosomal Location5070859-5085531 bp(-) (GRCm38)
Type of Mutationmissense
DNA Base Change (assembly) G to A at 5081892 bp
ZygosityHeterozygous
Amino Acid Change Arginine to Cysteine at position 429 (R429C)
Ref Sequence ENSEMBL: ENSMUSP00000076321 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000077066] [ENSMUST00000140389] [ENSMUST00000151413]
Predicted Effect probably benign
Transcript: ENSMUST00000077066
AA Change: R429C

PolyPhen 2 Score 0.358 (Sensitivity: 0.90; Specificity: 0.89)
SMART Domains Protein: ENSMUSP00000076321
Gene: ENSMUSG00000061451
AA Change: R429C

DomainStartEndE-ValueType
Pfam:TMEM151 26 373 8.6e-179 PFAM
low complexity region 420 431 N/A INTRINSIC
Predicted Effect noncoding transcript
Transcript: ENSMUST00000136372
Predicted Effect probably benign
Transcript: ENSMUST00000140389
Predicted Effect probably benign
Transcript: ENSMUST00000151413
SMART Domains Protein: ENSMUSP00000121084
Gene: ENSMUSG00000061451

DomainStartEndE-ValueType
low complexity region 37 48 N/A INTRINSIC
Coding Region Coverage
Validation Efficiency
Allele List at MGI
Other mutations in this stock
Total: 27 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
Acvr2a A G 2: 48,899,613 E456G probably damaging Het
Ahnak A T 19: 9,006,064 K1571* probably null Het
Arhgef2 G A 3: 88,631,919 V58M probably damaging Het
Ash2l A G 8: 25,819,624 probably null Het
C3 T C 17: 57,213,767 N1163S probably null Het
Cbfa2t2 A G 2: 154,517,773 T253A probably damaging Het
Dnah5 T C 15: 28,313,753 V1905A possibly damaging Het
Dsg1a C T 18: 20,322,236 R86C probably damaging Het
Fastkd1 A T 2: 69,708,501 probably benign Het
Fat3 T C 9: 15,998,790 D1972G probably damaging Het
Fxyd5 T C 7: 31,035,212 T163A probably damaging Het
Gm10717 C T 9: 3,025,616 S67L probably benign Het
Gm21738 G A 14: 19,416,979 S144L probably benign Het
H6pd A T 4: 149,994,463 probably benign Het
Klhdc2 T G 12: 69,302,358 S90A probably benign Het
Lcn2 A G 2: 32,387,145 V139A possibly damaging Het
Nup205 A G 6: 35,227,430 E1417G probably benign Het
Olfr1102 A T 2: 87,002,820 M284L possibly damaging Het
Olfr1250 T G 2: 89,657,340 I34L probably benign Het
Olfr209 A T 16: 59,361,931 C96S probably damaging Het
Pcdh18 C A 3: 49,755,249 S539I possibly damaging Het
Stat1 T C 1: 52,126,557 I104T probably benign Het
Vmn2r-ps159 C T 4: 156,338,254 noncoding transcript Het
Wdpcp A G 11: 21,748,931 D570G probably damaging Het
Zfp429 T C 13: 67,396,674 Y27C probably damaging Het
Zfp462 T C 4: 55,012,138 V1368A probably benign Het
Zfp651 T C 9: 121,763,969 C452R probably damaging Het
Other mutations in Tmem151a
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL02708:Tmem151a APN 19 5082847 nonsense probably null
IGL02887:Tmem151a APN 19 5082965 missense probably benign
IGL03144:Tmem151a APN 19 5085372 start codon destroyed probably benign 0.01
R0395:Tmem151a UTSW 19 5082233 missense probably damaging 1.00
R1732:Tmem151a UTSW 19 5082867 missense probably damaging 1.00
R2011:Tmem151a UTSW 19 5082938 missense probably benign
R4399:Tmem151a UTSW 19 5083071 missense probably damaging 1.00
R4612:Tmem151a UTSW 19 5071834 unclassified probably benign
R5171:Tmem151a UTSW 19 5082033 missense probably damaging 1.00
R6921:Tmem151a UTSW 19 5083091 missense probably damaging 1.00
R7205:Tmem151a UTSW 19 5082773 missense probably damaging 1.00
R7413:Tmem151a UTSW 19 5082674 missense probably damaging 1.00
R7544:Tmem151a UTSW 19 5071867 missense unknown
X0010:Tmem151a UTSW 19 5082986 missense probably damaging 1.00
Posted On2014-05-07