Incidental Mutation 'IGL01914:Atf7'
ID179887
Institutional Source Australian Phenomics Network (link to record)
Gene Symbol Atf7
Ensembl Gene ENSMUSG00000099083
Gene Nameactivating transcription factor 7
Synonyms
Accession Numbers
Is this an essential gene? Non essential (E-score: 0.000) question?
Stock #IGL01914
Quality Score
Status
Chromosome15
Chromosomal Location102525946-102625464 bp(-) (GRCm38)
Type of Mutationnonsense
DNA Base Change (assembly) A to T at 102551478 bp
ZygosityHeterozygous
Amino Acid Change Tyrosine to Stop codon at position 67 (Y67*)
Ref Sequence ENSEMBL: ENSMUSP00000139379 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000108828] [ENSMUST00000169033] [ENSMUST00000183452] [ENSMUST00000183765] [ENSMUST00000184077] [ENSMUST00000184485] [ENSMUST00000184616] [ENSMUST00000184772] [ENSMUST00000184906] [ENSMUST00000185070]
Predicted Effect probably null
Transcript: ENSMUST00000108828
AA Change: Y162*
SMART Domains Protein: ENSMUSP00000104456
Gene: ENSMUSG00000099083
AA Change: Y162*

DomainStartEndE-ValueType
ZnF_C2H2 7 31 6.32e-3 SMART
low complexity region 108 130 N/A INTRINSIC
low complexity region 228 244 N/A INTRINSIC
low complexity region 300 318 N/A INTRINSIC
low complexity region 319 326 N/A INTRINSIC
BRLZ 330 394 3.46e-18 SMART
Predicted Effect probably null
Transcript: ENSMUST00000169033
AA Change: Y162*
SMART Domains Protein: ENSMUSP00000130130
Gene: ENSMUSG00000099083
AA Change: Y162*

DomainStartEndE-ValueType
ZnF_C2H2 7 31 6.32e-3 SMART
low complexity region 108 130 N/A INTRINSIC
low complexity region 228 244 N/A INTRINSIC
low complexity region 300 318 N/A INTRINSIC
low complexity region 319 326 N/A INTRINSIC
BRLZ 330 394 3.46e-18 SMART
Predicted Effect probably benign
Transcript: ENSMUST00000183452
SMART Domains Protein: ENSMUSP00000139367
Gene: ENSMUSG00000099083

DomainStartEndE-ValueType
ZnF_C2H2 7 31 6.32e-3 SMART
Predicted Effect noncoding transcript
Transcript: ENSMUST00000183727
Predicted Effect probably null
Transcript: ENSMUST00000183765
AA Change: Y162*
SMART Domains Protein: ENSMUSP00000139054
Gene: ENSMUSG00000099083
AA Change: Y162*

DomainStartEndE-ValueType
ZnF_C2H2 7 31 6.32e-3 SMART
low complexity region 108 130 N/A INTRINSIC
Predicted Effect probably null
Transcript: ENSMUST00000184077
AA Change: Y67*
SMART Domains Protein: ENSMUSP00000139217
Gene: ENSMUSG00000099083
AA Change: Y67*

DomainStartEndE-ValueType
low complexity region 13 35 N/A INTRINSIC
Predicted Effect probably null
Transcript: ENSMUST00000184485
AA Change: Y162*
SMART Domains Protein: ENSMUSP00000139308
Gene: ENSMUSG00000099083
AA Change: Y162*

DomainStartEndE-ValueType
ZnF_C2H2 7 31 6.32e-3 SMART
low complexity region 108 130 N/A INTRINSIC
low complexity region 228 244 N/A INTRINSIC
low complexity region 300 318 N/A INTRINSIC
low complexity region 319 326 N/A INTRINSIC
BRLZ 330 394 3.46e-18 SMART
Predicted Effect probably null
Transcript: ENSMUST00000184616
AA Change: Y162*
SMART Domains Protein: ENSMUSP00000139181
Gene: ENSMUSG00000099083
AA Change: Y162*

DomainStartEndE-ValueType
ZnF_C2H2 7 31 6.32e-3 SMART
low complexity region 108 130 N/A INTRINSIC
low complexity region 228 244 N/A INTRINSIC
low complexity region 300 318 N/A INTRINSIC
low complexity region 319 326 N/A INTRINSIC
BRLZ 330 394 3.46e-18 SMART
Predicted Effect probably null
Transcript: ENSMUST00000184772
AA Change: Y162*
SMART Domains Protein: ENSMUSP00000138975
Gene: ENSMUSG00000052414
AA Change: Y162*

DomainStartEndE-ValueType
ZnF_C2H2 7 31 6.32e-3 SMART
low complexity region 108 130 N/A INTRINSIC
low complexity region 228 244 N/A INTRINSIC
low complexity region 300 318 N/A INTRINSIC
low complexity region 319 326 N/A INTRINSIC
BRLZ 330 394 3.46e-18 SMART
Predicted Effect probably null
Transcript: ENSMUST00000184906
AA Change: Y162*
SMART Domains Protein: ENSMUSP00000139243
Gene: ENSMUSG00000099083
AA Change: Y162*

DomainStartEndE-ValueType
ZnF_C2H2 7 31 6.32e-3 SMART
low complexity region 108 130 N/A INTRINSIC
low complexity region 228 244 N/A INTRINSIC
low complexity region 300 318 N/A INTRINSIC
low complexity region 319 326 N/A INTRINSIC
BRLZ 330 394 3.46e-18 SMART
Predicted Effect probably null
Transcript: ENSMUST00000185070
AA Change: Y67*
SMART Domains Protein: ENSMUSP00000139379
Gene: ENSMUSG00000099083
AA Change: Y67*

DomainStartEndE-ValueType
low complexity region 13 35 N/A INTRINSIC
Coding Region Coverage
Validation Efficiency
MGI Phenotype PHENOTYPE: Mice homozygous for one knock-out allele exhibit increased marble burying, increased startle response, and decreased prepulse inhibition. [provided by MGI curators]
Allele List at MGI
Other mutations in this stock
Total: 22 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
Atp6v1b2 C A 8: 69,096,280 probably benign Het
Cd24a T C 10: 43,582,703 S79P unknown Het
Col4a2 G A 8: 11,414,754 E340K possibly damaging Het
Dtna A T 18: 23,597,459 N301I possibly damaging Het
Ero1l T C 14: 45,306,612 D45G probably damaging Het
Gm21738 G A 14: 19,416,979 S144L probably benign Het
H6pd A T 4: 149,994,463 probably benign Het
Htt A G 5: 34,829,709 T1091A probably benign Het
Msto1 T C 3: 88,912,903 E82G probably benign Het
Mup11 T A 4: 60,659,822 probably benign Het
Nlrp9a T A 7: 26,557,264 N13K probably benign Het
Nsun7 C T 5: 66,276,634 P209L probably damaging Het
Olfr1042 C T 2: 86,160,047 V108I probably benign Het
Olfr1045 G A 2: 86,198,672 L27F probably benign Het
Olfr209 A T 16: 59,361,931 C96S probably damaging Het
Pecam1 A G 11: 106,699,867 I27T possibly damaging Het
Prkcd T C 14: 30,607,426 E19G possibly damaging Het
Slc4a11 A T 2: 130,687,279 I417N probably damaging Het
Stat1 T C 1: 52,126,557 I104T probably benign Het
Stk17b T C 1: 53,761,067 N251D probably damaging Het
Ttll4 C T 1: 74,679,058 H23Y probably benign Het
Vmn2r79 A T 7: 87,037,363 T651S probably benign Het
Other mutations in Atf7
AlleleSourceChrCoordTypePredicted EffectPPH Score
R2183:Atf7 UTSW 15 102546473 missense possibly damaging 0.93
R2516:Atf7 UTSW 15 102529004 intron probably benign
R3114:Atf7 UTSW 15 102534423 missense probably benign 0.10
R3115:Atf7 UTSW 15 102534423 missense probably benign 0.10
R4544:Atf7 UTSW 15 102534327 missense probably benign 0.08
R4545:Atf7 UTSW 15 102534327 missense probably benign 0.08
R4546:Atf7 UTSW 15 102534327 missense probably benign 0.08
R5148:Atf7 UTSW 15 102547173 missense probably benign 0.02
R5568:Atf7 UTSW 15 102563322 missense probably damaging 0.99
R5688:Atf7 UTSW 15 102551509 missense probably damaging 1.00
R5805:Atf7 UTSW 15 102557587 splice site probably null
R6021:Atf7 UTSW 15 102557473 missense probably benign 0.20
R6259:Atf7 UTSW 15 102547238 missense probably damaging 1.00
R6347:Atf7 UTSW 15 102546479 missense possibly damaging 0.91
R6476:Atf7 UTSW 15 102593712 missense probably benign 0.13
R6794:Atf7 UTSW 15 102557465 missense probably benign 0.09
R7104:Atf7 UTSW 15 102534235 missense probably benign 0.40
R7369:Atf7 UTSW 15 102553809 missense probably damaging 0.98
R8111:Atf7 UTSW 15 102563334 missense probably damaging 0.96
R8244:Atf7 UTSW 15 102528866 missense unknown
X0027:Atf7 UTSW 15 102593670 critical splice donor site probably null
Z1088:Atf7 UTSW 15 102547182 missense probably benign 0.00
Posted On2014-05-07