Mutagenetix > Incidental Mutation

Incidental Mutation 'IGL01917:Iqub'

179991

Institutional Source

Australian Phenomics Network (link to record)

Gene Symbol

Iqub

Ensembl Gene

ENSMUSG00000046192

Gene Name

IQ motif and ubiquitin domain containing

Synonyms

4932408B21Rik, Trs4

Accession Numbers

Essential gene?

Non essential (E-score: 0.000) question?

Stock #

IGL01917

Quality Score

Status

Chromosome

Chromosomal Location

24444864-24515066 bp(-) (GRCm39)

Type of Mutation

missense

DNA Base Change (assembly)

A to G at 24479318 bp (GRCm39)

Zygosity

Heterozygous

Amino Acid Change

Leucine to Proline at position 408 (L408P)

Ref Sequence

ENSEMBL: ENSMUSP00000051177 (fasta)

Gene Model

predicted gene model for transcript(s): [ENSMUST00000052277]

AlphaFold

Q8CDK3

Predicted Effect

probably damaging
Transcript: ENSMUST00000052277
AA Change: L408P

PolyPhen 2 Score 0.972 (Sensitivity: 0.77; Specificity: 0.96)

SMART Domains

Protein: ENSMUSP00000051177
Gene: ENSMUSG00000046192
AA Change: L408P

Domain	Start	End	E-Value	Type
PDB:2DAF\|A	119	216	1e-38	PDB
Blast:UBQ	129	199	3e-26	BLAST
low complexity region	218	229	N/A	INTRINSIC
low complexity region	289	306	N/A	INTRINSIC
IQ	333	355	1.74e-1	SMART
low complexity region	357	383	N/A	INTRINSIC
low complexity region	735	742	N/A	INTRINSIC

Coding Region Coverage

Validation Efficiency

Allele List at MGI

All alleles(2) : Targeted, knock-out(2)

Other mutations in this stock

Total: 23 list
Gene	Ref	Var	Chr/Loc	Mutation	Predicted Effect	Zygosity
Abt1	A	T	13: 23,607,959 (GRCm39)	M15K	unknown	Het
Adal	A	G	2: 120,973,035 (GRCm39)	S31G	possibly damaging	Het
C2cd5	T	C	6: 143,018,322 (GRCm39)	Y300C	probably benign	Het
Chia1	T	A	3: 106,035,536 (GRCm39)	V184E	probably damaging	Het
Fat4	T	A	3: 38,943,879 (GRCm39)	V924D	possibly damaging	Het
Fstl5	A	T	3: 76,615,153 (GRCm39)	H738L	probably damaging	Het
Gimap4	T	C	6: 48,667,854 (GRCm39)	M75T	probably benign	Het
Gm10238	A	T	15: 75,109,561 (GRCm39)		noncoding transcript	Het
Gm10718	A	T	9: 3,025,118 (GRCm39)	Y194F	probably benign	Het
Gm21738	G	A	14: 19,416,979 (GRCm38)	S144L	probably benign	Het
Gm5862	A	C	5: 26,227,769 (GRCm39)	W41G	probably benign	Het
Gsdmc	A	G	15: 63,650,434 (GRCm39)	Y307H	probably benign	Het
Lbx1	T	A	19: 45,222,652 (GRCm39)	K124*	probably null	Het
Naip2	C	A	13: 100,298,591 (GRCm39)	V482L	probably benign	Het
Or52e19	T	A	7: 102,959,564 (GRCm39)	L212*	probably null	Het
Pdcd11	C	A	19: 47,089,604 (GRCm39)	Q325K	possibly damaging	Het
Pik3c3	T	A	18: 30,407,499 (GRCm39)	S82R	probably damaging	Het
Pramel11	T	A	4: 143,624,284 (GRCm39)	E71V	probably benign	Het
Prickle1	T	C	15: 93,401,408 (GRCm39)	K359E	probably damaging	Het
Ptprj	A	G	2: 90,300,093 (GRCm39)	V236A	probably damaging	Het
Serpinb3d	T	A	1: 107,007,411 (GRCm39)	T192S	probably damaging	Het
Usp31	T	C	7: 121,278,708 (GRCm39)	N219S	probably benign	Het
Vmn2r129	C	T	4: 156,690,549 (GRCm39)		noncoding transcript	Het

Other mutations in Iqub

Allele	Source	Chr	Coord	Type	Predicted Effect	PPH Score
IGL01015:Iqub	APN	6	24,501,005 (GRCm39)	splice site	probably benign
IGL01447:Iqub	APN	6	24,505,627 (GRCm39)	missense	probably benign	0.01
IGL01621:Iqub	APN	6	24,446,211 (GRCm39)	missense	probably benign	0.45
IGL01702:Iqub	APN	6	24,500,312 (GRCm39)	missense	probably benign	0.13
IGL02411:Iqub	APN	6	24,449,810 (GRCm39)	missense	probably damaging	0.98
IGL02580:Iqub	APN	6	24,501,398 (GRCm39)	missense	probably benign	0.06
IGL02704:Iqub	APN	6	24,505,909 (GRCm39)	splice site	probably benign
IGL02901:Iqub	APN	6	24,454,194 (GRCm39)	missense	probably damaging	1.00
D4043:Iqub	UTSW	6	24,505,750 (GRCm39)	missense	possibly damaging	0.81
R0304:Iqub	UTSW	6	24,454,290 (GRCm39)	missense	probably damaging	0.99
R0391:Iqub	UTSW	6	24,446,154 (GRCm39)	missense	probably benign	0.00
R0453:Iqub	UTSW	6	24,450,829 (GRCm39)	missense	probably damaging	1.00
R0464:Iqub	UTSW	6	24,479,262 (GRCm39)	nonsense	probably null
R0465:Iqub	UTSW	6	24,503,783 (GRCm39)	missense	probably damaging	1.00
R0479:Iqub	UTSW	6	24,505,809 (GRCm39)	missense	probably benign	0.28
R0606:Iqub	UTSW	6	24,501,260 (GRCm39)	splice site	probably benign
R1146:Iqub	UTSW	6	24,505,627 (GRCm39)	missense	possibly damaging	0.89
R1146:Iqub	UTSW	6	24,505,627 (GRCm39)	missense	possibly damaging	0.89
R1238:Iqub	UTSW	6	24,505,884 (GRCm39)	missense	probably benign	0.03
R1452:Iqub	UTSW	6	24,491,558 (GRCm39)	missense	probably benign	0.13
R1927:Iqub	UTSW	6	24,491,670 (GRCm39)	missense	probably benign	0.11
R3195:Iqub	UTSW	6	24,462,036 (GRCm39)	splice site	probably benign
R4438:Iqub	UTSW	6	24,505,867 (GRCm39)	missense	probably benign	0.01
R4577:Iqub	UTSW	6	24,501,290 (GRCm39)	missense	probably damaging	0.99
R4671:Iqub	UTSW	6	24,479,183 (GRCm39)	missense	probably benign	0.00
R4860:Iqub	UTSW	6	24,450,841 (GRCm39)	missense	probably damaging	0.99
R4860:Iqub	UTSW	6	24,450,841 (GRCm39)	missense	probably damaging	0.99
R4906:Iqub	UTSW	6	24,501,368 (GRCm39)	missense	probably damaging	0.99
R5605:Iqub	UTSW	6	24,505,620 (GRCm39)	missense	probably benign
R5772:Iqub	UTSW	6	24,454,250 (GRCm39)	missense	possibly damaging	0.64
R5801:Iqub	UTSW	6	24,449,768 (GRCm39)	missense	probably benign	0.11
R5853:Iqub	UTSW	6	24,491,601 (GRCm39)	missense	probably benign	0.00
R6423:Iqub	UTSW	6	24,491,528 (GRCm39)	missense	probably damaging	0.98
R6475:Iqub	UTSW	6	24,449,744 (GRCm39)	missense	probably damaging	1.00
R6476:Iqub	UTSW	6	24,449,744 (GRCm39)	missense	probably damaging	1.00
R6477:Iqub	UTSW	6	24,449,744 (GRCm39)	missense	probably damaging	1.00
R6701:Iqub	UTSW	6	24,449,744 (GRCm39)	missense	probably damaging	1.00
R6702:Iqub	UTSW	6	24,449,744 (GRCm39)	missense	probably damaging	1.00
R6703:Iqub	UTSW	6	24,449,744 (GRCm39)	missense	probably damaging	1.00
R6860:Iqub	UTSW	6	24,505,737 (GRCm39)	missense	possibly damaging	0.81
R7331:Iqub	UTSW	6	24,500,393 (GRCm39)	missense	possibly damaging	0.73
R7530:Iqub	UTSW	6	24,450,622 (GRCm39)	missense	probably benign	0.00
R7997:Iqub	UTSW	6	24,501,413 (GRCm39)	missense	possibly damaging	0.86
R8050:Iqub	UTSW	6	24,503,784 (GRCm39)	missense	possibly damaging	0.95
R8141:Iqub	UTSW	6	24,491,608 (GRCm39)	missense	probably benign	0.00
R8153:Iqub	UTSW	6	24,450,789 (GRCm39)	nonsense	probably null
R8163:Iqub	UTSW	6	24,449,714 (GRCm39)	missense	probably benign	0.01
R8702:Iqub	UTSW	6	24,461,914 (GRCm39)	missense	probably damaging	1.00
R8824:Iqub	UTSW	6	24,479,307 (GRCm39)	nonsense	probably null
R8899:Iqub	UTSW	6	24,505,768 (GRCm39)	missense	probably benign	0.00
R9075:Iqub	UTSW	6	24,446,124 (GRCm39)	missense	probably damaging	1.00
R9186:Iqub	UTSW	6	24,450,766 (GRCm39)	missense	possibly damaging	0.92
R9240:Iqub	UTSW	6	24,505,622 (GRCm39)	missense	probably benign
R9256:Iqub	UTSW	6	24,446,198 (GRCm39)	missense	possibly damaging	0.92
X0025:Iqub	UTSW	6	24,500,383 (GRCm39)	missense	probably damaging	0.96
Z1088:Iqub	UTSW	6	24,500,242 (GRCm39)	splice site	probably null

Posted On

2014-05-07