Mutagenetix > Incidental Mutations

Incidental Mutation 'IGL01920:Csnk1g2'

180069

Institutional Source

Australian Phenomics Network (link to record)

Gene Symbol

Csnk1g2

Ensembl Gene

ENSMUSG00000003345

Gene Name

casein kinase 1, gamma 2

Synonyms

Accession Numbers

Is this an essential gene?

Non essential (E-score: 0.000) question?

Stock #

IGL01920

Quality Score

Status

Chromosome

Chromosomal Location

80622838-80640749 bp(+) (GRCm38)

Type of Mutation

missense

DNA Base Change (assembly)

T to C at 80638428 bp

Zygosity

Heterozygous

Amino Acid Change

Leucine to Proline at position 161 (L161P)

Ref Sequence

ENSEMBL: ENSMUSP00000082560 (fasta)

Gene Model

predicted gene model for transcript(s): [ENSMUST00000003434] [ENSMUST00000079773] [ENSMUST00000085435] [ENSMUST00000126980]

Predicted Effect

probably benign
Transcript: ENSMUST00000003434

SMART Domains

Protein: ENSMUSP00000003434
Gene: ENSMUSG00000003344

Domain	Start	End	E-Value	Type
low complexity region	27	68	N/A	INTRINSIC
BTB	115	215	9.96e-25	SMART
BACK	220	328	6.36e-13	SMART
Pfam:PHR	373	522	7.1e-57	PFAM

Predicted Effect

probably damaging
Transcript: ENSMUST00000079773
AA Change: L188P

PolyPhen 2 Score 1.000 (Sensitivity: 0.00; Specificity: 1.00)

SMART Domains

Protein: ENSMUSP00000078706
Gene: ENSMUSG00000003345
AA Change: L188P

Domain	Start	End	E-Value	Type
low complexity region	5	15	N/A	INTRINSIC
Pfam:Pkinase	126	329	2e-19	PFAM
Pfam:Pkinase_Tyr	128	329	6.2e-10	PFAM
Pfam:CK1gamma_C	382	412	4e-11	PFAM
low complexity region	425	436	N/A	INTRINSIC

Predicted Effect

probably damaging
Transcript: ENSMUST00000085435
AA Change: L161P

PolyPhen 2 Score 1.000 (Sensitivity: 0.00; Specificity: 1.00)

SMART Domains

Protein: ENSMUSP00000082560
Gene: ENSMUSG00000003345
AA Change: L161P

Domain	Start	End	E-Value	Type
low complexity region	5	15	N/A	INTRINSIC
Pfam:Pkinase_Tyr	46	308	1.3e-14	PFAM
Pfam:Pkinase	46	313	7.6e-35	PFAM
Pfam:CK1gamma_C	354	385	1.2e-11	PFAM
low complexity region	398	409	N/A	INTRINSIC

Predicted Effect

probably benign
Transcript: ENSMUST00000126980

SMART Domains

Protein: ENSMUSP00000120751
Gene: ENSMUSG00000003344

Domain	Start	End	E-Value	Type
low complexity region	12	53	N/A	INTRINSIC
BTB	100	200	9.96e-25	SMART
BACK	205	313	6.36e-13	SMART
Pfam:PHR	358	508	4.3e-54	PFAM

Predicted Effect

noncoding transcript
Transcript: ENSMUST00000147162

Predicted Effect

noncoding transcript
Transcript: ENSMUST00000217902

Predicted Effect

noncoding transcript
Transcript: ENSMUST00000218093

Predicted Effect

noncoding transcript
Transcript: ENSMUST00000219814

Predicted Effect

noncoding transcript
Transcript: ENSMUST00000220025

Predicted Effect

probably benign
Transcript: ENSMUST00000220163

Predicted Effect

noncoding transcript
Transcript: ENSMUST00000220431

Coding Region Coverage

Validation Efficiency

Allele List at MGI

Other mutations in this stock

Total: 24 list
Gene	Ref	Var	Chr/Loc	Mutation	Predicted Effect	Zygosity
Aars	C	T	8: 111,043,246	R326W	probably damaging	Het
Acad11	T	C	9: 104,063,905		probably null	Het
Acat2	A	G	17: 12,944,025	I312T	probably benign	Het
Adgrl3	T	C	5: 81,465,296	V192A	probably damaging	Het
Akap1	T	C	11: 88,839,633	H643R	probably damaging	Het
Akap7	A	T	10: 25,289,603	C85*	probably null	Het
Ankrd11	T	C	8: 122,915,897		probably benign	Het
Ano1	G	A	7: 144,611,454		probably benign	Het
C130026I21Rik	A	G	1: 85,254,186		probably benign	Het
Dvl2	A	G	11: 70,008,047	H420R	probably benign	Het
Fam135b	G	T	15: 71,622,036	H15N	possibly damaging	Het
Foxj1	G	T	11: 116,331,920	H352Q	possibly damaging	Het
Gm10717	C	T	9: 3,025,616	S67L	probably benign	Het
Gm10718	A	T	9: 3,025,118	Y194F	probably benign	Het
Hectd1	T	C	12: 51,782,554	I969M	probably damaging	Het
Kcnh3	C	A	15: 99,233,377	P544T	probably benign	Het
Olfr855	A	C	9: 19,585,022	M162L	probably benign	Het
Pcnt	A	G	10: 76,404,528	L1224P	probably damaging	Het
Prss2	A	G	6: 41,524,543	N182S	possibly damaging	Het
Sgsm1	A	T	5: 113,273,605	W594R	probably damaging	Het
Slc38a1	C	T	15: 96,586,897	A261T	probably benign	Het
Vcan	C	T	13: 89,689,205	G2740E	probably benign	Het
Vmn2r-ps159	C	T	4: 156,338,254		noncoding transcript	Het
Vwa7	G	A	17: 35,024,603	V729I	probably benign	Het

Other mutations in Csnk1g2

Allele	Source	Chr	Coord	Type	Predicted Effect	PPH Score
IGL01066:Csnk1g2	APN	10	80634647	unclassified	probably benign
IGL01657:Csnk1g2	APN	10	80639629	missense	probably benign	0.02
IGL02887:Csnk1g2	APN	10	80638535	missense	probably damaging	1.00
R2845:Csnk1g2	UTSW	10	80638604	missense	probably damaging	1.00
R4135:Csnk1g2	UTSW	10	80638296	missense	possibly damaging	0.84
R4626:Csnk1g2	UTSW	10	80639814	missense	probably damaging	0.98
R4717:Csnk1g2	UTSW	10	80637915	missense	probably benign	0.36
R4729:Csnk1g2	UTSW	10	80639204	missense	probably benign	0.01
R5546:Csnk1g2	UTSW	10	80638398	missense	probably benign	0.36
R6000:Csnk1g2	UTSW	10	80638944	missense	probably damaging	0.99
R6415:Csnk1g2	UTSW	10	80638296	missense	possibly damaging	0.84
R6449:Csnk1g2	UTSW	10	80640072	missense	probably damaging	1.00
R7144:Csnk1g2	UTSW	10	80637899	missense	probably damaging	1.00
R7263:Csnk1g2	UTSW	10	80634498	missense	probably damaging	0.97
R7316:Csnk1g2	UTSW	10	80639853	missense	possibly damaging	0.95
R8169:Csnk1g2	UTSW	10	80639802	missense	probably damaging	1.00
R8171:Csnk1g2	UTSW	10	80639802	missense	probably damaging	1.00
R8227:Csnk1g2	UTSW	10	80638629	critical splice donor site	probably null
R8724:Csnk1g2	UTSW	10	80638926	missense	probably damaging	1.00

Posted On

2014-05-07