Incidental Mutation 'IGL01921:Vmn1r71'
ID180091
Institutional Source Australian Phenomics Network (link to record)
Gene Symbol Vmn1r71
Ensembl Gene ENSMUSG00000059206
Gene Namevomeronasal 1 receptor 71
SynonymsV1re13
Accession Numbers
Is this an essential gene? Probably non essential (E-score: 0.051) question?
Stock #IGL01921
Quality Score
Status
Chromosome7
Chromosomal Location10744543-10754364 bp(-) (GRCm38)
Type of Mutationmissense
DNA Base Change (assembly) C to A at 10748272 bp
ZygosityHeterozygous
Amino Acid Change Arginine to Leucine at position 163 (R163L)
Ref Sequence ENSEMBL: ENSMUSP00000154779 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000079113] [ENSMUST00000226874] [ENSMUST00000227003] [ENSMUST00000227702] [ENSMUST00000227940] [ENSMUST00000228098] [ENSMUST00000228248] [ENSMUST00000228374] [ENSMUST00000228526] [ENSMUST00000228561]
Predicted Effect probably benign
Transcript: ENSMUST00000079113
AA Change: R163L

PolyPhen 2 Score 0.162 (Sensitivity: 0.92; Specificity: 0.87)
SMART Domains Protein: ENSMUSP00000078116
Gene: ENSMUSG00000059206
AA Change: R163L

DomainStartEndE-ValueType
Pfam:TAS2R 3 304 2e-8 PFAM
Pfam:7tm_1 22 289 3.1e-6 PFAM
Pfam:V1R 34 297 4.8e-28 PFAM
Predicted Effect noncoding transcript
Transcript: ENSMUST00000210233
Predicted Effect probably benign
Transcript: ENSMUST00000226874
AA Change: R163L

PolyPhen 2 Score 0.162 (Sensitivity: 0.92; Specificity: 0.87)
Predicted Effect probably benign
Transcript: ENSMUST00000227003
AA Change: R163L

PolyPhen 2 Score 0.162 (Sensitivity: 0.92; Specificity: 0.87)
Predicted Effect probably benign
Transcript: ENSMUST00000227702
AA Change: R163L

PolyPhen 2 Score 0.162 (Sensitivity: 0.92; Specificity: 0.87)
Predicted Effect probably benign
Transcript: ENSMUST00000227940
AA Change: R163L

PolyPhen 2 Score 0.162 (Sensitivity: 0.92; Specificity: 0.87)
Predicted Effect probably benign
Transcript: ENSMUST00000228098
AA Change: R163L

PolyPhen 2 Score 0.162 (Sensitivity: 0.92; Specificity: 0.87)
Predicted Effect probably benign
Transcript: ENSMUST00000228248
AA Change: R163L

PolyPhen 2 Score 0.162 (Sensitivity: 0.92; Specificity: 0.87)
Predicted Effect probably benign
Transcript: ENSMUST00000228374
AA Change: R163L

PolyPhen 2 Score 0.162 (Sensitivity: 0.92; Specificity: 0.87)
Predicted Effect probably benign
Transcript: ENSMUST00000228526
AA Change: R163L

PolyPhen 2 Score 0.162 (Sensitivity: 0.92; Specificity: 0.87)
Predicted Effect probably benign
Transcript: ENSMUST00000228561
AA Change: R97L

PolyPhen 2 Score 0.063 (Sensitivity: 0.94; Specificity: 0.84)
Coding Region Coverage
Validation Efficiency
Allele List at MGI
Other mutations in this stock
Total: 36 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
Agtpbp1 T C 13: 59,512,483 T310A possibly damaging Het
Ccdc102a T C 8: 94,913,391 T92A probably damaging Het
Cd163l1 G T 7: 140,228,719 E848* probably null Het
Ciao1 C T 2: 127,242,835 V328I probably benign Het
Col12a1 T A 9: 79,650,017 Q1943L possibly damaging Het
Diaph1 T C 18: 37,856,208 D898G possibly damaging Het
Dio3 A T 12: 110,279,355 T42S possibly damaging Het
Dnah8 T A 17: 30,736,141 I2048N probably benign Het
Egr2 T A 10: 67,540,378 probably null Het
Epc2 T A 2: 49,532,197 Y368N probably damaging Het
Furin A G 7: 80,395,954 probably benign Het
Gga1 T C 15: 78,893,795 M620T possibly damaging Het
Gm21976 T A 13: 98,305,321 Y45* probably null Het
Gm5346 C A 8: 43,625,511 V559L probably damaging Het
Gpn1 T C 5: 31,499,268 V105A probably damaging Het
Hoxb8 A T 11: 96,284,355 N206I probably damaging Het
Kif15 T A 9: 122,979,504 L67Q probably damaging Het
Krt40 T A 11: 99,543,163 probably benign Het
Mat1a T C 14: 41,114,335 probably benign Het
Mkrn1 T C 6: 39,405,913 D99G possibly damaging Het
Plxnb2 T C 15: 89,164,271 Y645C possibly damaging Het
Ppp1r13b A G 12: 111,833,237 V702A probably benign Het
Ppp4r4 G T 12: 103,576,310 M1I probably null Het
Prss21 T A 17: 23,872,440 M217K possibly damaging Het
R3hcc1l A G 19: 42,563,781 S406G possibly damaging Het
Rfesd T C 13: 76,008,266 E7G probably benign Het
Ripk4 T C 16: 97,743,365 E694G possibly damaging Het
Rlf T C 4: 121,146,746 D1679G probably damaging Het
Ryr2 C T 13: 11,554,550 C4956Y possibly damaging Het
Uri1 T A 7: 37,981,647 K111* probably null Het
Usf1 A G 1: 171,416,856 E108G possibly damaging Het
Vmn2r86 T C 10: 130,455,741 T52A probably benign Het
Vmn2r-ps159 C T 4: 156,338,254 noncoding transcript Het
Washc5 A T 15: 59,342,109 probably null Het
Zfp583 T C 7: 6,325,570 T7A possibly damaging Het
Zim1 T G 7: 6,682,185 probably benign Het
Other mutations in Vmn1r71
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL00984:Vmn1r71 APN 7 10748119 missense probably damaging 0.99
IGL02397:Vmn1r71 APN 7 10748272 missense probably benign 0.27
IGL02654:Vmn1r71 APN 7 10748315 missense probably benign 0.42
IGL02900:Vmn1r71 APN 7 10748674 missense probably benign 0.28
IGL03236:Vmn1r71 APN 7 10748284 missense probably benign 0.11
IGL03269:Vmn1r71 APN 7 10748644 missense possibly damaging 0.88
FR4976:Vmn1r71 UTSW 7 10748121 missense probably benign
R0389:Vmn1r71 UTSW 7 10748311 missense probably benign 0.05
R0443:Vmn1r71 UTSW 7 10748311 missense probably benign 0.05
R0470:Vmn1r71 UTSW 7 10748092 missense possibly damaging 0.64
R0471:Vmn1r71 UTSW 7 10748092 missense possibly damaging 0.64
R0472:Vmn1r71 UTSW 7 10748092 missense possibly damaging 0.64
R0567:Vmn1r71 UTSW 7 10748629 missense probably damaging 1.00
R1498:Vmn1r71 UTSW 7 10748648 missense probably benign 0.01
R1745:Vmn1r71 UTSW 7 10748269 missense probably benign 0.05
R2350:Vmn1r71 UTSW 7 10747919 missense probably benign 0.00
R2970:Vmn1r71 UTSW 7 10748714 missense possibly damaging 0.67
R3522:Vmn1r71 UTSW 7 10747865 missense probably benign 0.03
R4193:Vmn1r71 UTSW 7 10748248 missense possibly damaging 0.55
R4736:Vmn1r71 UTSW 7 10747864 missense possibly damaging 0.94
R5115:Vmn1r71 UTSW 7 10747958 missense probably benign 0.00
R6108:Vmn1r71 UTSW 7 10748618 missense probably benign 0.01
R6455:Vmn1r71 UTSW 7 10748404 missense probably benign 0.01
R6582:Vmn1r71 UTSW 7 10748681 missense probably benign 0.00
R6696:Vmn1r71 UTSW 7 10748474 missense probably damaging 0.96
R6778:Vmn1r71 UTSW 7 10748216 missense probably benign 0.02
R7347:Vmn1r71 UTSW 7 10748501 missense not run
R7631:Vmn1r71 UTSW 7 10748451 missense probably damaging 1.00
R7795:Vmn1r71 UTSW 7 10748209 missense probably damaging 0.98
R7820:Vmn1r71 UTSW 7 10748725 missense possibly damaging 0.85
R7836:Vmn1r71 UTSW 7 10748350 missense possibly damaging 0.51
Posted On2014-05-07