Incidental Mutation 'IGL01924:Yeats2'
ID 180200
Institutional Source Australian Phenomics Network (link to record)
Gene Symbol Yeats2
Ensembl Gene ENSMUSG00000041215
Gene Name YEATS domain containing 2
Synonyms
Accession Numbers
Essential gene? Probably essential (E-score: 0.964) question?
Stock # IGL01924
Quality Score
Status
Chromosome 16
Chromosomal Location 19959813-20051323 bp(+) (GRCm39)
Type of Mutation missense
DNA Base Change (assembly) A to G at 20024917 bp (GRCm39)
Zygosity Heterozygous
Amino Acid Change Asparagine to Aspartic acid at position 706 (N706D)
Ref Sequence ENSEMBL: ENSMUSP00000155891 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000090052] [ENSMUST00000115560] [ENSMUST00000232019] [ENSMUST00000232338]
AlphaFold Q3TUF7
Predicted Effect probably damaging
Transcript: ENSMUST00000090052
AA Change: N709D

PolyPhen 2 Score 1.000 (Sensitivity: 0.00; Specificity: 1.00)
SMART Domains Protein: ENSMUSP00000087506
Gene: ENSMUSG00000041215
AA Change: N709D

DomainStartEndE-ValueType
Pfam:YEATS 179 262 2.6e-27 PFAM
low complexity region 299 309 N/A INTRINSIC
low complexity region 312 333 N/A INTRINSIC
low complexity region 409 429 N/A INTRINSIC
low complexity region 458 467 N/A INTRINSIC
internal_repeat_1 471 675 3.72e-6 PROSPERO
low complexity region 683 702 N/A INTRINSIC
low complexity region 738 775 N/A INTRINSIC
internal_repeat_1 785 978 3.72e-6 PROSPERO
low complexity region 1240 1249 N/A INTRINSIC
Predicted Effect probably damaging
Transcript: ENSMUST00000115560
AA Change: N762D

PolyPhen 2 Score 1.000 (Sensitivity: 0.00; Specificity: 1.00)
SMART Domains Protein: ENSMUSP00000111222
Gene: ENSMUSG00000041215
AA Change: N762D

DomainStartEndE-ValueType
Pfam:YEATS 232 314 2.1e-28 PFAM
low complexity region 352 362 N/A INTRINSIC
low complexity region 365 386 N/A INTRINSIC
low complexity region 462 482 N/A INTRINSIC
low complexity region 511 520 N/A INTRINSIC
internal_repeat_1 524 728 4.68e-6 PROSPERO
low complexity region 736 755 N/A INTRINSIC
low complexity region 791 828 N/A INTRINSIC
internal_repeat_1 838 1031 4.68e-6 PROSPERO
low complexity region 1293 1302 N/A INTRINSIC
Predicted Effect noncoding transcript
Transcript: ENSMUST00000231671
Predicted Effect noncoding transcript
Transcript: ENSMUST00000231795
Predicted Effect probably damaging
Transcript: ENSMUST00000232019
AA Change: N724D

PolyPhen 2 Score 1.000 (Sensitivity: 0.00; Specificity: 1.00)
Predicted Effect noncoding transcript
Transcript: ENSMUST00000232094
Predicted Effect probably damaging
Transcript: ENSMUST00000232338
AA Change: N706D

PolyPhen 2 Score 1.000 (Sensitivity: 0.00; Specificity: 1.00)
Coding Region Coverage
Validation Efficiency
MGI Phenotype FUNCTION: [Summary is not available for the mouse gene. This summary is for the human ortholog.] YEATS2 is a scaffolding subunit of the ADA2A (TADA2A; MIM 602276)-containing (ATAC) histone acetyltransferase complex (Wang et al., 2008 [PubMed 18838386]).[supplied by OMIM, Apr 2010]
Allele List at MGI

All alleles(34) : Targeted(1) Gene trapped(33)

Other mutations in this stock
Total: 57 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
Acacb C T 5: 114,362,047 (GRCm39) probably benign Het
Adamts13 A G 2: 26,886,595 (GRCm39) E938G possibly damaging Het
Aox1 C T 1: 58,326,902 (GRCm39) T167I possibly damaging Het
Apba3 G T 10: 81,108,907 (GRCm39) A557S probably benign Het
Atad2b T C 12: 5,084,093 (GRCm39) L1382P probably damaging Het
Atrn C T 2: 130,777,485 (GRCm39) T178I probably damaging Het
B4galnt1 A G 10: 127,002,630 (GRCm39) S88G probably benign Het
Baz2b T C 2: 59,765,615 (GRCm39) K887E probably damaging Het
Castor2 T C 5: 134,164,441 (GRCm39) F134S probably benign Het
Ccdc162 A C 10: 41,445,883 (GRCm39) F430V probably damaging Het
Cdc42bpb T A 12: 111,283,887 (GRCm39) probably benign Het
Cfhr4 G A 1: 139,666,944 (GRCm39) L444F probably damaging Het
Chit1 A G 1: 134,077,148 (GRCm39) D317G probably benign Het
Chrnb1 A T 11: 69,685,845 (GRCm39) probably benign Het
Cobl G T 11: 12,204,596 (GRCm39) T620K probably benign Het
Creld1 T C 6: 113,460,921 (GRCm39) F20L probably benign Het
Csmd2 A T 4: 128,453,740 (GRCm39) D3475V unknown Het
Cyp3a57 A G 5: 145,309,439 (GRCm39) D259G probably benign Het
Dbnl A G 11: 5,747,142 (GRCm39) Y224C probably damaging Het
Det1 A T 7: 78,493,571 (GRCm39) C144* probably null Het
Fbxo47 G T 11: 97,746,986 (GRCm39) A360D probably damaging Het
Frrs1 G A 3: 116,678,888 (GRCm39) G237R probably damaging Het
Gm10718 A T 9: 3,025,118 (GRCm39) Y194F probably benign Het
Gm21738 G A 14: 19,416,979 (GRCm38) S144L probably benign Het
Gm5862 A C 5: 26,227,769 (GRCm39) W41G probably benign Het
Gria2 T C 3: 80,617,638 (GRCm39) T372A probably benign Het
Hmcn2 A T 2: 31,288,929 (GRCm39) Q2246L probably benign Het
Ide T C 19: 37,249,563 (GRCm39) M930V unknown Het
Kdm5a T C 6: 120,371,216 (GRCm39) probably null Het
Khnyn A G 14: 56,132,426 (GRCm39) T625A probably benign Het
Lrrtm1 T C 6: 77,221,169 (GRCm39) F209L possibly damaging Het
Med13 C A 11: 86,199,522 (GRCm39) probably benign Het
Myom2 A G 8: 15,119,685 (GRCm39) E147G probably benign Het
Myrip T A 9: 120,217,330 (GRCm39) V88D probably damaging Het
Nbeal2 T C 9: 110,460,482 (GRCm39) H1784R probably benign Het
Nlrp4e T A 7: 23,020,255 (GRCm39) C247* probably null Het
Nup54 G A 5: 92,572,294 (GRCm39) P252L probably benign Het
Or51ag1 A G 7: 103,156,003 (GRCm39) I50T possibly damaging Het
Otoa C A 7: 120,705,191 (GRCm39) N244K probably damaging Het
Pbrm1 G A 14: 30,804,561 (GRCm39) R960H probably damaging Het
Ptcd3 A T 6: 71,875,411 (GRCm39) N190K probably damaging Het
Rhobtb1 T A 10: 69,106,134 (GRCm39) L233H probably damaging Het
Sec24c T A 14: 20,739,757 (GRCm39) F545I probably damaging Het
Slc6a15 T C 10: 103,240,686 (GRCm39) probably null Het
Slitrk1 G A 14: 109,148,671 (GRCm39) A680V probably benign Het
Smpd1 C T 7: 105,204,655 (GRCm39) S178L probably benign Het
Spindoc A G 19: 7,360,042 (GRCm39) L42P probably damaging Het
Tenm4 A G 7: 96,544,419 (GRCm39) E2145G probably damaging Het
Tmem144 G T 3: 79,746,501 (GRCm39) A18E probably damaging Het
Tmem213 A T 6: 38,086,373 (GRCm39) S10C possibly damaging Het
Trav6-3 A T 14: 53,667,800 (GRCm39) I102L probably benign Het
Trip11 T G 12: 101,853,143 (GRCm39) N483T possibly damaging Het
Unc13b C T 4: 43,239,385 (GRCm39) R1056* probably null Het
Wdr27 T G 17: 15,137,488 (GRCm39) K433N probably damaging Het
Wls C A 3: 159,607,080 (GRCm39) S189* probably null Het
Zbp1 A G 2: 173,054,047 (GRCm39) V158A probably benign Het
Zfp595 G T 13: 67,465,847 (GRCm39) H139N possibly damaging Het
Other mutations in Yeats2
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL01118:Yeats2 APN 16 20,005,054 (GRCm39) missense probably damaging 0.99
IGL01128:Yeats2 APN 16 19,980,718 (GRCm39) splice site probably benign
IGL01139:Yeats2 APN 16 20,033,143 (GRCm39) missense probably damaging 1.00
IGL01394:Yeats2 APN 16 19,980,782 (GRCm39) missense probably damaging 0.99
IGL01482:Yeats2 APN 16 20,041,671 (GRCm39) missense probably damaging 1.00
IGL01925:Yeats2 APN 16 19,998,430 (GRCm39) splice site probably benign
IGL02106:Yeats2 APN 16 20,011,970 (GRCm39) missense possibly damaging 0.79
IGL02370:Yeats2 APN 16 19,969,221 (GRCm39) missense probably damaging 0.99
IGL02447:Yeats2 APN 16 20,012,429 (GRCm39) missense probably benign 0.00
IGL02669:Yeats2 APN 16 20,005,033 (GRCm39) missense probably benign 0.13
IGL03155:Yeats2 APN 16 20,048,323 (GRCm39) critical splice donor site probably null
tyrion UTSW 16 20,032,151 (GRCm39) splice site probably benign
P0045:Yeats2 UTSW 16 19,975,695 (GRCm39) missense possibly damaging 0.47
R0051:Yeats2 UTSW 16 20,012,474 (GRCm39) nonsense probably null
R0051:Yeats2 UTSW 16 20,012,474 (GRCm39) nonsense probably null
R0118:Yeats2 UTSW 16 19,975,692 (GRCm39) nonsense probably null
R0157:Yeats2 UTSW 16 20,040,427 (GRCm39) makesense probably null
R0184:Yeats2 UTSW 16 20,022,435 (GRCm39) missense possibly damaging 0.79
R0194:Yeats2 UTSW 16 19,971,719 (GRCm39) start codon destroyed probably null 1.00
R0612:Yeats2 UTSW 16 20,005,175 (GRCm39) missense probably benign 0.00
R0655:Yeats2 UTSW 16 20,012,574 (GRCm39) nonsense probably null
R0826:Yeats2 UTSW 16 20,011,966 (GRCm39) nonsense probably null
R1526:Yeats2 UTSW 16 20,024,836 (GRCm39) missense probably damaging 1.00
R1535:Yeats2 UTSW 16 20,008,115 (GRCm39) missense probably damaging 0.99
R1749:Yeats2 UTSW 16 20,005,018 (GRCm39) nonsense probably null
R1842:Yeats2 UTSW 16 19,989,988 (GRCm39) missense probably damaging 1.00
R1843:Yeats2 UTSW 16 20,048,314 (GRCm39) missense probably benign 0.01
R1926:Yeats2 UTSW 16 20,033,176 (GRCm39) missense probably benign
R2000:Yeats2 UTSW 16 20,005,141 (GRCm39) missense probably benign 0.20
R2017:Yeats2 UTSW 16 19,977,931 (GRCm39) missense probably benign 0.01
R2076:Yeats2 UTSW 16 20,005,032 (GRCm39) missense possibly damaging 0.47
R2153:Yeats2 UTSW 16 19,972,916 (GRCm39) missense probably damaging 1.00
R2167:Yeats2 UTSW 16 20,032,151 (GRCm39) splice site probably benign
R2981:Yeats2 UTSW 16 20,005,051 (GRCm39) missense probably damaging 0.99
R3160:Yeats2 UTSW 16 20,012,395 (GRCm39) missense probably damaging 1.00
R3161:Yeats2 UTSW 16 20,012,395 (GRCm39) missense probably damaging 1.00
R3162:Yeats2 UTSW 16 20,012,395 (GRCm39) missense probably damaging 1.00
R3774:Yeats2 UTSW 16 19,969,245 (GRCm39) missense probably damaging 1.00
R4250:Yeats2 UTSW 16 19,975,685 (GRCm39) missense possibly damaging 0.90
R4305:Yeats2 UTSW 16 20,027,172 (GRCm39) missense probably damaging 1.00
R4455:Yeats2 UTSW 16 19,980,743 (GRCm39) missense possibly damaging 0.88
R4458:Yeats2 UTSW 16 20,032,071 (GRCm39) missense probably damaging 0.99
R4811:Yeats2 UTSW 16 19,971,645 (GRCm39) splice site probably null
R4902:Yeats2 UTSW 16 20,026,418 (GRCm39) missense probably benign 0.00
R5043:Yeats2 UTSW 16 20,027,215 (GRCm39) missense probably damaging 1.00
R5047:Yeats2 UTSW 16 20,027,215 (GRCm39) missense probably damaging 1.00
R5319:Yeats2 UTSW 16 20,005,175 (GRCm39) missense probably benign 0.01
R5328:Yeats2 UTSW 16 19,989,955 (GRCm39) missense probably damaging 1.00
R5360:Yeats2 UTSW 16 19,972,912 (GRCm39) missense probably damaging 0.97
R5416:Yeats2 UTSW 16 20,030,319 (GRCm39) missense probably benign 0.01
R5672:Yeats2 UTSW 16 19,980,779 (GRCm39) missense probably damaging 1.00
R5684:Yeats2 UTSW 16 20,012,553 (GRCm39) missense possibly damaging 0.94
R5932:Yeats2 UTSW 16 20,011,913 (GRCm39) missense probably benign 0.06
R5946:Yeats2 UTSW 16 20,026,513 (GRCm39) nonsense probably null
R6168:Yeats2 UTSW 16 19,998,308 (GRCm39) missense probably benign 0.01
R6169:Yeats2 UTSW 16 20,038,417 (GRCm39) missense probably damaging 1.00
R6179:Yeats2 UTSW 16 20,033,225 (GRCm39) missense probably benign 0.16
R6371:Yeats2 UTSW 16 20,040,460 (GRCm39) missense possibly damaging 0.54
R6877:Yeats2 UTSW 16 19,998,344 (GRCm39) missense probably benign 0.00
R7149:Yeats2 UTSW 16 19,972,939 (GRCm39) missense probably damaging 1.00
R7405:Yeats2 UTSW 16 20,041,663 (GRCm39) missense probably damaging 1.00
R8353:Yeats2 UTSW 16 20,041,637 (GRCm39) nonsense probably null
R8367:Yeats2 UTSW 16 20,041,575 (GRCm39) missense probably damaging 1.00
R8453:Yeats2 UTSW 16 20,041,637 (GRCm39) nonsense probably null
R8506:Yeats2 UTSW 16 19,971,684 (GRCm39) missense probably damaging 0.98
R8535:Yeats2 UTSW 16 19,977,926 (GRCm39) missense probably damaging 1.00
R8828:Yeats2 UTSW 16 19,969,260 (GRCm39) missense probably benign 0.45
R8905:Yeats2 UTSW 16 20,009,144 (GRCm39) missense probably benign 0.02
R8924:Yeats2 UTSW 16 19,969,312 (GRCm39) critical splice donor site probably null
R9087:Yeats2 UTSW 16 20,030,500 (GRCm39) critical splice donor site probably null
R9276:Yeats2 UTSW 16 19,975,786 (GRCm39) missense probably benign 0.34
R9338:Yeats2 UTSW 16 20,041,533 (GRCm39) missense probably damaging 0.99
R9338:Yeats2 UTSW 16 20,032,078 (GRCm39) missense possibly damaging 0.69
R9378:Yeats2 UTSW 16 20,033,228 (GRCm39) missense probably benign
R9569:Yeats2 UTSW 16 19,972,902 (GRCm39) missense probably damaging 1.00
R9664:Yeats2 UTSW 16 20,047,491 (GRCm39) nonsense probably null
Posted On 2014-05-07