Incidental Mutation 'IGL01925:Morn3'
ID180244
Institutional Source Australian Phenomics Network (link to record)
Gene Symbol Morn3
Ensembl Gene ENSMUSG00000029477
Gene NameMORN repeat containing 3
Synonyms4930438O03Rik
Accession Numbers
Is this an essential gene? Probably non essential (E-score: 0.246) question?
Stock #IGL01925
Quality Score
Status
Chromosome5
Chromosomal Location123035769-123047016 bp(-) (GRCm38)
Type of Mutationmissense
DNA Base Change (assembly) T to C at 123046762 bp
ZygosityHeterozygous
Amino Acid Change Lysine to Arginine at position 5 (K5R)
Ref Sequence ENSEMBL: ENSMUSP00000041714 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000031437] [ENSMUST00000045843] [ENSMUST00000132775] [ENSMUST00000145257]
Predicted Effect probably damaging
Transcript: ENSMUST00000031437
AA Change: K5R

PolyPhen 2 Score 1.000 (Sensitivity: 0.00; Specificity: 1.00)
SMART Domains Protein: ENSMUSP00000031437
Gene: ENSMUSG00000029477
AA Change: K5R

DomainStartEndE-ValueType
MORN 36 57 3.24e-4 SMART
MORN 60 81 5.18e-3 SMART
MORN 89 110 3.51e0 SMART
MORN 112 133 3.09e-1 SMART
MORN 135 156 1.15e-4 SMART
MORN 158 179 2.57e-1 SMART
Predicted Effect probably damaging
Transcript: ENSMUST00000045843
AA Change: K5R

PolyPhen 2 Score 1.000 (Sensitivity: 0.00; Specificity: 1.00)
SMART Domains Protein: ENSMUSP00000041714
Gene: ENSMUSG00000029477
AA Change: K5R

DomainStartEndE-ValueType
MORN 36 57 3.24e-4 SMART
MORN 60 81 5.18e-3 SMART
MORN 89 110 3.51e0 SMART
MORN 112 133 3.09e-1 SMART
MORN 135 156 2.26e-3 SMART
Predicted Effect possibly damaging
Transcript: ENSMUST00000132775
AA Change: K5R

PolyPhen 2 Score 0.659 (Sensitivity: 0.86; Specificity: 0.91)
SMART Domains Protein: ENSMUSP00000120199
Gene: ENSMUSG00000029477
AA Change: K5R

DomainStartEndE-ValueType
MORN 36 57 3.24e-4 SMART
MORN 60 81 5.18e-3 SMART
MORN 89 110 3.51e0 SMART
MORN 112 133 3.09e-1 SMART
MORN 135 156 2.26e-3 SMART
Predicted Effect probably damaging
Transcript: ENSMUST00000145257
AA Change: K5R

PolyPhen 2 Score 0.998 (Sensitivity: 0.27; Specificity: 0.99)
SMART Domains Protein: ENSMUSP00000122306
Gene: ENSMUSG00000029477
AA Change: K5R

DomainStartEndE-ValueType
MORN 36 57 3.24e-4 SMART
MORN 60 81 5.18e-3 SMART
Predicted Effect noncoding transcript
Transcript: ENSMUST00000181022
Coding Region Coverage
Validation Efficiency
Allele List at MGI
Other mutations in this stock
Total: 45 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
1190002N15Rik A C 9: 94,520,456 D384E probably damaging Het
Aloxe3 A G 11: 69,128,633 D124G probably damaging Het
Arap3 C T 18: 37,984,246 V926I probably benign Het
Col6a3 C T 1: 90,802,236 V1176M possibly damaging Het
D5Ertd579e A T 5: 36,614,284 D922E possibly damaging Het
Epm2a T A 10: 11,448,758 I197N possibly damaging Het
Faim T G 9: 98,990,919 probably benign Het
Fkbp15 A G 4: 62,323,213 I565T probably damaging Het
Fli1 G A 9: 32,465,831 P47L probably damaging Het
Gli2 T C 1: 118,853,376 K187R probably damaging Het
Gm10717 C T 9: 3,025,616 S67L probably benign Het
Gm10718 A T 9: 3,025,118 Y194F probably benign Het
Gm16432 T A 1: 178,015,121 probably benign Het
Gm21738 G A 14: 19,416,979 S144L probably benign Het
Hspa5 G A 2: 34,774,718 V395I probably benign Het
Ide T C 19: 37,277,897 T836A unknown Het
Il9 T A 13: 56,481,871 probably benign Het
Ints8 C T 4: 11,235,617 probably benign Het
Lrrc37a T A 11: 103,498,419 H2060L probably benign Het
Mok T C 12: 110,808,212 N208S probably benign Het
Nalcn C T 14: 123,291,848 C1405Y possibly damaging Het
Ndufv3 T C 17: 31,527,486 S117P possibly damaging Het
Ninl A T 2: 150,971,059 C226S probably damaging Het
Olfr120 A G 17: 37,726,111 E29G probably benign Het
Olfr1364 T C 13: 21,574,171 D95G possibly damaging Het
Olfr1532-ps1 T A 7: 106,915,028 F277I probably damaging Het
Olfr275 A G 4: 52,825,910 N171S probably benign Het
Olfr366 A G 2: 37,220,046 T186A probably benign Het
Olfr558 T C 7: 102,710,203 S315P probably damaging Het
Onecut2 T C 18: 64,341,514 W360R probably damaging Het
Rai14 A G 15: 10,595,862 S118P possibly damaging Het
Serpinb7 T C 1: 107,451,669 S269P probably benign Het
Sesn3 C T 9: 14,320,400 T209I probably damaging Het
Slit1 T A 19: 41,608,378 N1094I probably damaging Het
Tep1 C T 14: 50,824,498 probably benign Het
Top1mt A G 15: 75,657,143 F584S possibly damaging Het
Trim44 A T 2: 102,400,017 L223Q probably benign Het
Trim69 T A 2: 122,167,916 L123Q probably damaging Het
Ubr2 A T 17: 46,954,949 L1153I possibly damaging Het
Unc13a G A 8: 71,634,543 T1520I possibly damaging Het
Vmn2r105 A C 17: 20,208,711 I701S possibly damaging Het
Wrn T C 8: 33,319,180 T263A probably benign Het
Yeats2 T G 16: 20,179,680 probably benign Het
Ythdf2 T C 4: 132,210,774 Y37C probably damaging Het
Zfp169 T C 13: 48,490,763 probably benign Het
Other mutations in Morn3
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL02257:Morn3 APN 5 123037725 missense probably damaging 1.00
IGL02516:Morn3 APN 5 123037300 nonsense probably null
R0052:Morn3 UTSW 5 123046663 missense probably damaging 1.00
R0052:Morn3 UTSW 5 123046663 missense probably damaging 1.00
R0433:Morn3 UTSW 5 123039333 missense probably benign 0.01
R1854:Morn3 UTSW 5 123046629 critical splice donor site probably null
R4893:Morn3 UTSW 5 123037682 missense probably damaging 1.00
R5854:Morn3 UTSW 5 123041115 missense probably damaging 1.00
R5899:Morn3 UTSW 5 123041103 missense probably damaging 1.00
R5983:Morn3 UTSW 5 123037788 missense possibly damaging 0.80
R6106:Morn3 UTSW 5 123046760 missense possibly damaging 0.83
R6766:Morn3 UTSW 5 123041207 missense probably damaging 0.98
R7512:Morn3 UTSW 5 123037280 critical splice donor site probably null
Posted On2014-05-07