Incidental Mutation 'IGL01927:Zfp623'
| ID |
180332 |
| Institutional Source |
Australian Phenomics Network
(link to record)
|
| Gene Symbol |
Zfp623
|
| Ensembl Gene |
ENSMUSG00000050846 |
| Gene Name |
zinc finger protein 623 |
| Synonyms |
2610029D06Rik |
| Accession Numbers |
|
| Essential gene? |
Possibly non essential
(E-score: 0.368)
|
| Stock # |
IGL01927
|
| Quality Score |
|
|
Status
|
|
| Chromosome |
15 |
| Chromosomal Location |
75812801-75821249 bp(+) (GRCm39) |
| Type of Mutation |
missense |
| DNA Base Change (assembly) |
T to A
at 75819354 bp (GRCm39)
|
| Zygosity |
Heterozygous |
| Amino Acid Change |
Asparagine to Lysine
at position 103
(N103K)
|
| Ref Sequence |
ENSEMBL: ENSMUSP00000036049
(fasta)
|
| Gene Model |
predicted gene model for transcript(s):
[ENSMUST00000037260]
|
| AlphaFold |
Q9CY99 |
| Predicted Effect |
possibly damaging
Transcript: ENSMUST00000037260
AA Change: N103K
PolyPhen 2
Score 0.571 (Sensitivity: 0.88; Specificity: 0.91)
|
| SMART Domains |
Protein: ENSMUSP00000036049
Gene: ENSMUSG00000050846
AA Change: N103K
| Domain | Start | End | E-Value | Type |
|---|
|
ZnF_C2H2
|
119 |
141 |
5.59e-4 |
SMART |
|
ZnF_C2H2
|
147 |
169 |
9.96e-1 |
SMART |
|
ZnF_C2H2
|
175 |
197 |
2.4e-3 |
SMART |
|
ZnF_C2H2
|
203 |
225 |
6.42e-4 |
SMART |
|
ZnF_C2H2
|
231 |
253 |
1.3e-4 |
SMART |
|
ZnF_C2H2
|
259 |
281 |
1.3e-4 |
SMART |
|
ZnF_C2H2
|
287 |
309 |
1.28e-3 |
SMART |
|
ZnF_C2H2
|
315 |
337 |
3.21e-4 |
SMART |
|
ZnF_C2H2
|
343 |
365 |
3.39e-3 |
SMART |
|
ZnF_C2H2
|
371 |
393 |
4.87e-4 |
SMART |
|
ZnF_C2H2
|
399 |
421 |
2.53e-2 |
SMART |
|
ZnF_C2H2
|
427 |
449 |
3.95e-4 |
SMART |
|
| Coding Region Coverage |
|
| Validation Efficiency |
|
| Allele List at MGI |
|
| Other mutations in this stock |
Total: 23 list
| Gene | Ref | Var | Chr/Loc | Mutation | Predicted Effect | Zygosity |
|---|
| 4930402F06Rik |
A |
G |
2: 35,266,026 (GRCm39) |
Y215H |
probably damaging |
Het |
| Acsm2 |
T |
C |
7: 119,177,435 (GRCm39) |
F317L |
possibly damaging |
Het |
| Akr1d1 |
A |
G |
6: 37,541,394 (GRCm39) |
D297G |
probably benign |
Het |
| Atp10b |
A |
G |
11: 43,150,231 (GRCm39) |
|
probably benign |
Het |
| Atp8b4 |
T |
C |
2: 126,164,896 (GRCm39) |
Y1140C |
probably damaging |
Het |
| Cap2 |
T |
A |
13: 46,789,109 (GRCm39) |
S105T |
probably benign |
Het |
| Cspg5 |
A |
T |
9: 110,091,152 (GRCm39) |
I414F |
probably damaging |
Het |
| Dipk1b |
A |
G |
2: 26,526,127 (GRCm39) |
M354V |
probably benign |
Het |
| Ereg |
T |
A |
5: 91,234,671 (GRCm39) |
V28E |
probably damaging |
Het |
| Gm10717 |
C |
T |
9: 3,025,616 (GRCm39) |
S67L |
probably benign |
Het |
| Gm5862 |
A |
C |
5: 26,227,769 (GRCm39) |
W41G |
probably benign |
Het |
| Ift81 |
G |
A |
5: 122,731,192 (GRCm39) |
T321M |
probably benign |
Het |
| Kcnip2 |
T |
A |
19: 45,784,044 (GRCm39) |
Q95L |
probably damaging |
Het |
| Meis1 |
C |
T |
11: 18,831,811 (GRCm39) |
R409H |
probably benign |
Het |
| Opa1 |
T |
C |
16: 29,405,813 (GRCm39) |
I126T |
probably benign |
Het |
| Osbpl8 |
T |
C |
10: 111,106,477 (GRCm39) |
Y295H |
probably benign |
Het |
| Ppip5k2 |
A |
T |
1: 97,640,848 (GRCm39) |
V1005E |
probably damaging |
Het |
| Prdm10 |
A |
G |
9: 31,246,694 (GRCm39) |
|
probably benign |
Het |
| Rptor |
T |
A |
11: 119,548,500 (GRCm39) |
V58E |
probably damaging |
Het |
| Togaram1 |
C |
T |
12: 65,023,476 (GRCm39) |
A687V |
probably benign |
Het |
| Vmn2r1 |
T |
C |
3: 63,989,105 (GRCm39) |
F15L |
probably benign |
Het |
| Vmn2r129 |
C |
T |
4: 156,690,549 (GRCm39) |
|
noncoding transcript |
Het |
| Vmn2r82 |
T |
C |
10: 79,213,906 (GRCm39) |
L164P |
probably damaging |
Het |
|
| Other mutations in Zfp623 |
| Allele | Source | Chr | Coord | Type | Predicted Effect | PPH Score |
|---|
|
IGL00226:Zfp623
|
APN |
15 |
75,820,052 (GRCm39) |
missense |
probably damaging |
1.00 |
|
IGL01524:Zfp623
|
APN |
15 |
75,819,528 (GRCm39) |
missense |
probably benign |
|
|
IGL03199:Zfp623
|
APN |
15 |
75,819,119 (GRCm39) |
missense |
probably benign |
0.40 |
|
R0076:Zfp623
|
UTSW |
15 |
75,819,058 (GRCm39) |
missense |
probably benign |
|
|
R0352:Zfp623
|
UTSW |
15 |
75,820,433 (GRCm39) |
missense |
probably benign |
0.00 |
|
R0360:Zfp623
|
UTSW |
15 |
75,820,510 (GRCm39) |
missense |
probably benign |
|
|
R0364:Zfp623
|
UTSW |
15 |
75,820,510 (GRCm39) |
missense |
probably benign |
|
|
R1783:Zfp623
|
UTSW |
15 |
75,819,760 (GRCm39) |
missense |
probably damaging |
0.99 |
|
R2219:Zfp623
|
UTSW |
15 |
75,819,379 (GRCm39) |
missense |
possibly damaging |
0.90 |
|
R5975:Zfp623
|
UTSW |
15 |
75,820,012 (GRCm39) |
missense |
probably benign |
0.43 |
|
R6161:Zfp623
|
UTSW |
15 |
75,820,470 (GRCm39) |
missense |
probably benign |
0.22 |
|
R6342:Zfp623
|
UTSW |
15 |
75,819,837 (GRCm39) |
nonsense |
probably null |
|
|
R6490:Zfp623
|
UTSW |
15 |
75,820,308 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R6513:Zfp623
|
UTSW |
15 |
75,819,317 (GRCm39) |
missense |
probably benign |
|
|
R7028:Zfp623
|
UTSW |
15 |
75,820,154 (GRCm39) |
missense |
probably damaging |
0.99 |
|
R7399:Zfp623
|
UTSW |
15 |
75,819,247 (GRCm39) |
missense |
probably damaging |
0.98 |
|
R7716:Zfp623
|
UTSW |
15 |
75,820,271 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R8362:Zfp623
|
UTSW |
15 |
75,819,488 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R8445:Zfp623
|
UTSW |
15 |
75,819,402 (GRCm39) |
nonsense |
probably null |
|
|
R9028:Zfp623
|
UTSW |
15 |
75,819,349 (GRCm39) |
missense |
probably damaging |
0.97 |
|
R9035:Zfp623
|
UTSW |
15 |
75,820,162 (GRCm39) |
missense |
possibly damaging |
0.93 |
|
R9310:Zfp623
|
UTSW |
15 |
75,819,949 (GRCm39) |
missense |
probably damaging |
1.00 |
|
| Posted On |
2014-05-07 |
Incidental Mutation