Incidental Mutation 'IGL01927:Zfp623'
ID180332
Institutional Source Australian Phenomics Network (link to record)
Gene Symbol Zfp623
Ensembl Gene ENSMUSG00000050846
Gene Namezinc finger protein 623
Synonyms2610029D06Rik
Accession Numbers
Is this an essential gene? Possibly essential (E-score: 0.597) question?
Stock #IGL01927
Quality Score
Status
Chromosome15
Chromosomal Location75940952-75949400 bp(+) (GRCm38)
Type of Mutationmissense
DNA Base Change (assembly) T to A at 75947505 bp
ZygosityHeterozygous
Amino Acid Change Asparagine to Lysine at position 103 (N103K)
Ref Sequence ENSEMBL: ENSMUSP00000036049 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000037260]
Predicted Effect possibly damaging
Transcript: ENSMUST00000037260
AA Change: N103K

PolyPhen 2 Score 0.571 (Sensitivity: 0.88; Specificity: 0.91)
SMART Domains Protein: ENSMUSP00000036049
Gene: ENSMUSG00000050846
AA Change: N103K

DomainStartEndE-ValueType
ZnF_C2H2 119 141 5.59e-4 SMART
ZnF_C2H2 147 169 9.96e-1 SMART
ZnF_C2H2 175 197 2.4e-3 SMART
ZnF_C2H2 203 225 6.42e-4 SMART
ZnF_C2H2 231 253 1.3e-4 SMART
ZnF_C2H2 259 281 1.3e-4 SMART
ZnF_C2H2 287 309 1.28e-3 SMART
ZnF_C2H2 315 337 3.21e-4 SMART
ZnF_C2H2 343 365 3.39e-3 SMART
ZnF_C2H2 371 393 4.87e-4 SMART
ZnF_C2H2 399 421 2.53e-2 SMART
ZnF_C2H2 427 449 3.95e-4 SMART
Coding Region Coverage
Validation Efficiency
Allele List at MGI
Other mutations in this stock
Total: 23 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
4930402F06Rik A G 2: 35,376,014 Y215H probably damaging Het
Acsm2 T C 7: 119,578,212 F317L possibly damaging Het
Akr1d1 A G 6: 37,564,459 D297G probably benign Het
Atp10b A G 11: 43,259,404 probably benign Het
Atp8b4 T C 2: 126,322,976 Y1140C probably damaging Het
Cap2 T A 13: 46,635,633 S105T probably benign Het
Cspg5 A T 9: 110,262,084 I414F probably damaging Het
Ereg T A 5: 91,086,812 V28E probably damaging Het
Fam69b A G 2: 26,636,115 M354V probably benign Het
Gm10717 C T 9: 3,025,616 S67L probably benign Het
Gm5862 A C 5: 26,022,771 W41G probably benign Het
Ift81 G A 5: 122,593,129 T321M probably benign Het
Kcnip2 T A 19: 45,795,605 Q95L probably damaging Het
Meis1 C T 11: 18,881,811 R409H probably benign Het
Opa1 T C 16: 29,586,995 I126T probably benign Het
Osbpl8 T C 10: 111,270,616 Y295H probably benign Het
Ppip5k2 A T 1: 97,713,123 V1005E probably damaging Het
Prdm10 A G 9: 31,335,398 probably benign Het
Rptor T A 11: 119,657,674 V58E probably damaging Het
Togaram1 C T 12: 64,976,702 A687V probably benign Het
Vmn2r1 T C 3: 64,081,684 F15L probably benign Het
Vmn2r82 T C 10: 79,378,072 L164P probably damaging Het
Vmn2r-ps159 C T 4: 156,338,254 noncoding transcript Het
Other mutations in Zfp623
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL00226:Zfp623 APN 15 75948203 missense probably damaging 1.00
IGL01524:Zfp623 APN 15 75947679 missense probably benign
IGL03199:Zfp623 APN 15 75947270 missense probably benign 0.40
R0076:Zfp623 UTSW 15 75947209 missense probably benign
R0352:Zfp623 UTSW 15 75948584 missense probably benign 0.00
R0360:Zfp623 UTSW 15 75948661 missense probably benign
R0364:Zfp623 UTSW 15 75948661 missense probably benign
R1783:Zfp623 UTSW 15 75947911 missense probably damaging 0.99
R2219:Zfp623 UTSW 15 75947530 missense possibly damaging 0.90
R5975:Zfp623 UTSW 15 75948163 missense probably benign 0.43
R6161:Zfp623 UTSW 15 75948621 missense probably benign 0.22
R6342:Zfp623 UTSW 15 75947988 nonsense probably null
R6490:Zfp623 UTSW 15 75948459 missense probably damaging 1.00
R6513:Zfp623 UTSW 15 75947468 missense probably benign
R7028:Zfp623 UTSW 15 75948305 missense probably damaging 0.99
R7399:Zfp623 UTSW 15 75947398 missense probably damaging 0.98
R7716:Zfp623 UTSW 15 75948422 missense probably damaging 1.00
Posted On2014-05-07