Mutagenetix > Incidental Mutations

Incidental Mutation 'IGL01927:Zfp623'

180332

Institutional Source

Australian Phenomics Network (link to record)

Gene Symbol

Zfp623

Ensembl Gene

Gene Name

zinc finger protein 623

Synonyms

2610029D06Rik

Accession Numbers

Is this an essential gene?

Possibly essential (E-score: 0.597) question?

Stock #

IGL01927

Quality Score

Status

Chromosome

Chromosomal Location

75940952-75949400 bp(+) (GRCm38)

Type of Mutation

missense

DNA Base Change (assembly)

T to A at 75947505 bp

Zygosity

Heterozygous

Amino Acid Change

Asparagine to Lysine at position 103 (N103K)

Ref Sequence

ENSEMBL: ENSMUSP00000036049 (fasta)

Gene Model

predicted gene model for transcript(s): [ENSMUST00000037260]

Predicted Effect

possibly damaging
Transcript: ENSMUST00000037260
AA Change: N103K

PolyPhen 2 Score 0.571 (Sensitivity: 0.88; Specificity: 0.91)

SMART Domains

Protein: ENSMUSP00000036049
Gene: ENSMUSG00000050846
AA Change: N103K

Domain	Start	End	E-Value	Type
ZnF_C2H2	119	141	5.59e-4	SMART
ZnF_C2H2	147	169	9.96e-1	SMART
ZnF_C2H2	175	197	2.4e-3	SMART
ZnF_C2H2	203	225	6.42e-4	SMART
ZnF_C2H2	231	253	1.3e-4	SMART
ZnF_C2H2	259	281	1.3e-4	SMART
ZnF_C2H2	287	309	1.28e-3	SMART
ZnF_C2H2	315	337	3.21e-4	SMART
ZnF_C2H2	343	365	3.39e-3	SMART
ZnF_C2H2	371	393	4.87e-4	SMART
ZnF_C2H2	399	421	2.53e-2	SMART
ZnF_C2H2	427	449	3.95e-4	SMART

Coding Region Coverage

Validation Efficiency

Allele List at MGI

Other mutations in this stock

Total: 23 list
Gene	Ref	Var	Chr/Loc	Mutation	Predicted Effect	Zygosity
4930402F06Rik	A	G	2: 35,376,014	Y215H	probably damaging	Het
Acsm2	T	C	7: 119,578,212	F317L	possibly damaging	Het
Akr1d1	A	G	6: 37,564,459	D297G	probably benign	Het
Atp10b	A	G	11: 43,259,404		probably benign	Het
Atp8b4	T	C	2: 126,322,976	Y1140C	probably damaging	Het
Cap2	T	A	13: 46,635,633	S105T	probably benign	Het
Cspg5	A	T	9: 110,262,084	I414F	probably damaging	Het
Ereg	T	A	5: 91,086,812	V28E	probably damaging	Het
Fam69b	A	G	2: 26,636,115	M354V	probably benign	Het
Gm10717	C	T	9: 3,025,616	S67L	probably benign	Het
Gm5862	A	C	5: 26,022,771	W41G	probably benign	Het
Ift81	G	A	5: 122,593,129	T321M	probably benign	Het
Kcnip2	T	A	19: 45,795,605	Q95L	probably damaging	Het
Meis1	C	T	11: 18,881,811	R409H	probably benign	Het
Opa1	T	C	16: 29,586,995	I126T	probably benign	Het
Osbpl8	T	C	10: 111,270,616	Y295H	probably benign	Het
Ppip5k2	A	T	1: 97,713,123	V1005E	probably damaging	Het
Prdm10	A	G	9: 31,335,398		probably benign	Het
Rptor	T	A	11: 119,657,674	V58E	probably damaging	Het
Togaram1	C	T	12: 64,976,702	A687V	probably benign	Het
Vmn2r1	T	C	3: 64,081,684	F15L	probably benign	Het
Vmn2r82	T	C	10: 79,378,072	L164P	probably damaging	Het
Vmn2r-ps159	C	T	4: 156,338,254		noncoding transcript	Het

Other mutations in Zfp623

Allele	Source	Chr	Coord	Type	Predicted Effect	PPH Score
IGL00226:Zfp623	APN	15	75948203	missense	probably damaging	1.00
IGL01524:Zfp623	APN	15	75947679	missense	probably benign
IGL03199:Zfp623	APN	15	75947270	missense	probably benign	0.40
R0076:Zfp623	UTSW	15	75947209	missense	probably benign
R0352:Zfp623	UTSW	15	75948584	missense	probably benign	0.00
R0360:Zfp623	UTSW	15	75948661	missense	probably benign
R0364:Zfp623	UTSW	15	75948661	missense	probably benign
R1783:Zfp623	UTSW	15	75947911	missense	probably damaging	0.99
R2219:Zfp623	UTSW	15	75947530	missense	possibly damaging	0.90
R5975:Zfp623	UTSW	15	75948163	missense	probably benign	0.43
R6161:Zfp623	UTSW	15	75948621	missense	probably benign	0.22
R6342:Zfp623	UTSW	15	75947988	nonsense	probably null
R6490:Zfp623	UTSW	15	75948459	missense	probably damaging	1.00
R6513:Zfp623	UTSW	15	75947468	missense	probably benign
R7028:Zfp623	UTSW	15	75948305	missense	probably damaging	0.99
R7399:Zfp623	UTSW	15	75947398	missense	probably damaging	0.98
R7716:Zfp623	UTSW	15	75948422	missense	probably damaging	1.00

Posted On

2014-05-07