Incidental Mutation 'R0066:Vmn1r231'
ID18042
Institutional Source Beutler Lab
Gene Symbol Vmn1r231
Ensembl Gene ENSMUSG00000050933
Gene Namevomeronasal 1 receptor 231
SynonymsV1re7
MMRRC Submission 038357-MU
Accession Numbers
Is this an essential gene? Probably non essential (E-score: 0.062) question?
Stock #R0066 (G1)
Quality Score
Status Validated
Chromosome17
Chromosomal Location20889716-20890651 bp(-) (GRCm38)
Type of Mutationmissense
DNA Base Change (assembly) T to C at 20889736 bp
ZygosityHeterozygous
Amino Acid Change Arginine to Glycine at position 306 (R306G)
Ref Sequence ENSEMBL: ENSMUSP00000056228 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000061278]
Predicted Effect probably benign
Transcript: ENSMUST00000061278
AA Change: R306G

PolyPhen 2 Score 0.270 (Sensitivity: 0.91; Specificity: 0.88)
SMART Domains Protein: ENSMUSP00000056228
Gene: ENSMUSG00000050933
AA Change: R306G

DomainStartEndE-ValueType
Pfam:TAS2R 6 294 1.6e-13 PFAM
Pfam:V1R 36 297 1.6e-27 PFAM
Predicted Effect noncoding transcript
Transcript: ENSMUST00000232004
Meta Mutation Damage Score 0.3430 question?
Coding Region Coverage
  • 1x: 89.0%
  • 3x: 85.6%
  • 10x: 75.4%
  • 20x: 57.8%
Validation Efficiency 94% (112/119)
Allele List at MGI
Other mutations in this stock
Total: 75 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
1810064F22Rik A G 9: 22,207,881 noncoding transcript Het
Aco2 T C 15: 81,903,465 probably benign Het
Arsa T A 15: 89,474,336 M288L possibly damaging Het
Atg2b A T 12: 105,648,449 D1074E probably benign Het
Baiap2l1 A T 5: 144,284,562 I174N probably damaging Het
Bptf A G 11: 107,062,136 V199A possibly damaging Het
Btn2a2 T A 13: 23,478,485 I432L probably benign Het
Ccdc150 A G 1: 54,356,691 I778V probably benign Het
Cd200r2 G A 16: 44,909,674 V194I possibly damaging Het
Cep350 A C 1: 155,911,218 L1421R probably damaging Het
Col6a6 A T 9: 105,702,213 C1938S probably damaging Het
Cspg4 A T 9: 56,888,134 D1051V probably damaging Het
Cstf1 T A 2: 172,373,056 N32K probably benign Het
Ctrb1 G A 8: 111,686,637 R248* probably null Het
Cyp2d11 T A 15: 82,391,757 M208L probably benign Het
Dbt A G 3: 116,543,829 Q334R probably benign Het
Dcaf12 A G 4: 41,298,338 V270A probably damaging Het
Dis3l T A 9: 64,319,165 N361I probably benign Het
Dnm3 A G 1: 162,407,361 V70A probably damaging Het
Dpy19l2 G A 9: 24,646,383 probably benign Het
Dst C A 1: 34,189,553 H2254N possibly damaging Het
Eif2b1 T G 5: 124,573,795 probably null Het
Epm2aip1 A G 9: 111,272,463 N168S probably benign Het
Fchsd2 A G 7: 101,278,424 Y691C possibly damaging Het
Fndc8 A T 11: 82,897,572 D76V probably benign Het
Frmd4a T C 2: 4,473,152 L48P probably damaging Het
Gimap6 T A 6: 48,702,470 I211F probably damaging Het
Gm15130 A G 2: 111,138,939 probably benign Het
Gm19618 A T 6: 87,714,245 Het
Gpatch1 G A 7: 35,287,227 S768L probably damaging Het
Grb14 T G 2: 64,938,492 probably null Het
Hnrnpd T C 5: 99,964,701 E222G probably damaging Het
Ighv1-4 A G 12: 114,487,369 S40P possibly damaging Het
Kcnh4 T C 11: 100,757,800 H26R probably benign Het
Kctd2 T G 11: 115,429,517 probably benign Het
Macf1 G A 4: 123,432,150 Q3066* probably null Het
Mfn2 G A 4: 147,885,445 probably benign Het
Mmab T C 5: 114,436,465 probably benign Het
Mrc1 T C 2: 14,261,200 S310P probably benign Het
Mrps21 T C 3: 95,862,885 Y44C probably null Het
Myh10 T A 11: 68,699,491 F121Y probably damaging Het
Myo1f A G 17: 33,601,703 D840G probably damaging Het
Nol6 G T 4: 41,119,572 probably benign Het
Ntsr2 T C 12: 16,654,119 I207T probably benign Het
Nwd1 T A 8: 72,711,856 S1552T probably benign Het
Olfr736 T A 14: 50,393,202 F149I probably benign Het
Pkd1l3 G T 8: 109,620,471 G159C unknown Het
Plcb4 T C 2: 135,961,769 S521P probably benign Het
Plcl1 A T 1: 55,713,475 I993F probably damaging Het
Plekha7 T C 7: 116,157,508 S640G probably damaging Het
Ptprn2 A C 12: 117,276,602 N993T probably benign Het
Reck A G 4: 43,930,936 N646D probably damaging Het
Rfx2 A T 17: 56,786,736 probably benign Het
Ripk2 G A 4: 16,123,868 Q436* probably null Het
Ryr1 C T 7: 29,005,567 probably benign Het
Sema6b A G 17: 56,128,271 V324A possibly damaging Het
Sik2 C A 9: 50,998,533 M73I probably benign Het
Slc39a6 T C 18: 24,599,269 K321E probably damaging Het
Slc7a4 C A 16: 17,574,011 V520F probably benign Het
Sptan1 C A 2: 30,003,667 probably benign Het
Stab1 C T 14: 31,157,070 probably benign Het
Tbc1d17 C T 7: 44,844,071 probably benign Het
Tbcd T A 11: 121,503,764 L49* probably null Het
Tulp4 A T 17: 6,201,733 N60I probably damaging Het
Ubqlnl A T 7: 104,148,938 W451R probably damaging Het
Usp53 G T 3: 122,953,307 C363* probably null Het
Utp4 A G 8: 106,922,898 T660A possibly damaging Het
Vmn1r194 A T 13: 22,244,471 Y86F probably benign Het
Vmn1r195 A T 13: 22,279,239 H293L possibly damaging Het
Vmn2r77 T C 7: 86,800,756 V70A probably benign Het
Vps8 A G 16: 21,477,523 E515G possibly damaging Het
Wdr18 C A 10: 79,961,103 Y104* probably null Het
Xab2 A T 8: 3,613,880 N346K probably damaging Het
Zdhhc12 C T 2: 30,092,535 R50H probably damaging Het
Zdhhc8 A G 16: 18,225,200 S379P probably benign Het
Other mutations in Vmn1r231
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL00233:Vmn1r231 APN 17 20890566 missense possibly damaging 0.68
IGL02124:Vmn1r231 APN 17 20890306 missense probably damaging 1.00
IGL02151:Vmn1r231 APN 17 20889735 missense probably benign 0.06
R0066:Vmn1r231 UTSW 17 20889736 missense probably benign 0.27
R0396:Vmn1r231 UTSW 17 20890399 missense probably damaging 0.98
R0427:Vmn1r231 UTSW 17 20890228 missense probably benign 0.05
R0470:Vmn1r231 UTSW 17 20890003 nonsense probably null
R0848:Vmn1r231 UTSW 17 20890171 missense probably damaging 1.00
R1692:Vmn1r231 UTSW 17 20890609 missense probably benign 0.02
R1987:Vmn1r231 UTSW 17 20889950 missense probably damaging 1.00
R1988:Vmn1r231 UTSW 17 20889950 missense probably damaging 1.00
R2105:Vmn1r231 UTSW 17 20890118 missense possibly damaging 0.66
R4440:Vmn1r231 UTSW 17 20890456 missense possibly damaging 0.48
R4634:Vmn1r231 UTSW 17 20890398 missense possibly damaging 0.46
R4646:Vmn1r231 UTSW 17 20890309 missense probably damaging 1.00
R4678:Vmn1r231 UTSW 17 20890227 missense possibly damaging 0.94
R4696:Vmn1r231 UTSW 17 20890639 missense possibly damaging 0.63
R4938:Vmn1r231 UTSW 17 20890351 missense possibly damaging 0.76
R5544:Vmn1r231 UTSW 17 20890578 missense probably damaging 1.00
R5942:Vmn1r231 UTSW 17 20890155 missense possibly damaging 0.83
R6053:Vmn1r231 UTSW 17 20889819 missense probably damaging 1.00
R6692:Vmn1r231 UTSW 17 20890483 missense possibly damaging 0.46
R6712:Vmn1r231 UTSW 17 20889730 missense possibly damaging 0.54
R7131:Vmn1r231 UTSW 17 20889878 missense possibly damaging 0.87
R7854:Vmn1r231 UTSW 17 20890632 missense probably damaging 0.98
R8187:Vmn1r231 UTSW 17 20890631 missense probably benign 0.10
R8238:Vmn1r231 UTSW 17 20890378 missense probably benign 0.08
R8313:Vmn1r231 UTSW 17 20890027 missense probably benign 0.02
RF010:Vmn1r231 UTSW 17 20889993 missense probably damaging 0.99
Posted On2013-03-25