Incidental Mutation 'IGL01932:Ffar4'
ID180470
Institutional Source Australian Phenomics Network (link to record)
Gene Symbol Ffar4
Ensembl Gene ENSMUSG00000054200
Gene Namefree fatty acid receptor 4
SynonymsGpr129, O3far1, Pgr4, Gpr120
Accession Numbers
Is this an essential gene? Probably non essential (E-score: 0.106) question?
Stock #IGL01932
Quality Score
Status
Chromosome19
Chromosomal Location38097079-38114263 bp(+) (GRCm38)
Type of Mutationmissense
DNA Base Change (assembly) A to G at 38097530 bp
ZygosityHeterozygous
Amino Acid Change Glutamic Acid to Glycine at position 135 (E135G)
Ref Sequence ENSEMBL: ENSMUSP00000063660 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000067098]
Predicted Effect probably damaging
Transcript: ENSMUST00000067098
AA Change: E135G

PolyPhen 2 Score 1.000 (Sensitivity: 0.00; Specificity: 1.00)
SMART Domains Protein: ENSMUSP00000063660
Gene: ENSMUSG00000054200
AA Change: E135G

DomainStartEndE-ValueType
Pfam:7tm_1 57 321 1.7e-39 PFAM
Coding Region Coverage
Validation Efficiency
MGI Phenotype FUNCTION: [Summary is not available for the mouse gene. This summary is for the human ortholog.] This gene encodes a G protein-coupled receptor (GPR) which belongs to the rhodopsin family of GPRs. The encoded protein functions as a receptor for free fatty acids, including omega-3, and participates in suppressing anti-inflammatory responses and insulin sensitizing. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Feb 2012]
PHENOTYPE: Homozygotes for a null allele show altered taste responses to fatty acids. Homozygotes for another null allele develop obesity, liver steatosis, and impaired glucose metabolism, adipogenesis and lipogenesis on a high-fat diet. Homozygotes for a third allele show altered islet somatostatin secretion. [provided by MGI curators]
Allele List at MGI
Other mutations in this stock
Total: 31 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
1110008L16Rik A G 12: 55,304,125 N73S probably benign Het
Adcy1 T A 11: 7,100,565 probably benign Het
Adipor2 G A 6: 119,361,864 H143Y probably damaging Het
Ankar A G 1: 72,698,987 I12T probably benign Het
Ankdd1a C T 9: 65,507,611 probably benign Het
Cadps A G 14: 12,373,609 probably benign Het
Cdh22 G A 2: 165,170,808 T119M probably benign Het
Col6a6 T A 9: 105,689,626 K2223N probably benign Het
Dnah11 G A 12: 118,192,270 probably benign Het
Ezh2 T C 6: 47,532,048 T674A probably damaging Het
Fsip2 G A 2: 82,994,005 R6694Q possibly damaging Het
Gm10717 A T 9: 3,026,287 Y195F probably damaging Het
Gm10718 A T 9: 3,025,118 Y194F probably benign Het
Gm21738 G A 14: 19,416,979 S144L probably benign Het
Gm4222 A G 2: 90,148,457 probably benign Het
Hipk3 T A 2: 104,470,981 N289Y probably damaging Het
Kndc1 T C 7: 139,923,790 L1003P probably damaging Het
Mdk T C 2: 91,931,116 N72S probably damaging Het
Olfr520 T A 7: 99,735,500 I119N probably damaging Het
Olfr666 T A 7: 104,893,218 I137F probably damaging Het
Pafah1b3 A T 7: 25,297,091 C56S probably benign Het
Pdzrn4 A G 15: 92,746,278 I189V probably damaging Het
Plekhh2 A G 17: 84,577,261 N801S probably benign Het
Pramel7 A T 2: 87,491,113 S193T possibly damaging Het
Prkag1 A G 15: 98,814,531 I171T probably damaging Het
Rap1b A T 10: 117,822,860 F23I probably damaging Het
Scamp2 A G 9: 57,561,116 probably benign Het
Ttn A T 2: 76,884,474 probably benign Het
Vmn2r17 A T 5: 109,427,050 R74S probably benign Het
Vmn2r-ps159 C T 4: 156,338,254 noncoding transcript Het
Wif1 G T 10: 121,096,035 C288F probably damaging Het
Other mutations in Ffar4
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL00402:Ffar4 APN 19 38107389 missense probably benign
IGL01734:Ffar4 APN 19 38113847 missense probably damaging 1.00
IGL02160:Ffar4 APN 19 38097455 missense possibly damaging 0.91
IGL02486:Ffar4 APN 19 38113760 missense possibly damaging 0.68
R0047:Ffar4 UTSW 19 38114004 unclassified probably benign
R0492:Ffar4 UTSW 19 38097182 missense probably benign
R4956:Ffar4 UTSW 19 38097580 missense probably benign 0.01
R5091:Ffar4 UTSW 19 38097179 missense probably benign
R5634:Ffar4 UTSW 19 38113925 unclassified probably benign
R5756:Ffar4 UTSW 19 38113958 missense probably damaging 0.99
R6778:Ffar4 UTSW 19 38113664 missense possibly damaging 0.56
R8030:Ffar4 UTSW 19 38107391 missense possibly damaging 0.80
Posted On2014-05-07