Incidental Mutation 'IGL01933:Stk4'
ID 180533
Institutional Source Australian Phenomics Network (link to record)
Gene Symbol Stk4
Ensembl Gene ENSMUSG00000018209
Gene Name serine/threonine kinase 4
Synonyms sterile 20-like kinase 1, Kas-2, Ysk3, Mst1
Accession Numbers
Essential gene? Non essential (E-score: 0.000) question?
Stock # IGL01933
Quality Score
Status
Chromosome 2
Chromosomal Location 163916033-163997444 bp(+) (GRCm39)
Type of Mutation unclassified
DNA Base Change (assembly) C to T at 163940505 bp (GRCm39)
Zygosity Heterozygous
Amino Acid Change
Gene Model predicted gene model for transcript(s): [ENSMUST00000018353]
AlphaFold Q9JI11
Predicted Effect probably benign
Transcript: ENSMUST00000018353
SMART Domains Protein: ENSMUSP00000018353
Gene: ENSMUSG00000018209

DomainStartEndE-ValueType
S_TKc 30 281 1.97e-104 SMART
low complexity region 311 326 N/A INTRINSIC
Pfam:Mst1_SARAH 433 480 2.4e-26 PFAM
Predicted Effect probably benign
Transcript: ENSMUST00000137866
SMART Domains Protein: ENSMUSP00000116745
Gene: ENSMUSG00000018209

DomainStartEndE-ValueType
Blast:S_TKc 2 26 8e-6 BLAST
PDB:3COM|B 2 26 4e-7 PDB
low complexity region 27 42 N/A INTRINSIC
Predicted Effect noncoding transcript
Transcript: ENSMUST00000153319
Coding Region Coverage
Validation Efficiency
MGI Phenotype FUNCTION: [Summary is not available for the mouse gene. This summary is for the human ortholog.] The protein encoded by this gene is a cytoplasmic kinase that is structurally similar to the yeast Ste20p kinase, which acts upstream of the stress-induced mitogen-activated protein kinase cascade. The encoded protein can phosphorylate myelin basic protein and undergoes autophosphorylation. A caspase-cleaved fragment of the encoded protein has been shown to be capable of phosphorylating histone H2B. The particular phosphorylation catalyzed by this protein has been correlated with apoptosis, and it's possible that this protein induces the chromatin condensation observed in this process. [provided by RefSeq, Jul 2008]
PHENOTYPE: Mice homozygous for a gene trap allele have low numbers of na�ve T cells that are hyper-responsive to stimulation. Mice homozygous for knock-out alleles exhibit decreased peripheral T cell numbers due to impaired emigration and homing. [provided by MGI curators]
Allele List at MGI
Other mutations in this stock
Total: 61 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
1700017B05Rik C A 9: 57,164,650 (GRCm39) V575F possibly damaging Het
Abca2 T A 2: 25,334,123 (GRCm39) V1800E probably damaging Het
Acacb C T 5: 114,322,251 (GRCm39) probably benign Het
Adam34 C A 8: 44,104,569 (GRCm39) G359W probably damaging Het
Ankrd42 G A 7: 92,254,493 (GRCm39) T372I probably benign Het
Apc2 A G 10: 80,147,574 (GRCm39) D847G probably damaging Het
Arap3 T A 18: 38,111,506 (GRCm39) T1137S possibly damaging Het
Atp10b A C 11: 43,085,457 (GRCm39) T279P probably damaging Het
Bmp2 T A 2: 133,396,578 (GRCm39) M78K possibly damaging Het
Ccdc61 T G 7: 18,626,483 (GRCm39) M369L probably benign Het
Cep78 A T 19: 15,933,304 (GRCm39) I758N probably benign Het
Ces2a A G 8: 105,468,047 (GRCm39) *526W probably null Het
Cgnl1 C T 9: 71,552,765 (GRCm39) probably benign Het
Clec14a A G 12: 58,315,104 (GRCm39) Y173H probably damaging Het
Cntn4 G A 6: 106,671,345 (GRCm39) S976N probably damaging Het
Col6a4 G A 9: 105,937,313 (GRCm39) T1401I probably benign Het
D5Ertd579e T C 5: 36,773,100 (GRCm39) T432A probably benign Het
Dixdc1 G A 9: 50,614,558 (GRCm39) R163* probably null Het
Dmxl1 C A 18: 50,010,852 (GRCm39) T1003K probably benign Het
Dnah1 G A 14: 31,032,872 (GRCm39) R388W probably benign Het
Eci3 C T 13: 35,132,772 (GRCm39) A202T probably damaging Het
Egr2 T C 10: 67,376,024 (GRCm39) S220P probably damaging Het
Fntb C T 12: 76,966,880 (GRCm39) P405S probably benign Het
Gm10718 A T 9: 3,025,118 (GRCm39) Y194F probably benign Het
Gm26602 C A 10: 79,746,955 (GRCm39) R236L probably benign Het
Hao2 T C 3: 98,787,648 (GRCm39) probably benign Het
Irgm2 A T 11: 58,110,783 (GRCm39) N170I possibly damaging Het
Klhl20 G A 1: 160,934,357 (GRCm39) R221W probably damaging Het
Kmt2b A G 7: 30,268,939 (GRCm39) probably null Het
Lrrc46 C T 11: 96,926,354 (GRCm39) E181K probably benign Het
Lztr1 T A 16: 17,338,455 (GRCm39) V226E probably damaging Het
Myh9 G T 15: 77,665,418 (GRCm39) D684E probably benign Het
Myo7a T C 7: 97,732,349 (GRCm39) T713A probably damaging Het
Nrap G T 19: 56,377,250 (GRCm39) N62K probably damaging Het
Or51a10 T C 7: 103,699,021 (GRCm39) Y180C probably damaging Het
Or5an1 A T 19: 12,261,069 (GRCm39) Y219F probably damaging Het
Osbp2 T C 11: 3,662,016 (GRCm39) D708G probably damaging Het
Pcnx2 G A 8: 126,488,393 (GRCm39) P1717L probably damaging Het
Pex1 A G 5: 3,683,789 (GRCm39) D1095G probably damaging Het
Ptpn3 T C 4: 57,197,576 (GRCm39) H771R probably benign Het
R3hcc1l G A 19: 42,551,389 (GRCm39) A129T probably damaging Het
Rbm15 G A 3: 107,238,419 (GRCm39) R660W probably damaging Het
Recql C T 6: 142,310,364 (GRCm39) V489M probably benign Het
Sash1 A T 10: 8,626,897 (GRCm39) S162R probably damaging Het
Sec11a T C 7: 80,584,810 (GRCm39) I42M probably benign Het
Slc25a23 G A 17: 57,359,813 (GRCm39) Q61* probably null Het
Son A T 16: 91,454,903 (GRCm39) M1217L probably benign Het
Sp140l2 A G 1: 85,231,907 (GRCm39) probably benign Het
Srgap2 T C 1: 131,339,593 (GRCm39) N123S probably damaging Het
Ssh1 T C 5: 114,088,441 (GRCm39) probably benign Het
St13 T C 15: 81,273,899 (GRCm39) probably null Het
St3gal3 A T 4: 117,889,072 (GRCm39) D57E probably damaging Het
Tln1 T A 4: 43,539,508 (GRCm39) T1605S probably benign Het
Tln1 T C 4: 43,555,894 (GRCm39) T107A possibly damaging Het
Tmem135 G T 7: 88,793,065 (GRCm39) probably benign Het
Tmtc3 A G 10: 100,283,467 (GRCm39) M696T probably benign Het
Trbv28 T A 6: 41,248,761 (GRCm39) L97Q probably damaging Het
Trpc4ap A T 2: 155,481,455 (GRCm39) F534I possibly damaging Het
Trpm8 T C 1: 88,254,127 (GRCm39) Y117H probably damaging Het
Zfp608 T C 18: 55,120,871 (GRCm39) T239A probably benign Het
Zmym5 T G 14: 57,041,617 (GRCm39) H162P probably damaging Het
Other mutations in Stk4
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL00672:Stk4 APN 2 163,959,999 (GRCm39) missense probably benign 0.05
IGL01583:Stk4 APN 2 163,916,134 (GRCm39) start codon destroyed probably null 0.21
IGL02084:Stk4 APN 2 163,928,527 (GRCm39) missense probably benign 0.05
IGL02423:Stk4 APN 2 163,928,419 (GRCm39) missense probably benign 0.00
IGL02601:Stk4 APN 2 163,928,462 (GRCm39) missense probably damaging 1.00
IGL02712:Stk4 APN 2 163,938,817 (GRCm39) missense probably damaging 1.00
hallon UTSW 2 163,941,747 (GRCm39) critical splice donor site probably null
iwo_jima UTSW 2 163,930,879 (GRCm39) missense possibly damaging 0.94
ribeye UTSW 2 163,921,486 (GRCm39) missense probably damaging 1.00
Sergeant UTSW 2 163,941,632 (GRCm39) missense probably benign
stryker UTSW 2 163,925,608 (GRCm39) nonsense probably null
R0377:Stk4 UTSW 2 163,938,720 (GRCm39) missense probably damaging 1.00
R0607:Stk4 UTSW 2 163,940,462 (GRCm39) missense probably damaging 1.00
R1403:Stk4 UTSW 2 163,942,448 (GRCm39) missense probably benign 0.04
R1403:Stk4 UTSW 2 163,942,448 (GRCm39) missense probably benign 0.04
R1404:Stk4 UTSW 2 163,942,448 (GRCm39) missense probably benign 0.04
R1404:Stk4 UTSW 2 163,942,448 (GRCm39) missense probably benign 0.04
R1405:Stk4 UTSW 2 163,942,448 (GRCm39) missense probably benign 0.04
R1405:Stk4 UTSW 2 163,942,448 (GRCm39) missense probably benign 0.04
R1406:Stk4 UTSW 2 163,942,448 (GRCm39) missense probably benign 0.04
R1406:Stk4 UTSW 2 163,942,448 (GRCm39) missense probably benign 0.04
R1972:Stk4 UTSW 2 163,942,448 (GRCm39) missense probably benign 0.04
R1973:Stk4 UTSW 2 163,942,448 (GRCm39) missense probably benign 0.04
R1976:Stk4 UTSW 2 163,942,448 (GRCm39) missense probably benign 0.04
R2025:Stk4 UTSW 2 163,938,751 (GRCm39) missense probably damaging 1.00
R3155:Stk4 UTSW 2 163,993,663 (GRCm39) missense probably benign 0.01
R3732:Stk4 UTSW 2 163,930,828 (GRCm39) missense probably benign 0.05
R3732:Stk4 UTSW 2 163,930,828 (GRCm39) missense probably benign 0.05
R3733:Stk4 UTSW 2 163,930,828 (GRCm39) missense probably benign 0.05
R3734:Stk4 UTSW 2 163,930,828 (GRCm39) missense probably benign 0.05
R4288:Stk4 UTSW 2 163,941,632 (GRCm39) missense probably benign
R4296:Stk4 UTSW 2 163,959,904 (GRCm39) missense possibly damaging 0.69
R4360:Stk4 UTSW 2 163,930,879 (GRCm39) missense possibly damaging 0.94
R4829:Stk4 UTSW 2 163,941,747 (GRCm39) critical splice donor site probably null
R4954:Stk4 UTSW 2 163,993,602 (GRCm39) missense probably damaging 1.00
R4954:Stk4 UTSW 2 163,993,601 (GRCm39) missense possibly damaging 0.75
R5088:Stk4 UTSW 2 163,925,608 (GRCm39) nonsense probably null
R5188:Stk4 UTSW 2 163,930,828 (GRCm39) missense possibly damaging 0.85
R5283:Stk4 UTSW 2 163,952,199 (GRCm39) nonsense probably null
R5554:Stk4 UTSW 2 163,941,645 (GRCm39) missense probably benign
R5605:Stk4 UTSW 2 163,921,486 (GRCm39) missense probably damaging 1.00
R5694:Stk4 UTSW 2 163,942,484 (GRCm39) missense possibly damaging 0.87
R5711:Stk4 UTSW 2 163,941,674 (GRCm39) missense probably benign 0.20
R7453:Stk4 UTSW 2 163,928,522 (GRCm39) missense probably benign 0.01
R7698:Stk4 UTSW 2 163,925,663 (GRCm39) missense probably damaging 1.00
R7726:Stk4 UTSW 2 163,952,146 (GRCm39) start codon destroyed probably null
R8177:Stk4 UTSW 2 163,930,777 (GRCm39) missense probably damaging 0.99
R9076:Stk4 UTSW 2 163,959,985 (GRCm39) missense probably benign
R9378:Stk4 UTSW 2 163,952,136 (GRCm39) intron probably benign
Posted On 2014-05-07