Incidental Mutation 'IGL01933:Tmem135'
ID 180537
Institutional Source Australian Phenomics Network (link to record)
Gene Symbol Tmem135
Ensembl Gene ENSMUSG00000039428
Gene Name transmembrane protein 135
Synonyms 2810439K08Rik
Accession Numbers
Essential gene? Probably non essential (E-score: 0.127) question?
Stock # IGL01933
Quality Score
Status
Chromosome 7
Chromosomal Location 88788922-89053430 bp(-) (GRCm39)
Type of Mutation unclassified
DNA Base Change (assembly) G to T at 88793065 bp (GRCm39)
Zygosity Heterozygous
Amino Acid Change
Ref Sequence ENSEMBL: ENSMUSP00000114097 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000041968] [ENSMUST00000117852]
AlphaFold Q9CYV5
Predicted Effect probably benign
Transcript: ENSMUST00000041968
SMART Domains Protein: ENSMUSP00000042783
Gene: ENSMUSG00000039428

DomainStartEndE-ValueType
Pfam:TMEM135_C_rich 9 142 2.2e-84 PFAM
transmembrane domain 147 169 N/A INTRINSIC
Pfam:Tim17 249 370 1.1e-9 PFAM
Predicted Effect probably benign
Transcript: ENSMUST00000117852
SMART Domains Protein: ENSMUSP00000114097
Gene: ENSMUSG00000039428

DomainStartEndE-ValueType
low complexity region 52 65 N/A INTRINSIC
transmembrane domain 67 89 N/A INTRINSIC
transmembrane domain 96 115 N/A INTRINSIC
transmembrane domain 147 169 N/A INTRINSIC
transmembrane domain 299 321 N/A INTRINSIC
transmembrane domain 331 353 N/A INTRINSIC
Predicted Effect noncoding transcript
Transcript: ENSMUST00000156153
Predicted Effect noncoding transcript
Transcript: ENSMUST00000207335
Coding Region Coverage
Validation Efficiency
Allele List at MGI
Other mutations in this stock
Total: 61 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
1700017B05Rik C A 9: 57,164,650 (GRCm39) V575F possibly damaging Het
Abca2 T A 2: 25,334,123 (GRCm39) V1800E probably damaging Het
Acacb C T 5: 114,322,251 (GRCm39) probably benign Het
Adam34 C A 8: 44,104,569 (GRCm39) G359W probably damaging Het
Ankrd42 G A 7: 92,254,493 (GRCm39) T372I probably benign Het
Apc2 A G 10: 80,147,574 (GRCm39) D847G probably damaging Het
Arap3 T A 18: 38,111,506 (GRCm39) T1137S possibly damaging Het
Atp10b A C 11: 43,085,457 (GRCm39) T279P probably damaging Het
Bmp2 T A 2: 133,396,578 (GRCm39) M78K possibly damaging Het
Ccdc61 T G 7: 18,626,483 (GRCm39) M369L probably benign Het
Cep78 A T 19: 15,933,304 (GRCm39) I758N probably benign Het
Ces2a A G 8: 105,468,047 (GRCm39) *526W probably null Het
Cgnl1 C T 9: 71,552,765 (GRCm39) probably benign Het
Clec14a A G 12: 58,315,104 (GRCm39) Y173H probably damaging Het
Cntn4 G A 6: 106,671,345 (GRCm39) S976N probably damaging Het
Col6a4 G A 9: 105,937,313 (GRCm39) T1401I probably benign Het
D5Ertd579e T C 5: 36,773,100 (GRCm39) T432A probably benign Het
Dixdc1 G A 9: 50,614,558 (GRCm39) R163* probably null Het
Dmxl1 C A 18: 50,010,852 (GRCm39) T1003K probably benign Het
Dnah1 G A 14: 31,032,872 (GRCm39) R388W probably benign Het
Eci3 C T 13: 35,132,772 (GRCm39) A202T probably damaging Het
Egr2 T C 10: 67,376,024 (GRCm39) S220P probably damaging Het
Fntb C T 12: 76,966,880 (GRCm39) P405S probably benign Het
Gm10718 A T 9: 3,025,118 (GRCm39) Y194F probably benign Het
Gm26602 C A 10: 79,746,955 (GRCm39) R236L probably benign Het
Hao2 T C 3: 98,787,648 (GRCm39) probably benign Het
Irgm2 A T 11: 58,110,783 (GRCm39) N170I possibly damaging Het
Klhl20 G A 1: 160,934,357 (GRCm39) R221W probably damaging Het
Kmt2b A G 7: 30,268,939 (GRCm39) probably null Het
Lrrc46 C T 11: 96,926,354 (GRCm39) E181K probably benign Het
Lztr1 T A 16: 17,338,455 (GRCm39) V226E probably damaging Het
Myh9 G T 15: 77,665,418 (GRCm39) D684E probably benign Het
Myo7a T C 7: 97,732,349 (GRCm39) T713A probably damaging Het
Nrap G T 19: 56,377,250 (GRCm39) N62K probably damaging Het
Or51a10 T C 7: 103,699,021 (GRCm39) Y180C probably damaging Het
Or5an1 A T 19: 12,261,069 (GRCm39) Y219F probably damaging Het
Osbp2 T C 11: 3,662,016 (GRCm39) D708G probably damaging Het
Pcnx2 G A 8: 126,488,393 (GRCm39) P1717L probably damaging Het
Pex1 A G 5: 3,683,789 (GRCm39) D1095G probably damaging Het
Ptpn3 T C 4: 57,197,576 (GRCm39) H771R probably benign Het
R3hcc1l G A 19: 42,551,389 (GRCm39) A129T probably damaging Het
Rbm15 G A 3: 107,238,419 (GRCm39) R660W probably damaging Het
Recql C T 6: 142,310,364 (GRCm39) V489M probably benign Het
Sash1 A T 10: 8,626,897 (GRCm39) S162R probably damaging Het
Sec11a T C 7: 80,584,810 (GRCm39) I42M probably benign Het
Slc25a23 G A 17: 57,359,813 (GRCm39) Q61* probably null Het
Son A T 16: 91,454,903 (GRCm39) M1217L probably benign Het
Sp140l2 A G 1: 85,231,907 (GRCm39) probably benign Het
Srgap2 T C 1: 131,339,593 (GRCm39) N123S probably damaging Het
Ssh1 T C 5: 114,088,441 (GRCm39) probably benign Het
St13 T C 15: 81,273,899 (GRCm39) probably null Het
St3gal3 A T 4: 117,889,072 (GRCm39) D57E probably damaging Het
Stk4 C T 2: 163,940,505 (GRCm39) probably benign Het
Tln1 T A 4: 43,539,508 (GRCm39) T1605S probably benign Het
Tln1 T C 4: 43,555,894 (GRCm39) T107A possibly damaging Het
Tmtc3 A G 10: 100,283,467 (GRCm39) M696T probably benign Het
Trbv28 T A 6: 41,248,761 (GRCm39) L97Q probably damaging Het
Trpc4ap A T 2: 155,481,455 (GRCm39) F534I possibly damaging Het
Trpm8 T C 1: 88,254,127 (GRCm39) Y117H probably damaging Het
Zfp608 T C 18: 55,120,871 (GRCm39) T239A probably benign Het
Zmym5 T G 14: 57,041,617 (GRCm39) H162P probably damaging Het
Other mutations in Tmem135
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL01459:Tmem135 APN 7 88,800,646 (GRCm39) missense probably damaging 1.00
IGL01730:Tmem135 APN 7 88,797,252 (GRCm39) missense possibly damaging 0.82
IGL02177:Tmem135 APN 7 88,987,661 (GRCm39) missense probably damaging 1.00
IGL02305:Tmem135 APN 7 88,814,331 (GRCm39) critical splice donor site probably null
IGL02747:Tmem135 APN 7 88,793,878 (GRCm39) missense probably damaging 0.98
IGL02801:Tmem135 APN 7 88,803,333 (GRCm39) missense probably benign 0.13
IGL03353:Tmem135 APN 7 88,791,161 (GRCm39) missense probably damaging 1.00
Skim UTSW 7 88,845,335 (GRCm39) nonsense probably null
R0631:Tmem135 UTSW 7 88,792,996 (GRCm39) nonsense probably null
R0657:Tmem135 UTSW 7 88,793,890 (GRCm39) missense probably damaging 0.96
R2233:Tmem135 UTSW 7 88,803,282 (GRCm39) missense probably damaging 1.00
R3118:Tmem135 UTSW 7 88,797,005 (GRCm39) missense probably benign 0.02
R3119:Tmem135 UTSW 7 88,797,005 (GRCm39) missense probably benign 0.02
R5094:Tmem135 UTSW 7 88,793,001 (GRCm39) missense probably damaging 1.00
R5225:Tmem135 UTSW 7 88,845,335 (GRCm39) nonsense probably null
R5248:Tmem135 UTSW 7 88,797,200 (GRCm39) missense probably damaging 1.00
R5356:Tmem135 UTSW 7 88,954,723 (GRCm39) missense probably benign 0.06
R5372:Tmem135 UTSW 7 88,814,382 (GRCm39) splice site probably null
R5442:Tmem135 UTSW 7 88,793,872 (GRCm39) missense probably damaging 1.00
R5789:Tmem135 UTSW 7 88,845,330 (GRCm39) missense possibly damaging 0.73
R5863:Tmem135 UTSW 7 88,797,176 (GRCm39) critical splice donor site probably null
R6158:Tmem135 UTSW 7 88,805,652 (GRCm39) missense probably benign 0.12
R6383:Tmem135 UTSW 7 88,793,878 (GRCm39) missense probably damaging 0.98
R6416:Tmem135 UTSW 7 88,797,002 (GRCm39) missense probably benign
R6659:Tmem135 UTSW 7 88,956,372 (GRCm39) nonsense probably null
R6659:Tmem135 UTSW 7 88,956,371 (GRCm39) missense probably benign 0.07
R6731:Tmem135 UTSW 7 88,893,172 (GRCm39) missense possibly damaging 0.96
R7545:Tmem135 UTSW 7 88,954,727 (GRCm39) missense probably damaging 1.00
R7626:Tmem135 UTSW 7 88,805,718 (GRCm39) splice site probably null
R8089:Tmem135 UTSW 7 88,805,703 (GRCm39) missense probably damaging 0.99
R8447:Tmem135 UTSW 7 88,803,240 (GRCm39) missense probably damaging 1.00
R8703:Tmem135 UTSW 7 88,808,170 (GRCm39) missense probably benign 0.00
R8750:Tmem135 UTSW 7 88,956,456 (GRCm39) missense probably damaging 0.99
R8758:Tmem135 UTSW 7 88,954,721 (GRCm39) missense probably benign 0.04
R8806:Tmem135 UTSW 7 88,797,186 (GRCm39) missense probably benign 0.25
R8807:Tmem135 UTSW 7 88,797,186 (GRCm39) missense probably benign 0.25
R8808:Tmem135 UTSW 7 88,797,186 (GRCm39) missense probably benign 0.25
R8835:Tmem135 UTSW 7 88,797,186 (GRCm39) missense probably benign 0.25
R8836:Tmem135 UTSW 7 88,797,186 (GRCm39) missense probably benign 0.25
R9093:Tmem135 UTSW 7 88,797,204 (GRCm39) missense probably benign 0.02
R9120:Tmem135 UTSW 7 88,797,186 (GRCm39) missense probably benign 0.25
R9122:Tmem135 UTSW 7 88,797,186 (GRCm39) missense probably benign 0.25
R9308:Tmem135 UTSW 7 88,797,186 (GRCm39) missense probably benign 0.25
R9649:Tmem135 UTSW 7 88,797,186 (GRCm39) missense probably benign 0.25
R9650:Tmem135 UTSW 7 88,797,186 (GRCm39) missense probably benign 0.25
Posted On 2014-05-07