Mutagenetix > Incidental Mutation

Incidental Mutation 'IGL01934:Vmn1r178'

180539

Institutional Source

Australian Phenomics Network (link to record)

Gene Symbol

Vmn1r178

Ensembl Gene

ENSMUSG00000062598

Gene Name

vomeronasal 1 receptor 178

Synonyms

V1rd13, LOC232959

Accession Numbers

Essential gene?

Probably non essential (E-score: 0.051) question?

Stock #

IGL01934

Quality Score

Status

Chromosome

Chromosomal Location

23592954-23593868 bp(+) (GRCm39)

Type of Mutation

missense

DNA Base Change (assembly)

T to C at 23593362 bp (GRCm39)

Zygosity

Heterozygous

Amino Acid Change

Tyrosine to Histidine at position 137 (Y137H)

Ref Sequence

ENSEMBL: ENSMUSP00000154244 (fasta)

Gene Model

predicted gene model for transcript(s): [ENSMUST00000078593] [ENSMUST00000226450] [ENSMUST00000226489] [ENSMUST00000226640] [ENSMUST00000227993]

AlphaFold

Q8R2B6

Predicted Effect

probably damaging
Transcript: ENSMUST00000078593
AA Change: Y137H

PolyPhen 2 Score 1.000 (Sensitivity: 0.00; Specificity: 1.00)

SMART Domains

Protein: ENSMUSP00000077666
Gene: ENSMUSG00000062598
AA Change: Y137H

Domain	Start	End	E-Value	Type
Pfam:TAS2R	8	297	7.9e-11	PFAM
Pfam:7tm_1	15	283	2.5e-7	PFAM
Pfam:V1R	41	296	7.8e-19	PFAM

Predicted Effect

probably damaging
Transcript: ENSMUST00000226450
AA Change: Y137H

PolyPhen 2 Score 1.000 (Sensitivity: 0.00; Specificity: 1.00)

Predicted Effect

probably damaging
Transcript: ENSMUST00000226489
AA Change: Y64H

PolyPhen 2 Score 1.000 (Sensitivity: 0.00; Specificity: 1.00)

Predicted Effect

probably damaging
Transcript: ENSMUST00000226640
AA Change: Y64H

PolyPhen 2 Score 1.000 (Sensitivity: 0.00; Specificity: 1.00)

Predicted Effect

probably damaging
Transcript: ENSMUST00000227993
AA Change: Y137H

PolyPhen 2 Score 1.000 (Sensitivity: 0.00; Specificity: 1.00)

Coding Region Coverage

Validation Efficiency

Allele List at MGI

Other mutations in this stock

Total: 58 list
Gene	Ref	Var	Chr/Loc	Mutation	Predicted Effect	Zygosity
4931414P19Rik	T	C	14: 54,823,112 (GRCm39)	K362E	probably damaging	Het
4932438H23Rik	T	A	16: 90,852,753 (GRCm39)	T128S	probably damaging	Het
Aars1	T	A	8: 111,774,650 (GRCm39)	I593N	probably damaging	Het
Abca6	A	T	11: 110,079,481 (GRCm39)	N1224K	probably benign	Het
Abcc5	A	T	16: 20,241,191 (GRCm39)		probably benign	Het
Adam7	A	G	14: 68,770,048 (GRCm39)	L35P	probably damaging	Het
Ahnak	T	A	19: 8,980,021 (GRCm39)	L435Q	probably damaging	Het
Ankef1	A	G	2: 136,394,451 (GRCm39)	E620G	possibly damaging	Het
Aoc1l3	A	T	6: 48,965,695 (GRCm39)	I568F	probably damaging	Het
Ap3d1	A	T	10: 80,545,092 (GRCm39)	L1082*	probably null	Het
Atp6v0a4	T	A	6: 38,028,481 (GRCm39)	I712F	possibly damaging	Het
Bco1	T	A	8: 117,822,784 (GRCm39)	F5L	possibly damaging	Het
Cacna2d4	A	T	6: 119,285,729 (GRCm39)	S794C	probably damaging	Het
Camk2d	T	C	3: 126,628,304 (GRCm39)		probably null	Het
Capn15	T	C	17: 26,181,998 (GRCm39)	T604A	probably damaging	Het
Cd180	A	T	13: 102,839,366 (GRCm39)	D83V	probably damaging	Het
Ces1a	C	A	8: 93,759,278 (GRCm39)	R286L	probably damaging	Het
Col6a6	A	G	9: 105,575,858 (GRCm39)		probably null	Het
Crnkl1	A	G	2: 145,773,202 (GRCm39)	V148A	probably benign	Het
Epas1	A	T	17: 87,131,157 (GRCm39)	K312N	probably damaging	Het
Fbxw2	T	C	2: 34,712,618 (GRCm39)	S148G	probably damaging	Het
Fig4	T	C	10: 41,104,108 (GRCm39)	T791A	probably benign	Het
Galnt9	A	T	5: 110,750,502 (GRCm39)	I340F	possibly damaging	Het
Gfap	G	A	11: 102,785,286 (GRCm39)	A230V	probably damaging	Het
Gm10718	A	T	9: 3,025,118 (GRCm39)	Y194F	probably benign	Het
Gm454	T	C	5: 138,205,424 (GRCm39)		noncoding transcript	Het
Il24	A	T	1: 130,811,614 (GRCm39)	L115Q	probably damaging	Het
Ipp	C	A	4: 116,367,852 (GRCm39)	N28K	probably damaging	Het
Kalrn	A	T	16: 34,018,882 (GRCm39)		probably null	Het
Klf10	C	T	15: 38,297,528 (GRCm39)	V171M	probably benign	Het
Man1b1	T	C	2: 25,235,523 (GRCm39)	S350P	probably benign	Het
Mfsd4a	T	C	1: 131,974,049 (GRCm39)	Y343C	probably damaging	Het
Mrpl58	C	A	11: 115,301,555 (GRCm39)		probably benign	Het
Myo7b	A	G	18: 32,134,394 (GRCm39)		probably null	Het
Nbas	T	C	12: 13,339,880 (GRCm39)		probably benign	Het
Nisch	A	G	14: 30,898,696 (GRCm39)		probably benign	Het
Or1o2	A	T	17: 37,542,439 (GRCm39)	V274D	probably damaging	Het
Or52z14	T	C	7: 103,253,182 (GRCm39)	F107S	probably damaging	Het
Or5p69	A	G	7: 107,967,368 (GRCm39)	I224V	probably damaging	Het
Parva	T	A	7: 112,187,760 (GRCm39)	C352*	probably null	Het
Ptf1a	T	A	2: 19,451,431 (GRCm39)	C254S	possibly damaging	Het
R3hdm1	G	T	1: 128,164,272 (GRCm39)	R1062L	probably benign	Het
Rnf44	A	G	13: 54,829,763 (GRCm39)	V407A	probably damaging	Het
Shank3	T	C	15: 89,434,049 (GRCm39)	L1598P	probably damaging	Het
Slit2	T	C	5: 48,395,747 (GRCm39)	S717P	possibly damaging	Het
Tdpoz4	A	G	3: 93,704,779 (GRCm39)	K359E	probably damaging	Het
Tmtc4	A	T	14: 123,165,047 (GRCm39)	L604*	probably null	Het
Tnfrsf21	A	T	17: 43,376,078 (GRCm39)	N488I	probably benign	Het
Tnfsf8	A	G	4: 63,752,747 (GRCm39)		probably benign	Het
Tnpo3	A	T	6: 29,575,019 (GRCm39)	L382M	probably benign	Het
Tut1	T	C	19: 8,931,355 (GRCm39)	C18R	probably damaging	Het
Ugt8a	A	G	3: 125,708,424 (GRCm39)	S229P	probably benign	Het
Usp22	T	C	11: 61,046,114 (GRCm39)	E476G	probably damaging	Het
Vill	G	T	9: 118,895,877 (GRCm39)	A146S	probably damaging	Het
Wdfy1	A	T	1: 79,717,833 (GRCm39)	W51R	probably damaging	Het
Zc3hav1	A	T	6: 38,296,768 (GRCm39)		probably null	Het
Zfp236	A	T	18: 82,651,245 (GRCm39)	V889E	probably damaging	Het
Zscan20	T	C	4: 128,486,277 (GRCm39)	D141G	possibly damaging	Het

Other mutations in Vmn1r178

Allele	Source	Chr	Coord	Type	Predicted Effect	PPH Score
IGL01697:Vmn1r178	APN	7	23,593,114 (GRCm39)	missense	probably damaging	0.99
IGL01781:Vmn1r178	APN	7	23,593,434 (GRCm39)	missense	probably damaging	1.00
IGL02571:Vmn1r178	APN	7	23,593,660 (GRCm39)	missense	probably damaging	0.99
IGL02727:Vmn1r178	APN	7	23,593,871 (GRCm39)	splice site	probably null
IGL03112:Vmn1r178	APN	7	23,593,086 (GRCm39)	missense	probably damaging	1.00
R0112:Vmn1r178	UTSW	7	23,593,609 (GRCm39)	missense	possibly damaging	0.93
R0830:Vmn1r178	UTSW	7	23,593,452 (GRCm39)	missense	possibly damaging	0.91
R1186:Vmn1r178	UTSW	7	23,593,317 (GRCm39)	nonsense	probably null
R1340:Vmn1r178	UTSW	7	23,593,281 (GRCm39)	missense	probably benign	0.34
R1640:Vmn1r178	UTSW	7	23,593,548 (GRCm39)	missense	possibly damaging	0.70
R1696:Vmn1r178	UTSW	7	23,593,625 (GRCm39)	missense	probably damaging	0.99
R1746:Vmn1r178	UTSW	7	23,593,329 (GRCm39)	missense	probably benign	0.00
R3084:Vmn1r178	UTSW	7	23,593,331 (GRCm39)	missense	possibly damaging	0.94
R4368:Vmn1r178	UTSW	7	23,593,447 (GRCm39)	missense	probably damaging	1.00
R5199:Vmn1r178	UTSW	7	23,593,814 (GRCm39)	missense	probably benign	0.11
R6380:Vmn1r178	UTSW	7	23,592,984 (GRCm39)	missense	possibly damaging	0.62
R7000:Vmn1r178	UTSW	7	23,593,762 (GRCm39)	missense	probably benign	0.21
R7142:Vmn1r178	UTSW	7	23,593,035 (GRCm39)	missense	probably damaging	1.00
R7268:Vmn1r178	UTSW	7	23,593,378 (GRCm39)	missense	probably benign	0.05
R8829:Vmn1r178	UTSW	7	23,593,264 (GRCm39)	missense	probably damaging	1.00
R8832:Vmn1r178	UTSW	7	23,593,264 (GRCm39)	missense	probably damaging	1.00
R9068:Vmn1r178	UTSW	7	23,593,404 (GRCm39)	missense	probably damaging	1.00
R9798:Vmn1r178	UTSW	7	23,593,733 (GRCm39)	nonsense	probably null

Posted On

2014-05-07