Mutagenetix > Incidental Mutation

Incidental Mutation 'IGL01935:Or11g1'

180596

Institutional Source

Australian Phenomics Network (link to record)

Gene Symbol

Or11g1

Ensembl Gene

ENSMUSG00000094692

Gene Name

olfactory receptor family 11 subfamily G member 1

Synonyms

GA_x6K02T2PMLR-6110726-6111661, Olfr738, MOR106-3

Accession Numbers

Essential gene?

Probably non essential (E-score: 0.088) question?

Stock #

IGL01935

Quality Score

Status

Chromosome

Chromosomal Location

50651003-50651938 bp(+) (GRCm39)

Type of Mutation

missense

DNA Base Change (assembly)

T to C at 50651012 bp (GRCm39)

Zygosity

Heterozygous

Amino Acid Change

Phenylalanine to Leucine at position 4 (F4L)

Ref Sequence

ENSEMBL: ENSMUSP00000150351 (fasta)

Gene Model

predicted gene model for transcript(s): [ENSMUST00000058972] [ENSMUST00000214320] [ENSMUST00000214853]

AlphaFold

L7N1X7

Predicted Effect

probably benign
Transcript: ENSMUST00000058972
AA Change: F4L

PolyPhen 2 Score 0.000 (Sensitivity: 1.00; Specificity: 0.00)

SMART Domains

Protein: ENSMUSP00000059540
Gene: ENSMUSG00000094692
AA Change: F4L

Domain	Start	End	E-Value	Type
Pfam:7tm_4	35	311	2.5e-50	PFAM
Pfam:7TM_GPCR_Srsx	39	309	1.3e-5	PFAM
Pfam:7tm_1	45	294	6.9e-22	PFAM

Predicted Effect

noncoding transcript
Transcript: ENSMUST00000205382

Predicted Effect

probably benign
Transcript: ENSMUST00000214320
AA Change: F4L

PolyPhen 2 Score 0.000 (Sensitivity: 1.00; Specificity: 0.00)

Predicted Effect

probably benign
Transcript: ENSMUST00000214853
AA Change: F4L

PolyPhen 2 Score 0.000 (Sensitivity: 1.00; Specificity: 0.00)

Coding Region Coverage

Validation Efficiency

MGI Phenotype

FUNCTION: Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitter and hormone receptors and are responsible for the recognition and G protein-mediated transduction of odorant signals. The olfactory receptor gene family is the largest in the genome. The nomenclature assigned to the olfactory receptor genes and proteins for this organism is independent of other organisms. [provided by RefSeq, Jul 2008]

Allele List at MGI

Other mutations in this stock

Total: 55 list
Gene	Ref	Var	Chr/Loc	Mutation	Predicted Effect	Zygosity
Aebp2	C	T	6: 140,583,383 (GRCm39)		probably benign	Het
Akr1c12	A	T	13: 4,322,244 (GRCm39)	V266E	probably damaging	Het
Arhgef1	A	G	7: 24,621,307 (GRCm39)	T186A	probably damaging	Het
Atp8b5	A	G	4: 43,366,638 (GRCm39)	T801A	probably benign	Het
Card11	T	A	5: 140,869,301 (GRCm39)	I832F	possibly damaging	Het
Catsperg1	T	C	7: 28,895,296 (GRCm39)		probably null	Het
Ccdc180	A	G	4: 45,906,889 (GRCm39)	T455A	possibly damaging	Het
Cfhr1	T	A	1: 139,478,740 (GRCm39)	Y210F	probably benign	Het
Chrna5	T	C	9: 54,912,127 (GRCm39)	V309A	probably benign	Het
Clstn2	A	G	9: 97,345,521 (GRCm39)	V609A	probably damaging	Het
Dnah6	T	C	6: 73,037,126 (GRCm39)	D3372G	probably benign	Het
Dtymk	T	C	1: 93,722,465 (GRCm39)	K113E	probably benign	Het
Eef2k	T	C	7: 120,485,054 (GRCm39)	F307S	probably damaging	Het
Flnc	T	A	6: 29,454,279 (GRCm39)	V1864E	probably damaging	Het
Gm10717	C	T	9: 3,025,616 (GRCm39)	S67L	probably benign	Het
Herc2	A	G	7: 55,803,541 (GRCm39)	Y2192C	probably benign	Het
Hkdc1	A	T	10: 62,236,165 (GRCm39)	V459E	probably damaging	Het
Iqsec3	T	C	6: 121,360,951 (GRCm39)	D969G	probably damaging	Het
Irf3	A	G	7: 44,650,194 (GRCm39)	T237A	probably benign	Het
Jade2	G	A	11: 51,719,211 (GRCm39)	T245I	possibly damaging	Het
Kctd8	A	G	5: 69,497,707 (GRCm39)	I313T	possibly damaging	Het
Kdm5a	T	A	6: 120,385,284 (GRCm39)	S835R	probably benign	Het
Lama2	A	C	10: 27,298,600 (GRCm39)	H165Q	probably damaging	Het
Lrp1b	T	A	2: 41,158,367 (GRCm39)	N1617Y	probably damaging	Het
Mcc	C	T	18: 44,652,583 (GRCm39)		probably null	Het
Mfsd14b	T	A	13: 65,215,739 (GRCm39)	M405L	probably benign	Het
Myom3	T	A	4: 135,515,692 (GRCm39)	F794I	probably damaging	Het
Napsa	G	T	7: 44,236,046 (GRCm39)	A362S	probably benign	Het
Ncf4	A	T	15: 78,140,186 (GRCm39)	D195V	probably damaging	Het
Pank4	T	G	4: 155,063,987 (GRCm39)	D659E	probably damaging	Het
Pcnx1	T	A	12: 81,964,590 (GRCm39)	D252E	probably benign	Het
Pglyrp2	G	A	17: 32,637,551 (GRCm39)	A159V	probably benign	Het
Phaf1	T	C	8: 105,966,633 (GRCm39)	F127L	probably damaging	Het
Pisd	C	A	5: 32,896,476 (GRCm39)		probably null	Het
Ppfia4	A	G	1: 134,245,674 (GRCm39)	S627P	probably benign	Het
Ppp1r15b	T	C	1: 133,059,761 (GRCm39)	F93L	probably benign	Het
Pramel13	C	T	4: 144,119,172 (GRCm39)		probably benign	Het
Qrfpr	A	T	3: 36,235,200 (GRCm39)		probably null	Het
Rapgef4	C	A	2: 72,064,467 (GRCm39)	T623K	probably benign	Het
Rapgef6	A	G	11: 54,501,668 (GRCm39)	T184A	possibly damaging	Het
Ssrp1	T	C	2: 84,877,056 (GRCm39)	*709Q	probably null	Het
St7	T	G	6: 17,930,822 (GRCm39)	I442S	probably damaging	Het
Syne2	T	A	12: 75,972,087 (GRCm39)	H992Q	probably damaging	Het
Syt14	T	C	1: 192,615,679 (GRCm39)	R436G	probably damaging	Het
Tbc1d5	A	G	17: 51,270,793 (GRCm39)		probably benign	Het
Thsd7a	T	A	6: 12,317,418 (GRCm39)	N1630I	probably damaging	Het
Tinagl1	T	C	4: 130,061,794 (GRCm39)	K180R	probably damaging	Het
Tmed7	T	C	18: 46,730,190 (GRCm39)	T54A	probably benign	Het
Tmprss2	A	T	16: 97,379,795 (GRCm39)	Y48*	probably null	Het
Tns2	C	T	15: 102,020,069 (GRCm39)		probably null	Het
Unc13d	T	C	11: 115,960,577 (GRCm39)	M496V	probably benign	Het
Vmn2r129	C	T	4: 156,690,549 (GRCm39)		noncoding transcript	Het
Zbtb39	A	G	10: 127,578,235 (GRCm39)	T270A	probably benign	Het
Zfr	T	C	15: 12,180,798 (GRCm39)	S976P	probably benign	Het
Zscan29	A	G	2: 121,000,538 (GRCm39)	F23S	probably damaging	Het

Other mutations in Or11g1

Allele	Source	Chr	Coord	Type	Predicted Effect	PPH Score
IGL01608:Or11g1	APN	14	50,651,910 (GRCm39)	missense	probably benign
IGL02431:Or11g1	APN	14	50,651,226 (GRCm39)	missense	probably damaging	1.00
BB008:Or11g1	UTSW	14	50,651,786 (GRCm39)	missense	probably damaging	0.96
BB018:Or11g1	UTSW	14	50,651,786 (GRCm39)	missense	probably damaging	0.96
PIT4480001:Or11g1	UTSW	14	50,651,372 (GRCm39)	missense	probably benign	0.14
R0620:Or11g1	UTSW	14	50,651,154 (GRCm39)	missense	probably benign	0.20
R1445:Or11g1	UTSW	14	50,651,858 (GRCm39)	missense	probably damaging	1.00
R1831:Or11g1	UTSW	14	50,651,658 (GRCm39)	splice site	probably null
R1915:Or11g1	UTSW	14	50,651,798 (GRCm39)	missense	probably damaging	1.00
R4748:Or11g1	UTSW	14	50,651,333 (GRCm39)	missense	possibly damaging	0.77
R5301:Or11g1	UTSW	14	50,651,030 (GRCm39)	missense	probably benign	0.09
R5767:Or11g1	UTSW	14	50,651,235 (GRCm39)	missense	possibly damaging	0.55
R5831:Or11g1	UTSW	14	50,651,439 (GRCm39)	splice site	probably null
R6173:Or11g1	UTSW	14	50,651,654 (GRCm39)	missense	possibly damaging	0.70
R6176:Or11g1	UTSW	14	50,651,847 (GRCm39)	missense	probably damaging	1.00
R7356:Or11g1	UTSW	14	50,651,159 (GRCm39)	missense	probably damaging	1.00
R7678:Or11g1	UTSW	14	50,651,471 (GRCm39)	missense	probably damaging	0.98
R7931:Or11g1	UTSW	14	50,651,786 (GRCm39)	missense	probably damaging	0.96
R8508:Or11g1	UTSW	14	50,651,132 (GRCm39)	missense	probably benign	0.00
R8696:Or11g1	UTSW	14	50,651,420 (GRCm39)	missense	possibly damaging	0.95
R9374:Or11g1	UTSW	14	50,651,625 (GRCm39)	missense	probably benign	0.38
R9470:Or11g1	UTSW	14	50,651,235 (GRCm39)	missense	possibly damaging	0.55
R9551:Or11g1	UTSW	14	50,651,625 (GRCm39)	missense	probably benign	0.38

Posted On

2014-05-07