Mutagenetix > Incidental Mutation

Incidental Mutation 'R0063:Dock2'

18074

Institutional Source

Beutler Lab

Gene Symbol

Dock2

Ensembl Gene

ENSMUSG00000020143

Gene Name

dedicator of cyto-kinesis 2

Synonyms

CED-5, MBC, Hch

MMRRC Submission

038355-MU

Accession Numbers

Essential gene?

Non essential (E-score: 0.000) question?

Stock #

R0063 (G1)

Quality Score

Status

Validated

Chromosome

Chromosomal Location

34226815-34783892 bp(-) (GRCm38)

Type of Mutation

critical splice acceptor site

DNA Base Change (assembly)

T to A at 34756284 bp (GRCm38)

Zygosity

Heterozygous

Amino Acid Change

Ref Sequence

ENSEMBL: ENSMUSP00000098916 (fasta)

Gene Model

predicted gene model for transcript(s): [ENSMUST00000093193] [ENSMUST00000101365] [ENSMUST00000143540]

AlphaFold

Q8C3J5

Predicted Effect

probably null
Transcript: ENSMUST00000093193

SMART Domains

Protein: ENSMUSP00000090884
Gene: ENSMUSG00000020143

Domain	Start	End	E-Value	Type
SH3	11	68	1.22e-11	SMART
Pfam:DOCK_N	71	414	2e-113	PFAM
Pfam:DOCK-C2	419	616	1e-60	PFAM
Pfam:DHR-2	1114	1614	6.3e-96	PFAM
low complexity region	1691	1706	N/A	INTRINSIC
low complexity region	1793	1800	N/A	INTRINSIC

Predicted Effect

probably null
Transcript: ENSMUST00000101365

SMART Domains

Protein: ENSMUSP00000098916
Gene: ENSMUSG00000020143

Domain	Start	End	E-Value	Type
SH3	11	68	1.22e-11	SMART
Pfam:DOCK_N	71	414	1.4e-113	PFAM
Pfam:DOCK-C2	419	616	5.5e-61	PFAM
low complexity region	1163	1171	N/A	INTRINSIC

Predicted Effect

probably benign
Transcript: ENSMUST00000143540

SMART Domains

Protein: ENSMUSP00000116893
Gene: ENSMUSG00000020143

Domain	Start	End	E-Value	Type
SH3	11	68	1.22e-11	SMART
Pfam:DOCK-C2	418	617	1.8e-55	PFAM

Predicted Effect

noncoding transcript
Transcript: ENSMUST00000154178

Meta Mutation Damage Score

0.9498

Coding Region Coverage

1x: 89.1%
3x: 86.1%
10x: 78.0%
20x: 64.7%

Validation Efficiency

99% (86/87)

MGI Phenotype

FUNCTION: [Summary is not available for the mouse gene. This summary is for the human ortholog.] The protein encoded by this gene belongs to the CDM protein family. It is specifically expressed in hematopoietic cells and is predominantly expressed in peripheral blood leukocytes. The protein is involved in remodeling of the actin cytoskeleton required for lymphocyte migration in response to chemokine signaling. It activates members of the Rho family of GTPases, for example RAC1 and RAC2, by acting as a guanine nucleotide exchange factor (GEF) to exchange bound GDP for free GTP. [provided by RefSeq, Oct 2016]
PHENOTYPE: Homozygous mutants are defective in the migration of T and B lympohcytes in response to chemokines, and thus display immune defects such as lymphocytopenia, atrophy of lymphoid follicles and loss of marginal-zone B cells. [provided by MGI curators]

Allele List at MGI

Other mutations in this stock

Total: 45 list
Gene	Ref	Var	Chr/Loc	Mutation	Predicted Effect	Zygosity
4930562C15Rik	C	T	16: 4,861,048 (GRCm38)	R245*	probably null	Het
4930563I02Rik	T	A	14: 60,096,028 (GRCm38)		probably benign	Het
Acss1	T	C	2: 150,627,292 (GRCm38)	T435A	probably damaging	Het
Aoc2	T	A	11: 101,326,071 (GRCm38)	S327T	probably damaging	Het
Arid5a	T	A	1: 36,318,564 (GRCm38)	Y252N	probably damaging	Het
AU040320	T	C	4: 126,839,672 (GRCm38)	Y662H	probably damaging	Het
Bcam	C	T	7: 19,766,848 (GRCm38)	V134I	probably benign	Het
Btbd16	A	T	7: 130,823,166 (GRCm38)	T426S	probably benign	Het
Cap2	T	C	13: 46,638,032 (GRCm38)		probably benign	Het
Capn8	T	A	1: 182,602,112 (GRCm38)	D299E	probably damaging	Het
Cdipt	G	A	7: 126,979,600 (GRCm38)	V160I	probably benign	Het
Cyb5r3	T	C	15: 83,161,936 (GRCm38)	T60A	probably benign	Het
Dazl	T	C	17: 152,705,859 (NCBIm37)	T212A	probably damaging	Het
Dgkb	T	G	12: 38,604,113 (GRCm38)	S744A	probably benign	Het
Ece2	A	G	16: 20,642,317 (GRCm38)	T442A	probably benign	Het
Elapor2	T	C	5: 9,440,709 (GRCm38)		probably benign	Het
Emid1	A	T	11: 5,139,704 (GRCm38)		probably benign	Het
Eml3	C	A	19: 8,938,478 (GRCm38)	A644D	probably damaging	Het
Foxp1	A	G	6: 98,944,723 (GRCm38)		probably benign	Het
Ints8	T	C	4: 11,252,857 (GRCm38)	N75S	probably damaging	Het
Irs1	T	A	1: 82,288,859 (GRCm38)	E545D	probably damaging	Het
Lama3	T	C	18: 12,528,705 (GRCm38)		probably benign	Het
Nat8f2	A	T	6: 85,867,833 (GRCm38)	S182R	possibly damaging	Het
Nrcam	G	T	12: 44,550,028 (GRCm38)	V343F	possibly damaging	Het
Pdk2	T	C	11: 95,032,480 (GRCm38)	H106R	probably benign	Het
Pkhd1	G	A	1: 20,211,950 (GRCm38)	T2889I	probably benign	Het
Pkhd1l1	T	A	15: 44,529,237 (GRCm38)	L1656H	probably damaging	Het
Plxna2	A	T	1: 194,644,939 (GRCm38)	T394S	probably benign	Het
Pnpla8	T	A	12: 44,282,832 (GRCm38)	C56S	probably damaging	Het
Prdm8	G	T	5: 98,184,594 (GRCm38)	R118L	probably damaging	Het
Prkce	T	C	17: 86,482,111 (GRCm38)		probably benign	Het
Ptprk	T	A	10: 28,263,767 (GRCm38)	Y163N	probably damaging	Het
Rbbp8	T	A	18: 11,734,557 (GRCm38)		probably benign	Het
Sephs1	A	G	2: 4,899,560 (GRCm38)	T250A	probably benign	Het
Slc2a2	T	C	3: 28,717,440 (GRCm38)	M173T	probably damaging	Het
Slc2a8	T	A	2: 32,979,999 (GRCm38)		probably null	Het
Tmem131	C	T	1: 36,819,128 (GRCm38)	V713I	probably benign	Het
Tmem89	A	G	9: 108,914,812 (GRCm38)	N60S	probably benign	Het
Trio	G	T	15: 27,881,437 (GRCm38)		probably benign	Het
Tulp2	T	C	7: 45,520,860 (GRCm38)		probably benign	Het
Uggt2	A	G	14: 119,007,130 (GRCm38)		probably benign	Het
Vwa8	A	G	14: 79,164,216 (GRCm38)		probably benign	Het
Xirp2	A	G	2: 67,509,083 (GRCm38)	D556G	probably damaging	Het
Xrn1	T	C	9: 95,969,535 (GRCm38)	L202P	probably damaging	Het
Zfp354a	A	T	11: 51,069,571 (GRCm38)	H203L	probably damaging	Het

Other mutations in Dock2

Allele	Source	Chr	Coord	Type	Predicted Effect	PPH Score
IGL00334:Dock2	APN	11	34,704,661 (GRCm38)	missense	probably damaging	1.00
IGL00469:Dock2	APN	11	34,229,603 (GRCm38)	splice site	probably benign
IGL01061:Dock2	APN	11	34,705,826 (GRCm38)	missense	probably damaging	1.00
IGL01319:Dock2	APN	11	34,698,790 (GRCm38)	missense	possibly damaging	0.61
IGL01451:Dock2	APN	11	34,310,390 (GRCm38)	missense	probably damaging	1.00
IGL01490:Dock2	APN	11	34,705,781 (GRCm38)	missense	probably damaging	0.97
IGL01601:Dock2	APN	11	34,239,528 (GRCm38)	critical splice donor site	probably null
IGL01800:Dock2	APN	11	34,756,273 (GRCm38)	missense	probably damaging	1.00
IGL01804:Dock2	APN	11	34,262,433 (GRCm38)	missense	probably benign	0.01
IGL01823:Dock2	APN	11	34,262,391 (GRCm38)	missense	probably damaging	1.00
IGL01829:Dock2	APN	11	34,705,841 (GRCm38)	missense	probably damaging	0.98
IGL01830:Dock2	APN	11	34,691,917 (GRCm38)	nonsense	probably null
IGL01835:Dock2	APN	11	34,310,435 (GRCm38)	missense	possibly damaging	0.51
IGL01845:Dock2	APN	11	34,708,865 (GRCm38)	missense	probably benign	0.02
IGL01953:Dock2	APN	11	34,732,356 (GRCm38)	missense	probably benign	0.28
IGL01989:Dock2	APN	11	34,268,053 (GRCm38)	missense	probably benign
IGL02081:Dock2	APN	11	34,254,355 (GRCm38)	missense	probably benign
IGL02105:Dock2	APN	11	34,714,525 (GRCm38)	missense	probably damaging	1.00
IGL02153:Dock2	APN	11	34,230,670 (GRCm38)	missense	probably benign	0.01
IGL02170:Dock2	APN	11	34,267,949 (GRCm38)	missense	probably damaging	1.00
IGL02344:Dock2	APN	11	34,731,510 (GRCm38)	missense	probably damaging	0.98
IGL02389:Dock2	APN	11	34,698,740 (GRCm38)	splice site	probably benign
IGL02409:Dock2	APN	11	34,501,204 (GRCm38)	missense	probably benign	0.00
IGL02472:Dock2	APN	11	34,249,801 (GRCm38)	missense	probably benign	0.00
IGL02625:Dock2	APN	11	34,501,168 (GRCm38)	critical splice donor site	probably null
IGL02929:Dock2	APN	11	34,268,048 (GRCm38)	missense	probably damaging	1.00
IGL02951:Dock2	APN	11	34,310,448 (GRCm38)	unclassified	probably benign
IGL02999:Dock2	APN	11	34,692,259 (GRCm38)	missense	probably damaging	0.99
IGL03165:Dock2	APN	11	34,687,533 (GRCm38)	missense	probably damaging	0.99
Arches	UTSW	11	34,689,760 (GRCm38)	missense	probably damaging	1.00
capitol_reef	UTSW	11	34,294,170 (GRCm38)	critical splice acceptor site	probably null
Croesus	UTSW	11	34,721,027 (GRCm38)	missense	probably damaging	1.00
denali	UTSW	11	34,229,472 (GRCm38)	critical splice donor site	probably null
dew	UTSW	11	34,248,636 (GRCm38)	nonsense	probably null
Dinghy	UTSW	11	34,262,460 (GRCm38)	missense	possibly damaging	0.70
Dry	UTSW	11	34,231,652 (GRCm38)	missense	possibly damaging	0.79
frazz	UTSW	11	34,248,572 (GRCm38)	critical splice donor site	probably benign
frizz	UTSW	11	34,258,184 (GRCm38)	splice site	probably benign
gildenstern	UTSW	11	34,732,339 (GRCm38)	critical splice donor site	probably null
godsgrace	UTSW	11	34,695,453 (GRCm38)	missense	probably damaging	1.00
Harborside	UTSW	11	34,262,445 (GRCm38)	missense	probably benign
Landing	UTSW	11	34,714,501 (GRCm38)	missense	possibly damaging	0.83
latest	UTSW	11	34,756,222 (GRCm38)	missense	probably damaging	1.00
Launch	UTSW	11	34,256,562 (GRCm38)	missense	probably damaging	1.00
liaoning	UTSW	11	34,708,793 (GRCm38)	missense	probably damaging	1.00
lucre	UTSW	11	34,704,609 (GRCm38)	frame shift	probably null
midas	UTSW	11	34,294,323 (GRCm38)	missense	probably damaging	0.99
muelle	UTSW	11	34,687,538 (GRCm38)	missense	probably damaging	1.00
narrowest	UTSW	11	34,282,652 (GRCm38)	missense	probably damaging	0.98
pier	UTSW	11	34,689,766 (GRCm38)	missense	probably damaging	1.00
Plank	UTSW	11	34,783,795 (GRCm38)	missense	possibly damaging	0.51
resplendent	UTSW	11	34,727,460 (GRCm38)	nonsense	probably null
riches	UTSW	11	34,688,452 (GRCm38)	critical splice donor site	probably null
skiff	UTSW	11	34,262,388 (GRCm38)	missense	probably null	0.80
Slip	UTSW	11	34,294,286 (GRCm38)	missense	probably benign	0.25
toothskin	UTSW	11	34,464,922 (GRCm38)	missense	probably damaging	1.00
Touch	UTSW	11	34,273,750 (GRCm38)	missense	possibly damaging	0.95
wassup	UTSW	11	34,503,413 (GRCm38)	missense	probably damaging	1.00
Wharf	UTSW	11	34,732,371 (GRCm38)	missense	possibly damaging	0.81
BB009:Dock2	UTSW	11	34,267,998 (GRCm38)	missense	probably benign	0.00
BB019:Dock2	UTSW	11	34,267,998 (GRCm38)	missense	probably benign	0.00
IGL03052:Dock2	UTSW	11	34,232,853 (GRCm38)	missense	probably benign	0.01
PIT4377001:Dock2	UTSW	11	34,721,008 (GRCm38)	missense	probably benign	0.02
R0006:Dock2	UTSW	11	34,312,453 (GRCm38)	unclassified	probably benign
R0012:Dock2	UTSW	11	34,783,795 (GRCm38)	missense	possibly damaging	0.51
R0063:Dock2	UTSW	11	34,756,284 (GRCm38)	critical splice acceptor site	probably null
R0116:Dock2	UTSW	11	34,688,565 (GRCm38)	intron	probably benign
R0149:Dock2	UTSW	11	34,438,327 (GRCm38)	missense	probably damaging	1.00
R0361:Dock2	UTSW	11	34,438,327 (GRCm38)	missense	probably damaging	1.00
R0462:Dock2	UTSW	11	34,268,052 (GRCm38)	missense	possibly damaging	0.74
R0471:Dock2	UTSW	11	34,688,553 (GRCm38)	missense	probably benign	0.30
R0538:Dock2	UTSW	11	34,704,718 (GRCm38)	splice site	probably benign
R0543:Dock2	UTSW	11	34,294,325 (GRCm38)	missense	probably damaging	1.00
R0660:Dock2	UTSW	11	34,248,621 (GRCm38)	missense	probably damaging	1.00
R0676:Dock2	UTSW	11	34,695,236 (GRCm38)	missense	probably damaging	0.99
R0722:Dock2	UTSW	11	34,464,970 (GRCm38)	splice site	probably benign
R0801:Dock2	UTSW	11	34,708,793 (GRCm38)	missense	probably damaging	1.00
R1110:Dock2	UTSW	11	34,256,535 (GRCm38)	missense	possibly damaging	0.78
R1171:Dock2	UTSW	11	34,695,241 (GRCm38)	missense	probably damaging	1.00
R1387:Dock2	UTSW	11	34,273,309 (GRCm38)	splice site	probably benign
R1445:Dock2	UTSW	11	34,239,705 (GRCm38)	missense	probably benign
R1494:Dock2	UTSW	11	34,282,761 (GRCm38)	nonsense	probably null
R1589:Dock2	UTSW	11	34,706,461 (GRCm38)	missense	probably damaging	0.99
R1597:Dock2	UTSW	11	34,704,647 (GRCm38)	missense	probably benign	0.00
R1629:Dock2	UTSW	11	34,262,480 (GRCm38)	splice site	probably null
R1749:Dock2	UTSW	11	34,232,767 (GRCm38)	critical splice donor site	probably null
R1888:Dock2	UTSW	11	34,707,342 (GRCm38)	missense	probably damaging	1.00
R1888:Dock2	UTSW	11	34,707,342 (GRCm38)	missense	probably damaging	1.00
R1899:Dock2	UTSW	11	34,294,286 (GRCm38)	missense	probably benign	0.25
R1924:Dock2	UTSW	11	34,464,934 (GRCm38)	missense	possibly damaging	0.69
R2031:Dock2	UTSW	11	34,727,470 (GRCm38)	splice site	probably benign
R2045:Dock2	UTSW	11	34,294,106 (GRCm38)	splice site	probably null
R2098:Dock2	UTSW	11	34,719,005 (GRCm38)	missense	probably damaging	0.99
R2098:Dock2	UTSW	11	34,266,279 (GRCm38)	missense	probably benign	0.16
R2129:Dock2	UTSW	11	34,727,415 (GRCm38)	missense	probably damaging	1.00
R2147:Dock2	UTSW	11	34,229,472 (GRCm38)	critical splice donor site	probably null
R2149:Dock2	UTSW	11	34,229,472 (GRCm38)	critical splice donor site	probably null
R2150:Dock2	UTSW	11	34,229,472 (GRCm38)	critical splice donor site	probably null
R2176:Dock2	UTSW	11	34,695,217 (GRCm38)	missense	probably benign	0.00
R2230:Dock2	UTSW	11	34,294,323 (GRCm38)	missense	probably damaging	0.99
R2508:Dock2	UTSW	11	34,312,485 (GRCm38)	missense	probably benign	0.04
R2875:Dock2	UTSW	11	34,718,885 (GRCm38)	missense	probably damaging	1.00
R2885:Dock2	UTSW	11	34,689,766 (GRCm38)	missense	probably damaging	1.00
R2910:Dock2	UTSW	11	34,232,910 (GRCm38)	splice site	probably benign
R3081:Dock2	UTSW	11	34,231,610 (GRCm38)	missense	probably benign
R3418:Dock2	UTSW	11	34,689,760 (GRCm38)	missense	probably damaging	1.00
R3552:Dock2	UTSW	11	34,720,960 (GRCm38)	missense	probably benign	0.22
R3731:Dock2	UTSW	11	34,708,895 (GRCm38)	missense	probably damaging	1.00
R3846:Dock2	UTSW	11	34,732,371 (GRCm38)	missense	possibly damaging	0.81
R4135:Dock2	UTSW	11	34,714,501 (GRCm38)	missense	possibly damaging	0.83
R4598:Dock2	UTSW	11	34,239,536 (GRCm38)	missense	probably damaging	1.00
R4599:Dock2	UTSW	11	34,239,536 (GRCm38)	missense	probably damaging	1.00
R4715:Dock2	UTSW	11	34,294,118 (GRCm38)	missense	probably damaging	1.00
R4722:Dock2	UTSW	11	34,695,471 (GRCm38)	missense	probably damaging	1.00
R4742:Dock2	UTSW	11	34,294,170 (GRCm38)	critical splice acceptor site	probably null
R4830:Dock2	UTSW	11	34,273,767 (GRCm38)	splice site	probably null
R4884:Dock2	UTSW	11	34,266,248 (GRCm38)	missense	probably damaging	1.00
R4990:Dock2	UTSW	11	34,695,251 (GRCm38)	missense	probably damaging	1.00
R5334:Dock2	UTSW	11	34,228,643 (GRCm38)	missense	probably benign	0.00
R5570:Dock2	UTSW	11	34,727,406 (GRCm38)	missense	probably damaging	1.00
R5602:Dock2	UTSW	11	34,254,391 (GRCm38)	missense	probably benign	0.16
R5681:Dock2	UTSW	11	34,249,836 (GRCm38)	missense	probably benign	0.06
R5809:Dock2	UTSW	11	34,262,445 (GRCm38)	missense	probably benign
R5860:Dock2	UTSW	11	34,256,562 (GRCm38)	missense	probably damaging	1.00
R6111:Dock2	UTSW	11	34,708,787 (GRCm38)	missense	probably damaging	0.99
R6155:Dock2	UTSW	11	34,294,123 (GRCm38)	missense	probably benign	0.06
R6156:Dock2	UTSW	11	34,247,789 (GRCm38)	missense	possibly damaging	0.51
R6173:Dock2	UTSW	11	34,262,388 (GRCm38)	missense	probably null	0.80
R6182:Dock2	UTSW	11	34,229,476 (GRCm38)	missense	probably damaging	0.97
R6188:Dock2	UTSW	11	34,503,396 (GRCm38)	missense	probably damaging	0.98
R6191:Dock2	UTSW	11	34,231,652 (GRCm38)	missense	possibly damaging	0.79
R6283:Dock2	UTSW	11	34,707,325 (GRCm38)	missense	probably damaging	0.99
R6395:Dock2	UTSW	11	34,232,874 (GRCm38)	missense	probably damaging	1.00
R6465:Dock2	UTSW	11	34,503,413 (GRCm38)	missense	probably damaging	1.00
R6500:Dock2	UTSW	11	34,362,822 (GRCm38)	missense	possibly damaging	0.76
R6561:Dock2	UTSW	11	34,687,538 (GRCm38)	missense	probably damaging	1.00
R6745:Dock2	UTSW	11	34,705,843 (GRCm38)	missense	probably damaging	1.00
R6745:Dock2	UTSW	11	34,705,842 (GRCm38)	missense	probably damaging	1.00
R6880:Dock2	UTSW	11	34,688,452 (GRCm38)	critical splice donor site	probably null
R6913:Dock2	UTSW	11	34,756,222 (GRCm38)	missense	probably damaging	1.00
R6997:Dock2	UTSW	11	34,464,922 (GRCm38)	missense	probably damaging	1.00
R7057:Dock2	UTSW	11	34,695,217 (GRCm38)	missense	probably benign	0.00
R7057:Dock2	UTSW	11	34,227,684 (GRCm38)	missense	probably benign	0.10
R7134:Dock2	UTSW	11	34,310,363 (GRCm38)	missense	probably benign	0.03
R7188:Dock2	UTSW	11	34,239,675 (GRCm38)	missense	possibly damaging	0.87
R7239:Dock2	UTSW	11	34,231,677 (GRCm38)	missense	probably benign	0.00
R7247:Dock2	UTSW	11	34,714,513 (GRCm38)	nonsense	probably null
R7250:Dock2	UTSW	11	34,695,293 (GRCm38)	missense	probably damaging	1.00
R7250:Dock2	UTSW	11	34,695,205 (GRCm38)	missense	probably benign	0.01
R7271:Dock2	UTSW	11	34,273,750 (GRCm38)	missense	possibly damaging	0.95
R7284:Dock2	UTSW	11	34,230,672 (GRCm38)	missense	probably benign	0.01
R7397:Dock2	UTSW	11	34,718,989 (GRCm38)	missense	probably benign	0.00
R7464:Dock2	UTSW	11	34,695,278 (GRCm38)	missense	probably damaging	0.99
R7512:Dock2	UTSW	11	34,312,542 (GRCm38)	missense	possibly damaging	0.95
R7556:Dock2	UTSW	11	34,720,951 (GRCm38)	missense	probably benign	0.43
R7663:Dock2	UTSW	11	34,721,027 (GRCm38)	missense	probably damaging	1.00
R7779:Dock2	UTSW	11	34,714,455 (GRCm38)	missense	probably benign	0.38
R7797:Dock2	UTSW	11	34,282,652 (GRCm38)	missense	probably damaging	0.98
R7855:Dock2	UTSW	11	34,273,698 (GRCm38)	missense	probably damaging	1.00
R7922:Dock2	UTSW	11	34,707,327 (GRCm38)	missense	probably benign	0.29
R7932:Dock2	UTSW	11	34,267,998 (GRCm38)	missense	probably benign	0.00
R8013:Dock2	UTSW	11	34,705,850 (GRCm38)	missense	probably damaging	0.96
R8192:Dock2	UTSW	11	34,732,339 (GRCm38)	critical splice donor site	probably null
R8244:Dock2	UTSW	11	34,695,453 (GRCm38)	missense	probably damaging	1.00
R8307:Dock2	UTSW	11	34,310,362 (GRCm38)	missense	possibly damaging	0.95
R8418:Dock2	UTSW	11	34,718,968 (GRCm38)	missense	probably benign	0.01
R8460:Dock2	UTSW	11	34,230,825 (GRCm38)	critical splice acceptor site	probably null
R8495:Dock2	UTSW	11	34,231,622 (GRCm38)	missense	probably benign	0.14
R8556:Dock2	UTSW	11	34,262,457 (GRCm38)	missense	possibly damaging	0.84
R8690:Dock2	UTSW	11	34,727,460 (GRCm38)	nonsense	probably null
R8743:Dock2	UTSW	11	34,273,252 (GRCm38)	nonsense	probably null
R8757:Dock2	UTSW	11	34,695,240 (GRCm38)	missense	probably benign	0.13
R8759:Dock2	UTSW	11	34,695,240 (GRCm38)	missense	probably benign	0.13
R8793:Dock2	UTSW	11	34,501,215 (GRCm38)	missense	probably benign	0.00
R8882:Dock2	UTSW	11	34,704,609 (GRCm38)	frame shift	probably null
R8885:Dock2	UTSW	11	34,310,396 (GRCm38)	missense	probably benign	0.01
R8943:Dock2	UTSW	11	34,708,819 (GRCm38)	missense	possibly damaging	0.63
R9171:Dock2	UTSW	11	34,698,843 (GRCm38)	missense	probably benign	0.12
R9182:Dock2	UTSW	11	34,310,398 (GRCm38)	missense	possibly damaging	0.51
R9203:Dock2	UTSW	11	34,731,539 (GRCm38)	missense	possibly damaging	0.92
R9310:Dock2	UTSW	11	34,294,139 (GRCm38)	missense	possibly damaging	0.71
R9388:Dock2	UTSW	11	34,262,460 (GRCm38)	missense	possibly damaging	0.70
R9490:Dock2	UTSW	11	34,698,755 (GRCm38)	missense	possibly damaging	0.90
R9568:Dock2	UTSW	11	34,708,811 (GRCm38)	missense	possibly damaging	0.83
R9593:Dock2	UTSW	11	34,228,607 (GRCm38)	missense	probably benign	0.34
R9694:Dock2	UTSW	11	34,268,054 (GRCm38)	missense	probably benign
R9697:Dock2	UTSW	11	34,254,417 (GRCm38)	missense	probably benign
R9753:Dock2	UTSW	11	34,273,673 (GRCm38)	missense	possibly damaging	0.68
R9783:Dock2	UTSW	11	34,258,128 (GRCm38)	missense	possibly damaging	0.83
X0017:Dock2	UTSW	11	34,266,271 (GRCm38)	missense	probably benign	0.08
X0018:Dock2	UTSW	11	34,232,833 (GRCm38)	missense	possibly damaging	0.65
X0058:Dock2	UTSW	11	34,256,564 (GRCm38)	missense	probably damaging	1.00
X0066:Dock2	UTSW	11	34,310,357 (GRCm38)	missense	possibly damaging	0.95
Z1088:Dock2	UTSW	11	34,692,382 (GRCm38)	missense	probably damaging	1.00
Z1088:Dock2	UTSW	11	34,438,300 (GRCm38)	missense	probably benign	0.14
Z1088:Dock2	UTSW	11	34,695,212 (GRCm38)	nonsense	probably null
Z1176:Dock2	UTSW	11	34,718,924 (GRCm38)	missense	probably benign	0.04
Z1177:Dock2	UTSW	11	34,312,553 (GRCm38)	missense	possibly damaging	0.68

Posted On

2013-03-25