Mutagenetix > Incidental Mutation

Incidental Mutation 'IGL01940:Vmn2r58'

180829

Institutional Source

Australian Phenomics Network (link to record)

Gene Symbol

Vmn2r58

Ensembl Gene

ENSMUSG00000090383

Gene Name

vomeronasal 2, receptor 58

Synonyms

EG628422

Accession Numbers

Essential gene?

Possibly non essential (E-score: 0.377) question?

Stock #

IGL01940

Quality Score

Status

Chromosome

Chromosomal Location

41486305-41522094 bp(-) (GRCm39)

Type of Mutation

missense

DNA Base Change (assembly)

A to G at 41487071 bp (GRCm39)

Zygosity

Heterozygous

Amino Acid Change

Valine to Alanine at position 608 (V608A)

Ref Sequence

ENSEMBL: ENSMUSP00000126966 (fasta)

Gene Model

predicted gene model for transcript(s): [ENSMUST00000171671]

AlphaFold

K7N6V2

Predicted Effect

probably benign
Transcript: ENSMUST00000171671
AA Change: V608A

PolyPhen 2 Score 0.002 (Sensitivity: 0.99; Specificity: 0.30)

SMART Domains

Protein: ENSMUSP00000126966
Gene: ENSMUSG00000090383
AA Change: V608A

Domain	Start	End	E-Value	Type
signal peptide	1	18	N/A	INTRINSIC
Pfam:ANF_receptor	77	471	8e-43	PFAM
Pfam:NCD3G	514	567	1.8e-23	PFAM
Pfam:7tm_3	597	835	2.9e-52	PFAM

Coding Region Coverage

Validation Efficiency

Allele List at MGI

Other mutations in this stock

Total: 37 list
Gene	Ref	Var	Chr/Loc	Mutation	Predicted Effect	Zygosity
Abca13	T	C	11: 9,517,661 (GRCm39)		probably benign	Het
Ahnak	A	T	19: 8,983,921 (GRCm39)	D1735V	probably benign	Het
Alkbh3	G	A	2: 93,811,940 (GRCm39)	T231I	probably damaging	Het
Ap4e1	T	C	2: 126,885,431 (GRCm39)	V344A	probably damaging	Het
Brip1	T	A	11: 85,955,792 (GRCm39)	D907V	probably benign	Het
Clca3a1	A	T	3: 144,452,737 (GRCm39)	M582K	probably benign	Het
Csf2	G	T	11: 54,140,351 (GRCm39)	P29H	probably damaging	Het
Cyp2d26	C	T	15: 82,676,758 (GRCm39)	R196H	probably benign	Het
Dagla	A	G	19: 10,229,535 (GRCm39)	V575A	probably benign	Het
Dimt1	T	A	13: 107,085,206 (GRCm39)		probably benign	Het
Ei24	A	T	9: 36,693,687 (GRCm39)	F288L	probably damaging	Het
Fam107a	T	C	14: 8,298,766 (GRCm38)	H120R	probably benign	Het
Fancl	G	T	11: 26,409,752 (GRCm39)	V203F	probably damaging	Het
Fgd6	T	A	10: 93,925,512 (GRCm39)		probably null	Het
Flrt2	A	G	12: 95,747,012 (GRCm39)	Y450C	probably damaging	Het
Gm21738	G	A	14: 19,416,979 (GRCm38)	S144L	probably benign	Het
Ift122	A	G	6: 115,864,332 (GRCm39)		probably benign	Het
Kcnk13	A	G	12: 100,027,683 (GRCm39)	S253G	probably benign	Het
Lcp1	A	T	14: 75,453,805 (GRCm39)	N469I	probably benign	Het
Lrrc24	T	C	15: 76,600,257 (GRCm39)	Y294C	probably damaging	Het
Odam	C	A	5: 88,035,192 (GRCm39)	S52Y	possibly damaging	Het
Or14j7	C	T	17: 38,235,177 (GRCm39)	T240I	probably damaging	Het
Or4a71	T	A	2: 89,358,154 (GRCm39)	N200I	probably damaging	Het
Or51i2	A	G	7: 103,689,129 (GRCm39)	N42S	probably damaging	Het
Pkd1	G	T	17: 24,798,720 (GRCm39)	R2676L	possibly damaging	Het
Plec	T	C	15: 76,064,529 (GRCm39)	D1915G	probably damaging	Het
Ptbp2	A	G	3: 119,519,764 (GRCm39)	V9A	possibly damaging	Het
Ptk2b	A	G	14: 66,396,062 (GRCm39)	I802T	probably benign	Het
Rabgap1	G	T	2: 37,377,079 (GRCm39)	A304S	probably damaging	Het
Sema3f	T	C	9: 107,560,896 (GRCm39)		probably benign	Het
Serpinb3a	A	T	1: 106,973,915 (GRCm39)	V332E	probably damaging	Het
Skil	T	A	3: 31,165,793 (GRCm39)	M370K	probably benign	Het
Slc25a1	T	A	16: 17,744,304 (GRCm39)	Y209F	probably benign	Het
Smim15	A	G	13: 108,184,164 (GRCm39)	K57E	probably damaging	Het
Taar3	T	A	10: 23,825,855 (GRCm39)	C134S	probably damaging	Het
Tns4	C	T	11: 98,959,047 (GRCm39)	S684N	probably benign	Het
Zbtb26	A	T	2: 37,325,987 (GRCm39)	C350S	possibly damaging	Het

Other mutations in Vmn2r58

Allele	Source	Chr	Coord	Type	Predicted Effect	PPH Score
IGL00089:Vmn2r58	APN	7	41,513,854 (GRCm39)	missense	possibly damaging	0.53
IGL00924:Vmn2r58	APN	7	41,486,891 (GRCm39)	missense	probably damaging	1.00
IGL01291:Vmn2r58	APN	7	41,513,935 (GRCm39)	missense	probably benign	0.02
IGL01480:Vmn2r58	APN	7	41,514,116 (GRCm39)	missense	probably benign	0.01
IGL01551:Vmn2r58	APN	7	41,514,703 (GRCm39)	missense	probably damaging	0.97
IGL01591:Vmn2r58	APN	7	41,514,753 (GRCm39)	missense	probably benign	0.03
IGL01994:Vmn2r58	APN	7	41,486,394 (GRCm39)	missense	probably damaging	0.98
IGL02041:Vmn2r58	APN	7	41,514,703 (GRCm39)	missense	probably damaging	0.97
IGL02222:Vmn2r58	APN	7	41,513,449 (GRCm39)	missense	possibly damaging	0.81
IGL02317:Vmn2r58	APN	7	41,486,765 (GRCm39)	missense	possibly damaging	0.89
IGL02614:Vmn2r58	APN	7	41,486,553 (GRCm39)	missense	probably damaging	1.00
IGL02673:Vmn2r58	APN	7	41,514,082 (GRCm39)	missense	possibly damaging	0.90
IGL03323:Vmn2r58	APN	7	41,511,295 (GRCm39)	missense	probably benign	0.06
IGL03337:Vmn2r58	APN	7	41,513,810 (GRCm39)	missense	possibly damaging	0.93
IGL03380:Vmn2r58	APN	7	41,513,874 (GRCm39)	missense	probably benign	0.00
ANU05:Vmn2r58	UTSW	7	41,513,935 (GRCm39)	missense	probably benign	0.02
R0138:Vmn2r58	UTSW	7	41,487,048 (GRCm39)	missense	probably damaging	1.00
R0141:Vmn2r58	UTSW	7	41,511,309 (GRCm39)	missense	probably benign	0.11
R0421:Vmn2r58	UTSW	7	41,514,628 (GRCm39)	missense	probably benign	0.02
R0604:Vmn2r58	UTSW	7	41,510,000 (GRCm39)	missense	possibly damaging	0.78
R0854:Vmn2r58	UTSW	7	41,486,562 (GRCm39)	missense	probably damaging	1.00
R1413:Vmn2r58	UTSW	7	41,513,387 (GRCm39)	missense	probably benign	0.01
R1441:Vmn2r58	UTSW	7	41,486,864 (GRCm39)	missense	probably damaging	1.00
R1678:Vmn2r58	UTSW	7	41,513,480 (GRCm39)	missense	probably benign	0.40
R1691:Vmn2r58	UTSW	7	41,486,913 (GRCm39)	missense	possibly damaging	0.95
R1699:Vmn2r58	UTSW	7	41,509,951 (GRCm39)	missense	probably benign
R1865:Vmn2r58	UTSW	7	41,486,682 (GRCm39)	missense	possibly damaging	0.95
R2008:Vmn2r58	UTSW	7	41,509,924 (GRCm39)	missense	probably damaging	1.00
R2036:Vmn2r58	UTSW	7	41,513,417 (GRCm39)	missense	probably benign
R2202:Vmn2r58	UTSW	7	41,513,594 (GRCm39)	missense	probably benign	0.07
R3787:Vmn2r58	UTSW	7	41,513,498 (GRCm39)	missense	probably benign	0.01
R3883:Vmn2r58	UTSW	7	41,513,914 (GRCm39)	nonsense	probably null
R3944:Vmn2r58	UTSW	7	41,513,885 (GRCm39)	missense	probably benign	0.03
R3949:Vmn2r58	UTSW	7	41,513,348 (GRCm39)	missense	probably benign	0.08
R4232:Vmn2r58	UTSW	7	41,487,011 (GRCm39)	missense	possibly damaging	0.91
R4409:Vmn2r58	UTSW	7	41,522,051 (GRCm39)	missense	possibly damaging	0.69
R4411:Vmn2r58	UTSW	7	41,511,360 (GRCm39)	missense	possibly damaging	0.85
R4413:Vmn2r58	UTSW	7	41,511,360 (GRCm39)	missense	possibly damaging	0.85
R4600:Vmn2r58	UTSW	7	41,522,046 (GRCm39)	missense	probably benign	0.03
R4610:Vmn2r58	UTSW	7	41,487,117 (GRCm39)	missense	probably benign
R4646:Vmn2r58	UTSW	7	41,509,935 (GRCm39)	missense	probably damaging	0.96
R4793:Vmn2r58	UTSW	7	41,514,495 (GRCm39)	missense	probably damaging	0.99
R4870:Vmn2r58	UTSW	7	41,486,639 (GRCm39)	missense	possibly damaging	0.76
R4981:Vmn2r58	UTSW	7	41,486,885 (GRCm39)	missense	probably damaging	1.00
R4993:Vmn2r58	UTSW	7	41,487,176 (GRCm39)	missense	probably benign	0.00
R5024:Vmn2r58	UTSW	7	41,513,746 (GRCm39)	missense	probably damaging	0.99
R5064:Vmn2r58	UTSW	7	41,486,534 (GRCm39)	missense	probably damaging	0.99
R5330:Vmn2r58	UTSW	7	41,513,384 (GRCm39)	nonsense	probably null
R5526:Vmn2r58	UTSW	7	41,522,069 (GRCm39)	missense	probably benign	0.01
R5980:Vmn2r58	UTSW	7	41,514,480 (GRCm39)	missense	possibly damaging	0.81
R6163:Vmn2r58	UTSW	7	41,486,825 (GRCm39)	missense	probably benign	0.31
R6365:Vmn2r58	UTSW	7	41,513,607 (GRCm39)	missense	probably benign	0.42
R6567:Vmn2r58	UTSW	7	41,514,673 (GRCm39)	missense	probably benign	0.34
R6594:Vmn2r58	UTSW	7	41,486,535 (GRCm39)	missense	possibly damaging	0.69
R6980:Vmn2r58	UTSW	7	41,513,662 (GRCm39)	missense	possibly damaging	0.64
R7373:Vmn2r58	UTSW	7	41,487,212 (GRCm39)	missense	probably damaging	1.00
R7458:Vmn2r58	UTSW	7	41,487,123 (GRCm39)	missense	probably benign	0.06
R7630:Vmn2r58	UTSW	7	41,513,611 (GRCm39)	missense	probably damaging	0.99
R7807:Vmn2r58	UTSW	7	41,521,910 (GRCm39)	missense	probably benign	0.05
R8114:Vmn2r58	UTSW	7	41,511,392 (GRCm39)	missense	probably damaging	1.00
R8232:Vmn2r58	UTSW	7	41,514,076 (GRCm39)	missense	probably damaging	0.97
R8313:Vmn2r58	UTSW	7	41,521,952 (GRCm39)	missense	probably benign	0.01
R8412:Vmn2r58	UTSW	7	41,513,722 (GRCm39)	missense	probably benign	0.01
R8530:Vmn2r58	UTSW	7	41,513,576 (GRCm39)	missense	probably damaging	1.00
R8851:Vmn2r58	UTSW	7	41,487,219 (GRCm39)	missense	probably benign
R8881:Vmn2r58	UTSW	7	41,486,609 (GRCm39)	missense	probably benign	0.05
R8936:Vmn2r58	UTSW	7	41,513,981 (GRCm39)	missense
R9045:Vmn2r58	UTSW	7	41,487,087 (GRCm39)	missense	probably benign	0.00
R9166:Vmn2r58	UTSW	7	41,513,431 (GRCm39)	missense	probably damaging	1.00
R9706:Vmn2r58	UTSW	7	41,510,000 (GRCm39)	missense	probably damaging	0.99
RF006:Vmn2r58	UTSW	7	41,486,383 (GRCm39)	frame shift	probably null
RF027:Vmn2r58	UTSW	7	41,486,383 (GRCm39)	frame shift	probably null
Z1176:Vmn2r58	UTSW	7	41,513,789 (GRCm39)	missense	probably benign	0.01

Posted On

2014-05-07